High antibody levels to P. gingivalis in cardiovascular disease

Journal of Dental Research

Volumn 89, Issue 9, 2010, Pages 938-942

  Bohnstedt, S ^a   Cullinan, M P ^a,b   Ford, P J ^a   Palmer, J E ^a   Leishman, S J ^a   Westerman, B ^a   Marshall, R I ^a   West, M J ^a   Seymour, G J ^a,b  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

cardiovascular disease; periodontal disease; Porphyromonas gingivalis; serum antibodies; strain variation

Indexed keywords

BACTERIUM ANTIBODY; IMMUNOGLOBULIN G;

ADOLESCENT; ADULT; AGED; ANALYSIS OF VARIANCE; ARTICLE; BLOOD; CARDIOVASCULAR DISEASE; CASE CONTROL STUDY; CHRONIC PERIODONTITIS; CLASSIFICATION; CROSS-SECTIONAL STUDY; ENZYME IMMUNOASSAY; FEMALE; HUMAN; IMMUNOLOGY; MALE; MICROBIOLOGY; MIDDLE AGED; NONPARAMETRIC TEST; PATHOGENICITY; PORPHYROMONAS GINGIVALIS; RISK FACTOR; SPECIES DIFFERENCE; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; ANALYSIS OF VARIANCE; ANTIBODIES, BACTERIAL; CARDIOVASCULAR DISEASES; CASE-CONTROL STUDIES; CHRONIC PERIODONTITIS; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; IMMUNOGLOBULIN G; MALE; MIDDLE AGED; PORPHYROMONAS GINGIVALIS; RISK FACTORS; SPECIES SPECIFICITY; STATISTICS, NONPARAMETRIC; YOUNG ADULT;

EID: 77956016933     PISSN: 00220345     EISSN: 15440591     Source Type: Journal    
DOI: 10.1177/0022034510370817     Document Type: Article

References (33)

1. Amabile N., Susini G., Pettenati-Soubayroux I., Bonello L., Gil JM, Arques S., et al. (2008). Severity of periodontal disease correlates to inflammatory systemic status and independently predicts the presence and angiographic extent of stable coronary artery disease. J Intern Med 263: 644-652.
2. Amano A., Kuboniwa M., Nakagawa I., Akiyama S., Morisaki I., Hamada S. (2000). Prevalence of specific genotypes of Porphyromonas gingivalis fimA and periodontal health status. J Dent Res 79: 1664-1668.
3. Amano A., Nakagawa I., Okahashi N., Hamada N. (2004). Variations of Porphyromonas gingivalis fimbriae in relation to microbial pathogenesis. J Periodontal Res 39: 136-142.
4. Bahekar AA, Singh S., Saha S., Molnar J., Arora R. (2007). The prevalence and incidence of coronary heart disease is significantly increased in periodontitis: a meta analysis. Am Heart J 154: 830-837.
5. Beck J., Garcia R., Heiss G., Vokonas PS, Offenbacher S. (1996). Periodontal disease and cardiovascular disease. J Periodontol 67 (10 Suppl). 1123S1137S.
6. Cullinan MP, Hamlet SM, Westerman B., Palmer JE, Faddy MJ, Seymour GJ (2003). Acquisition and loss of Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans and Prevotella intermedia over a 5-year period: effect of a triclosan/copolymer dentifrice. J Clin Periodontol 30: 532-541.
7. DeStefano F., Anda RF, Kahn HS, Williamson DF, Russell CM (1993). Dental disease and risk of coronary heart disease and mortality. BMJ 306: 688-691.
8. Dorn BR, Burks JN, Seifert KN, Progulske-Fox A. (2000). Invasion of endothelial and epithelial cells by strains of Porphyromonas gingivalis. FEMS Microbiol Lett 187: 139-144.
9. Epstein SE, Zhou YF, Zhu J. (1999). Infection and atherosclerosis: emerging mechanistic paradigms. Circulation 100: e20 - e28.
10. Fabricant CG, Fabricant J., Litrenta MM, Minick CR (1978). Virus-induced atherosclerosis. J Exp Med 148: 335-340.
11. Ford PJ, Gemmell E., Hamlet SM, Hasan A., Walker PJ, West MJ, et al. (2005). Cross-reactivity of GroEL antibodies with human heat shock protein 60 and quantification of pathogens in atherosclerosis. Oral Microbiol Immunol 20: 296-302.
12. Ford PJ, Gemmell E., Chan A., Carter CL, Walker PJ, Bird PS, et al. (2006). Inflammation, heat shock proteins and periodontal pathogens in atherosclerosis: an immunohistologic study. Oral Microbiol Immunol 21: 206-211.
13. Ford PJ, Gemmell E., Timms P., Chan A., Preston FM, Seymour GJ (2007). Anti-P. gingivalis response correlates with atherosclerosis. J Dent Res 86: 35-40.
14. Gemmell E., Bird P., Carter CL, Drysdale KE, Seymour GJ (2002). Effect of Fusobacterium nucleatum on the T and B cell responses to Porphyromonas gingivalis in a mouse model. Clin Exp Immunol 128: 238-244.
15. Humphrey LL, Fu R., Buckley DI, Freeman M., Helfand M. (2008). Periodontal disease and coronary heart disease incidence: a systematic review and meta-analysis. J Gen Intern Med 23: 2079-2086.
16. Inaba H., Nakano K., Kato T., Nomura R., Kawai S., Kuboniwa M., et al. (2008). Heterogenic virulence and related factors among clinical isolates of Porphyromonas gingivalis with type II fimbriae. Oral Microbiol Immunol 23: 29-35.
17. Kato T., Kawai S., Nakano K., Inaba H., Kuboniwa M., Nakagawa I., et al. (2007). Virulence of Porphyromonas gingivalis is altered by substitution of fimbria gene with different genotype. Cell Microbiol 9: 753-765.
18. Katz JT, Shannon RP (2006). Bacteria and coronary atheroma: more fingerprints but no smoking gun. Circulation 113: 920-922.
19. Kozarov EV, Dorn BR, Shelburne CE, Dunn WAJR Progulske-Fox A. (2005). Human atherosclerotic plaque contains viable invasive Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis. Arterioscler Thromb Vasc Biol 25: e17 - e18.
20. Lalla E., Lamster IB, Hofmann MA, Bucciarelli L., Jerud AP, Tucker S., et al. (2003). Oral infection with a periodontal pathogen accelerates early atherosclerosis in apolipoprotein E-null mice. Arterioscler Thromb Vasc Biol 23: 1405-1411.
21. Li L., Messas E., Batista EL Jr, Levine RA, Amar S. (2002). Porphyromonas gingivalis infection accelerates the progression of atherosclerosis in a heterozygous apolipoprotein E-deficient murine model. Circulation 105: 861-867.
22. Lindy O., Suomalainen K., Makela M., Lindy S. (2008). Statin use is associated with fewer periodontal lesions: a retrospective study. BMC Oral Health 8: 16.
23. Mustapha IZ, Debrey S., Oladubu M., Ugarte R. (2007). Markers of systemic bacterial exposure in periodontal disease and cardiovascular disease risk: a systematic review and meta-analysis. J Periodontol 78: 2289-2302.
24. Nakano K., Inaba H., Nomura R., Nemoto H., Takeuchi H., Yoshioka H., et al. (2008). Distribution of Porphyromonas gingivalis fimA genotypes in cardiovascular specimens from Japanese patients. Oral Microbiol Immunol 23: 170-172.
25. No Authors Listed (1996). Consensus Report for Periodontal Diseases: pathogenesis and microbial factors. Ann Periodontol 1: 926-932.
26. Persson GR, Ohlsson O., Pettersson T., Renvert S. (2003). Chronic periodontitis, a significant relationship with acute myocardial infarction. Eur Heart J 24: 2108-2115.
27. Ross R. (1999). Atherosclerosis-an inflammatory disease. New Engl J Med 340: 115-126.
28. Rupprecht HJ, Blankenberg S., Bickel C., Rippin G., Hafner G., Prellwitz W., et al. (2001). Impact of viral and bacterial infectious burden on long-term prognosis in patients with coronary artery disease. Circulation 104: 25-31.
29. Seymour GJ, Ford PJ, Cullinan MP, Leishman S., Yamazaki K. (2007). Relationship between periodontal infections and systemic disease. Clin Microbiol Infect 13 (Suppl 4). 3-10.
30. Starkhammar Johansson C., Richter A., Lundstrom A., Thorstensson H., Ravald N. (2008). Periodontal conditions in patients with coronary heart disease: a case-control study. J Clin Periodontol 35: 199-205.
31. Tabeta K., Yamazaki K., Hotokezaka H., Yoshie H., Hara K. (2000). Elevated humoral immune response to heat shock protein 60 (hsp60) family in periodontitis patients. Clin Exp Immunol 120: 285-293.
32. Yamazaki K., Honda T., Domon H., Okui T., Kajita K., Amanuma R., et al. (2007). Relationship of periodontal infection to serum antibody levels to periodontopathic bacteria and inflammatory markers in periodontitis patients with coronary heart disease. Clin Exp Immunol 149: 445-452.
33. Zhu J., Nieto FJ, Horne BD, Anderson JL, Muhlestein JB, Epstein SE (2001). Prospective study of pathogen burden and risk of myocardial infarction or death. Circulation 103: 45-51.