Stem cell-based delivery of Hypoxamir-210 to the infarcted heart: Implications on stem cell survival and preservation of infarcted heart function

Journal of Molecular Medicine

Volumn 90, Issue 9, 2012, Pages 997-1010

  Kim, Ha Won ^a   Jiang, Shujia ^a   Ashraf, Muhammad ^a   Haider, Khawaja Husnain ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Connexin 43; miR 210; Myocardium; Preconditioning; Stem cells

Indexed keywords

HYPOXAMIR 210; MICRORNA 210; NANOPARTICLE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; COCULTURE; CONTROLLED STUDY; GAP JUNCTION; GENE EXPRESSION; GENE INDUCTION; GENETIC TRANSFECTION; HEART FUNCTION; HEART INFARCTION; HEART MUSCLE CELL; ISCHEMIC PRECONDITIONING; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; NONHUMAN; RAT; RNA ANALYSIS;

ANIMALS; CELL SURVIVAL; CELLS, CULTURED; COCULTURE TECHNIQUES; FEMALE; GAP JUNCTIONS; GENE TRANSFER TECHNIQUES; HEART; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; MICRORNAS; MYOCARDIAL INFARCTION; MYOCYTES, CARDIAC; RATS; RATS, INBRED F344; UP-REGULATION;

EID: 84867330674     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-012-0920-1     Document Type: Article

References (31)

1. Lau NC, Lim LP, Weinstein EG, Bartel DP (2001) An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science 294:858-862
2. Rane S, Sayed D, Abdellatif M (2007) MicroRNA with a Macro-Function. Cell Cycle 6:1850-1855
3. Semenza GL, Agani F, Feldser D, Iyer N, Kotch L, Laughner E, Yu A (2000) Hypoxia, HIF-1, and the pathophysiology of common human diseases. Adv Exp Med Biol 475:123-130
4. Ivan M, Harris AL, Martelli F, Kulshreshtha R (2008) Hypoxia response and microRNAs: no longer two separate worlds. J Cell Mol Med 12:1426-1431
5. Haider KH, Kim HW, Ashraf M (2009) Hypoxia-inducible factor-1alpha in stem cell preconditioning: mechanistic role of hypoxia-related micro-RNAs. J Thorac Cardiovasc Surg 138:257
6. Kulshreshtha R, Ferracin M, Negrini M, Calin GA, Davuluri RV, Ivan M (2007) Regulation of microRNA expression: the hypoxic component. Cell Cycle 6:1426-1431
7. Fasanaro P, D'Alessandra Y, Di Stefano V, Melchionna R, Romani S, Pompilio G, Capogrossi MC, Martelli F (2008) MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand Ephrin-A3. J Biol Chem 283:15878-15883
8. Mathew LK, Simon MC (2009) mir-210: a sensor for hypoxic stress during tumorigenesis. Mol Cell 35:737-738
9. Huang X, Le QT, Giaccia AJ (2010) MiR-210-micromanager of the hypoxia pathway. Trends Mol Med 16:230-237
10. Lu G, Haider HK, Jiang S, Ashraf M (2009) Sca-1+ stem cell survival and engraftment in the infarcted heart: dual role for preconditioning-induced connexin-43. Circulation 119:2587-2596
11. Suzuki Y, Kim HW, Ashraf M, Haider H (2011) Diazoxide potentiates mesenchymal stem cell survival via NF-kappaB-dependent miR-146a expression by targeting Fas. Am J Physiol Heart Circ Physiol 299:H1077-H1082
12. Lu G, Jiang S., Ashraf, M., Haider, KH (2012) Sub-cellular preconditioning of stem cells: mitochondrial targeting of connexin-43 transgene is cytoprotective and involves shift of balance between mitochondrial Bak and Bcl-xL. Regen Med 7(3):323-334
13. Haider H, Ashraf M (2010) Preconditioning and stem cell survival. J Cardiovasc Transl Res 3:89-102
14. Kim HW, Haider HK, Jiang S, Ashraf M (2009) Ischemic preconditioning augments survival of stem cells via miR-210 expression by targeting caspase-8-associated protein 2. J Biol Chem 284:33161-33168
15. Haider KH, Idris NM, Kim HW, Ahmed RP, Shujia J, Ashraf M (2010) MicroRNA-21 is a key determinant in IL-11/Stat3 antiapoptotic signalling pathway in preconditioning of skeletal myoblasts. Cardiovasc Res 88:168-178
16. Ye L, Haider H, Tan R, Toh W, Law PK, Tan W, Su L, Zhang W, Ge R, Zhang Y et al (2007) Transplantation of nanoparticle transfected skeletal myoblasts overexpressing vascular endothelial growth factor-165 for cardiac repair. Circulation 116:I113-I120
17. Chan SY, Loscalzo J (2010) MicroRNA-210: a unique and pleiotropic hypoxamir. Cell Cycle 9:1072-1083
18. Zhu XM, Han T, Sargent IL, Yin GW, Yao YQ (2009) Differential expression profile of microRNAs in human placentas from preeclamptic pregnancies vs normal pregnancies. Am J Obstet Gynecol 200(661):e1-e7
19. Camps C, Buffa FM, Colella S, Moore J, Sotiriou C, Sheldon H, Harris AL, Gleadle JM, Ragoussis J (2008) hsa-miR-210 is induced by hypoxia and is an independent prognostic factor in breast cancer. Clin Cancer Res 14:1340-1348
20. Giannakakis A, Sandaltzopoulos R, Greshock J, Liang S, Huang J, Hasegawa K, Li C, O'Brien-Jenkins A, Katsaros D, Weber BL et al (2008) miR-210 links hypoxia with cell cycle regulation and is deleted in human epithelial ovarian cancer. Cancer Biol Ther 7:255-264
21. Pulkkinen K, Malm T, Turunen M, Koistinaho J, Yla-Herttuala S (2008) Hypoxia induces microRNA miR-210 in vitro and in vivo ephrin-A3 and neuronal pentraxin 1 are potentially regulated by miR-210. FEBS Lett 582:2397-2401
22. Crosby ME, Kulshreshtha R, Ivan M, Glazer PM (2009) Micro-RNA regulation of DNA repair gene expression in hypoxic stress. Cancer Res 69:1221-1229
23. Hu S, Huang M, Li Z, Jia F, Ghosh Z, Lijkwan MA, Fasanaro P, Sun N, Wang X, Martelli F et al (2010) MicroRNA-210 as a novel therapy for treatment of ischemic heart disease. Circulation 122:S124-S131
24. Muralidharan-Chari V, Clancy JW, Sedgwick A, D'Souza-Schorey C (2010) Microvesicles: mediators of extracellular communication during cancer progression. J Cell Sci 123:1603-1611
25. Valiunas V, Polosina YY, Miller H, Potapova IA, Valiuniene L, Doronin S, Mathias RT, Robinson RB, Rosen MR, Cohen IS et al (2005) Connexin-specific cell-to-cell transfer of short interfering RNA by gap junctions. J Physiol 568:459-468
26. Kizana E, Cingolani E, Marban E (2009) Non-cell-autonomous effects of vector-expressed regulatory RNAs in mammalian heart cells. Gene Ther 16:1163-1168
27. Hosoda T, Zheng H, Cabral-da-Silva M, Sanada F, Ide-Iwata N, Ogorek B, Ferreira-Martins J, Arranto C, D'Amario D, Del Monte F et al (2011) Human cardiac stem cell differentiation is regulated by a mircrine mechanism. Circulation 123:1287-1296
28. Lim PK, Bliss SA, Patel SA, Taborga M, Dave MA, Gregory LA, Greco SJ, Bryan M, Patel PS, Rameshwar P (2011) Gap junctionmediated import of microrna from bone marrow stromal cells can elicit cell cycle quiescence in breast cancer cells. Cancer Res 71:1550-1560
29. Barcaroli D, Bongiorno-Borbone L, Terrinoni A, Hofmann TG, Rossi M, Knight RA, Matera AG, Melino G, De Laurenzi V (2006) FLASH is required for histone transcription and S-phase progression. Proc Natl Acad Sci USA 103:14808-14812
30. Milovic-Holm K, Krieghoff E, Jensen K, Will H, Hofmann TG (2007) FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies. EMBO J 26:391-401
31. Kim HW, Mallick F, Durrani S, Ashraf M, Jiang S, Haider KH (2012) Concomitant activation of miR-107/PDCD10 and hypoxamir-210/Casp8ap2 and their role in cytoprotection during ischemic preconditioning of stem cells. Antioxid Redox Signal. doi:10.1089/ars.2012.4518