Dopamine D4 receptor transmission in the prefrontal cortex controls the salience of emotional memory via modulation of calcium calmodulin-dependent kinase II

Cerebral Cortex

Volumn 22, Issue 11, 2012, Pages 2486-2494

  Lauzon, Nicole M ^a   Ahmad, Tasha ^a   Laviolette, Steven R ^a  

^a WESTERN UNIVERSITY   (Canada)

Author keywords

CaMKII; D4; dopamine; emotion; memory; prefrontal cortex; schizophrenia

Indexed keywords

1 [N,O BIS(5 ISOQUINOLINESULFONYL) N METHYLTYROSYL] 4 PHENYLPIPERAZINE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CYCLIC AMP DEPENDENT PROTEIN KINASE; DOPAMINE 4 RECEPTOR; DOPAMINE RECEPTOR STIMULATING AGENT; N [4 (2 CYANOPHENYL) 1 PIPERAZINYLMETHYL] 3 METHYLBENZAMIDE; TAUTOMYCIN;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; BRAIN CORTEX; CONDITIONING; DOPAMINERGIC SYSTEM; DOPAMINERGIC TRANSMISSION; EMOTION; ENZYME ACTIVITY; ENZYME SUBSTRATE; EXPLORATORY BEHAVIOR; FEAR; HISTOLOGY; MALE; MEMORY; NONHUMAN; ODOR; PREFRONTAL CORTEX; PRIORITY JOURNAL; RAT; RECALL; SIGNAL TRANSDUCTION;

ANIMALS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CONDITIONING (PSYCHOLOGY); CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOPAMINE AGONISTS; EMOTIONS; FEAR; LIMBIC SYSTEM; MALE; MEMORY; PHOSPHORYLATION; PREFRONTAL CORTEX; PROTEIN PHOSPHATASE 1; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DOPAMINE D4; SIGNAL TRANSDUCTION; SMELL; SYNAPTIC TRANSMISSION;

EID: 84867298696     PISSN: 10473211     EISSN: 14602199     Source Type: Journal    
DOI: 10.1093/cercor/bhr326     Document Type: Article

References (30)

1. Ariano MA, Wang J, Noblett KL, Larson ER, Sibley DR. 1997. Cellular distribution of the rat D4 dopamine receptor protein in the CNS using anti-receptor antisera. Brain Res. 752:26-34. (Pubitemid 27143894)
2. Corrigan MH, Gallen CC, Bonura ML, Merchant KM. 2004. Effectiveness of the selective D4 antagonist sonepiprazole in schizophrenia: a placebo controlled trial. Biol Psychiatry. 55:445-451. (Pubitemid 38338530)
3. De Almeida J, Mengod G. 2010. D2 and D4 dopamine receptor mRNA distribution in pyramidal neurons and GABAergic subpopulations in monkey prefrontal cortex: implications for schizophrenia treatment. Neuroscience. 170:1133-1139.
4. Dickie EW, Brunet A, Akerib V, Armony JL. 2011. Neural correlates of recovery from post-traumatic stress disorder: a longitudinal fMRI investigation of memory encoding. Neuropsychologia. 49:1771-1778.
5. Dresler T, Hahn T, Plichta MM, Ernst LH, Tupak SV, Ehlis AC, Warrings B, Deckert K, Fallgater AJ. 2011. Neural correlates of spontaneous panic attacks. J Neural Transm. 118:263-269.
6. Frankland PW, O'brien C, Ohon M, Kirkwood A, Silva AJ. 2001. Alpha-CAMKII-dependent plasticity in the cortex is required for permanent memory. Nature. 411:309-313. (Pubitemid 32467036)
7. Frankland PW, Sakaguchi M, Arruda-Carvalho M. 2008. Starting at the endophenotype: a role for alpha-CaMKII in schizophrenia? Mol Brain. 6:1-3.
8. Govindaiah G, Wang T, Gillette MU, Crandall SR, Cox CL. 2010. Regulation of inhibitory synapses by presynaptic D4 dopamine receptors in thalamus. J Neurophysiol. 104:2757-2765.
9. Greenstein R, Novak G, Seeman P. 2007. Amphetamine sensitization elevates CaMKIIb mRNA. Synapse. 61:827-834. (Pubitemid 47328801)
10. Gu Z, Jiang Q, Yuen EY, Yan Z. 2006. Activation of dopamine D4 receptors induces synaptic translocation of Ca2 +calmodulindependent protein kinase II in cultured prefrontal cortical neurons. Mol Pharmacol. 69:813-822. (Pubitemid 43363856)
11. Gu Z, Yan Z. 2004. Bidirectional regulation of Ca2 +calmodulindependent protein kinase II activity by dopamine D4 receptors in prefrontal cortex. Mol Pharmacol. 66:948-955. (Pubitemid 39319467)
12. Hidaka H, Yokokura H. 1996. Molecular and cellular pharmacology of a calcium/calmodulin-dependent protein kinase II (CaM kinase II) inhibitor, KN-62, and proposal of CaM kinase phosphorylation cascades. Adv Pharmacol. 36:193-219.
13. Ishida A, Kameshita I, Okuno S, Kitani T, Fujisawa H. 1995. A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II. Biochem Biophys Res Commun. 212:806-812.
14. Kramer MS, Last B, Getson A, Reines SA. 1997. The effects of a selective D4 dopamine receptor antagonist (L-745-870) in acutely psychotic inpatients with schizophrenia. Arch Gen Psychiatry. 54:567-572. (Pubitemid 27258555)
15. Lauzon NM, Bishop SF, Laviolette SR. 2009. Dopamine D1 versus D4 receptors differentially modulate the encoding of salient versus nonsalient emotional information in the medial prefrontal cortex. J Neurosci. 29:4836-4845.
16. Lauzon NM, Laviolette SR. 2010. Dopamine D4-receptor modulation of cortical neuronal network activity and emotional processing: implications for neuropsychiatric disorders. Behav Brain Res. 208:12-22.
17. Laviolette SR, Grace AA. 2006. Cannabinoids potentiate emotional learning plasticity in neurons of the medical prefrontal cortex through basolateral amygdala inputs. J Neurosci. 26:6458-6468. (Pubitemid 44318326)
18. Laviolette SR, Lipski WJ, Grace AA. 2005. A subpopulation of neurons in the medial prefrontal cortex encodes emotional learning with burst and frequency codes through a dopamine D4 receptor-dependent basolateral amygdala input. J Neurosci. 25:6066-6075. (Pubitemid 40923473)
19. Malenka RC, Nicoll RA. 1999. Long-term potentiation-a decade of progress? Science. 285:325-334.
20. Novak G, Seeman P. 2010. Hyperactive mice show elevated D2 high receptors, a model for schizophrenia: calcium/calmodulindependent kinase II alpha knockouts. Synapse. 64:794-800.
21. Novak G, Seeman P, Tallerico T. 2006. Increased expression of calcium/calmodulin-dependent protein kinase IIb in frontal cortex in schizophrenia and depression. Synapse. 59:61-68. (Pubitemid 41706155)
22. Paunio T, Ekelund J, Varilo T, Parker A, Hovatta I, Turunen JS, Rinard K, Foti A, Terwilliger JD, Juvonen H, et al. 2001. Genome-wide scan in a nationwide study sample of schizophrenia families in Finland reveals susceptibility loci on chromosome 2q and 5q. Hum Mol Genet. 10:3037-3048. (Pubitemid 34083490)
23. Paxinos G, Watson C. 1996. The rat brain in stereotaxic coordinates. 2nd ed. San Diego (CA): Academic.
24. Seeman P, Guan HC, Van Tol HHM. 1993. Dopamine D4 receptors elevated in schizophrenia. Nature. 365:441-445. (Pubitemid 23311038)
25. Sklar P, Pato MT, Kirby A, Petryshen TL, Medeiros H, Carvalho C, Macedo A, Dourado A, Coelho I, Valente J, et al. 2004. Genome-wide scan in Portuguese island families identifies 5q31-5q35 as a susceptibility locus for schizophrenia and psychosis. Mol Psychiatry. 9:213-218. (Pubitemid 38299537)
26. Sumi M, Kiuch K, Ishikawa T, Ishii A, Hagiwara M, Nagatsu T, Hidaka H. 1991. The newly synthesized selective Ca2 +calmodulin-dependent protein kinase II inhibitor KN 93 reduces dopamine contents in PC12h cells. Biochem Biophys Res Commun. 181:968-975.
27. Surguladze SA, Chu EM, Marshall N, Evans A, Anilkumar AP, Timehin C, McDonale C, Ecker C, Philips ML, David AS. 2011. Emotion processing in schizophrenia: fMRI study of patients treated with risperidone long-acting injections or conventional depot medication. J Psychopharmacol. 25:722-733.
28. Yamasaki N, Maekawa M, Kobayashi K, Kajii Y, Maeda J, Soma M, Takao K, Tanda K, Ohira K, Toyama K, et al. 2008. Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate phenotype of psychiatric disorders. Mol Brain. 6:1-21.
29. Yang HW, Hu XD, Zhang HM, Xin WJ, Li MT, Zhang T, Zhou LJ, Liu XG. 2004. Roles of CaMKII, PKA and PKC in the induction and maintenance of LTP of C-fiber-evoked field potentials in rat dorsal spinal horn. J Neurophysiol. 91:1122-1133. (Pubitemid 38250397)
30. Yuen EY, Yan Z. 2011. Cellular mechanisms for dopamine D4 receptorinduced homeostatic regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. J Biol Chem. 286:24957-24965.