Modulation of conotoxin structure and function is achieved through a multienzyme complex in the venom glands of cone snails

Journal of Biological Chemistry

Volumn 287, Issue 41, 2012, Pages 34288-34303

  Safavi Hemami, Helena ^a,b   Gorasia, Dhana G ^a,b   Steiner, Andrew M ^c   Williamson, Nicholas A ^b   Karas, John A ^b   Gajewiak, Joanna ^c   Olivera, Baldomero M ^c   Bulaj, Grzegorz ^c   Purcell, Anthony W ^d  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c UNIVERSITY OF UTAH   (United States)

^d MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CIS-TRANS; CONE SNAILS; CONOTOXINS; CONUS VENOMS; DISULFIDE BONDS; ISOMERASES; MULTIENZYME COMPLEXES; NON-NATIVE; OXIDATION AND REDUCTION; OXIDATIVE FOLDING; PEPTIDE SUBSTRATES; PROTEIN DISULFIDE ISOMERASES; VENOM GLAND;

ANIMALS; COVALENT BONDS; ISOMERS; PEPTIDES; SULFUR COMPOUNDS;

ENZYMES;

CONOTOXIN; CONOTOXIN ALPHA GI; CONOTOXIN ALPHA IMI; IMMUNOGLOBULIN BINDING FACTOR; MULTIENZYME COMPLEX; PEPTIDYLPROLYL ISOMERASE; PROTEIN DISULFIDE ISOMERASE; UNCLASSIFIED DRUG;

ANIMAL STRUCTURES; ARTICLE; CATALYSIS; CONTROLLED STUDY; CONUS IMPERIALIS; CONUS SNAIL; DISULFIDE BOND; ENDOPLASMIC RETICULUM; ISOMER; MICROSOME; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; REDUCTION; SEQUENCE ANALYSIS; TOXIN STRUCTURE; TOXIN SYNTHESIS; VENOM GLAND;

ANIMALS; CONOTOXINS; CONUS SNAIL; EXOCRINE GLANDS; HEAT-SHOCK PROTEINS; MULTIENZYME COMPLEXES; OXIDATION-REDUCTION; PEPTIDYLPROLYL ISOMERASE; PROTEIN DISULFIDE-ISOMERASES; PROTEIN FOLDING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84867245662     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.366781     Document Type: Article

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