Homocysteine-impaired angiogenesis is associated with VEGF/VEGFR inhibition

Frontiers in Bioscience - Elite

Volumn 4 E, Issue 7, 2012, Pages 2525-2535

  Zhang, Quan ^a   Li, Qian ^a   Chen, Yu ^b   Huang, Xiao ^c,d   Yang, Irene Hwa ^e   Cao, Lu ^a   Wu, Wei Kang ^a   Tan, Hong Mei ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

^c TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d NANCHANG UNIVERSITY   (China)

^e YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adenosine; Angiogenesis; Homocysteine; VEGF; Zebrafish

Indexed keywords

ADENOSINE; HOMOCYSTEINE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN KINASE B; RECOMBINANT VASCULOTROPIN; VASCULOTROPIN; VASCULOTROPIN RECEPTOR; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; PRIMER DNA; VASCULOTROPIN A;

ANGIOGENESIS; ANTIANGIOGENIC ACTIVITY; ARTICLE; CELL COUNT; CELL GROWTH; CELL LEVEL; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DNA METHYLATION; EMBRYO; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; MIGRATION INHIBITION; PROTEIN CONTENT; UMBILICAL VEIN ENDOTHELIAL CELL; ZEBRA FISH; ANIMAL; CELL CULTURE; CELL CYCLE; CELL MOTION; CYTOLOGY; DRUG ANTAGONISM; GENETICS; METABOLISM; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; VASCULAR ENDOTHELIUM;

DANIO RERIO;

ANIMALS; BASE SEQUENCE; CELL CYCLE; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; DNA PRIMERS; ENDOTHELIUM, VASCULAR; HOMOCYSTEINE; HUMANS; NEOVASCULARIZATION, PHYSIOLOGIC; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; RNA, MESSENGER; VASCULAR ENDOTHELIAL GROWTH FACTOR A; ZEBRAFISH;

EID: 84867307869     PISSN: 19450494     EISSN: 19450508     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. S R Lentz: Mechanisms of homocysteine-induced atherothrombosis. J Thromb Haemost, 3(8), 1646-54 (2005) (Pubitemid 41716550)
2. H McNulty, K Pentieva, L Hoey and M Ward: Homocysteine, B-vitamins and CVD. Proc Nutr Soc, 67(2), 232-7 (2008) (Pubitemid 351543405)
3. X Jiang, F Yang, H Tan, D Liao, R M Bryan Jr, J K Randhawa, R E Rumbaut, W Durante, A I Schafer, X Yang and H Wang: Hyperhomocystinemia impairs endothelial function and eNOS activity via PKC activation. Arterioscler Thromb Vasc Biol, 25(12), 2515-21 (2005) (Pubitemid 43732272)
4. H Tan, X Jiang, F Yang, Z Li, D Liao, J Trial, M J Magera, W Durante, X Yang and H Wang: Hyperhomocysteinemia inhibits post-injury reendothelialization in mice. Cardiovasc Res, 69(1), 253-62 (2006) (Pubitemid 41818973)
5. T T Yan, Q Li, X H Zhang, W K Wu, J Sun, L Li, Q Zhang and H M Tan: Homocysteine impaired endothelial function through compromised vascular endothelial growth factor/Akt/endothelial nitric oxide synthase signalling. Clin Exp Pharmacol Physiol, 37(11), 1071-7 (2010)
6. D Liao, H Tan, R Hui, Z Li, X Jiang, J Gaubatz, F Yang, W Durante, L Chan, A I Schafer, H J Pownall, X Yang and H Wang: Hyperhomocysteinemia decreases circulating high-density lipoprotein by inhibiting apolipoprotein A-I Protein synthesis and enhancing HDL cholesterol clearance. Circ Res, 99(6), 598-606 (2006) (Pubitemid 44401451)
7. M Kumar, N Tyagi, K S Moshal, U Sen, S Kundu, P K Mishra, S Givvimani and S C Tyagi: Homocysteine decreases blood flow to the brain due to vascular resistance in carotid artery. Neurochem Int, 53(6-8), 214-9 (2008)
8. M Kumar, N Tyagi, K S Moshal, U Sen, S B Pushpakumar, T Vacek, D Lominadze and S C Tyagi: GABAA receptor agonist mitigates homocysteine-induced cerebrovascular remodeling in knockout mice. Brain Res, 1221, 147-53 (2008)
9. X Liu, J Shen, R Zhan, X Wang, Z Zhang, X Leng, Z Yang and L Qian: Proteomic analysis of homocysteine induced proliferation of cultured neonatal rat vascular smooth muscle cells. Biochim Biophys Acta, 1794(2), 177-84 (2009)
10. J Duan, T Murohara, H Ikeda, K Sasaki, S Shintani, T Akita, T Shimada and T Imaizumi: Hyperhomocysteinemia impairs angiogenesis in response to hindlimb ischemia. Arterioscler Thromb Vasc Biol, 20(12), 2579-85 (2000)
11. K S Latacha and T H Rosenquist: Homocysteine inhibits extra-embryonic vascular development in the avian embryo. Dev Dyn, 234(2), 323-31 (2005) (Pubitemid 41369141)
12. Y Nagai, H Tasaki, H Takatsu, S Nihei, K Yamashita, T Toyokawa and Y Nakashima: Homocysteine inhibits angiogenesis in vitro and in vivo. Biochem Biophys Res Commun, 281(3), 726-31 (2001) (Pubitemid 32917861)
13. S Jesmin, C N Mowa, S N Sultana, S Mia, R Islam, S Zaedi, I Sakuma, Y Hattori, M Hiroe and N Yamaguchi: Estrogen receptor alpha and beta are both involved in the cerebral VEGF/Akt/NO pathway and cerebral angiogenesis in female mice. Biomed Res, 31(6), 337-46 (2010)
14. M S Jamaluddin, X Yang and H Wang: Hyperhomocysteinemia, DNA methylation and vascular disease. Clin Chem Lab Med, 45(12), 1660-6 (2007) (Pubitemid 350232976)
15. R Castro, I Rivera, E A Struys, E E Jansen, P Ravasco, M E Camilo, H J Blom, C Jakobs and I Tavares de Almeida: Increased homocysteine and Sadenosylhomocysteine concentrations and DNA hypomethylation in vascular disease. Clin Chem, 49(8), 1292-6 (2003) (Pubitemid 36900615)
16. S Zaina, M W Lindholm and G Lund: Nutrition and aberrant DNA methylation patterns in atherosclerosis: more than just hyperhomocysteinemia? J Nutr, 135(1), 5-8 (2005) (Pubitemid 40094312)
17. R D Starke, F Ferraro, K E Paschalaki, N H Dryden, T A McKinnon, R E Sutton, E M Payne, D O Haskard, A D Hughes, D F Cutler, M A Laffan and A M Randi: Endothelial von Willebrand factor regulates angiogenesis. Blood, 117(3), 1071-80 (2011)
18. R Benelli and A Albini: In vitro models of angiogenesis: the use of Matrigel. Int J Biol Markers, 14(4), 243-6 (1999) (Pubitemid 30064176)
19. M Raghunath, Y Sy Wong, M Farooq and R Ge: Pharmacologically induced angiogenesis in transgenic zebrafish. Biochem Biophys Res Commun, 378(4), 766-71 (2009)
20. H W Lam, H C Lin, S C Lao, J L Gao, S J Hong, C W Leong, P Y Yue, Y W Kwan, A Y Leung, Y T Wang and S M. Lee: The angiogenic effects of Angelica sinensis extract on HUVEC in vitro and zebrafish in vivo. J Cell Biochem, 103(1), 195-211 (2008)
21. P Y Chang, S C Lu, C M. Lee, Y J Chen, T A Dugan, W H Huang, S F Chang, W S Liao, C H Chen and Y T Lee: Homocysteine inhibits arterial endothelial cell growth through transcriptional downregulation of fibroblast growth factor-2 involving G protein and DNA methylation. Circ Res, 102(8), 933-41 (2008) (Pubitemid 351591555)
22. C J Corrigan, W Wang, Q Meng, C Fang, H Wu, V Reay, Z Lv, Y Fan, Y An, Y H Wang, Y J Liu, T H Lee and S Ying: T-helper cell type 2 (Th2) memory T cellpotentiating cytokine IL-25 has the potential to promote angiogenesis in asthma. Proc Natl Acad Sci U S A, 108(4), 1579-84 (2011)
23. S S Kang, P W Wong and M R Malinow: Hyperhomocyst(e)inemia as a risk factor for occlusive vascular disease. Annu Rev Nutr, 12, 279-98 (1992)
24. S G Heil, A S De Vriese, L A Kluijtmans, S Mortier, M Den Heijer and H J Blom: The role of hyperhomocysteinemia in nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF)- mediated vasodilatation. Cell Mol Biol (Noisy-le-grand), 50(8), 911-6 (2004)
25. D Lang, M B Kredan, S J Moat, S A Hussain, C A Powell, M F Bellamy, H J Powers and M J Lewis: Homocysteine-induced inhibition of endotheliumdependent relaxation in rabbit aorta: role for superoxide anions. Arterioscler Thromb Vasc Biol, 20(2), 422-7 (2000) (Pubitemid 30086099)
26. M C Stuhlinger, P S Tsao, J H Her, M Kimoto, R F Balint and J P Cooke: Homocysteine impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine. Circulation, 104(21), 2569-75 (2001) (Pubitemid 33104795)
27. J Loscalzo: The oxidant stress of hyperhomocyst(e)inemia. J Clin Invest, 98(1), 5-7 (1996)
28. M D Jamaluddin, I Chen, F Yang, X Jiang, M Jan, X Liu, A I Schafer, W Durante, X Yang and H Wang: Homocysteine inhibits endothelial cell growth via DNA hypomethylation of the cyclin A gene. Blood, 110(10), 3648-55 (2007) (Pubitemid 350159633)
29. H Wang, X Jiang, F Yang, G B Chapman, W Durante, N E Sibinga and A I Schafer: Cyclin A transcriptional suppression is the major mechanism mediating homocysteine-induced endothelial cell growth inhibition. Blood, 99(3), 939-45 (2002) (Pubitemid 34525556)
30. L M Ellis, W Liu, S A Ahmad, F Fan, Y D Jung, R M Shaheen and N Reinmuth: Overview of angiogenesis: Biologic implications for antiangiogenic therapy. Semin Oncol, 28(5 Suppl 16), 94-104 (2001) (Pubitemid 33065115)
31. N D Lawson and B M Weinstein: In vivo imaging of embryonic vascular development using transgenic zebrafish. Dev Biol, 248(2), 307-18 (2002) (Pubitemid 35002091)
32. L M Cross, M A Cook, S Lin, J N Chen and A L Rubinstein: Rapid analysis of angiogenesis drugs in a live fluorescent zebrafish assay. Arterioscler Thromb Vasc Biol, 23(5), 911-2 (2003) (Pubitemid 36566186)
33. J Favier and P Corvol: [Physiological angiogenesis]. Therapie, 56(5), 455-63 (2001) (Pubitemid 34027017)
34. N Ferrara: The role of VEGF in the regulation of physiological and pathological angiogenesis. EXS(94), 209-31 (2005)
35. P Carmeliet, V Ferreira, G Breier, S Pollefeyt, L Kieckens, M Gertsenstein, M Fahrig, A Vandenhoeck, K Harpal, C Eberhardt, C Declercq, J Pawling, L Moons, D Collen, W Risau and A Nagy: Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature, 380(6573), 435-9 (1996) (Pubitemid 26102719)
36. L E Harry and E M Paleolog: From the cradle to the clinic: VEGF in developmental, physiological, and pathological angiogenesis. Birth Defects Res C Embryo Today, 69(4), 363-74 (2003) (Pubitemid 38076459)
37. A K Olsson, A Dimberg, J Kreuger and L Claesson- Welsh: VEGF receptor signalling - in control of vascular function. Nat Rev Mol Cell Biol, 7(5), 359-71 (2006)
38. S Shastry, N Tyagi, M R Hayden and S C Tyagi: Proteomic analysis of homocysteine inhibition of microvascular endothelial cell angiogenesis. Cell Mol Biol (Noisy-le-grand), 50(8), 931-7 (2004)
39. M Maeda, I Yamamoto, Y Fujio and J Azuma: Homocysteine induces vascular endothelial growth factor expression in differentiated THP-1 macrophages. Biochim Biophys Acta, 1623(1), 41-6 (2003) (Pubitemid 37098289)
40. C N Roybal, S Yang, C W Sun, D Hurtado, D L Vander Jagt, T M Townes and S F Abcouwer: Homocysteine increases the expression of vascular endothelial growth factor by a mechanism involving endoplasmic reticulum stress and transcription factor ATF4. J Biol Chem, 279(15), 14844-52 (2004) (Pubitemid 38618874)
41. R Srinivasan, T Zabuawala, H Huang, J Zhang, P Gulati, S Fernandez, J C Karlo, G E Landreth, G Leone and M C Ostrowski: Erk1 and Erk2 regulate endothelial cell proliferation and migration during mouse embryonic angiogenesis. PLoS One, 4(12), e8283 (2009)
42. B Elayappan, H Ravinarayannan, S P Sardar Pasha, K J Lee and S Gurunathan: Retraction Note: PEDF inhibits VEGF- and EPO- induced angiogenesis in retinal endothelial cells through interruption of PI3K/Akt phosphorylation. Angiogenesis,14(3),407 (2011)
43. Z Liang, J Brooks, M Willard, K.Liang, Y Yoon, S Kang and H Shim: CXCR4/CXCL12 axis promotes VEGFmediated tumor angiogenesis through Akt signaling pathway. Biochem Biophys Res Commun, 359(3), 716-22 (2007) (Pubitemid 46908803)
44. R Adya, B K Tan, A Punn, J Chen and H S Randeva: Visfatin induces human endothelial VEGF and MMP-2/9 production via MAPK and PI3K/Akt signalling pathways: novel insights into visfatin-induced angiogenesis. Cardiovasc Res, 78(2), 356-65 (2008) (Pubitemid 351556097)
45. B H Chung, J D Kim, C K Kim, J H Kim, M H Won, H S Lee, M S Dong, K S Ha, Y G Kwon and Y M Kim: Icariin stimulates angiogenesis by activating the MEK/ERK- and PI3K/Akt/eNOS-dependent signal pathways in human endothelial cells. Biochem Biophys Res Commun, 376(2), 404-8 (2008)