Histone deacetylases inhibitor Trichostatin A ameliorates DNFB-induced allergic contact dermatitis and reduces epidermal Langerhans cells in mice

Journal of Dermatological Science

Volumn 68, Issue 2, 2012, Pages 99-107

  Shi, Yu Ling ^a,b   Gu, Jun ^c   Park, Jun Yang ^a   Xu, Ying Ping ^a   Yu, Fu Shin ^d   Zhou, Li ^a   Mi, Qing Sheng ^a  

^a HENRY FORD HEALTH SYSTEM   (United States)

^b TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

^c SECOND MILITARY MEDICAL UNIVERSITY   (China)

^d WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Allergic contact dermatitis; Histone deacetylases; Langerhans cells; NKT cells; Regulatory T cells; Trichostatin A

Indexed keywords

1 FLUORO 2,4 DINITROBENZENE; GAMMA INTERFERON; INTERLEUKIN 4; TRANSCRIPTION FACTOR FOXP3; TRICHOSTATIN A;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL MATURATION; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFECT; DRUG MECHANISM; GAMMA DELTA T LYMPHOCYTE; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; LANGERHANS CELL; LYMPHOCYTE COUNT; LYMPHOCYTE MIGRATION; MOUSE; NATURAL KILLER T CELL; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SKIN ALLERGY; SKIN BIOPSY; SKIN DEFECT; SKIN PROTECTION; SKIN SENSITIZATION;

ANIMALS; DERMATITIS, ALLERGIC CONTACT; DINITROFLUOROBENZENE; FORKHEAD TRANSCRIPTION FACTORS; HISTONE DEACETYLASE INHIBITORS; HYDROXAMIC ACIDS; LANGERHANS CELLS; MICE; MICE, INBRED C57BL; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; T-LYMPHOCYTES;

EID: 84867194829     PISSN: 09231811     EISSN: 1873569X     Source Type: Journal    
DOI: 10.1016/j.jdermsci.2012.09.001     Document Type: Article

References (46)

1. Coenraads P.J., Goncalo M. Skin diseases with high public health impact. Contact dermatitis. Eur J Dermatol 2007, 17:564-565.
2. Banchereau J., Steinman R.M. Dendritic cells and the control of immunity. Nature 1998, 392:245-252.
3. Martin S.F., Jakob T. From innate to adaptive immune responses in contact hypersensitivity. Curr Opin Allergy Clin Immunol 2008, 8:289-293.
4. Grabbe S., Schwarz T. Immunoregulatory mechanisms involved in elicitation of allergic contact hypersensitivity. Immunol Today 1998, 19:37-44.
5. Valladeau J., Ravel O., Dezutter-Dambuyant C., Moore K., Kleijmeer M., Liu Y., et al. Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunity 2000, 12:71-81.
6. Romani N., Holzmann S., Tripp C.H., Koch F., Stoitzner P. Langerhans cells - dendritic cells of the epidermis. APMIS 2003, 111:725-740.
7. Merad M., Ginhoux F., Collin M. Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells. Nat Rev Immunol 2008, 8:935-947.
8. Romani N., Clausen B.E., Stoitzner P. Langerhans cells and more: langerin-expressing dendritic cell subsets in the skin. Immunol Rev 2010, 234:120-141.
9. Kaplan D.H. In vivo function of Langerhans cells and dermal dendritic cells. Trends Immunol 2010, 31:446-451.
10. Haberland M., Montgomery R.L., Olson E.N. The many roles of histone deacetylases in development and physiology: implications for disease and therapy. Nat Rev Genet 2009, 10:32-42.
11. Wang Z., Zang C., Cui K., Schones D.E., Barski A., Peng W., et al. Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes. Cell 2009, 138:1019-1031.
12. Minucci S., Pelicci P.G. Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer. Nat Rev Cancer 2006, 6:38-51.
13. Glauben R., Batra A., Fedke I., Zeitz M., Lehr H.A., Leoni F., et al. Histone hyperacetylation is associated with amelioration of experimental colitis in mice. J Immunol 2006, 176:5015-5022.
14. Reilly C.M., Regna N., Mishra N. HDAC inhibition in lupus models. Mol Med 2011, 17:417-425.
15. Horwitz S.M. The emerging role of histone deacetylase inhibitors in treating T-cell lymphomas. Curr Hematol Malig Rep 2011, 6:67-72.
16. Finnin M.S., Donigian J.R., Cohen A., Richon V.M., Rifkind R.A., Marks P.A., et al. Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors. Nature 1999, 401:188-193.
17. Choi J.H., Oh S.W., Kang M.S., Kwon H.J., Oh G.T., Kim D.Y. Trichostatin A attenuates airway inflammation in mouse asthma model. Clin Exp Allergy 2005, 35:89-96.
18. Zhou X., Hua X., Ding X., Bian Y., Wang X. Trichostatin differentially regulates Th1 and Th2 responses and alleviates rheumatoid arthritis in mice. J Clin Immunol 2011, 31:395-405.
19. Qi R., Liu M., Gao X.H., Yu F.S., Chen H.D., Lim H.W., et al. Histone deacetylase activity is required for skin Langerhans cell maturation and phagocytosis. J Dermatol Sci 2012, 65:152-155.
20. Bennett C.L., Noordegraaf M., Martina C.A., Clausen B.E. Langerhans cells are required for efficient presentation of topically applied hapten to T cells. J Immunol 2007, 179:6830-6835.
21. Askenase P.W., Majewska-Szczepanik M., Kerfoot S., Szczepanik M. Participation of iNKT cells in the early and late components of Tc1-mediated DNFB contact sensitivity: cooperative role of gammadelta-T cells. Scand J Immunol 2011, 73:465-477.
22. Kaplan D.H., Kissenpfennig A., Clausen B.E. Insights into Langerhans cell function from Langerhans cell ablation models. Eur J Immunol 2008, 38:2369-2376.
23. Singh N., Thangaraju M., Prasad P.D., Martin P.M., Lambert N.A., Boettger T., et al. Blockade of dendritic cell development by bacterial fermentation products butyrate and propionate through a transporter (Slc5a8)-dependent inhibition of histone deacetylases. J Biol Chem 2010, 285:27601-27608.
24. Kim E.S., Lee J.K. Histone deacetylase inhibitors decrease the antigen presenting activity of murine bone marrow derived dendritic cells. Cell Immunol 2010, 262:52-57.
25. Nosbaum A., Vocanson M., Rozieres A., Hennino A., Nicolas J.F. Allergic and irritant contact dermatitis. Eur J Dermatol 2009, 19:325-332.
26. Vocanson M., Hennino A., Rozieres A., Poyet G., Nicolas J.F. Effector and regulatory mechanisms in allergic contact dermatitis. Allergy 2009, 64:1699-1714.
27. Campos R.A., Szczepanik M., Lisbonne M., Itakura A., Leite-de-Moraes M., Askenase P.W., Invariant N.K.T. cells rapidly activated via immunization with diverse contact antigens collaborate in vitro with B-1 cells to initiate contact sensitivity. J Immunol 2006, 177:3686-3694.
28. Joosten L.A., Leoni F., Meghji S., Mascagni P. Inhibition of HDAC activity by ITF2357 ameliorates joint inflammation and prevents cartilage and bone destruction in experimental arthritis. Mol Med 2011, 17:391-396.
29. Reilly C.M., Thomas M., Gogal R., Olgun S., Santo A., Sodhi R., et al. The histone deacetylase inhibitor trichostatin A upregulates regulatory T cells and modulates autoimmunity in NZB/W F1 mice. J Autoimmun 2008, 31:123-130.
30. Qi R., Liu M., Gao X.H., Yu F.S., Chen H.D., Lim H.W., et al. Histone deacetylase activity is required for skin Langerhans cell maturation and phagocytosis. J Dermatol Sci 2012.
31. Bennett C.L., van Rijn E., Jung S., Inaba K., Steinman R.M., Kapsenberg M.L., et al. Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity. J Cell Biol 2005, 169:569-576.
32. Kaplan D.H., Jenison M.C., Saeland S., Shlomchik W.D., Shlomchik M.J. Epidermal langerhans cell-deficient mice develop enhanced contact hypersensitivity. Immunity 2005, 23:611-620.
33. Bobr A., Olvera-Gomez I., Igyarto B.Z., Haley K.M., Hogquist K.A., Kaplan D.H. Acute ablation of Langerhans cells enhances skin immune responses. J Immunol 2010, 185:4724-4728.
34. Zahner S.P., Kel J.M., Martina C.A., Brouwers-Haspels I., van Roon M.A., Clausen B.E. Conditional deletion of TGF-betaR1 using Langerin-Cre mice results in Langerhans cell deficiency and reduced contact hypersensitivity. J Immunol 2011, 187:5069-5076.
35. Flacher V., Douillard P., Ait-Yahia S., Stoitzner P., Clair-Moninot V., Romani N., et al. Expression of langerin/CD207 reveals dendritic cell heterogeneity between inbred mouse strains. Immunology 2008, 123:339-347.
36. + dendritic cells. J Exp Med 2007, 204:3147-3156.
37. Douillard P., Stoitzner P., Tripp C.H., Clair-Moninot V., Ait-Yahia S., McLellan A.D., et al. Mouse lymphoid tissue contains distinct subsets of langerin/CD207 dendritic cells, only one of which represents epidermal-derived Langerhans cells. J Invest Dermatol 2005, 125:983-994.
38. Zhou L., Seo K.H., He H.Z., Pacholczyk R., Meng D.M., Li C.G., et al. Tie2cre-induced inactivation of the miRNA-processing enzyme Dicer disrupts invariant NKT cell development. Proc Natl Acad Sci U S A 2009, 106:10266-10271.
39. Askenase P.W., Itakura A., Leite-de-Moraes M.C., Lisbonne M., Roongapinun S., Goldstein D.R., et al. TLR-dependent IL-4 production by invariant Valpha14+Jalpha18+ NKT cells to initiate contact sensitivity in vivo. J Immunol 2005, 175:6390-6401.
40. Askenase P.W., Szczepanik M., Itakura A., Kiener C., Campos R.A. Extravascular T-cell recruitment requires initiation begun by Valpha14+ NKT cells and B-1 B cells. Trends Immunol 2004, 25:441-449.
41. Gorbachev A.V., Fairchild R.L., Activated NKT cells increase dendritic cell migration and enhance CD8+ T cell responses in the skin. Eur J Immunol 2006, 36:2494-2503.
42. Szczepanik M., Anderson L.R., Ushio H., Ptak W., Owen M.J., Hayday A.C., et al. Gamma delta T cells from tolerized alpha beta T cell receptor (TCR)-deficient mice inhibit contact sensitivity-effector T cells in vivo, and their interferon-gamma production in vitro. J Exp Med 1996, 184:2129-2139.
43. Yokozeki H., Watanabe K., Igawa K., Miyazaki Y., Katayama I., Nishioka K., Gammadelta T cells assist alphabeta T cells in the adoptive transfer of contact hypersensitivity to para-phenylenediamine. Clin Exp Immunol 2001, 125:351-359.
44. Lucas J.L., Mirshahpanah P., Haas-Stapleton E., Asadullah K., Zollner T.M., Numerof R.P. Induction of Foxp3+ regulatory T cells with histone deacetylase inhibitors. Cell Immunol 2009, 257:97-104.
45. Tao R., de Zoeten E.F., Ozkaynak E., Chen C., Wang L., Porrett P.M., et al. Deacetylase inhibition promotes the generation and function of regulatory T cells. Nat Med 2007, 13:1299-1307.
46. Liu Z., Zhang C., Sun J. Deacetylase inhibitor trichostatin A down-regulates Foxp3 expression and reduces CD4+CD25+ regulatory T cells. Biochem Biophys Res Commun 2010, 400:409-412.