Ahumanized single-chain antibody against beta 3 integrin inhibits pulmonary metastasis by preferentially fragmenting activated platelets in the tumor microenvironment

Blood

Volumn 120, Issue 14, 2012, Pages 2889-2898

  Zhang, Wei ^a,b   Dang, Suying ^c   Hong, Tao ^d   Tang, Jian ^a   Fan, Jing ^a   Bu, Dawei ^a   Sun, Yanjie ^e   Wang, Zhugang ^c   Wisniewski, Thomas ^e  

^a EAST CHINA NORMAL UNIVERSITY   (China)

^b Shanghai Engineering Research Center of Molecular Therapy and Pharmaceutical Innovation   (China)

^c SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^d B326 Science Building   (China)

^e NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

A11 ANTIBODY; ALBUMIN; ANTIMETASTATIC AGENT; EPITOPE; GLYCOPROTEIN IIIA; GLYCOPROTEIN IIIA49-66; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; UNCLASSIFIED DRUG; FIBRINOGEN RECEPTOR; MONOCLONAL ANTIBODY; PEPTIDE FRAGMENT;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASSAY; CONTROLLED STUDY; ENDOTHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LEWIS CARCINOMA; LUNG METASTASIS; LUNG NODULE; MELANOMA; METASTASIS INHIBITION; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; THROMBOCYTE ACTIVATION; TUMOR MICROENVIRONMENT; TUMOR THROMBUS; ANIMAL; C57BL MOUSE; CELL ADHESION; CELL MOTION; CYTOLOGY; EXPERIMENTAL MELANOMA; IMMUNOLOGY; METASTASIS; NEOVASCULARIZATION (PATHOLOGY); UMBILICAL VEIN ENDOTHELIAL CELL;

ANIMALS; ANTIBODIES, MONOCLONAL, HUMANIZED; CARCINOMA, LEWIS LUNG; CELL ADHESION; CELL MOVEMENT; FEMALE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; NEOVASCULARIZATION, PATHOLOGIC; PEPTIDE FRAGMENTS; PLATELET ACTIVATION; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; SINGLE-CHAIN ANTIBODIES; TUMOR MICROENVIRONMENT;

EID: 84867306135     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2012-04-425207     Document Type: Article

References (36)

1. Gay LJ, Felding-Habermann B. Contribution of platelets to tumour metastasis. Nat Rev Cancer. 2011;11(2):123-134.
2. Labelle M, Begum S, Hynes RO. Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis. Cancer Cell. 2011;20(5):576-590.
3. Tomita M, Shimizu T, Hara M, et al. Prognostic impact of thrombocytosis in resectable non-small cell lung cancer. Interact Cardiovasc Thorac Surg. 2008;7(4):613-615.
4. Suppiah R, Shaheen PE, Elson P, et al. Thrombocytosis as a prognostic factor for survival in patients with metastatic renal cell carcinoma. Cancer. 2006;107(8):1793-1800. (Pubitemid 44582948)
5. Ayhan A, Bozdag G, Taskiran C, et al. The value of preoperative platelet count in the prediction of cervical involvement and poor prognostic variable in patients with endometrial carcinoma. Gynecol Oncol. 2006;103(3):902-905. (Pubitemid 44830067)
6. Shimada H, Oohira G, Okazumi S, et al. Thrombocytosis associated with poor prognosis in patients with esophageal carcinoma. J Am Coll Surg. 2004;198(5):737-741. (Pubitemid 38542902)
7. Borsig L. The role of platelet activation in tumor metastasis. Expert Rev Anticancer Ther. 2008;8(8):1247-1255.
8. Francis JL, Amirkhosravi A. Effect of antihemostatic agents on experimental tumor dissemination. Semin Thromb Hemost. 2002;28(1):29-38. (Pubitemid 34194870)
9. Amirkhosravi A, Amaya M, Siddiqui F, et al. Blockage of GPIIb/IIIa inhibits the release of vascular endothelial growth factor (VEGF) from tumor cell-activated platelets and experimental metastasis. Platelets. 1999;10(5):285-292. (Pubitemid 29490854)
10. Troxler M, Dickinson K, Homer-Vanniasinkam S. Platelet function and antiplatelet therapy. Br J Surg. 2007;94(6):674-682. (Pubitemid 46910058)
11. Rothwell PM, Wilson M, Price JF, et al. Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomized controlled trials. Lancet. 2012;379(9826):1591-1601.
12. Sierko E, Wojtukiewicz MZ. Inhibition of platelet function: does it offer a chance of better cancer progression control? Semin Thromb Hemost. 2007;33(7):712-721. (Pubitemid 350157017)
13. Trikha M, Raso E, Cai Y, et al. Role of alphaII(b) beta3 integrin in prostate cancer metastasis. Prostate. 1998; 35(3):185-192. (Pubitemid 28211292)
14. Jain S, Zuka M, Liu J, et al. Platelet glycoprotein Ib (alpha) supports experimental lung metastasis. Proc Natl Acad Sci U S A. 2007;104(21):9024-9028. (Pubitemid 47175430)
15. Nieswandt B, Hafner M, Echtenacher B, et al. Lysis of tumor cells by natural killer cells in mice is impeded by platelets. Cancer Res. 1999;59(6):1295-1300. (Pubitemid 29136261)
16. Palumbo JS, Talmage KE, Massari JV, et al. Platelets and fibrinogen increase metastatic potential by impeding natural killer cell-mediated elimination of tumor cells. Blood. 2005;105(1):178-185. (Pubitemid 40053080)
17. Shattil SJ, Ginsberg MH. Perspectives series: cell adhesion in vascular biology. Integrin signaling in vascular biology. J Clin Invest. 1997;100(1):1-5.
18. Nardi M, Tomlinson S, Greco MA, et al. Complement- independent peroxide-induced antibody lysis of platelets in HIV-1-related immune thrombocytopenia. Cell. 2001;106(5):551-561. (Pubitemid 32879317)
19. Nardi M, Feinmark SJ, Hu L, et al. Complement-independent Ab-induced peroxide lysis of platelets requires 12-lipoxygenase and a platelet NADPH oxidase pathway. J Clin Invest. 2004;113(7):973-980. (Pubitemid 38544118)
20. Li Z, Nardi MA, Karpatkin S. Role of molecular mimicry to HIV-1 peptides in HIV-1 related immunologic thrombocytopenia. Blood. 2005;106(2):572-576. (Pubitemid 40981253)
21. Zhang W, Dang S, Wang J, et al. Specific crossreaction of anti-dsDNA antibody with platelet integrin GPIIIa49-66. Autoimmunity. 2010;43(8):682-689.
22. Zhang W, Nardi MA, Borkowsky W, et al. Role of molecular mimickry of hepatitis C (HCV) protein with platelet GPIIIa in hepatitis C-related thrombocytopenia. Blood. 2009;113(17):4086-4093.
23. Zhang W, Li YS, Nardi M, et al. Dissolution of arterial platelet thrombi in vivo with a bifunctional platelet GPIIIa49-66 ligand which specifically targets the platelet thrombus. Blood. 2010;116(13):2336-2344.
24. Li Z, Nardi MA, Wu J, et al. Platelet fragmentation requires a specific structural conformation of human monoclonal antibody against beta3 integrin. J Biol Chem. 2008;283(6):3224-3230.
25. Dang S, Hong T, Ding BS, et al. A humanized single-chain variable fragment antibody against beta3 integrin in Escherichia coli. Hybridoma. 2011;30(6):543-548.
26. de Almeida MC, Silva AC, Barral A, et al. A simple method for human peripheral monocyte isolation. Mem Inst Oswaldo Cruz. 2000;95(2):221-223.
27. Larsen E, Palabrica T, Sajer S, et al. PADGEM-dependent adhesion of platelets to monocytes and neutrophlis is mediated by lineage-specific carbohydrate, LNF III (CD 15). Cell. 1990;63(3):467-474.
28. Karpatkin S, Ambrogio C, Pearlstein E. Lack of effect of in vivo prostacyclin on the development of pulmonary metastases in mice following intravenous injection of CT26 colon carcinoma, Lewis lung carcinoma, or B16 amelanotic melanoma cells. Cancer Res. 1984;44(9):3880-3883. (Pubitemid 14041608)
29. Drabkin DL, Austin JH. Spectrophotometric constants for common hemoglobin derivatives in human, dog, and rabbit blood. J Biol Chem. 1932;98:719-733.
30. Gasic GJ. Role of plasma, platelets, and endothelial cells in tumor metastasis. Cancer Metastasis Rev. 1984;3(2):99-114.
31. Karpatkin S, Pearlstein E, Salk PL, et al. Role of platelets in tumor cell metastases. Ann N Y Acad Sci. 1981;370:101-118. (Pubitemid 11049623)
32. Lonsdorf AS, Kramer BF, Fahrleitner M, et al. Engagement of alphaIIbbeta3 (GPIIb/IIIa) with alphanubeta3 integrin mediates interaction of melanoma cells with platelets: a connection to hematogenous metastasis. J Biol.Chem. 2012;287(3):2168-2178.
33. Karpatkin S, Pearlstein E, Ambrogio C, et al. Role of adhesive proteins in platelet tumor interaction in vitro and metastasis formation in vitro. J Clin Invest. 1988;81(4):1012-1019.
34. Amirkhosravi A, Mousa SA, Amaya M, et al. Inhibition of tumor cell-induced platelet aggregation and lung metastasis by the oral GPIIb/IIIa antagonist XV454. Thromb Haemost. 2003;90(3):549-554. (Pubitemid 37138780)
35. Leclerc JR. Platelet glycoprotein IIb/IIIa antagonists: lessons learned from clinical trials and future directions. Crit Care Med. 2002;30(5):S332-S340. (Pubitemid 34508011)
36. Im JH, Fu W, Wang H, et al. Coagulation facilitates tumor cell spreading in the pulmonary vasculature during early metastatic colony formation. Cancer Res. 2004;64(23):8613-8619. (Pubitemid 39552074)