메뉴 건너뛰기




Volumn 47, Issue 6, 2012, Pages 719-728

Nicotine and lipopolysaccharide stimulate the production of MMPs and prostaglandin E2 by hypoxia-inducible factor-1α up-regulation in human periodontal ligament cells

Author keywords

Hypoxia inducible factor 1 ; Lipopolysaccharide; MMPs; Nicotine; Periodontal ligament cells; Prostaglandin E2

Indexed keywords

CYCLOOXYGENASE 2; GELATINASE A; GELATINASE B; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINE; PROSTAGLANDIN E2;

EID: 84867229554     PISSN: 00223484     EISSN: 16000765     Source Type: Journal    
DOI: 10.1111/j.1600-0765.2012.01487.x     Document Type: Article
Times cited : (45)

References (50)
  • 1
    • 0025464798 scopus 로고
    • Lipopolysaccharide-induced production of cytokines by bone marrow-derived macrophages: dissociation between intracellular interleukin 1 production and interleukin 1 release
    • Aznar C, Fitting C, Cavaillon JM. Lipopolysaccharide-induced production of cytokines by bone marrow-derived macrophages: dissociation between intracellular interleukin 1 production and interleukin 1 release. Cytokine 1990;2:259-265.
    • (1990) Cytokine , vol.2 , pp. 259-265
    • Aznar, C.1    Fitting, C.2    Cavaillon, J.M.3
  • 2
    • 0029283278 scopus 로고
    • Differential expression of IL-1β, TNF-α, IL-6, and IL-8 in human monocytes in response to lipopolysaccharides from different microbes
    • Agarwal S, Piesco NP, Johns LP, Riccelli AE. Differential expression of IL-1β, TNF-α, IL-6, and IL-8 in human monocytes in response to lipopolysaccharides from different microbes. J Dent Res 1995;74:1057-1065.
    • (1995) J Dent Res , vol.74 , pp. 1057-1065
    • Agarwal, S.1    Piesco, N.P.2    Johns, L.P.3    Riccelli, A.E.4
  • 3
    • 33846685950 scopus 로고    scopus 로고
    • Gingival crevicular fluid prostaglandin E(2) and thiobarbituric acid reactive substance levels in smokers and non-smokers with chronic periodontitis following phase I periodontal therapy and adjunctive use of flurbiprofen
    • Kurtiş B, Tüter G, Serdar M, Pinar S, Demirel I, Toyman U. Gingival crevicular fluid prostaglandin E(2) and thiobarbituric acid reactive substance levels in smokers and non-smokers with chronic periodontitis following phase I periodontal therapy and adjunctive use of flurbiprofen. J Periodontol 2007;78:104-111.
    • (2007) J Periodontol , vol.78 , pp. 104-111
    • Kurtiş, B.1    Tüter, G.2    Serdar, M.3    Pinar, S.4    Demirel, I.5    Toyman, U.6
  • 4
    • 0032011510 scopus 로고    scopus 로고
    • Measurement of prostaglandin E2 and leukotriene B4 in the gingival crevicular fluid
    • Tsai CC, Hong YC, Chen CC, Wu YM. Measurement of prostaglandin E2 and leukotriene B4 in the gingival crevicular fluid. J Dent 1998;26:97-103.
    • (1998) J Dent , vol.26 , pp. 97-103
    • Tsai, C.C.1    Hong, Y.C.2    Chen, C.C.3    Wu, Y.M.4
  • 5
    • 0024438067 scopus 로고
    • Altering the progression of human alveolar bone loss with the non-steroidal anti-inflammatory drug flurbiprofen
    • Williams RC, Jeffcoat MK, Howell TH et al. Altering the progression of human alveolar bone loss with the non-steroidal anti-inflammatory drug flurbiprofen. J Periodontol 1989;60:485-490.
    • (1989) J Periodontol , vol.60 , pp. 485-490
    • Williams, R.C.1    Jeffcoat, M.K.2    Howell, T.H.3
  • 7
    • 0028488241 scopus 로고
    • Matrix metalloproteinases (MMP-2 and MMP-9) of the oral cavity: cellular origin and relationship to periodontal status
    • Mäkelä M, Salo T, Uitto V-J, Larjava H. Matrix metalloproteinases (MMP-2 and MMP-9) of the oral cavity: cellular origin and relationship to periodontal status. J Dent Res 1994;73:1397-1406.
    • (1994) J Dent Res , vol.73 , pp. 1397-1406
    • Mäkelä, M.1    Salo, T.2    Uitto, V.-J.3    Larjava, H.4
  • 8
    • 33645077356 scopus 로고    scopus 로고
    • Cytokine pattern determines the progression of experimental periodontal disease induced by Actinobacillus actinomycetemcomitans through the modulation of MMPs, RANKL, and their physiological inhibitors
    • Garlet GP, Cardoso CR, Silva TA et al. Cytokine pattern determines the progression of experimental periodontal disease induced by Actinobacillus actinomycetemcomitans through the modulation of MMPs, RANKL, and their physiological inhibitors. Oral Microbiol Immunol 2006;21:12-20.
    • (2006) Oral Microbiol Immunol , vol.21 , pp. 12-20
    • Garlet, G.P.1    Cardoso, C.R.2    Silva, T.A.3
  • 9
    • 0030338160 scopus 로고    scopus 로고
    • Matrix metalloproteinases and their inhibitors in gingival crevicular fluid and saliva of periodontitis patients
    • Ingman T, Tervahartiala T, Ding Y et al. Matrix metalloproteinases and their inhibitors in gingival crevicular fluid and saliva of periodontitis patients. J Clin Periodontol 1996;23:1127-1132.
    • (1996) J Clin Periodontol , vol.23 , pp. 1127-1132
    • Ingman, T.1    Tervahartiala, T.2    Ding, Y.3
  • 10
    • 33748638853 scopus 로고    scopus 로고
    • Matrix metalloproteinases: contribution to pathogenesis, diagnosis and treatment of periodontal inflammation
    • Sorsa T, Tjäderhane L, Konttinen YT et al. Matrix metalloproteinases: contribution to pathogenesis, diagnosis and treatment of periodontal inflammation. Ann Med 2006;38:306-321.
    • (2006) Ann Med , vol.38 , pp. 306-321
    • Sorsa, T.1    Tjäderhane, L.2    Konttinen, Y.T.3
  • 11
    • 34247631302 scopus 로고    scopus 로고
    • The impact of cigarette smoking on periodontal disease and treatment
    • Johnson GK, Guthmiller JM. The impact of cigarette smoking on periodontal disease and treatment. Periodontol 2000 2007;44:178-194.
    • (2007) Periodontol 2000 , vol.44 , pp. 178-194
    • Johnson, G.K.1    Guthmiller, J.M.2
  • 12
    • 0024653499 scopus 로고
    • Cotinine in saliva and gingival crevicular fluid of smokers with periodontal disease
    • McGuire JR, McQuade MJ, Rossmann JA et al. Cotinine in saliva and gingival crevicular fluid of smokers with periodontal disease. J Periodontol 1989;60:176-181.
    • (1989) J Periodontol , vol.60 , pp. 176-181
    • McGuire, J.R.1    McQuade, M.J.2    Rossmann, J.A.3
  • 13
    • 33947683135 scopus 로고    scopus 로고
    • Nicotine increases the collagen-degrading ability of human gingival fibroblasts
    • Zhou J, Olson BL, Windsor LJ. Nicotine increases the collagen-degrading ability of human gingival fibroblasts. J Periodontal Res 2007;42:228-235.
    • (2007) J Periodontal Res , vol.42 , pp. 228-235
    • Zhou, J.1    Olson, B.L.2    Windsor, L.J.3
  • 14
    • 33845637928 scopus 로고    scopus 로고
    • Nicotine treatment induces expression of matrix metalloproteinases in human osteoblastic Saos-2 cells
    • Katono T, Kawato T, Tanabe N et al. Nicotine treatment induces expression of matrix metalloproteinases in human osteoblastic Saos-2 cells. Acta Biochim Biophys Sin 2006;38:874-882.
    • (2006) Acta Biochim Biophys Sin , vol.38 , pp. 874-882
    • Katono, T.1    Kawato, T.2    Tanabe, N.3
  • 15
    • 68749109409 scopus 로고    scopus 로고
    • Effects of nicotine on antioxidant defense enzymes and RANKL expression in human periodontal ligament cells
    • Lee HJ, Pi SH, Kim Y et al. Effects of nicotine on antioxidant defense enzymes and RANKL expression in human periodontal ligament cells. J Periodontol 2009;80:1281-1288.
    • (2009) J Periodontol , vol.80 , pp. 1281-1288
    • Lee, H.J.1    Pi, S.H.2    Kim, Y.3
  • 16
    • 57549110837 scopus 로고    scopus 로고
    • Effects of nicotine and lipopolysaccharide on the expression of matrix metalloproteinases, plasminogen activators, and their inhibitors in human osteoblasts
    • Katono T, Kawato T, Tanabe N et al. Effects of nicotine and lipopolysaccharide on the expression of matrix metalloproteinases, plasminogen activators, and their inhibitors in human osteoblasts. Arch Oral Biol 2009;54:146-155.
    • (2009) Arch Oral Biol , vol.54 , pp. 146-155
    • Katono, T.1    Kawato, T.2    Tanabe, N.3
  • 17
    • 33244467025 scopus 로고    scopus 로고
    • Nicotine and lipopolysaccharide stimulate the formation of osteoclast-like cells by increasing macrophage colony-stimulating factor and prostaglandin E2 production by osteoblasts
    • Tanaka H, Tanabe N, Shoji M et al. Nicotine and lipopolysaccharide stimulate the formation of osteoclast-like cells by increasing macrophage colony-stimulating factor and prostaglandin E2 production by osteoblasts. Life Sci 2006;78:1733-1740.
    • (2006) Life Sci , vol.78 , pp. 1733-1740
    • Tanaka, H.1    Tanabe, N.2    Shoji, M.3
  • 18
    • 33947277989 scopus 로고    scopus 로고
    • Lipopolysaccharide enhances the production of nicotine-induced prostaglandin E2 by an increase in cyclooxygenase-2 expression in osteoblasts
    • Shoji M, Tanabe N, Mitsui N et al. Lipopolysaccharide enhances the production of nicotine-induced prostaglandin E2 by an increase in cyclooxygenase-2 expression in osteoblasts. Acta Biochim Biophys Sin 2007;39:163-172.
    • (2007) Acta Biochim Biophys Sin , vol.39 , pp. 163-172
    • Shoji, M.1    Tanabe, N.2    Mitsui, N.3
  • 19
    • 77950276116 scopus 로고    scopus 로고
    • Heme oxygenase-1 mediates nicotine- and lipopolysaccharide-induced expression of cyclooxygenase-2 and inducible nitric oxide synthase in human periodontal ligament cells
    • Pi SH, Jeong GS, Oh HW et al. Heme oxygenase-1 mediates nicotine- and lipopolysaccharide-induced expression of cyclooxygenase-2 and inducible nitric oxide synthase in human periodontal ligament cells. J Periodontal Res 2010;45:177-183.
    • (2010) J Periodontal Res , vol.45 , pp. 177-183
    • Pi, S.H.1    Jeong, G.S.2    Oh, H.W.3
  • 20
    • 0032190614 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1, master regulator of O2 homeostasis
    • Semenza GL. Hypoxia-inducible factor 1, master regulator of O2 homeostasis. Curr Opin Genet Dev 1998;8:588-594.
    • (1998) Curr Opin Genet Dev , vol.8 , pp. 588-594
    • Semenza, G.L.1
  • 21
    • 0029761644 scopus 로고    scopus 로고
    • Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor-1
    • Forsythe JA, Jiang BH, Iyer NV et al. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor-1. Mol Cell Biol 1996;16:4604-4613.
    • (1996) Mol Cell Biol , vol.16 , pp. 4604-4613
    • Forsythe, J.A.1    Jiang, B.H.2    Iyer, N.V.3
  • 22
    • 0347334750 scopus 로고    scopus 로고
    • IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis
    • Jung YJ, Isaacs JS, Lee S, Trepel J, Neckers L. IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis. FASEB J 2003;17:2115-2117.
    • (2003) FASEB J , vol.17 , pp. 2115-2117
    • Jung, Y.J.1    Isaacs, J.S.2    Lee, S.3    Trepel, J.4    Neckers, L.5
  • 23
    • 33745003285 scopus 로고    scopus 로고
    • Bacterial lipopolysaccharide induces HIF-1 activation in human monocytes via p44/42 MAPK and NF-kappaB
    • Frede S, Stockmann C, Freitag P, Fandrey J. Bacterial lipopolysaccharide induces HIF-1 activation in human monocytes via p44/42 MAPK and NF-kappaB. Biochem J 2006;396:517-527.
    • (2006) Biochem J , vol.396 , pp. 517-527
    • Frede, S.1    Stockmann, C.2    Freitag, P.3    Fandrey, J.4
  • 24
    • 34548102391 scopus 로고    scopus 로고
    • Nicotine induces hypoxia-inducible factor-1alpha expression in human lung cancer cells via nicotinic acetylcholine receptor-mediated signaling pathways
    • Zhang Q, Tang X, Zhang ZF, Velikina R, Shi S, Le AD. Nicotine induces hypoxia-inducible factor-1alpha expression in human lung cancer cells via nicotinic acetylcholine receptor-mediated signaling pathways. Clin Cancer Res 2007;15:4686-4694.
    • (2007) Clin Cancer Res , vol.15 , pp. 4686-4694
    • Zhang, Q.1    Tang, X.2    Zhang, Z.F.3    Velikina, R.4    Shi, S.5    Le, A.D.6
  • 26
    • 0034663561 scopus 로고    scopus 로고
    • Interleukin 1 induces hypoxia-inducible factor 1 in human gingival and synovial fibroblasts
    • Thornton RD, Lane P, Borghaei RC, Pease EA, Caro J, Mochan E. Interleukin 1 induces hypoxia-inducible factor 1 in human gingival and synovial fibroblasts. Biochem J 2000;350:307-312.
    • (2000) Biochem J , vol.350 , pp. 307-312
    • Thornton, R.D.1    Lane, P.2    Borghaei, R.C.3    Pease, E.A.4    Caro, J.5    Mochan, E.6
  • 27
    • 33748594198 scopus 로고    scopus 로고
    • Effect of F-spondin on cementoblastic differentiation of human periodontal ligament cells
    • Kitagawa M, Kudo Y, Iizuka S et al. Effect of F-spondin on cementoblastic differentiation of human periodontal ligament cells. Biochem Biophys Res Commun 2006;349:1050-1056.
    • (2006) Biochem Biophys Res Commun , vol.349 , pp. 1050-1056
    • Kitagawa, M.1    Kudo, Y.2    Iizuka, S.3
  • 28
    • 84860003450 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress modulates nicotine-induced extracellular matrix degradation in human periodontal ligament cells
    • PMID 224889671.
    • Lee SI, Kang KI, Shin SI, Heer Y, Lee YM, Kim EC. Endoplasmic reticulum stress modulates nicotine-induced extracellular matrix degradation in human periodontal ligament cells. J Periodontal Res 2012; PMID 224889671.
    • (2012) J Periodontal Res
    • Lee, S.I.1    Kang, K.I.2    Shin, S.I.3    Heer, Y.4    Lee, Y.M.5    Kim, E.C.6
  • 30
    • 0028432584 scopus 로고
    • Acessing the nicotine content of smokeless tobacco products
    • Tilashalski K, Rodu B, Mayfield C. Acessing the nicotine content of smokeless tobacco products. J Am Dent Assoc 1994;125:590-594.
    • (1994) J Am Dent Assoc , vol.125 , pp. 590-594
    • Tilashalski, K.1    Rodu, B.2    Mayfield, C.3
  • 31
    • 0019782616 scopus 로고
    • Carcinogenic tobacco-specific N-nitrosamines in snuff and in the saliva of snuff dippers
    • Hoffmann D, Adams JD. Carcinogenic tobacco-specific N-nitrosamines in snuff and in the saliva of snuff dippers. Cancer Res 1981;41:4305-4308.
    • (1981) Cancer Res , vol.41 , pp. 4305-4308
    • Hoffmann, D.1    Adams, J.D.2
  • 32
    • 0024215844 scopus 로고
    • Drug therapy. Pharmacologic aspects of cigarette smoking and nicotine addition
    • Benowitz NL. Drug therapy. Pharmacologic aspects of cigarette smoking and nicotine addition. N Engl J Med 1988;319:1318-1330.
    • (1988) N Engl J Med , vol.319 , pp. 1318-1330
    • Benowitz, N.L.1
  • 33
    • 0031991133 scopus 로고    scopus 로고
    • Histopathological investigation of gingival tissue from patients with rapidly progressive periodontitis
    • Hillmann G, Dogan S, Geurtsen W. Histopathological investigation of gingival tissue from patients with rapidly progressive periodontitis. J Periodontol 1998;69:195-208.
    • (1998) J Periodontol , vol.69 , pp. 195-208
    • Hillmann, G.1    Dogan, S.2    Geurtsen, W.3
  • 34
    • 0032014863 scopus 로고    scopus 로고
    • Nicotine-induced alterations in human primary periodontal ligament and gingiva fibroblast cultures
    • Alpar B, Leyhausen G, Sapotnick A, Günay H, Geurtsen W. Nicotine-induced alterations in human primary periodontal ligament and gingiva fibroblast cultures. Clin Oral Invest 1998;2:40-46.
    • (1998) Clin Oral Invest , vol.2 , pp. 40-46
    • Alpar, B.1    Leyhausen, G.2    Sapotnick, A.3    Günay, H.4    Geurtsen, W.5
  • 35
    • 1542270766 scopus 로고    scopus 로고
    • The effect of cigarette smoking on gingival bleeding
    • Dietrich T, Bernimoulin JP, Glynn RJ. The effect of cigarette smoking on gingival bleeding. J Periodontol 2004;75:16-22.
    • (2004) J Periodontol , vol.75 , pp. 16-22
    • Dietrich, T.1    Bernimoulin, J.P.2    Glynn, R.J.3
  • 36
    • 0036691058 scopus 로고    scopus 로고
    • Mechanisms of cytotoxicity of nicotine in human periodontal ligament fibroblast cultures in vitro
    • Chang YC, Huang FM, Tai KW, Yang LC, Chou MY. Mechanisms of cytotoxicity of nicotine in human periodontal ligament fibroblast cultures in vitro. J Periodontal Res 2002;37:279-285.
    • (2002) J Periodontal Res , vol.37 , pp. 279-285
    • Chang, Y.C.1    Huang, F.M.2    Tai, K.W.3    Yang, L.C.4    Chou, M.Y.5
  • 38
    • 78249235307 scopus 로고    scopus 로고
    • Antioxidants counteract nicotine and promote migration via RacGTP in oral fibroblast cells
    • San Miguel SM, Opperman LA, Allen EP, Zielinski J, Svoboda KK. Antioxidants counteract nicotine and promote migration via RacGTP in oral fibroblast cells. J Periodontol 2010;81:1675-1690.
    • (2010) J Periodontol , vol.81 , pp. 1675-1690
    • San Miguel, S.M.1    Opperman, L.A.2    Allen, E.P.3    Zielinski, J.4    Svoboda, K.K.5
  • 39
    • 26444560225 scopus 로고    scopus 로고
    • Nicotine inhibits myofibroblast differentiation in human gingival fibroblasts
    • Fang Y, Svoboda KK. Nicotine inhibits myofibroblast differentiation in human gingival fibroblasts. J Cell Biochem 2005;95:1108-1119.
    • (2005) J Cell Biochem , vol.95 , pp. 1108-1119
    • Fang, Y.1    Svoboda, K.K.2
  • 40
    • 0036073921 scopus 로고    scopus 로고
    • Porphyromonas gingivalis lipopolysaccharide signaling in gingival fibroblasts-CD14 and Toll-like receptors
    • Wang PL, Ohura K. Porphyromonas gingivalis lipopolysaccharide signaling in gingival fibroblasts-CD14 and Toll-like receptors. Crit Rev Oral Biol Med 2002;13:132-142.
    • (2002) Crit Rev Oral Biol Med , vol.13 , pp. 132-142
    • Wang, P.L.1    Ohura, K.2
  • 41
    • 35348925095 scopus 로고    scopus 로고
    • Relationship between angiogenesis and inflammation in experimental arthritis
    • Clavel G, Valvason C, Yamaoka K et al. Relationship between angiogenesis and inflammation in experimental arthritis. Eur Cytokine Netw 2006;17:202-210.
    • (2006) Eur Cytokine Netw , vol.17 , pp. 202-210
    • Clavel, G.1    Valvason, C.2    Yamaoka, K.3
  • 42
    • 0034936994 scopus 로고    scopus 로고
    • Expression of hypoxia inducible factor 1alpha by macrophages in the rheumatoid synovium: implications for targeting of therapeutic genes to the inflamed joint
    • Hollander AP, Corke KP, Freemont AJ, Lewis CE. Expression of hypoxia inducible factor 1alpha by macrophages in the rheumatoid synovium: implications for targeting of therapeutic genes to the inflamed joint. Arthritis Rheum 2001;44:1540-1544.
    • (2001) Arthritis Rheum , vol.44 , pp. 1540-1544
    • Hollander, A.P.1    Corke, K.P.2    Freemont, A.J.3    Lewis, C.E.4
  • 43
    • 0036593233 scopus 로고    scopus 로고
    • Effects of TNF alpha and prostaglandin E2 on the expression of MMPs in human periodontal ligament fibroblasts
    • Nishikawa M, Yamaguchi Y, Yoshitake K, Saeki Y. Effects of TNF alpha and prostaglandin E2 on the expression of MMPs in human periodontal ligament fibroblasts. J Periodontal Res 2002;37:167-176.
    • (2002) J Periodontal Res , vol.37 , pp. 167-176
    • Nishikawa, M.1    Yamaguchi, Y.2    Yoshitake, K.3    Saeki, Y.4
  • 44
    • 53549120206 scopus 로고    scopus 로고
    • The effects of selective COX-2 inhibitor/celecoxib and omega-3 fatty acid on matrix metalloproteinases, TIMP-1, and laminin-5gamma2-chain immunolocalization in experimental periodontitis
    • Vardar-Sengul S, Buduneli E, Turkoglu O et al. The effects of selective COX-2 inhibitor/celecoxib and omega-3 fatty acid on matrix metalloproteinases, TIMP-1, and laminin-5gamma2-chain immunolocalization in experimental periodontitis. J Periodontol 2008;79:1934-1941.
    • (2008) J Periodontol , vol.79 , pp. 1934-1941
    • Vardar-Sengul, S.1    Buduneli, E.2    Turkoglu, O.3
  • 45
    • 0842280605 scopus 로고    scopus 로고
    • Cyclooxygenase-2 inhibitors decrease interleukin-1beta-stimulated prostaglandin E2 and IL-6 production by human gingival fibroblasts
    • Tipton DA, Flynn JC, Stein SH, Dabbous MKH. Cyclooxygenase-2 inhibitors decrease interleukin-1beta-stimulated prostaglandin E2 and IL-6 production by human gingival fibroblasts. J Periodontol 2003;74:1754-1763.
    • (2003) J Periodontol , vol.74 , pp. 1754-1763
    • Tipton, D.A.1    Flynn, J.C.2    Stein, S.H.3    Dabbous, M.K.H.4
  • 46
    • 0031127305 scopus 로고    scopus 로고
    • Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα
    • Alessi DR, James SR, Downes CP et al. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα. Curr Biol 1997;7:261-269.
    • (1997) Curr Biol , vol.7 , pp. 261-269
    • Alessi, D.R.1    James, S.R.2    Downes, C.P.3
  • 47
    • 0036710591 scopus 로고    scopus 로고
    • Signal transduction to hypoxia-inducible factor 1
    • Semenza GL. Signal transduction to hypoxia-inducible factor 1. Biochem Pharmacol 2002;64:993-998.
    • (2002) Biochem Pharmacol , vol.64 , pp. 993-998
    • Semenza, G.L.1
  • 48
    • 0037388863 scopus 로고    scopus 로고
    • Adrenocorticotropin induces mitogen-activated protein kinase phosphatase-1 in Y1 adrenocortical tumor cells
    • Bey P, Gorostizaga AB, Maloberti PM et al. Adrenocorticotropin induces mitogen-activated protein kinase phosphatase-1 in Y1 adrenocortical tumor cells. Endocrinology 2003;144:1399-1406.
    • (2003) Endocrinology , vol.144 , pp. 1399-1406
    • Bey, P.1    Gorostizaga, A.B.2    Maloberti, P.M.3
  • 49
    • 10944258108 scopus 로고    scopus 로고
    • PKC-eta mediates glioblastoma cell proliferation through the Akt and mTOR signaling pathways
    • Aeder SE, Martin PM, Soh JW, Hussaini IM. PKC-eta mediates glioblastoma cell proliferation through the Akt and mTOR signaling pathways. Oncogene 2004;23:9062-9069.
    • (2004) Oncogene , vol.23 , pp. 9062-9069
    • Aeder, S.E.1    Martin, P.M.2    Soh, J.W.3    Hussaini, I.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.