Viral Toll Like Receptor activation of pulmonary vascular smooth muscle cells results in endothelin-1 generation; relevance to pathogenesis of pulmonary arterial hypertension

Biochemical and Biophysical Research Communications

Volumn 426, Issue 4, 2012, Pages 486-491

  George, Peter M ^a   Badiger, Rekha ^a   Shao, Dongmin ^b   Edwards, Michael R ^a,c,d   Wort, Stephen J ^b   Paul Clark, Mark J ^a   Mitchell, Jane A ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b ROYAL BROMPTON HOSPITAL   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d Centre for Respiratory Infections   (United Kingdom)

Author keywords

Endothelin 1; Interferon; Pulmonary hypertension; TLR3; Toll Like Receptor; Virus

Indexed keywords

BACTERIAL PROTEIN; ENDOTHELIN 1; INTERLEUKIN 3; INTERLEUKIN 8; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 6; VIRUS PROTEIN;

ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INNATE IMMUNITY; LUNG BLOOD VESSEL; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; PULMONARY ARTERY; PULMONARY HYPERTENSION; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

CELLS, CULTURED; CHEMOKINES; CYTOKINES; ENDOTHELIN-1; GENE EXPRESSION; HUMANS; HYPERTENSION, PULMONARY; INTERLEUKIN-8; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; POLY I-C; RECEPTORS, CYTOKINE; TOLL-LIKE RECEPTOR 3; TUMOR NECROSIS FACTOR-ALPHA;

BACTERIA (MICROORGANISMS);

EID: 84867209784     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.08.106     Document Type: Article

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