A novel approach to recovery of function of mutant proteins by slowing down translation

Journal of Biological Chemistry

Volumn 287, Issue 41, 2012, Pages 34264-34272

  Meriin, Anatoli B ^a   Mense, Martin ^b   Colbert, Jeff D ^c   Liang, Feng ^d   Bihler, Hermann ^d   Zaarur, Nava ^a   Rock, Kenneth L ^c   Sherman, Michael Y ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Cystic Fibrosis Foundation Therapeutics   (United States)

^c UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^d Flatley Discovery Lab   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATORS; MAMMALIAN CELLS; MINIMAL EFFECTS; MUTANT PROTEINS; RECOVERY OF FUNCTIONS; TRANSLATION ELONGATION;

PROTEINS;

BIOSYNTHESIS;

CHAPERONE; GFP PROTEIN; MUTANT PROTEIN; POLYPEPTIDE; PROTEASOME; TRANSMEMBRANE CONDUCTANCE REGULATOR; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHAGY; CONTROLLED STUDY; CONVALESCENCE; COPEPOD; DISEASE ASSOCIATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; MAMMAL CELL; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN HOMEOSTASIS; PROTEIN INDUCTION; PROTEIN LOCALIZATION; PROTEIN MISFOLDING DISORDER; PROTEIN SYNTHESIS; PROTEIN UNFOLDING; RNA TRANSLATION; TRANSLATION INITIATION; TRANSLATION REGULATION;

ANIMALS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; GREEN FLUORESCENT PROTEINS; HELA CELLS; HUMANS; MODELS, BIOLOGICAL; MUTATION; PEPTIDE CHAIN ELONGATION, TRANSLATIONAL; PROTEIN FOLDING; RATS;

EID: 84867263287     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.397307     Document Type: Article

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