Synthetic two-way communication between mammalian cells

Nature Biotechnology

Volumn 30, Issue 10, 2012, Pages 991-996

  Bacchus, William ^a   Lang, Moritz ^a   El Baba, Marie Daoud ^b   Weber, Wilfried ^a,c   Stelling, Jörg ^a   Fussenegger, Martin ^a,d  

^a ETH ZURICH   (Switzerland)

^b Institut Universitaire de Technologie   (France)

^c UNIVERSITY OF FREIBURG   (Germany)

^d UNIVERSITY OF BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CONTROL DEVICE; INTERCELLULAR COMMUNICATIONS; MAMMALIAN CELLS; METABOLIC INFORMATION; METABOLIC SIGNALS; MULTI-CHANNEL NETWORK; MULTI-STEP; MULTICELLULAR ORGANISMS; TWO WAY COMMUNICATIONS; VASCULAR ENDOTHELIAL CELLS; VASCULATURE;

DATA PROCESSING; ENDOTHELIAL CELLS; METABOLISM; TISSUE ENGINEERING;

COMMUNICATION SYSTEMS;

ARTICLE; CELL COMMUNICATION; CELL ENGINEERING; CELL MEMBRANE PERMEABILITY; CELL METABOLISM; CONTROL SYSTEM; ENDOTHELIUM CELL; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SYNTHETIC BIOLOGY; TISSUE ENGINEERING; VASCULAR ENDOTHELIUM;

ALKALINE PHOSPHATASE; ANIMALS; BIOREACTORS; CELL COMMUNICATION; CELL COUNT; HEK293 CELLS; HELA CELLS; HUMANS; MAMMALS; MICE; NIH 3T3 CELLS; REPRODUCIBILITY OF RESULTS; SYNTHETIC BIOLOGY; TRYPTOPHAN;

EID: 84867340856     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.2351     Document Type: Article

References (30)

1. Weber, W., Daoud-El Baba, M. & Fussenegger, M. Synthetic ecosystems based on airborne inter- and intrakingdom communication. Proc. Natl. Acad. Sci. USA 104, 10435-10440 (2007). (Pubitemid 47185683)
2. Freeman, M. Feedback control of intercellular signalling in development. Nature 408, 313-319 (2000).
3. Thurston, G. et al. Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1. Science 286, 2511-2514 (1999). (Pubitemid 30026340)
4. Thurston, G. Complementary actions of VEGF and angiopoietin-1 on blood vessel growth and leakage. J. Anat. 200, 575-580 (2002). (Pubitemid 34823049)
5. Lee, S.W., Kim, W.J., Jun, H.O., Choi, Y.K. & Kim, K.W. Angiopoietin-1 reduces vascular endothelial growth factor-induced brain endothelial permeability via upregulation of ZO-2. Int. J. Mol. Med. 23, 279-284 (2009).
6. Guido, N.J. et al. A bottom-up approach to gene regulation. Nature 439, 856-860 (2006). (Pubitemid 43255704)
7. Gardner, T.S., Cantor, C.R. & Collins, J.J. Construction of a genetic toggle switch in Escherichia coli. Nature 403, 339-342 (2000). (Pubitemid 30062394)
8. Kramer, B.P. et al. An engineered epigenetic transgene switch in mammalian cells. Nat Biotechnol. 22, 867-870 (2004). (Pubitemid 38886606)
9. Auslander, S., Auslander, D., Muller, M., Wieland, M. & Fussenegger, M. Programmable single-cell mammalian biocomputers. Nature 487, 123-127 (2012).
10. Danino, T., Mondragon-Palomino, O., Tsimring, L. & Hasty, J. A synchronized quorum of genetic clocks. Nature 463, 326-330 (2010).
11. Weber, W. et al. A synthetic time-delay circuit in mammalian cells and mice. Proc. Natl. Acad. Sci. USA 104, 2643-2648 (2007). (Pubitemid 46327933)
12. Friedland, A.E. et al. Synthetic gene networks that count. Science 324, 1199-1202 (2009).
13. Tigges, M., Marquez-Lago, T.T., Stelling, J. & Fussenegger, M. A tunable synthetic mammalian oscillator. Nature 457, 309-312 (2009).
14. Weber, W. et al. A synthetic mammalian gene circuit reveals antituberculosis compounds. Proc. Natl. Acad. Sci. USA 105, 9994-9998 (2008).
15. Weber, W. & Fussenegger, M. Emerging biomedical applications of synthetic biology. Nat Rev. Genet. 13, 21-35 (2012).
16. Kemmer, C. et al. Self-suffcient control of urate homeostasis in mice by a synthetic circuit. Nat Biotechnol. 28, 355-360 (2010).
17. Ye, H., Daoud-El Baba, M., Peng, R.W. & Fussenegger, M. A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice. Science 332, 1565-1568 (2011).
18. Miki, T. et al. ATP-sensitive K+ channels in the hypothalamus are essential for the maintenance of glucose homeostasis. Nat Neurosci. 4, 507-512 (2001). (Pubitemid 32397188)
19. Yarilina, A., Park-Min, K.H., Antoniv, T., Hu, X. & Ivashkiv, L.B. TNF activates an IRF1-dependent autocrine loop leading to sustained expression of chemokines and STAT1-dependent type I interferon-response genes. Nat Immunol. 9, 378-387 (2008). (Pubitemid 351405107)
20. Tamsir, A., Tabor, J.J. & Voigt, C.A. Robust multicellular computing using genetically encoded NOR gates and chemical 'wires'. Nature 469, 212-215 (2011).
21. Regot, S. et al. Distributed biological computation with multicellular engineered networks. Nature 469, 207-211 (2011).
22. Chen, M.T. & Weiss, R. Artifcial cell-cell communication in yeast Saccharomyces cerevisiae using signaling elements from Arabidopsis thaliana. Nat Biotechnol. 23, 1551-1555 (2005). (Pubitemid 41752933)
23. Shou, W., Ram, S. & Vilar, J.M. Synthetic cooperation in engineered yeast populations. Proc. Natl. Acad. Sci. USA 104, 1877-1882 (2007). (Pubitemid 46239872)
24. Basu, S., Gerchman, Y., Collins, C.H., Arnold, F.H. & Weiss, R. A synthetic multicellular system for programmed pattern formation. Nature 434, 1130-1134 (2005). (Pubitemid 40663491)
25. Basu, S., Mehreja, R., Thiberge, S., Chen, M.T. & Weiss, R. Spatiotemporal control of gene expression with pulse-generating networks. Proc. Natl. Acad. Sci. USA 101, 6355-6360 (2004). (Pubitemid 38585978)
26. Hartman, S.C. & Mulligan, R.C. Two dominant-acting selectable markers for gene transfer studies in mammalian cells. Proc. Natl. Acad. Sci. USA 85, 8047-8051 (1988).
27. Akers, J.C. & Tan, M. Molecular mechanism of tryptophan-dependent transcriptional regulation in Chlamydia trachomatis. J. Bacteriol. 188, 4236-4243 (2006). (Pubitemid 43865743)
28. Weber, W. et al. Gas-inducible transgene expression in mammalian cells and mice. Nat Biotechnol. 22, 1440-1444 (2004). (Pubitemid 39482865)
29. Schlatter, S., Rimann, M., Kelm, J. & Fussenegger, M. SAMY, a novel mammalian reporter gene derived from Bacillus stearothermophilus alpha-amylase. Gene 282, 19-31 (2002). (Pubitemid 34117558)
30. Lee, S.W. et al. SSeCKS regulates angiogenesis and tight junction formation in blood-brain barrier. Nat Med. 9, 900-906 (2003).