Investigation of unusual high serum indices for lipemia in clear serum samples on Siemens analysers Dimension

Biochemia Medica

Volumn 22, Issue 3, 2012, Pages 352-362

  Fliser, Eva ^a   Jerkovič, Ksenija ^a   Vidovič, Tanja ^a   Gorenjak, Maksimiljan ^a  

^a UNIVERSITY MEDICAL CENTRE MARIBOR   (Slovenia)

Author keywords

Artifacts; Hyperlipidemia; Immunoglobulins; Multiple myeloma; Paraproteins

Indexed keywords

APOLIPOPROTEIN A1; APOLIPOPROTEIN B; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; IMMUNOGLOBULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PARAPROTEIN; RHEUMATOID FACTOR; TRIACYLGLYCEROL;

ADOLESCENT; ADULT; AGED; ANALYZER; ARTICLE; CHOLESTEROL BLOOD LEVEL; FEMALE; HUMAN; HYPERLIPIDEMIA; IMMUNOELECTROPHORESIS; MAJOR CLINICAL STUDY; MALE; PATIENT MONITORING; PROTEIN BLOOD LEVEL; PROTEIN ELECTROPHORESIS; SERUM;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; APOLIPOPROTEIN A-I; APOLIPOPROTEINS B; CHOLESTEROL; CHOLESTEROL, HDL; CHOLESTEROL, LDL; HUMANS; HYPERLIPIDEMIAS; MALE; MIDDLE AGED; TRIGLYCERIDES; YOUNG ADULT;

EID: 84867274925     PISSN: 13300962     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Grafmeyer D, Bondon M, Manchon M, Levillain P. The influence of bilirubin, haemolysis, and turbidity on 20 analytical tests performed on automated analyzers. Eur J Clin Chem Clin Biochem 1995;33:31-52.
2. Steen G, Klerk A, Laan K, Eppens EF. Evaluation of the interference due to haemoglobin, bilirubin and lipids on Immulite 2500 assays: a practical approach. Ann Clin Biochem 2011;48:170-5.
3. Kroll MH, Elin RJ. Interference with clinical laboratory analyses. Clin Chem 1994;40:1996-2005.
4. Simundic AM, Nikolac N, Ivankovic V, Ferenec-Ruzic D, Magdic B, Kvaternik M, Topic E. Comparison of visual vs. automated detection of lipemic, icteric and hemolyzed specimens: can we rely on a human eye? Clin Chem Lab Med 2009;47:1361-5.
5. Vermeer HJ, Thomassen E, de Jonge N. Automated processing of serum indices used for interference detection by the laboratory information system. Clin Chem 2005;51:244-7.
6. Roche Diagnostics. Serum indices: Reduction of clinical errors in laboratory medicine. Available at: http://www.roche-diagnostics.cz/download/program/Serum%20Indices_ maly.pdf. Accessed May 15th 2012.
7. Monk C, Wallage M, Wassell J, Whiteway A, James J, Beetham R. A monoclonal protein identified by an anomalous lipaemia index. Ann Clin Biochem 2009;46:250-2.
8. Brady J, O'Leary N. Interference due to lipaemia in routine photometric analysis-survey of an underrated problem. Ann Clin Biochem 1994;31:281-8.
9. Sheppard CA, Allen RC, Austin GE, Young AN, Fantz CR. Paraprotein interference in automated chemistry analysers. Clin Chem 2005;51:1077-8.
10. Bowles SA, Tait RC, Jefferson SG, Gilleece MH, Haeney MR. Characteristics of monoclonal immunoglobulins that interfere with serum inorganic phosphate measurement. Ann Clin Biochem 1994;31:249-54.
11. Smogorzewska A, Flood JG, Long WH, Dighe AS. Paraprotein interference in automated chemistry analyzers. Clin Chem 2004;50:1691-3.
12. Berth M, Delanghe J. Protein precipitation as possible important pitfall in the Clinical Chemistry analysis of blood samples containing monoclonal immunoglobulins: 2 case reports and a review of the literature. Acta Clinica Belgica 2004;59:263-73.
13. Fritz ML. Performance characteristics of the HIL specimen quality feature on the Dimension(r) RXL MaxTM clinical chemistry system. Dade Behring Technical Bulletin D-01184, 2004.
14. Customer Support Unit, Olympus Life and Material Science Europa GmbH. Olympus Product Information Update, LIH Reagent OSR62166,2005.
15. Šimundić AM. Practical recommendations for statistical analysis and data presentation in Biochemia Medica journal. Biochem Med 2012;22:15-23.
16. Lovett-Moseley CA. Paraproteinemia: Predictive value of Kunkeĺs zinc sulfate turbidity test. Canad Med Ass J 1968;98:1057-9.