Endogenous concentrations of ouabain act as a cofactor to stimulate fluid secretion and cyst growth of in vitro ADPKD models via cAMP and EGFR-Src-MEK pathways

American Journal of Physiology - Renal Physiology

Volumn 303, Issue 7, 2012, Pages

  Jansson, Kyle ^a,b   Nguyen, Anh Nguyet T ^a,b   Magenheimer, Brenda S ^a,b   Reif, Gail A ^a,b   Aramadhaka, Lavakumar Reddy ^a,b   Bello Reuss, Elsa ^c   Wallace, Darren P ^a,b   Calvet, James P ^a,b   Blanco, Gustavo ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^c TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

Author keywords

Na K ATPase; Polycystic kidney disease

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; 4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; 8 BROMO CYCLIC AMP; CHLORIDE ION; COLLAGEN; CYCLIC AMP; EPIDERMAL GROWTH FACTOR RECEPTOR; FORSKOLIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE KINASE; OUABAIN; PROTEIN TYROSINE KINASE; SODIUM POTASSIUM CHLORIDE COTRANSPORTER; TRANSMEMBRANE CONDUCTANCE REGULATOR; TUBULIN;

ANIMAL CELL; APICAL MEMBRANE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE EXACERBATION; EMBRYO; ENZYME ACTIVATION; FLUID TRANSPORT; HETEROZYGOTE; HOMOZYGOTE; HUMAN; HUMAN CELL; IN VITRO STUDY; KIDNEY EPITHELIUM; KIDNEY POLYCYSTIC DISEASE; MONOLAYER CULTURE; MOUSE; NONHUMAN; ORGAN CULTURE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; WILD TYPE;

EID: 84867137812     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00677.2011     Document Type: Article

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