How to use the IUPHAR receptor database to navigate pharmacological data

Methods in Molecular Biology

Volumn 897, Issue , 2012, Pages 15-29

  Mpamhanga, Chidochangu P ^a   Sharman, Joanna L ^a   Harmar, Anthony J ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Biocuration; Database; Drug target; Experimental tool; GPCR; Ion channel; Ligand; Nuclear receptor; Pharmacology; Receptor

Indexed keywords

ION CHANNEL; LIGAND; RECEPTOR;

ARTICLE; CLINICAL PHARMACOLOGY; DATA BASE; DRUG INFORMATION; DRUG NOMENCLATURE; HEALTH CARE PLANNING; HUMAN; INTERNET; MEDICAL LITERATURE; ONLINE SYSTEM; PRIORITY JOURNAL; WEB BROWSER; ANIMAL; BIOLOGY; METABOLISM; METHODOLOGY; MOUSE; NOMENCLATURE; NON PROFIT ORGANIZATION; PHARMACOLOGY; PROTEIN DATABASE; RAT;

ANIMALS; COMPUTATIONAL BIOLOGY; DATABASES, PROTEIN; HUMANS; INTERNET; ION CHANNELS; LIGANDS; MICE; ORGANIZATIONS, NONPROFIT; PHARMACOLOGY; RATS; TERMINOLOGY AS TOPIC;

EID: 84867306393     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-61779-909-9_2     Document Type: Article

References (30)

1. Harmar AJ, Hills RA, Rosser EM et al (2009) IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels. Nucleic Acids Res 37:D680-D685
2. NC-IUPHAR. http://www.iuphar-db.org/nciuphar.jsp. Accessed 12 April 2012
3. Sharman JL, Mpamhanga CP, Spedding M et al (2011) IUPHAR-DB: new receptors and tools for easy searching and visualization of pharmacological data. Nucleic Acids Res 39:D534-D538
4. Hopkins AL, Groom CR (2002) The drugga-ble genome. Nat Rev Drug Discov 1:727-730
5. Foord SM, Bonner TI, Neubig RR et al (2005) International union of pharmacology. XLVI. G protein-coupled receptor list. Pharmacol Rev 57:279-288
6. Germain P, Staels B, Dacquet C et al (2006) Overview of nomenclature of nuclear receptors. Pharmacol Rev 58:685-704
7. Collingridge GL, Olsen RW, Peters J et al (2009) A nomenclature for ligand-gated ion channels. Neuropharmacology 56:2-5
8. Yu FH, Yarov-Yarovoy V, Gutman GA et al (2005) Overview of molecular relationships in the voltage-gated ion channel superfamily. Pharmacol Rev 57:387-395
9. Seal RL, Gordon SM, Lush MJ et al (2011) genenames.org: the HGNC resources in 2011. Nucleic Acids Res 39:D514-D519
10. Blake JA, Bult CJ, Kadin JA et al (2011) The Mouse Genome Database (MGD): premier model organism resource for mammalian genomics and genetics. Nucleic Acids Res 39:D842-D848
11. Dwinell MR, Worthey EA, Shimoyama M et al (2009) The Rat Genome Database 2009: variation, ontologies and pathways. Nucleic Acids Res 37:D744-D749
12. Pruitt KD, Tatusova T, Klimke W et al (2009) NCBI reference sequences: current status, policy and new initiatives. Nucleic Acids Res 37:D32-D36
13. Maglott D, Ostell J, Pruitt KD et al (2011) Entrez Gene: gene-centered information at NCBI. Nucleic Acids Res 39:D52-D57
14. Amberger J, Bocchini CA, Scott AF et al (2009) McKusick's Online Mendelian Inheritance in Man (OMIM). Nucleic Acids Res 37: D793-D796
15. UniProt-Consortium (2011) Ongoing and future developments at the Universal Protein Resource. Nucleic Acids Res 39:D214-D219
16. Flicek P, Amode MR, Barrell D et al (2011) Ensembl 2011. Nucleic Acids Res 39: D800-D806
17. Safran M, Solomon I, Shmueli O et al (2002) GeneCards 2002: towards a complete, object-oriented, human gene compendium. Bioinformatics 18:1542-1543
18. Berman HM, Westbrook J, Feng Z et al (2000) The Protein Data Bank. Nucleic Acids Res 28:235-242
19. Wishart DS, Knox C, Guo AC et al (2008) DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res 36:D901-D906
20. Wang Y, Xiao J, Suzek TO et al (2009) PubChem: a public information system for analyzing bioactivities of small molecules. Nucleic Acids Res 37:W623-W633
21. Overington J (2009) ChEMBL. An interview with John Overington, team leader, chemog-enomics at the European Bioinformatics Institute Outstation of the European Molecular Biology Laboratory (EMBL-EBI). Interview by Wendy A. Warr. J Comput Aided Mol Des 23:195-198
22. Steinbeck C, Hoppe C, Kuhn S et al (2006) Recent developments of the chemistry development kit (CDK)-an open-source java library for chemo-and bioinformatics. Curr Pharm Des 12:2111-2120
23. Lipinski CA, Lombardo F, Dominy BW et al (2001) Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev 46:3-26
24. PostgreSQL, version 9.0. http://www.postgresql. org. Accessed 30 March 2011
25. PubMed. http://www.ncbi.nlm.nih.gov/pubmed. Accessed 30 March 2011
26. Andrade R, Barnes NM, Baxter G et al. 5-Hydroxytryptamine receptors. IUPHAR Database. http://www.iuphar-db.org/DATABASE/FamilyMenuForward?familyId=1. Modified 28 Jan 2011. Accessed 30 March 2011
27. Peters JA, Lummis SCR, Barnes NM et al. 5-HT3 receptors. IUPHAR Database. http://www.iuphar-db.org/DATABASE/FamilyMenuForward?familyId=68. Modified 7 Jan 2010. Accessed 30 March 2011
28. Gutman GA, Aldrich R, Chandy KG et al. Calcium-activated potassium channels: KCa2.3. IUPHAR database. http://www.iuphar-db. org/DATABASE/ ObjectDisplayForward?obje ctId=383. Modified 31 Jan 2011. Accessed 30 March 2011
29. Pin JP, Neubig R, Bouvier M et al (2007) International union of basic and clinical pharmacology. LXVII. Recommendations for the recognition and nomenclature of G protein-coupled receptor heteromultimers. Pharmacol Rev 59:5-13
30. The Open Babel Package, version 2.2.3. http://openbabel.sourceforge.net/. Accessed 30 March 2011