메뉴 건너뛰기




Volumn 4, Issue 6, 2012, Pages 987-992

Tesaglitazar ameliorates non-alcoholic fatty liver disease and atherosclerosis development in diabetic low-density lipoprotein receptor-deficient mice

Author keywords

Atherosclerosis; Inflammation; Mice; Non alcoholic fatty liver disease; Peroxisome proliferator activated receptor; Type 2 diabetes

Indexed keywords

AUTACOID; GLUCOSE; LIPID; LOW DENSITY LIPOPROTEIN RECEPTOR; TESAGLITAZAR;

EID: 84867249671     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2012.713     Document Type: Article
Times cited : (6)

References (24)
  • 1
    • 84856551460 scopus 로고    scopus 로고
    • TIMP3 over- expression in macrophages protects from insulin resistance, adipose inflammation, and nonalcoholic fatty liver disease in mice
    • Menghini R, Casagrande V, Menini S, et al: TIMP3 over- expression in macrophages protects from insulin resistance, adipose inflammation, and nonalcoholic fatty liver disease in mice. Diabetes 61: 454-462, 2012.
    • (2012) Diabetes , vol.61 , pp. 454-462
    • Menghini, R.1    Casagrande, V.2    Menini, S.3
  • 2
    • 84858818014 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease and cardiovascular risk: Metabolic aspects and novel treatments
    • Scorletti E, Calder PC, Byrne CD, et al: Non-alcoholic fatty liver disease and cardiovascular risk: metabolic aspects and novel treatments. Endocrine 40: 332-343, 2011.
    • (2011) Endocrine , vol.40 , pp. 332-343
    • Scorletti, E.1    Calder, P.C.2    Byrne, C.D.3
  • 3
    • 84857055199 scopus 로고    scopus 로고
    • Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury
    • Baeck C, Wehr A, Karlmark KR, et al: Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury. Gut 61: 416-426, 2012.
    • (2012) Gut , vol.61 , pp. 416-426
    • Baeck, C.1    Wehr, A.2    Karlmark, K.R.3
  • 4
    • 34948846112 scopus 로고    scopus 로고
    • Mice heterozygous for tumor necrosis factor-alpha converting enzyme are protected from obesity-induced insulin resistance and diabetes
    • Serino M, Menghini R, Fiorentino L, et al: Mice heterozygous for tumor necrosis factor-alpha converting enzyme are protected from obesity-induced insulin resistance and diabetes. Diabetes 56: 2541-2546, 2007.
    • (2007) Diabetes , vol.56 , pp. 2541-2546
    • Serino, M.1    Menghini, R.2    Fiorentino, L.3
  • 5
    • 77956335194 scopus 로고    scopus 로고
    • Interleukin-6 signaling in liver-parenchymal cells suppresses hepatic inflam-mation and improves systemic insulin action
    • Wunderlich FT, Ströhle P, Könner AC, et al: Interleukin-6 signaling in liver-parenchymal cells suppresses hepatic inflam-mation and improves systemic insulin action. Cell Metab 12: 237-249, 2010.
    • (2010) Cell Metab , vol.12 , pp. 237-249
    • Wunderlich, F.T.1    Ströhle, P.2    Könner, A.C.3
  • 6
    • 33644693579 scopus 로고    scopus 로고
    • Liver markers and development of the metabolic syndrome: The insulin resistance atherosclerosis study
    • Hanley AJ, Williams K, Festa A, et al: Liver markers and development of the metabolic syndrome: the insulin resistance atherosclerosis study. Diabetes 54: 3140-3147, 2005.
    • (2005) Diabetes , vol.54 , pp. 3140-3147
    • Hanley, A.J.1    Williams, K.2    Festa, A.3
  • 7
    • 84855937154 scopus 로고    scopus 로고
    • NASH and atherosclerosis are two aspects of a shared disease: Central role for macrophages
    • Bieghs V, Rensen PC, Hofker MH and Shiri-Sverdlov R: NASH and atherosclerosis are two aspects of a shared disease: central role for macrophages. Atherosclerosis 220: 287-293, 2012.
    • (2012) Atherosclerosis , vol.220 , pp. 287-293
    • Bieghs, V.1    Rensen, P.C.2    Hofker, M.H.3    Shiri-Sverdlov, R.4
  • 8
    • 84861029037 scopus 로고    scopus 로고
    • Diverse roles of macrophages in atherosclerosis: From inflammatory biology to biomarker discovery
    • Gui T, Shimokado A, Sun Y, et al: Diverse roles of macrophages in atherosclerosis: from inflammatory biology to biomarker discovery. Mediators Inflamm 2012: 693083, 2012.
    • (2012) Mediators Inflamm , vol.2012 , pp. 693083
    • Gui, T.1    Shimokado, A.2    Sun, Y.3
  • 9
    • 84859313174 scopus 로고    scopus 로고
    • Differential regulation of acid sphingomyelinase in macrophages stimulated with oxidized low-density lipoprotein (LDL) and oxidized LDL immune complexes: Role in phagocytosis and cytokine release
    • Truman JP, Al Gadban MM, Smith KJ, et al: Differential regulation of acid sphingomyelinase in macrophages stimulated with oxidized low-density lipoprotein (LDL) and oxidized LDL immune complexes: role in phagocytosis and cytokine release. Immunology 136: 30-45, 2012.
    • (2012) Immunology , vol.136 , pp. 30-45
    • Truman, J.P.1    Al Gadban, M.M.2    Smith, K.J.3
  • 10
    • 49649110937 scopus 로고    scopus 로고
    • Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis
    • Wouters K, van Gorp PJ, Bieghs V, et al: Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis. Hepatology 48: 474-486, 2008.
    • (2008) Hepatology , vol.48 , pp. 474-486
    • Wouters, K.1    van Gorp, P.J.2    Bieghs, V.3
  • 11
    • 33749993658 scopus 로고    scopus 로고
    • Novel approach to treat insulin resistance, type 2 diabetes, and the metabolic syndrome: Simultaneous activation of PPARalpha, PPARgamma, and PPARdelta
    • Evans JL, Lin JJ and Goldfine ID: Novel approach to treat insulin resistance, type 2 diabetes, and the metabolic syndrome: simultaneous activation of PPARalpha, PPARgamma, and PPARdelta. Curr Diabetes Rev 1: 299-307, 2005.
    • (2005) Curr Diabetes Rev , vol.1 , pp. 299-307
    • Evans, J.L.1    Lin, J.J.2    Goldfine, I.D.3
  • 12
    • 34547597709 scopus 로고    scopus 로고
    • PPARalpha in atherosclerosis and inflammation
    • Zandbergen F, Plutzky J: PPARalpha in atherosclerosis and inflammation. Biochim Biophys Acta 1771: 972-982, 2007.
    • (2007) Biochim Biophys Acta , vol.1771 , pp. 972-982
    • Zandbergen, F.1    Plutzky, J.2
  • 13
    • 84857719360 scopus 로고    scopus 로고
    • Update on cardiovascular safety of PPARgamma agonists and relevance to medicinal chemistry and clinical pharmacology
    • Ciudin A, Hernandez C and Simó R: Update on cardiovascular safety of PPARgamma agonists and relevance to medicinal chemistry and clinical pharmacology. Curr Top Med Chem 12: 585-604, 2012.
    • (2012) Curr Top Med Chem , vol.12 , pp. 585-604
    • Ciudin, A.1    Hernandez, C.2    Simó, R.3
  • 14
    • 33748331194 scopus 로고    scopus 로고
    • Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic beta-cell mass and function in a rodent model of type 2 diabetes
    • Mu J, Woods J, Zhou YP, et al: Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic beta-cell mass and function in a rodent model of type 2 diabetes. Diabetes 55: 1695-1704, 2006.
    • (2006) Diabetes , vol.55 , pp. 1695-1704
    • Mu, J.1    Woods, J.2    Zhou, Y.P.3
  • 15
    • 33750211451 scopus 로고    scopus 로고
    • Dual PPARalpha/ gamma agonist tesaglitazar reduces atherosclerosis in insulin-resistant and hypercholesterolemic ApoE*3Leiden mice
    • Zadelaar AS, Boesten LS, Jukema JW, et al: Dual PPARalpha/ gamma agonist tesaglitazar reduces atherosclerosis in insulin-resistant and hypercholesterolemic ApoE*3Leiden mice. Arterioscler Thromb Vasc Biol 26: 2560-2566, 2006.
    • (2006) Arterioscler Thromb Vasc Biol , vol.26 , pp. 2560-2566
    • Zadelaar, A.S.1    Boesten, L.S.2    Jukema, J.W.3
  • 16
    • 35248816864 scopus 로고    scopus 로고
    • Tesaglitazar, a dual peroxisome proliferator-activated receptor alpha/gamma agonist, reduces atherosclerosis in female low density lipoprotein receptor deficient mice
    • Chira EC, McMillen TS, Wang S, et al: Tesaglitazar, a dual peroxisome proliferator-activated receptor alpha/gamma agonist, reduces atherosclerosis in female low density lipoprotein receptor deficient mice. Atherosclerosis 195: 100-109, 2007.
    • (2007) Atherosclerosis , vol.195 , pp. 100-109
    • Chira, E.C.1    McMillen, T.S.2    Wang, S.3
  • 17
    • 51349135630 scopus 로고    scopus 로고
    • Inflammatory stress exacerbates lipid accumulation in hepatic cells and fatty livers of apolipoprotein E knockout mice
    • Ma KL, Ruan XZ, Powis SH, et al: Inflammatory stress exacerbates lipid accumulation in hepatic cells and fatty livers of apolipoprotein E knockout mice. Hepatology 48: 770-781, 2008.
    • (2008) Hepatology , vol.48 , pp. 770-781
    • Ma, K.L.1    Ruan, X.Z.2    Powis, S.H.3
  • 18
    • 76449107634 scopus 로고    scopus 로고
    • Monocytes in atherosclerosis: Subsets and functions
    • Woollard KJ and Geissmann F: Monocytes in atherosclerosis: subsets and functions. Nat Rev Cardiol 7: 77-86, 2010.
    • (2010) Nat Rev Cardiol , vol.7 , pp. 77-86
    • Woollard, K.J.1    Geissmann, F.2
  • 19
    • 53549112749 scopus 로고    scopus 로고
    • Increased risk of cardio-vascular disease in non-alcoholic fatty liver disease: Causal effect or epiphenomenon?
    • Targher G, Marra F and Marchesini G: Increased risk of cardio-vascular disease in non-alcoholic fatty liver disease: causal effect or epiphenomenon? Diabetologia 51: 1947-1953, 2008.
    • (2008) Diabetologia , vol.51 , pp. 1947-1953
    • Targher, G.1    Marra, F.2    Marchesini, G.3
  • 20
    • 84861417701 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease: A new and important cardiovascular risk factor?
    • Bhatia LS, Curzen NP, Calder PC and Byrne CD: Non-alcoholic fatty liver disease: a new and important cardiovascular risk factor? Eur Heart J 33: 1190-1200, 2012.
    • (2012) Eur Heart J , vol.33 , pp. 1190-1200
    • Bhatia, L.S.1    Curzen, N.P.2    Calder, P.C.3    Byrne, C.D.4
  • 21
    • 44049089850 scopus 로고    scopus 로고
    • Atherosclerosis and liver inflammation induced by increased dietary cholesterol intake: A combined transcriptomics and metabolomics analysis
    • Kleemann R, Verschuren L, van Erk MJ, et al: Atherosclerosis and liver inflammation induced by increased dietary cholesterol intake: a combined transcriptomics and metabolomics analysis. Genome Biol 8: R200, 2007.
    • (2007) Genome Biol , vol.8
    • Kleemann, R.1    Verschuren, L.2    van Erk, M.J.3
  • 22
    • 84860243402 scopus 로고    scopus 로고
    • Bias in macrophage activation pattern influences non-alcoholic steatohepatitis (NASH) in mice
    • Maina V, Sutti S, Locatelli I, et al: Bias in macrophage activation pattern influences non-alcoholic steatohepatitis (NASH) in mice. Clin Sci (Lond) 122: 545-553, 2012.
    • (2012) Clin Sci (Lond) , vol.122 , pp. 545-553
    • Maina, V.1    Sutti, S.2    Locatelli, I.3
  • 23
    • 84861096946 scopus 로고    scopus 로고
    • Myeloid-specific Krüppel-like factor 2 inactivation increases macrophage and neutrophil adhesion and promotes atherosclerosis
    • Lingrel JB, Pilcher-Roberts R, Basford JE, et al: Myeloid-specific Krüppel-like factor 2 inactivation increases macrophage and neutrophil adhesion and promotes atherosclerosis. Circ Res 110: 1294-1302, 2012.
    • (2012) Circ Res , vol.110 , pp. 1294-1302
    • Lingrel, J.B.1    Pilcher-Roberts, R.2    Basford, J.E.3
  • 24
    • 33646830285 scopus 로고    scopus 로고
    • Interleukin 6 is associated with subclinical atherosclerosis: A link with soluble intercellular adhesion molecule 1
    • Amar J, Fauvel J, Drouet L, et al: Interleukin 6 is associated with subclinical atherosclerosis: a link with soluble intercellular adhesion molecule 1. J Hypertens 24: 1083-1088, 2006.
    • (2006) J Hypertens , vol.24 , pp. 1083-1088
    • Amar, J.1    Fauvel, J.2    Drouet, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.