HLA-DQ typing in the diagnostic algorithm of celiac disease

Revista Espanola de Enfermedades Digestivas

Volumn 104, Issue 5, 2012, Pages 248-254

  Piccini, Barbara ^a   Vascotto, Marina ^a   Serracca, Lucia ^a   Luddi, Alice ^a   Margollicci, Maria Antonietta ^a   Balestri, Paolo ^a   Vindigni, Carla ^a   Bassotti, Gabrio ^b   Villanacci, Vincenzo ^c  

^a UNIVERSITY OF SIENA   (Italy)

^b UNIVERSITY OF PERUGIA   (Italy)

^c Spedali Civili of Brescia ^*  (Italy)

Author keywords

Celiac disease; Children; HLA heterodimer; MHC class II; Relative risk

Indexed keywords

HETERODIMER; HLA DQ ANTIGEN; HLA DQ2 ALPHA5 ANTIGEN; HLA DQ2 ANTIGEN; HLA DQ2 BETA ANTIGEN; HLA DQ8 ANTIGEN; HLA DQB1 ANTIGEN; UNCLASSIFIED DRUG;

ALGORITHM; ARTICLE; CELIAC DISEASE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE COURSE; DR DQ GENE; FAMILIAL DISEASE; FEMALE; GENE; GENETIC PREDISPOSITION; GENETIC RISK; HETEROZYGOSITY; HLA TYPING; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; PARENT; RISK ASSESSMENT; SIBLING; ADOLESCENT; CASE CONTROL STUDY; CHILD; EVALUATION; GENETIC MARKER; GENETICS; HISTOCOMPATIBILITY TEST; RETROSPECTIVE STUDY;

ADOLESCENT; ALGORITHMS; CASE-CONTROL STUDIES; CELIAC DISEASE; CHILD; FEMALE; GENETIC MARKERS; HISTOCOMPATIBILITY TESTING; HLA-DQ ANTIGENS; HUMANS; MALE; RETROSPECTIVE STUDIES;

EID: 84867320824     PISSN: 11300108     EISSN: None     Source Type: Journal    
DOI: 10.4321/S1130-01082012000500005     Document Type: Article

References (30)

1. Koning F. Celiac disease: Caught between a rock and a hard place. Gastroenterol 2005;129:1294-301.
2. Alarida K, Harown J, Di Pierro MR, Drago S, Catassi C. HLA-DQ2 and -DQ8 genotypes in celiac and healthy Libyan children. Dig Liver Dis 2010;42:425-7.
3. Vermeulen BA, Hogen Esch CE, Yuksel Z, Koning F, Verduijn W, Doxiadis II, et al. Phenotypic variance in childhood coeliac disease and the HLA-DQ/DR dose effect. Scand J Gatroenterol 2009;44:40-5.
4. Green PH, Cellier C. Celiac disease. N Engl J Med 2007;357:1731-43.
5. Nenna R, Mora B, Megiorni F, Mazzilli MC, Magliocca FM, Tiberti C, et al. HLA-DQB1.02 dose effect on RIA anti-tissue transglutaminase autoantibody levels and clinicopathological expressivity of celiac disease. J Pediatr Gastroenterol Nutr 2008;47:288-92.
6. Setty M, Guandalini S. Celiac disease. Mol Diag Ther 2008;12:289-98.
7. Rodrigo L, Alvarez N, Salas-Puig J, Hernández-Lahoz C. Angelman syndrome and celiac disease. Rev Esp Enferm Dig 2010;102:450-1.
8. Hill ID, Dirks MH, Liptak GS, Colletti RB, Fasano A, Guandalini S, et al. Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North America Society for Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr 2005;40:1-19.
9. Revised criteria for diagnosis of coeliac disease. Report of working group of European Society of Pediatric Gastroenterology and Nutrition. Arch Dis Child 1990;65:909-11.
10. Megiorni F, Mora B, Bonamico M, Barbato M, Nenna R, Maiella G, et al. HLA-DQ and risk gradient for celiac disease. Hum Immunol 2009;70:55-9.
11. Bourgey M, Calcagno G, Tinto N, Gennarelli D, Margaritte-Jeannin P, Greco L, et al. HLA related genetic risk for celiac disease. Gut 2007;56:1054-9.
12. Margaritte-Jeannin P, Babron MC, Bourgey M, Louka AS, Clot F, Percopo S, et al. HLA-DQ relative risks for coeliac disease in European populations: a study of the European Genetics Cluster on Coeliac Disease. Tiss Antig 2004;63:562-7.
13. Rodrigo-Sáez L, Fuentes-Álvarez D, Pérez-Martínez I, Alvarez-Mieres N, Niño-García P, de-Francisco-García R, et al. Differences between pediatric and adult celiac disease. Rev Esp Enferm Dig 2011;103:238-44.
14. Marsh MN. Gluten, major histocompatibility complex and the small intestine. Gastroenterol 1992;102:330-54.
15. Corazza GR, Villanacci V. Coeliac Disease. Some considerations on the histological classification. J Clin Pathol 2005;58:573-4.
16. Liu E, Rewers M, Eisenbarth GS. Genetic testing: who should do the testing and what is the role of genetic testing in the setting of celiac disease? Gatroenterol 2005;128:S33-S37.
17. Karrel K, Louka AS, Moodie SJ, Ascher H, Clot F, Greco L, et al. HLA types in celiac disease patients not carrying the DQA1*05-DQB1*02 (DQ2) heterodimer: Results from the European Genetic Cluster on Coeliac Disease. Hum Immunol 2003;64:469-77.
18. Pietzak M, Schofield TC, Mcginniss M, Nakamura RM. Stratifying risk for celiac disease in a large at risk united states population by using HLA alleles. Clin Gastroenterol Hepatol 2009;7:966-71.
19. Wolters VM, Wijmenga C. Genetic background of celiac disease and its clinical implications. Am J Gastroenterol 2008;103:190-5.
20. Van Heel DA, Hunt K, Greco L, Wijmenga C. Genetics in celiac disease. Best Pract Res Clin Gastroenterol 2005;19:323-39.
21. Dubois PC, van Heel DA. Translational mini-review series on the immunogenetics of gut disease: Immunogenetics of coeliac disease. Clin and Exper Immunol 2008;153:162-73.
22. Stepniak D, Wiesner M, de Ru AH, Moustakas AK, Drijfhout JW, Papadopoulos GK, et al. Large-scale characterization of natural ligands explains the unique gluten-binding properties of HLA-DQ2. J Immunol 2008;180:3268-78.
23. Chang M, Green PH. Genetic testing before serologic screening in relatives of patients with celiac disease as a cost containment method. J Clin Gastroenterol 2009;43:43-50.
24. Goldberg D, Fasano A. Screening for celiac disease in family members: is follow-up testing necessary? Dig Dis Sci 2007;52:1082-6.
25. Bonamico M, Ferri M, Mariani P, Nenna R, Thanasi E, Luparia RP, et al. Serologic and genetic markers of celiac disease: a sequential study in the screening of first degree relatives. J Pediatr Gastroenterol Nut 2006;42:150-4.
26. Mustalahti K, Holopainen P, Karell K, Mäki M, Partanen J. Genetic dissection between silent and clinically diagnosed symptomatic forms of coeliac disease in multiplex families. Dig Liver Dis 2002;34: 842-5.
27. Karinen H, Kärkkäinen P, Pihlajamäki J, Janatuinen E, Heikkinen M, Julkunen R, et al. Gene dose effect of the DQB1*0201 allele contributes to severity of coeliac disease. Scand J Gastroenterol 2006;41:191-9.
28. Cerf-Bensussan N. Autoimmunity and diet. Nestle Nutr Workshop Ser Pediatr Program 2009;64:91-104.
29. Norris JM, Barriga K, Hoffenberg EJ, Taki I, Miao D, Haas JE, et al. Risk of celiac disease autoimmunity and timing of gluten introduction in the diet of infants at increased risk of disease. JAMA 2005;293: 2343-51.
30. Romanos J, Van Diemen CC, Nolte IM, Trynka G, Zhernakova A, Fu J, et al. Analysis of HLA and Non-HLA Alleles Can Identify Individuals at High Risk for Celiac Disease. Gastroenterology 2009; 137:834-40.