메뉴 건너뛰기




Volumn 15, Issue 8, 2012, Pages 656-665

High content screening for compounds that induce early stages of human embryonic stem cell differentiation

Author keywords

Human embryonic stem cells; Image based screening; Phenotypic classification

Indexed keywords

ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL THERAPY; COMPUTER PROGRAM; EMBRYO; EMBRYONIC STEM CELL; HIGH CONTENT SCREENING; HUMAN; HUMAN CELL; IMAGE ANALYSIS; PRIORITY JOURNAL; SCREENING;

EID: 84867244819     PISSN: 13862073     EISSN: 18755402     Source Type: Journal    
DOI: 10.2174/138620712802650540     Document Type: Article
Times cited : (4)

References (42)
  • 1
    • 77951975169 scopus 로고    scopus 로고
    • High content screening: Seeing is believing
    • Zanella, F.; Lorens, J. B.; Link, W. High content screening: seeing is believing. Trends Biotechnol., 2010, 28 (5), 237-245.
    • (2010) Trends Biotechnol , vol.28 , Issue.5 , pp. 237-245
    • Zanella, F.1    Lorens, J.B.2    Link, W.3
  • 2
    • 34447502161 scopus 로고    scopus 로고
    • Image-based chemical screening
    • Carpenter, A. E. Image-based chemical screening. Nat. Chem. Biol., 2007, 3 (8), 461-465.
    • (2007) Nat. Chem. Biol , vol.3 , Issue.8 , pp. 461-465
    • Carpenter, A.E.1
  • 3
    • 37749053190 scopus 로고    scopus 로고
    • Microscopic imaging techniques for drug discovery
    • Bullen, A. Microscopic imaging techniques for drug discovery. Nat. Rev. Drug Discov., 2008, 7 (1), 54-67.
    • (2008) Nat. Rev. Drug Discov , vol.7 , Issue.1 , pp. 54-67
    • Bullen, A.1
  • 5
    • 35348858911 scopus 로고    scopus 로고
    • Cell-based high-content screening of smallmolecule libraries
    • Korn, K.; Krausz, E. Cell-based high-content screening of smallmolecule libraries. Curr. Opin. Chem. Biol., 2007, 11 (5), 503-510.
    • (2007) Curr. Opin. Chem. Biol , vol.11 , Issue.5 , pp. 503-510
    • Korn, K.1    Krausz, E.2
  • 6
    • 34447562370 scopus 로고    scopus 로고
    • A Pharmaceutical company user's perspective on the potential of high content screening in drug discovery
    • Hoffman, A. F.; Garippa, R. J. A pharmaceutical company user's perspective on the potential of high content screening in drug discovery. Methods Mol. Biol., 2007, 356, 19-31.
    • (2007) Methods Mol. Biol , vol.356 , pp. 19-31
    • Hoffman, A.F.1    Garippa, R.J.2
  • 8
    • 77951879452 scopus 로고    scopus 로고
    • Human stem cells and drug screening: Opportunities and challenges
    • Ebert, A. D.; Svendsen, C. N. Human stem cells and drug screening: opportunities and challenges. Nat. Rev. Drug Discov., 2010, 9 (5), 367-372.
    • (2010) Nat. Rev. Drug Discov , vol.9 , Issue.5 , pp. 367-372
    • Ebert, A.D.1    Svendsen, C.N.2
  • 10
    • 0035200623 scopus 로고    scopus 로고
    • In vitro differentiation of transplantable neural precursors from human embryonic stem cells
    • Zhang, S. C.; Wernig, M.; Duncan, I.D.; Brustle, O.; Thomson, J. A. In vitro differentiation of transplantable neural precursors from human embryonic stem cells. Nat. Biotechnol., 2001, 19 (12), 1129-1133.
    • (2001) Nat. Biotechnol , vol.19 , Issue.12 , pp. 1129-1133
    • Zhang, S.C.1    Wernig, M.2    Duncan, I.D.3    Brustle, O.4    Thomson, J.A.5
  • 14
    • 62949210744 scopus 로고    scopus 로고
    • Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells
    • Borowiak, M.; Maehr, R.; Chen, S.; Chen, A. E.; Tang, W.; Fox, J. L.; Schreiber, S. L.; Melton, D. A. Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell Stem Cell, 2009, 4 (4), 348-358.
    • (2009) Cell Stem Cell , vol.4 , Issue.4 , pp. 348-358
    • Borowiak, M.1    Maehr, R.2    Chen, S.3    Chen, A.E.4    Tang, W.5    Fox, J.L.6    Schreiber, S.L.7    Melton, D.A.8
  • 15
    • 34548129588 scopus 로고    scopus 로고
    • High-throughput analysis of signals regulating stem cell fate and function
    • Underhill, G. H.; Bhatia, S. N. High-throughput analysis of signals regulating stem cell fate and function. Curr. Opin. Chem. Biol., 2007, 11 (4), 357-366.
    • (2007) Curr. Opin. Chem. Biol , vol.11 , Issue.4 , pp. 357-366
    • Underhill, G.H.1    Bhatia, S.N.2
  • 16
    • 65349181366 scopus 로고    scopus 로고
    • Screening for novel regulators of embryonic stem cell identity
    • Subramanian, V.; Klattenhoff, C. A.; Boyer, L. A. Screening for novel regulators of embryonic stem cell identity. Cell Stem Cell, 2009, 4 (5), 377-378.
    • (2009) Cell Stem Cell , vol.4 , Issue.5 , pp. 377-378
    • Subramanian, V.1    Klattenhoff, C.A.2    Boyer, L.A.3
  • 17
    • 37749027080 scopus 로고    scopus 로고
    • Small molecules in stem cell self-renewal and differentiation
    • Schugar, R. C.; Robbins, P. D.; Deasy, B. M. Small molecules in stem cell self-renewal and differentiation. Gene Therapy, 2008, 15 (2), 126-35.
    • (2008) Gene Therapy , vol.15 , Issue.2 , pp. 126-135
    • Schugar, R.C.1    Robbins, P.D.2    Deasy, B.M.3
  • 19
    • 3042744026 scopus 로고    scopus 로고
    • A role for chemistry in stem cell biology
    • Ding, S.; Schultz, P. G. A role for chemistry in stem cell biology. Nat Biotechnol., 2004, 22 (7), 833-840.
    • (2004) Nat Biotechnol , vol.22 , Issue.7 , pp. 833-840
    • Ding, S.1    Schultz, P.G.2
  • 20
    • 44349152907 scopus 로고    scopus 로고
    • High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells
    • Desbordes, S. C.; Placantonakis, D. G.; Ciro, A.; Socci, N. D.; Lee, G.; Djaballah, H.; Studer, L. High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells. Cell Stem Cell, 2008, 2 (6), 602-612.
    • (2008) Cell Stem Cell , vol.2 , Issue.6 , pp. 602-612
    • Desbordes, S.C.1    Placantonakis, D.G.2    Ciro, A.3    Socci, N.D.4    Lee, G.5    Djaballah, H.6    Studer, L.7
  • 22
    • 77955843624 scopus 로고    scopus 로고
    • Novel regulators of stem cell fates identified by a multivariate phenotype screen of small compounds on human embryonic stem cell colonies
    • Barbaric, I.; Gokhale, P. J.; Jones, M.; Glen, A.; Baker, D.; Andrews, P. W. Novel regulators of stem cell fates identified by a multivariate phenotype screen of small compounds on human embryonic stem cell colonies. Stem Cell Res., 2010, 5 (2), 104-119.
    • (2010) Stem Cell Res , vol.5 , Issue.2 , pp. 104-119
    • Barbaric, I.1    Gokhale, P.J.2    Jones, M.3    Glen, A.4    Baker, D.5    Andrews, P.W.6
  • 23
    • 57849151241 scopus 로고    scopus 로고
    • Im. Grid, a grid computing approach for image mining of high throughput-high content screening
    • In: Tsukuba, Japan, Sept 29- Oct 1, 2008; IEEE Computer Society: Washington DC, USA
    • Moon, H.; Genovesio, A. In: Im.Grid, a grid computing approach for image mining of high throughput-high content screening, Proceedings of the 9th IEEE/ACM International Conference on Grid Computing. Tsukuba, Japan, Sept 29- Oct 1, 2008; IEEE Computer Society: Washington DC, USA, 2008; pp.334-9.
    • (2008) Proceedings of the 9th IEEE/ACM International Conference on Grid Computing , pp. 334-339
    • Moon, H.1    Genovesio, A.2
  • 25
    • 77749299137 scopus 로고    scopus 로고
    • Transcriptional regulation of the Oct4 gene, a master gene for pluripotency
    • Kellner, S.; Kikyo, N. Transcriptional regulation of the Oct4 gene, a master gene for pluripotency. Histol. Histopathol., 2010, 25 (3), 405-412.
    • (2010) Histol. Histopathol , vol.25 , Issue.3 , pp. 405-412
    • Kellner, S.1    Kikyo, N.2
  • 27
    • 35549000259 scopus 로고    scopus 로고
    • Manipulation of OCT4 levels in human embryonic stem cells results in induction of differential cell types
    • Rodriguez, R. T.; Velkey, J. M.; Lutzko, C.; Seerke, R.; Kohn, D. B.; O'Shea, K. S.; Firpo, M. T. Manipulation of OCT4 levels in human embryonic stem cells results in induction of differential cell types. Exp. Biol. Med. (Maywood), 2007, 232 (10), 1368-1380.
    • (2007) Exp. Biol. Med. (Maywood , vol.232 , Issue.10 , pp. 1368-1380
    • Rodriguez, R.T.1    Velkey, J.M.2    Lutzko, C.3    Seerke, R.4    Kohn, D.B.5    O'Shea, K.S.6    Firpo, M.T.7
  • 30
    • 44749084234 scopus 로고
    • Fronts propagating with curvaturedependent speed: Algorithms based on Hamilton-Jacobi formulations
    • Osher, S.; Sethian, J. A. Fronts propagating with curvaturedependent speed: Algorithms based on Hamilton-Jacobi formulations, J. Comput. Phys., 1988, 79(1), 12-49.
    • (1988) J. Comput. Phys. , vol.79 , Issue.1 , pp. 12-49
    • Osher, S.1    Sethian, J.A.2
  • 31
    • 0033003760 scopus 로고    scopus 로고
    • A simple statistical parameter for use in evaluation and validation of high throughput screening assays
    • Zhang, J. H.; Chung, T. D.; Oldenburg, K. R. A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. J. Biomol. Screen., 1999, 4 (2), 67-73.
    • (1999) J. Biomol. Screen , vol.4 , Issue.2 , pp. 67-73
    • Zhang, J.H.1    Chung, T.D.2    Oldenburg, K.R.3
  • 32
    • 77955849106 scopus 로고    scopus 로고
    • Human embryonic stem cells (hESCs) cultured under distinctive feeder-free culture conditions display global gene expression patterns similar to hESCs from feeder-dependent culture conditions
    • Yoon, T. M.; Chang, B.; Kim, H. T.; Jee, J. H.; Kim, D. W.; Hwang, D. Y. Human embryonic stem cells (hESCs) cultured under distinctive feeder-free culture conditions display global gene expression patterns similar to hESCs from feeder-dependent culture conditions. Stem Cell Rev., 2010, 6 (3), 425-437.
    • (2010) Stem Cell Rev , vol.6 , Issue.3 , pp. 425-437
    • Yoon, T.M.1    Chang, B.2    Kim, H.T.3    Jee, J.H.4    Kim, D.W.5    Hwang, D.Y.6
  • 33
    • 36249022693 scopus 로고    scopus 로고
    • Niche-mediated control of human embryonic stem cell self-renewal and differentiation
    • Peerani, R.; Rao, B. M.; Bauwens, C.; Yin, T.; Wood, G. A.; Nagy, A.; Kumacheva, E.; Zandstra, P. W. Niche-mediated control of human embryonic stem cell self-renewal and differentiation. EMBO J, 2007, 26 (22), 4744-4755.
    • (2007) Embo J , vol.26 , Issue.22 , pp. 4744-4755
    • Peerani, R.1    Rao, B.M.2    Bauwens, C.3    Yin, T.4    Wood, G.A.5    Nagy, A.6    Kumacheva, E.7    Zandstra, P.W.8
  • 35
    • 34648816863 scopus 로고    scopus 로고
    • Retinoic acid in the development, regeneration and maintenance of the nervous system
    • Maden, M. Retinoic acid in the development, regeneration and maintenance of the nervous system. Nat. Rev. Neurosci., 2007, 8 (10), 755-765.
    • (2007) Nat. Rev. Neurosci , vol.8 , Issue.10 , pp. 755-765
    • Maden, M.1
  • 36
    • 33947100875 scopus 로고    scopus 로고
    • Role of retinoic acid in the differentiation of embryonal carcinoma and embryonic stem cells
    • Soprano, D. R.; Teets, B. W.; Soprano, K. J. Role of retinoic acid in the differentiation of embryonal carcinoma and embryonic stem cells. Vitam. Horm., 2007, 75, 69-95.
    • (2007) Vitam. Horm , vol.75 , pp. 69-95
    • Soprano, D.R.1    Teets, B.W.2    Soprano, K.J.3
  • 37
    • 33748463173 scopus 로고    scopus 로고
    • Cryopreservation by slow cooling with DMSO diminished production of Oct-4 pluripotency marker in human embryonic stem cells
    • Katkov, II; Kim, M. S.; Bajpai, R.; Altman, Y. S.; Mercola, M.; Loring, J. F.; Terskikh, A. V.; Snyder, E. Y.; Levine, F., Cryopreservation by slow cooling with DMSO diminished production of Oct-4 pluripotency marker in human embryonic stem cells. Cryobiology, 2006, 53 (2), 194-205.
    • (2006) Cryobiology , vol.53 , Issue.2 , pp. 194-205
    • Katkov, I.I.1    Kim, M.S.2    Bajpai, R.3    Altman, Y.S.4    Mercola, M.5    Loring, J.F.6    Terskikh, A.V.7    Snyder, E.Y.8    Levine, F.9
  • 38
    • 33646474117 scopus 로고    scopus 로고
    • Long-term self-renewal and directed differentiation of human embryonic stem cells in chemically defined conditions
    • Yao, S.; Chen, S.; Clark, J.; Hao, E.; Beattie, G. M.; Hayek, A.; Ding, S. Long-term self-renewal and directed differentiation of human embryonic stem cells in chemically defined conditions. Proc. Natl. Acad. Sci. USA, 2006, 103 (18), 6907-6912.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , Issue.18 , pp. 6907-6912
    • Yao, S.1    Chen, S.2    Clark, J.3    Hao, E.4    Beattie, G.M.5    Hayek, A.6    Ding, S.7
  • 40
    • 33947233409 scopus 로고    scopus 로고
    • MEK/ERK signaling contributes to the maintenance of human embryonic stem cell self-renewal
    • Li, J.; Wang, G.; Wang, C.; Zhao, Y.; Zhang, H.; Tan, Z.; Song, Z.; Ding, M.; Deng, H. MEK/ERK signaling contributes to the maintenance of human embryonic stem cell self-renewal. Differentiation, 2007, 75 (4), 299-307.
    • (2007) Differentiation , vol.75 , Issue.4 , pp. 299-307
    • Li, J.1    Wang, G.2    Wang, C.3    Zhao, Y.4    Zhang, H.5    Tan, Z.6    Song, Z.7    Ding, M.8    Deng, H.9
  • 41
    • 77955843886 scopus 로고    scopus 로고
    • Inhibition of ERK1/2 prevents neural and mesendodermal differentiation and promotes human embryonic stem cell self-renewal
    • Na, J.; Furue, M. K.; Andrews, P. W. Inhibition of ERK1/2 prevents neural and mesendodermal differentiation and promotes human embryonic stem cell self-renewal. Stem Cell Res., 2010, 5 (2), 157-169.
    • (2010) Stem Cell Res , vol.5 , Issue.2 , pp. 157-169
    • Na, J.1    Furue, M.K.2    Andrews, P.W.3
  • 42
    • 33744758028 scopus 로고    scopus 로고
    • The role of PI3K/AKT, MAPK/ERK and NFkappabeta signalling in the maintenance of human embryonic stem cell pluripotency and viability highlighted by transcriptional profiling and functional analysis
    • Armstrong, L.; Hughes, O.; Yung, S.; Hyslop, L.; Stewart, R.; Wappler, I.; Peters, H.; Walter, T.; Stojkovic, P.; Evans, J.; Stojkovic, M.; Lako, M. The role of PI3K/AKT, MAPK/ERK and NFkappabeta signalling in the maintenance of human embryonic stem cell pluripotency and viability highlighted by transcriptional profiling and functional analysis. Hum. Mol. Gen., 2006, 15 (11), 1894-1913.
    • (2006) Hum. Mol. Gen , vol.15 , Issue.11 , pp. 1894-1913
    • Armstrong, L.1    Hughes, O.2    Yung, S.3    Hyslop, L.4    Stewart, R.5    Wappler, I.6    Peters, H.7    Walter, T.8    Stojkovic, P.9    Evans, J.10    Stojkovic, M.11    Lako, M.12


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.