Integrin adhesions: Who's on first? What's on second?: Connections between FAK and talin

Cell Adhesion and Migration

Volumn 6, Issue 4, 2012, Pages 302-306

  Lawson, Christine ^a   Schlaepfer, David D ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Adhesion assembly; Focal adhesion kinase; Focal adhesion turnover; Motility; Nascent adhesion; Recruitment; Talin; 1 integrin

Indexed keywords

BETA1 INTEGRIN; CYTOSKELETON PROTEIN; FOCAL ADHESION KINASE; PAXILLIN; SCLEROPROTEIN; TALIN; VINCULIN;

CANONICAL ANALYSIS; CARCINOMA CELL; CELL ADHESION; CELL MIGRATION; CYTOPLASM; DESMOSOME; EMBRYO CELL; ENZYME ACTIVATION; FIBROBLAST; HUMAN; NONHUMAN; NOTE; OVARY CARCINOMA; PROTEIN BINDING; PROTEIN INTERACTION;

EID: 84867243955     PISSN: 19336918     EISSN: 19336926     Source Type: Journal    
DOI: 10.4161/cam.20488     Document Type: Note

References (41)

1. Parsons JT, Horwitz AR, Schwartz MA. Cell adhesion: integrating cytoskeletal dynamics and cellular tension. Nat Rev Mol Cell Biol 2010; 11:633-43; PMID: 20729930; http://dx.doi.org/10.1038/nrm2957
2. Gardel ML, Schneider IC, Aratyn-Schaus Y, Waterman CM. Mechanical integration of actin and adhesion dynamics in cell migration. Annu Rev Cell Dev Biol 2010; 26:315-33; PMID:19575647; http://dx.doi.org/10.1146/annurev.cellbio. 011209.122036
3. Kubow KE, Horwitz AR. Reducing background fluorescence reveals adhesions in 3D matrices. Nat Cell Biol 2011; 13:3-5, author reply 5-7; PMID: 21173800; http://dx.doi.org/10.1038/ncb0111-3
4. Vicente-Manzanares M, Choi CK, Horwitz AR. Integrins in cell migration-the actin connection. J Cell Sci 2009; 122:199-206; PMID:19118212; http://dx.doi.org/10.1242/jcs.018564
5. Zaidel-Bar R, Geiger B. The switchable integrin adhesome. J Cell Sci 2010; 123:1385-8; PMID: 20410370; http://dx.doi.org/10.1242/jcs.066183
6. Kuo JC, Han X, Hsiao CT, Yates JR, 3rd, Waterman CM. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat Cell Biol 2011; 13:383-93; PMID:21423176; http://dx.doi.org/10.1038/ncb2216
7. Pasapera AM, Schneider IC, Rericha E, Schlaepfer DD, Waterman CM. Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation. J Cell Biol 2010; 188:877-90; PMID:20308429; http://dx.doi.org/10.1083/jcb.200906012
8. Ilić D, Kovacic B, Johkura K, Schlaepfer DD, Tomasević N, Han Q, et al. FAK promotes organization of fibronectin matrix and fibrillar adhesions. J Cell Sci 2004; 117:177-87; PMID:14657279; http://dx.doi.org/10. 1242/jcs.00845
9. Ziegler WH, Gingras AR, Critchley DR, Emsley J. Integrin connections to the cytoskeleton through talin and vinculin. Biochem Soc Trans 2008; 36: 235-9; PMID:18363566; http://dx.doi.org/10.1042/BST0360235
10. Ye F, Hu G, Taylor D, Ratnikov B, Bobkov AA, McLean MA, et al. Recreation of the terminal events in physiological integrin activation. J Cell Biol 2010; 188:157-73; PMID:20048261; http://dx.doi.org/10.1083/jcb.200908045
11. Schaller MD. Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions. J Cell Sci 2010; 123:1007-13; PMID:20332118; http://dx.doi.org/10.1242/jcs.045112
12. Choi CK, Zareno J, Digman MA, Gratton E, Horwitz AR. Cross-correlated fluctuation analysis reveals phosphorylation- regulated paxillin-FAK complexes in nascent adhesions. Biophys J 2011; 100:583-92; PMID:21281572; http://dx.doi.org/10.1016/j.bpj.2010.12.3719
13. Lim ST, Chen XL, Tomar A, Miller NL, Yoo J, Schlaepfer DD. Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation. J Biol Chem 2010; 285:21526-36; PMID:20442405; http://dx.doi.org/10.1074/jbc.M110. 129999
14. Kanchanawong P, Shtengel G, Pasapera AM, Ramko EB, Davidson MW, Hess HF, et al. Nanoscale architecture of integrin-based cell adhesions. Nature 2010; 468:580-4; PMID:21107430; http://dx.doi.org/10.1038/nature09621
15. Lawson C, Lim ST, Uryu S, Chen XL, Calderwood DA, Schlaepfer DD. FAK promotes recruitment of talin to nascent adhesions to control cell motility. J Cell Biol 2012; 196:223-32; PMID:22270917; http://dx.doi.org/10.1083/jcb. 201108078
16. Zhang X, Jiang G, Cai Y, Monkley SJ, Critchley DR, Sheetz MP. Talin depletion reveals independence of initial cell spreading from integrin activation and traction. Nat Cell Biol 2008; 10:1062-8; PMID: 19160486; http://dx.doi.org/10.1038/ncb1765
17. Kopp PM, Bate N, Hansen TM, Brindle NP, Praekelt U, Debrand E, et al. Studies on the morphology and spreading of human endothelial cells define key inter-and intramolecular interactions for talin1. Eur J Cell Biol 2010; 89:661-73; PMID:20605055; http://dx.doi.org/10.1016/j.ejcb.2010.05.003
18. Wang P, Ballestrem C, Streuli CH. The C terminus of talin links integrins to cell cycle progression. J Cell Biol 2011; 195:499-513; PMID:22042621; http://dx.doi.org/10.1083/jcb.201104128
19. Malinin NL, Plow EF, Byzova TV. Kindlins in FERM adhesion. Blood 2010; 115:4011-7; PMID:20228270; http://dx.doi.org/10.1182/blood-2009-10-239269
20. Legate KR, Takahashi S, Bonakdar N, Fabry B, Boettiger D, Zent R, et al. Integrin adhesion and force coupling are independently regulated by localized PtdIns(4,5)2 synthesis. EMBO J 2011; 30:4539-53; PMID:21926969; http://dx.doi.org/10.1038/emboj.2011.332
21. Nieves B, Jones CW, Ward R, Ohta Y, Reverte CG, LaFlamme SE. The NPIY motif in the integrin beta1 tail dictates the requirement for talin-1 in outside-in signaling. J Cell Sci 2010; 123:1216-26; PMID: 20332112; http://dx.doi.org/10.1242/jcs.056549
22. Hagel M, George EL, Kim A, Tamimi R, Opitz SL, Turner CE, et al. The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling. Mol Cell Biol 2002; 22:901-15; PMID:11784865; http://dx.doi.org/10.1128/MCB.22.3.901-915.2002
23. Scheswohl DM, Harrell JR, Rajfur Z, Gao G, Campbell SL, Schaller MD. Multiple paxillin binding sites regulate FAK function. J Mol Signal 2008; 3:1; PMID:18171471; http://dx.doi.org/10.1186/1750-2187-3-1
24. Frame MC, Patel H, Serrels B, Lietha D, Eck MJ. The FERM domain: organizing the structure and function of FAK. Nat Rev Mol Cell Biol 2010; 11:802-14; PMID:20966971; http://dx.doi.org/10.1038/nrm2996
25. Serrels B, Serrels A, Brunton VG, Holt M, McLean GW, Gray CH, et al. Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex. Nat Cell Biol 2007; 9:1046-56; PMID:17721515; http://dx.doi.org/10.1038/ncb1626
26. Serrels B, Sandilands E, Serrels A, Baillie G, Houslay MD, Brunton VG, et al. A complex between FAK, RACK1, and PDE4D5 controls spreading initiation and cancer cell polarity. Curr Biol 2010; 20:1086-92; PMID:20493699; http://dx.doi.org/10.1016/j.cub.2010.04.042
27. Lim ST, Chen XL, Lim Y, Hanson DA, Vo TT, Howerton K, et al. Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation. Mol Cell 2008; 29:9-22; PMID:18206965; http://dx.doi.org/10.1016/j.molcel.2007. 11.031
28. Cai X, Lietha D, Ceccarelli DF, Karginov AV, Rajfur Z, Jacobson K, et al. Spatial and temporal regulation of focal adhesion kinase activity in living cells. Mol Cell Biol 2008; 28:201-14; PMID:17967873; http://dx.doi.org/10.1128/ MCB.01324-07
29. McNamee HP, Ingber DE, Schwartz MA. Adhesion to fibronectin stimulates inositol lipid synthesis and enhances PDGF-induced inositol lipid breakdown. J Cell Biol 1993; 121:673-8; PMID:8387531; http://dx.doi.org/10.1083/jcb.121.3.673
30. McNamee HP, Liley HG, Ingber DE. Integr-independent control of inositol lipid synthesis in vascular endothelial cells and smooth muscle cells. Exp Cell Res 1996; 224:116-22; PMID:8612675; http://dx.doi.org/10.1006/excr.1996.0118
31. Wu Z, Li X, Sunkara M, Spearman H, Morris AJ, Huang C. PIPKIc regulates focal adhesion dynamics and colon cancer cell invasion. PLoS One 2011; 6: e24775; PMID:21931851; http://dx.doi.org/10.1371/journal.pone.0024775
32. Ling K, Doughman RL, Firestone AJ, Bunce MW, Anderson RA. Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions. Nature 2002; 420:89-93; PMID:12422220; http://dx.doi.org/10.1038/nature01082
33. Martel V, Racaud-Sultan C, Dupe S, Marie C, Paulhe F, Galmiche A, et al. Conformation, localization, and integrin binding of talin depend on its interaction with phosphoinositides. J Biol Chem 2001; 276:21217-27; PMID:11279249; http://dx.doi.org/10.1074/jbc.M102373200
34. Nayal A, Webb DJ, Horwitz AF. Talin: an emerging focal point of adhesion dynamics. Curr Opin Cell Biol 2004; 16:94-8; PMID:15037311; http://dx.doi.org/ 10.1016/j.ceb.2003.11.007
35. Toutant M, Costa A, Studler JM, Kadaré G, Carnaud M, Girault JA. Alternative splicing controls the mechanisms of FAK autophosphorylation. Mol Cell Biol 2002; 22:7731-43; PMID:12391143; http://dx.doi.org/10.1128/MCB.22.22. 7731-7743.2002
36. Yu CH, Law JB, Suryana M, Low HY, Sheetz MP. Early integrin binding to Arg-Gly-Asp peptide activates actin polymerization and contractile movement that stimulates outward translocation. Proc Natl Acad Sci U S A 2011; 108:20585-90; PMID:22139375; http://dx.doi.org/10.1073/pnas.1109485108
37. Tomar A, Schlaepfer DD. Focal adhesion kinase: switching between GAPs and GEFs in the regulation of cell motility. Curr Opin Cell Biol 2009; 21:676-83; PMID:19525103; http://dx.doi.org/10.1016/j.ceb.2009.05.006
38. Mitra SK, Hanson DA, Schlaepfer DD. Focal adhesion kinase: in command and control of cell motility. Nat Rev Mol Cell Biol 2005; 6:56-68; PMID:15688067; http://dx.doi.org/10.1038/nrm1549
39. Barbero S, Mielgo A, Torres V, Teitz T, Shields DJ, Mikolon D, et al. Caspase-8 association with the focal adhesion complex promotes tumor cell migration and metastasis. Cancer Res 2009; 69:3755-63; PMID: 19383910; http://dx.doi.org/10.1158/0008-5472.CAN-08-3937
40. Franco SJ, Rodgers MA, Perrin BJ, Han J, Bennin DA, Critchley DR, et al. Calpain-mediated proteolysis of talin regulates adhesion dynamics. Nat Cell Biol 2004; 6:977-83; PMID:15448700; http://dx.doi.org/10.1038/ncb1175
41. Huang C, Rajfur Z, Yousefi N, Chen Z, Jacobson K, Ginsberg MH. Talin phosphorylation by Cdk5 regulates Smurf1-mediated talin head ubiquitylation and cell migration. Nat Cell Biol 2009; 11:624-30; PMID:19363486; http://dx.doi.org/10.1038/ncb1868