Protein Kinase C ε Expression in Platelets from Patients with Acute Myocardial Infarction

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Carubbi, Cecilia ^a   Mirandola, Prisco ^a   Mattioli, Maria ^a   Galli, Daniela ^a   Marziliano, Nicola ^b   Merlini, Piera Angelica ^b   Lina, Daniela ^c   Notarangelo, Francesca ^c   Cozzi, Maria Rita ^d   Gesi, Marco ^e   Ardissino, Diego ^c   De Marco, Luigi ^d   Vitale, Marco ^a   Gobbi, Giuliana ^a  

^a UNIVERSITY OF PARMA   (Italy)

^b OSPEDALE NIGUARDA CA GRANDA   (Italy)

^c UNIVERSITY HOSPITAL OF PARMA   (Italy)

^d CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

^e UNIVERSITY OF PISA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; COLLAGEN; MESSENGER RNA; PROTEIN KINASE C EPSILON;

ACUTE HEART INFARCTION; AGED; ARTICLE; CELL DIFFERENTIATION; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DOWN REGULATION; ENZYME ACTIVITY; FEMALE; FOLLOW UP; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; MALE; MEGAKARYOCYTE; MEGAKARYOPOIESIS; PATHOPHYSIOLOGY; PROTEIN ANALYSIS; PROTEIN EXPRESSION; ST SEGMENT ELEVATION; THROMBOCYTE; THROMBOCYTE ACTIVATION; THROMBOCYTE ADHESION; THROMBOCYTOPOIESIS;

AGED; BASE SEQUENCE; BLOOD PLATELETS; CASE-CONTROL STUDIES; DNA PRIMERS; DNA, COMPLEMENTARY; FEMALE; FLOW CYTOMETRY; HUMANS; MALE; MYOCARDIAL INFARCTION; PLATELET ACTIVATION; PROTEIN KINASE C-EPSILON; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84867160100     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0046409     Document Type: Article

References (52)

1. Massberg S, Brand K, Gruner S, Page S, Muller E, et al. (2002) A critical role of platelet adhesion in the initiation of atherosclerotic lesion formation. J Exp Med 196: 887-896.
2. Harper MT, Poole AW, (2007) Isoform-specific functions of protein kinase C: the platelet paradigm. Biochem Soc Trans 35: 1005-1008.
3. Rink TJ, Sanchez A, Hallam TJ, (1983) Diacylglycerol and phorbol ester stimulate secretion without raising cytoplasmic free calcium in human platelets. Nature 305: 317-319.
4. Walker TR, Watson SP, (1993) Synergy between Ca2+ and protein kinase C is the major factor in determining the level of secretion from human platelets. Biochem J 289 (Pt 1): 277-282.
5. Yoshioka A, Shirakawa R, Nishioka H, Tabuchi A, Higashi T, et al. (2001) Identification of protein kinase Calpha as an essential, but not sufficient, cytosolic factor for Ca2+-induced alpha- and dense-core granule secretion in platelets. J Biol Chem 276: 39379-39385.
6. Jin J, Kunapuli SP, (1998) Coactivation of two different G protein-coupled receptors is essential for ADP-induced platelet aggregation. Proc Natl Acad Sci U S A 95: 8070-8074.
7. Paul BZ, Jin J, Kunapuli SP, (1999) Molecular mechanism of thromboxane A(2)-induced platelet aggregation. Essential role for p2t(ac) and alpha(2a) receptors. J Biol Chem 274: 29108-29114.
8. van Willigen G, Akkerman JW, (1991) Protein kinase C and cyclic AMP regulate reversible exposure of binding sites for fibrinogen on the glycoprotein IIB-IIIA complex of human platelets. Biochem J 273 (Pt 1): 115-120.
9. Hers I, Donath J, Litjens PE, van Willigen G, Akkerman JW, (2000) Inhibition of platelet integrin alpha(IIb)beta(3) by peptides that interfere with protein kinases and the beta(3) tail. Arterioscler Thromb Vasc Biol 20: 1651-1660.
10. Hartwig JH, Kung S, Kovacsovics T, Janmey PA, Cantley LC, et al. (1996) D3 phosphoinositides and outside-in integrin signaling by glycoprotein IIb-IIIa mediate platelet actin assembly and filopodial extension induced by phorbol 12-myristate 13-acetate. J Biol Chem 271: 32986-32993.
11. Buensuceso CS, Obergfell A, Soriani A, Eto K, Kiosses WB, et al. (2005) Regulation of outside-in signaling in platelets by integrin-associated protein kinase C beta. J Biol Chem 280: 644-653.
12. Rosado JA, Sage SO, (2000) Protein kinase C activates non-capacitative calcium entry in human platelets. J Physiol 529 Pt 1: 159-169.
13. Polanowska-Grabowska R, Gear AR, (1999) Activation of protein kinase C is required for the stable attachment of adherent platelets to collagen but is not needed for the initial rapid adhesion under flow conditions. Arterioscler Thromb Vasc Biol 19: 3044-3054.
14. Strehl A, Munnix IC, Kuijpers MJ, van der Meijden PE, Cosemans JM, et al. (2007) Dual role of platelet protein kinase C in thrombus formation: stimulation of pro-aggregatory and suppression of procoagulant activity in platelets. J Biol Chem 282: 7046-7055.
15. Crosby D, Poole AW, (2002) Interaction of Bruton's tyrosine kinase and protein kinase Ctheta in platelets. Cross-talk between tyrosine and serine/threonine kinases. J Biol Chem 277: 9958-9965.
16. Khan WA, Blobe G, Halpern A, Taylor W, Wetsel WC, et al. (1993) Selective regulation of protein kinase C isoenzymes by oleic acid in human platelets. J Biol Chem 268: 5063-5068.
17. Tsukuda M, Asaoka Y, Sekiguchi K, Kikkawa U, Nishizuka Y, (1988) Properties of protein kinase C subspecies in human platelets. Biochem Biophys Res Commun 155: 1387-1395.
18. Quinton TM, Kim S, Dangelmaier C, Dorsam RT, Jin J, et al. (2002) Protein kinase C- and calcium-regulated pathways independently synergize with Gi pathways in agonist-induced fibrinogen receptor activation. Biochem J 368: 535-543.
19. Murugappan S, Shankar H, Bhamidipati S, Dorsam RT, Jin J, et al. (2005) Molecular mechanism and functional implications of thrombin-mediated tyrosine phosphorylation of PKCdelta in platelets. Blood 106: 550-557.
20. Moussazadeh M, Haimovich B, (1998) Protein kinase C-delta activation and tyrosine phosphorylation in platelets. FEBS Lett 438: 225-230.
21. Hall KJ, Jones ML, Poole AW, (2007) Coincident regulation of PKCdelta in human platelets by phosphorylation of Tyr311 and Tyr565 and phospholipase C signalling. Biochem J 406: 501-509.
22. Crosby D, Poole AW, (2003) Physical and functional interaction between protein kinase C delta and Fyn tyrosine kinase in human platelets. J Biol Chem 278: 24533-24541.
23. Soriani A, Moran B, de Virgilio M, Kawakami T, Altman A, et al. (2006) A role for PKCtheta in outside-in alpha(IIb)beta3 signaling. J Thromb Haemost 4: 648-655.
24. Pears CJ, Thornber K, Auger JM, Hughes CE, Grygielska B, et al. (2008) Differential roles of the PKC novel isoforms, PKCdelta and PKCepsilon, in mouse and human platelets. PLoS One 3: e3793.
25. Murugappan S, Tuluc F, Dorsam RT, Shankar H, Kunapuli SP, (2004) Differential role of protein kinase C delta isoform in agonist-induced dense granule secretion in human platelets. J Biol Chem 279: 2360-2367.
26. Bynagari-Settipalli YS, Lakhani P, Jin J, Bhavaraju K, Rico MC, et al. (2012) Protein kinase C isoform ε negatively regulates ADP-induced calcium mobilization and thromboxane generation in platelets. Arterioscler Thromb Vasc Biol 32: 1211-1219.
27. Gong N, Wei H, Chowdhury SH, Chatterjee S, (2004) Lactosylceramide recruits PKCalpha/epsilon and phospholipase A2 to stimulate PECAM-1 expression in human monocytes and adhesion to endothelial cells. Proc Natl Acad Sci U S A 101: 6490-6495.
28. Gnatenko DV, Dunn JJ, McCorkle SR, Weissmann D, Perrotta PL, et al. (2003) Transcript profiling of human platelets using microarray and serial analysis of gene expression. Blood 101: 2285-2293.
29. Landry P, Plante I, Ouellet DL, Perron MP, Rousseau G, et al. (2009) Existence of a microRNA pathway in anucleate platelets. Nat Struct Mol Biol 16: 961-966.
30. Healy AM, Pickard MD, Pradhan AD, Wang Y, Chen Z, et al. (2006) Platelet expression profiling and clinical validation of myeloid-related protein-14 as a novel determinant of cardiovascular events. Circulation 113: 2278-2284.
31. Raghavachari N, Xu X, Harris A, Villagra J, Logun C, et al. (2007) Amplified expression profiling of platelet transcriptome reveals changes in arginine metabolic pathways in patients with sickle cell disease. Circulation 115: 1551-1562.
32. Denis MM, Tolley ND, Bunting M, Schwertz H, Jiang H, et al. (2005) Escaping the nuclear confines: signal-dependent pre-mRNA splicing in anucleate platelets. Cell 122: 379-391.
33. Schwertz H, Tolley ND, Foulks JM, Denis MM, Risenmay BW, et al. (2006) Signal-dependent splicing of tissue factor pre-mRNA modulates the thrombogenicity of human platelets. J Exp Med 203: 2433-2440.
34. Gobbi G, Mirandola P, Sponzilli I, Micheloni C, Malinverno C, et al. (2007) Timing and expression level of protein kinase C epsilon regulate the megakaryocytic differentiation of human CD34 cells. Stem Cells 25: 2322-2329.
35. Gobbi G, Mirandola P, Carubbi C, Micheloni C, Malinverno C, et al. (2009) Phorbol ester-induced PKCepsilon down-modulation sensitizes AML cells to TRAIL-induced apoptosis and cell differentiation. Blood 113: 3080-3087.
36. Bassini A, Zauli G, Migliaccio G, Migliaccio AR, Pascuccio M, et al. (1999) Lineage-restricted expression of protein kinase C isoforms in hematopoiesis. Blood 93: 1178-1188.
37. Mirandola P, Gobbi G, Ponti C, Sponzilli I, Cocco L, et al. (2006) PKCepsilon controls protection against TRAIL in erythroid progenitors. Blood 107: 508-513.
38. Solinas E, Gobbi G, Dangas G, Mehran R, Fahy M, et al. (2009) Comparison of the effects of pretreatment with tirofiban, clopidogrel or both on the inhibition of platelet aggregation and activation in patients with acute coronary syndromes. J Thromb Thrombolysis 27: 36-43.
39. Mazzucato M, Cozzi MR, Pradella P, Ruggeri ZM, De Marco L, (2004) Distinct roles of ADP receptors in von Willebrand factor-mediated platelet signaling and activation under high flow. Blood 104: 3221-3227.
40. Folie BJ, McIntire LV, Lasslo A, (1988) Effects of a novel antiplatelet agent in mural thrombogenesis on collagen-coated glass. Blood 72: 1393-1400.
41. Savage B, Almus-Jacobs F, Ruggeri ZM, (1998) Specific synergy of multiple substrate-receptor interactions in platelet thrombus formation under flow. Cell 94: 657-666.
42. Smitherman TC, Milam M, Woo J, Willerson JT, Frenkel EP, (1981) Elevated beta thromboglobulin in peripheral venous blood of patients with acute myocardial ischemia: direct evidence for enhanced platelet reactivity in vivo. Am J Cardiol 48: 395-402.
43. Langford EJ, Wainwright RJ, Martin JF, (1996) Platelet activation in acute myocardial infarction and unstable angina is inhibited by nitric oxide donors. Arterioscler Thromb Vasc Biol 16: 51-55.
44. Theroux P, Fuster V, (1998) Acute coronary syndromes: unstable angina and non-Q-wave myocardial infarction. Circulation 97: 1195-1206.
45. Vaitkus PT, Watkins MW, Witmer WT, Tracy RP, Sobel BE, (1995) Characterization of platelet activation and thrombin generation accompanying percutaneous transluminal coronary angioplasty. Coron Artery Dis 6: 587-592.
46. Hamm CW, Lorenz RL, Bleifeld W, Kupper W, Wober W, et al. (1987) Biochemical evidence of platelet activation in patients with persistent unstable angina. J Am Coll Cardiol 10: 998-1006.
47. Dorn GW 2nd, Liel N, Trask JL, Mais DE, Assey ME, et al. (1990) Increased platelet thromboxane A2/prostaglandin H2 receptors in patients with acute myocardial infarction. Circulation 81: 212-218.
48. Konopatskaya O, Gilio K, Harper MT, Zhao Y, Cosemans JM, et al. (2009) PKCalpha regulates platelet granule secretion and thrombus formation in mice. J Clin Invest 119: 399-407.
49. Jennings LK, (2009) Role of platelets in atherothrombosis. Am J Cardiol 103: 4A-10A.
50. Bigalke B, Langer H, Geisler T, Lindemann S, Gawaz M, (2007) Platelet glycoprotein VI: a novel marker for acute coronary syndrome. Semin Thromb Hemost 33: 179-184.
51. Davi G, Patrono C, (2007) Platelet activation and atherothrombosis. N Engl J Med 357: 2482-2494.
52. Ouwehand WH, (2007) Platelet genomics and the risk of atherothrombosis. J Thromb Haemost 5 Suppl 1: 188-195.