Vascular endothelium as a target for endogenous ouabain: Studies on the effect of ouabain on human endothelial cells

Cellular and Molecular Biology

Volumn 52, Issue 8, 2006, Pages 64-70

  Trevisi, L ^a   Pighin, I ^a   Luciani, S ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; NITROBLUE TETRAZOLIUM; OUABAIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN TYROSINE KINASE;

APOPTOSIS; CONCENTRATION RESPONSE; ENDOCYTOSIS; ENDOTHELIUM CELL; ENZYME ACTIVATION; HUMAN; PARTICLE SIZE; PATHOPHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION; UMBILICAL VEIN; VASCULAR ENDOTHELIUM;

1-PHOSPHATIDYLINOSITOL 3-KINASE; APOPTOSIS; CARDIAC GLYCOSIDES; CELLS, CULTURED; ENDOCYTOSIS; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; NA(+)-K(+)-EXCHANGING ATPASE; OUABAIN; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; TETRAZOLIUM SALTS; THIAZOLES;

STROPHANTHUS GRATUS;

EID: 34249110326     PISSN: 01455680     EISSN: 1165158X     Source Type: Journal    
DOI: 10.1170/T762     Document Type: Review

References (43)

1. Hamlyn J.M., Blaustein M.P., Bova S., DuCharme D.W., Mandel F., Mathews W.R., Ludens J.H., Identification and characterization of a ouabain-like compound from human plasma, Proc. Natl. Acad. Sci. USA, 1991, 88: 6259-6263.
2. Hamlyn J.M., Hamilton B.P., Manunta P., Endogenous ouabain, sodium balance and blood pressure: a review and a hypothesis, J. Hypertens. 1996, 14: 151-167.
3. Ferrari P., Ferrandi M., Valentini G., Bianchi G., Rostafuroxin: an ouabain antagonist that corrects renal and vascular Na+-K+- ATPase alterations in ouabain and adducin-dependent hypertension. Am. J. Physiol. Regul. Integr. Comp. Physiol., 2006, 290:R529-535.
4. Dostanic-Larson I., Van Huysse J.W., Lorenz J.N., Lingrel J.B. The highly conserved cardiac glycoside binding site of Na,K-ATPase plays a role in blood pressure regulation, Proc. Natl. Acad. Sci. USA, 2005, 102: 15845-15850.
5. Schoner W., Endogenous cardiac glycosides, a new class of steroid hormones, Eur. J. Biochem., 2002, 269: 2440-2448.
6. Schoner W., Bauer N., Muller-Ehmsen J., Kramer U, Hambarchian N., Schwinger R., Moeller H., Kost H., Weitkamp C., Schweitzer T., Kirch U., Neu H., Grunbaum E.G., Ouabain as a mammaliam hormone, Ann. N.Y. Acad. Sci., 2003, 986: 678-684.
7. Yuan C.M., Manunta P., Hamlym G.M., Chen S., Bohen E., Yeun J., Haddy F.J., Pamnani M.B., Long-term ouabain administration produces hypertension in rats. Hypertension, 1993, 22:178-187.
8. Rossoni L.V., Salaices M., Marìn J., Vassallo D.V., Alonso M.J., Alterations in phenylephrine-induced contractions and the vascular expression of Na+,K+-ATPase in ouabain-induced hypertension, Br. J. Pharmacol., 2002, 135: 771-781.
9. Cargnelli G., Trevisi L., Debetto P., Luciani S., Bova S., Effect of long-term ouabain treatment on contractile responses of rat aortae, J. Cardiovasc. Pharmacol., 2000, 35: 538-542
10. Ceolotto G., Sartori M., Papparella I., Candiotto M., Baritono E., Filippelli A., Cargnelli G., Luciani S., Semplicini A., Bova S., Different effect of ouabain on endothelin - induced extracellular signal-regulated kinase stimulation in rat heart and tail artery, J. Cardiovasc. Pharmacol., 2003, 41: 553-561.
11. Li M., Martin A., Wen C., Turner S.W., Lewis L.K., Whithworth J.A., Long-term ouabain administration does not alter blood pressare in conscious Sprague-Dawley rats, Clin. Exp. Pharmacol. Physiol., 1995, 22: 919-923.
12. Pidgeon G.B., Richards A.M., Nicholls M.G., Charles C.J., Rademaker M.T., Lynn K.L., Bailey R.R., Lewis L.K., Yandle T.G., Chronic ouabain infusion does not cause hypertension in sheep, Am. J. Physiol., 1996, 270: E386-392.
13. Xavier F.E., Rossoni L.V., Alonso M.J., Balfagon G., Vassallo D.V., Salaices M., Ouabain-induced hypertension alters the participation of endothelial factors in β-adrenergic responses differently in rat resistance and conductance mesenteric arteries, Br. J. Pharmacol., 2004, 143: 215-225.
14. Trevisi L, Visentin B, Cusinato F, Pighin I, Luciani S., Antiapoptotic effect of ouabain on human umbilical vein endothelial cells, Biochem Biophys Res Commun., 2004, 321: 716-21.
15. Xie Z. and Cai T. Na+-K+-ATPase-mediated signal transduction: from protein interaction to cellular function, Mol. Interv., 2003, 3: 157-168.
16. Huang L., Li H., Xie Z., Ouabain-induced hypertrophy in cultured cardiac myocytes is accompanied by changes in expression of several late response genes. J. Mol. Cell. Cardiol., 1997, 29: 429-437.
17. Koksoy A.A., Abramowitz J., Allen J.C., Ouabain-induced signalling and vascular smooth muscle cell proliferation, J. Biol. Chem., 2001, 276: 46605-46611.
18. Allen J.C., Abramowitz J., Aydemir-Koksoy A., Low concentrations of ouabain activate vascular smooth muscle proliferation, Ann. N. Y. Acad. Sci., 2003, 986: 504-508.
19. Abramowitz J., Dai C., Hirschi K.K.,. Dmitrieva R.I, Doris P.A., Liu L., Allen J.C., Ouabain- and marinobufagenin-induced proliferation of human umbilical vein smooth muscle cells and a rat vascular smooth muscle cell line, A7r5, Circulation, 2003, 108: 1049-1054.
20. Chueh S.C., Guh J.H., Chen J., Lai M.K., Teng C.M., Dual effects of ouabain on the regulation of proliferation and apoptosis in human prostatic smooth muscle cells, J. Urol., 2001, 166: 347-353.
21. Dmitrieva R.I., Doris P.A., Ouabain is a potent promoter of growth and activator of ERK1/2 in ouabain-resistant rat renal epithelial cells, J. Biol. Chem. 2003, 278: 28160-28166.
22. Orlov S.N., Thorin-Trescases N., Kotelevtsev S.V., Tremblay J., Hamet P., Inversion of the intracellular Na+/K+ ratio blocks apoptosis in vascular smooth muscle at a site upstream of caspase-3, J. Biol. Chem., 1999, 274:16545-16552.
23. Zhou X., Jiang G., Zhao A., Bondeva T., Hirrszel P., Balla T., Inhibition of Na,K-ATPase activates PI3 kinase and inhibits apoptosis in LLC-PK1 cells, Biochem. Biophys. Res. Commun., 2001, 285:46-51.
24. Li J., Zelenin S., Aperia A., Aizman O., Low doses of ouabain protect from serum deprivation-triggered apoptosis and stimulate kidney cell proliferation via activation of NF-κB. J. Am. Soc. Nephrol, 2006, 17: 1848-1857.
25. Zhang S., Malmersjo S., Li J., Ando H., Aizman A., Uhlen P., Mikoshiba K., Aperia A., Distino role of the N-terminal tail of the Na,K-ATPase catalytic subunit as a signal transducer, J. Biol. Chem., 2006, 281: 21954-21962.
26. Mallat Z., Tedgui A., Apoptosis in the vasculature: mechanisms and functional importance, Br. J. Pharmacol., 2000, 130: 947-962.
27. Trevisi L, Pighin I, Bazzan S, Luciani S., Inhibition of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) endocytosis by ouabain in human endothelial cells, FEBS Lett. 2006, 580: 2769-2773.
28. Vinci M.C., Visentin B., Cusinato F., Nardelli G.B, Trevisi L., Luciani S., Effect of vascular endohelial growth factor and epidermal growth factor on iatrogenic apoptosis in human endothelial cells, Biochem. Pharmacol., 2004, 67: 277-284.
29. Gerber H.P, McMurtrey A., Kowalski J., Yan M., Keyt B.A., Dixit V., Ferrara N.. Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation. J. Biol. Chem., 1998, 273: 30336-30343.
30. Yilmaz A., Kliche S., Mayr-Beyrle U., Fellbrich G., Waltenberger J., p38 MAPK inhibition is critically involved in VEGFR-2-mediated endothelial cell survival, Biochem. Biophys. Res. Commun., 2003, 306: 730-736.
31. Cantley L.C., The phosphoinositide 3-kinase pathway, Science, 2002, 296:1655-1657.
32. Yudowski G.A., Efendiev R., Pedemonte C.H., Katz A.I., Berggren P., and Bertorello A.M. Phosphoinositide-3 kinase binds to a proline-rich motif in the Na+ ,K+ -ATPase α subunit and regulates its trafficking, Proc. Natl. Acad. Sci. U.S.A. 2000, 97: 6556-6561.
33. Liu J., Kesiry R., Periyasamy S.M., Malhotra D., Xie Z., Shapiro J.I., Ouabain induces endocytosis of plasmalemmal Na/K-ATPase in LLC-PK1 cells by a clatrhin-dependent mechanism, Kidney Int., 2004, 66: 227-241.
34. Haas M., Askari A., Xie Z., Involvement of Src and epidermal growth factor receptor in the signal-transducing function of Na+/K+-ATPase, J. Biol. Chem., 2000, 275: 27832-27837.
35. Haas M, Wang H, Tian J, Xie Z., Src-mediated interreceptor cross-talk between the Na+/K+-ATPase and the epidermal growth factor receptor relays the signal from ouabain to mitogen-activated protein kinases, J. Biol. Chem., 2002, 277: 18694-186702.
36. Saunders R., Scheiner-Bobis G., Ouabain stimulates endothelin release and expression in human endothelial cells without inhibiting the sodium pump, Eur. J. Biochem., 2004, 271: 1054-1062.
37. Liu Y., Peterson D.A., Kimura H., Schubert D., Mechanism of cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction. J. Neurochem., 1997, 69: 581-593.
38. Liu L., Mohammadi K., Aynasfshar B., Wang H., Li D., Liu J., Ivanov A.V., Xie Z., Askari A., Role of caveolae in signal-transducing function of cardiac Na+/K+-ATPase, Am. J. Physiol. Cell. Physiol. 2003, 284: C1550-C1560.
39. Wang H., Haas M., Liang M., Cai T., Tian J., Shengwen L., Xie Z, Ouabain assembles signaling cascades through the caveolar Na+/K+-ATPase. J. Biol. Chem., 2004, 279: 17250-17259.
40. Liu L, Abramowitz J, Askari A, Allen J.C., Role of caveolae in ouabain-induced proliferation of cultured vascular smooth muscle cells of the synthetic phenotype. Am J Physiol Heart Circ Physiol. 2004, 287: H2173-2182.
41. Razani B., Woodman S., Lisanti M.P. Caveole: from cell biology to animal physiology. Pharmacol. Rev., 2002, 54: 431-467.
42. Haas M, Wang H, Tian J, Xie Z. Src-mediated interreceptor cross-talk between the Na+/K+-ATPase and the epidermal growth factor receptor relays the signal from ouabain to mitogen-activated protein kinases J Biol Chem., 2002, 277: 18694-186702.
43. Mayol V, Dignat-George F, Gerbi A, Martin-Vasallo P, Lesaule G, Sampol J, Maixent J.M., Evidence that human endothelial cells express different isoforms of Na,K-ATPase, J Hypertens.,1998, 16: 145-150.