Deacetylase inhibitor trichostatin A down-regulates Foxp3 expression and reduces CD4+CD25+ regulatory T cells

Biochemical and Biophysical Research Communications

Volumn 400, Issue 3, 2010, Pages 409-412

  Liu, Zhijian ^a   Zhang, Chenquan ^a   Sun, Jian ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Foxp3; Regulatory T cells (Treg); Trichostatin A (TSA)

Indexed keywords

CD4 ANTIGEN; DACTINOMYCIN; MESSENGER RNA; TRANSCRIPTION FACTOR FOXP3; TRICHOSTATIN A; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; HISTONE DEACETYLASE INHIBITOR; HYDROXAMIC ACID; INTERLEUKIN 2 RECEPTOR ALPHA;

ACETYLATION; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CELL COUNT; CELL FUNCTION; DOWN REGULATION; GENETIC TRANSCRIPTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY T LYMPHOCYTE; SPLEEN CELL; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; C57BL MOUSE; DRUG EFFECTS; GENETICS; IMMUNOLOGY; METABOLISM; PROMOTER REGION; RNA STABILITY;

ANIMALS; ANTIGENS, CD4; FORKHEAD TRANSCRIPTION FACTORS; HISTONE DEACETYLASE INHIBITORS; HYDROXAMIC ACIDS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; MICE; MICE, INBRED C57BL; PROMOTER REGIONS, GENETIC; RNA STABILITY; RNA, MESSENGER; T-LYMPHOCYTES, REGULATORY;

MUS;

EID: 77956944748     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.08.090     Document Type: Article

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