Management of Incidentally Found Nonfunctional Pituitary Tumors

Neurosurgery Clinics of North America

Volumn 23, Issue 4, 2012, Pages 543-553

  Molitch, Mark E ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Adenoma; Incidentaloma; Pituitary; Transsphenoidal surgery; Tumor

Indexed keywords

DOPAMINE RECEPTOR STIMULATING AGENT;

ACTH SECRETING ADENOMA; ASYMPTOMATIC DISEASE; AUTOPSY; COMPUTER ASSISTED TOMOGRAPHY; ENDOCRINE FUNCTION TEST; ENDOCRINE SURGERY; FOLLOW UP; GROWTH HORMONE SECRETING ADENOMA; HUMAN; HYPOPHYSIS ADENOMA; HYPOPITUITARISM; HYPOTHALAMUS DISEASE; IMMUNOHISTOCHEMISTRY; INCIDENTAL FINDING; MEDICAL HISTORY; NONFUNCTIONING PITUITARY ADENOMA; NUCLEAR MAGNETIC RESONANCE IMAGING; PITUITARY INCIDENTALOMA; PREVALENCE; PRIORITY JOURNAL; PROLACTINOMA; REVIEW; SCREENING TEST; TREATMENT INDICATION; TUMOR GROWTH; TUMOR VOLUME; VISUAL FIELD DEFECT;

HUMANS; INCIDENTAL FINDINGS; MAGNETIC RESONANCE IMAGING; PITUITARY GLAND; PITUITARY NEOPLASMS;

EID: 84867129877     PISSN: 10423680     EISSN: 15581349     Source Type: Journal    
DOI: 10.1016/j.nec.2012.06.003     Document Type: Review

References (95)

1. Young W.F., Scheithauer B.W., Kovacs K.T., et al. Gonadotroph adenoma of the pituitary gland: a clinicopathologic analysis of 100 cases. Mayo Clin Proc 1996, 71:649-656.
2. Yamada S., Kovacs K., Horvath E., et al. Morphological study of clinically nonsecreting pituitary adenomas in patients under 40 years of age. J Neurosurg 1991, 75:902-905.
3. Chambers E.F., Turski P.A., LaMasters D., et al. Regions of low density in the contrast-enhanced pituitary gland: normal and pathologic processes. Radiology 1982, 144:109-113.
4. Elster A.D. Modern imaging of the pituitary. Radiology 1993, 187:1-14.
5. Freda P.U., Wardlaw S.L., Post K.D. Unusual causes of sellar/parasellar masses in a large transsphenoidal surgical series. J Clin Endocrinol Metab 1996, 81:3455-3459.
6. Naidich M.J., Russell E.J. Current approaches to imaging of the sellar region and pituitary. Endocrinol Metab Clin North Am 1999, 28:45-79.
7. Molitch M.E., Gilliam M.P. Lymphocytic hypophysitis. Horm Res 2007, 68(Suppl 5):145-150.
8. Doraiswamy P.M., Potts J.M., Axelson D.A., et al. MR assessment of pituitary gland morphology in healthy volunteers: age- and gender-related differences. AJNR Am J Neuroradiol 1992, 13:1295-1299.
9. Elster A.D., Chen M.Y., Williams D.W., et al. Pituitary gland: MR imaging of physiologic hypertrophy in adolescence. Radiology 1999, 174:681-685.
10. Tsunoda A., Okuda O., Sato K. MR height of the pituitary gland as a function of age and sex: especially physiological hypertrophy in adolescence and in climacterium. AJNR Am J Neuroradiol 1997, 18:551-554.
11. Chanson P., Daujat F., Young J., et al. Normal pituitary hypertrophy as a frequent cause of pituitary incidentalomas: a follow-up study. J Clin Endocrinol Metab 2001, 86:3009-3015.
12. Susman W. Pituitary adenoma. Br Med J 1933, 2:1215.
13. Close H.G. The incidence of adenoma of the pituitary body in some types of new growth. Lancet 1934, 1:732-734.
14. Costello R.T. Subclinical adenoma of the pituitary gland. Am J Pathol 1936, 12:205-215.
15. Sommers S.C. Pituitary cell relations to body states. Lab Invest 1959, 8:588-621.
16. McCormick W.F., Halmi N.S. Absence of chromophobe adenomas from a large series of pituitary tumors. Arch Pathol 1971, 92:231-238.
17. Haugen O.A. Pituitary adenomas and the histology of the prostate in elderly men. Acta Pathol Microbiol Scand A 1973, 81:425-434.
18. Kovacs K., Ryan N., Horvath E. Pituitary adenomas in old age. J Gerontol 1980, 35:16-22.
19. Landolt A.M. Biology of pituitary microadenomas. Pituitary microadenomas 1980, 107-122. Academic Press, New York. G. Faglia, M.A. Giovanelli, R.M. MacLeod (Eds.).
20. Mosca L., Solcia E., Capella C., et al. Pituitary adenomas: surgical versus post-mortem findings today. Pituitary microadenomas 1980, 137-142. Academic Press, New York. G. Faglia, M.A. Giovanelli, R.M. MacLeod (Eds.).
21. Burrows G.N., Wortzman G., Rewcastle N.B., et al. Microadenomas of the pituitary and abnormal sellar tomograms in an unselected autopsy series. N Engl J Med 1981, 304:156-158.
22. Parent A.D., Bebin J., Smith R.R. Incidental pituitary adenomas. J Neurosurg 1981, 54:228-231.
23. Muhr C., Bergstrom K., Grimelius L., et al. A parallel study of the roentgen anatomy of the sella turcica and the histopathology of the pituitary gland in 205 autopsy specimens. Neuroradiology 1981, 21:55-65.
24. Max M.B., Deck M.D., Rottenberg D.A. Pituitary metastasis: incidence in cancer patients and clinical differentiation from pituitary adenoma. Neurology 1981, 31:998-1002.
25. Schwezinger G., Warzok R. Hyperplasien und adenome der hypophyse im unselektierten sektionsgut. Zentralbl Allg Pathol 1982, 126:495-498. [in German].
26. Coulon G., Fellmann D., Arbez-Gindre F., et al. Les adenome hypophysaires latents. Etude autopsique. Sem Hop 1983, 59:2747-2750. [in French].
27. Siqueira M.G., Guembarovski A.L. Subclinical pituitary microadenomas. Surg Neurol 1984, 22:134-140.
28. Char G., Persaud V. Asymptomatic microadenomas of the pituitary gland in an unselected autopsy series. West Indian Med J 1986, 35:275-279.
29. Gorczyca W., Hardy J. Microadenomas of the human pituitary and their vascularization. Neurosurgery 1988, 22:1-6.
30. El-Hamid M.W., Joplin G.F., Lewis P.D. Incidentally found small pituitary adenomas may have no effect on fertility. Acta Endocrinol 1988, 117:361-364.
31. Scheithauer B.W., Kovacs K.T., Randall R.V., et al. Effects of estrogen on the human pituitary: a clinicopathologic study. Mayo Clin Proc 1989, 64:1077-1084.
32. Kontogeorgos G., Kovacs K., Horvath E., et al. Multiple adenomas of the human pituitary. A retrospective autopsy study with clinical implications. J Neurosurg 1991, 74:243-247.
33. Marin F., Kovacs K.T., Scheithauer B.W., et al. The pituitary gland in patients with breast carcinoma: a histologic and immunocytochemical study of 125 cases. Mayo Clin Proc 1992, 67:949-956.
34. Sano T., Kovacs K.T., Scheithauer B.W., et al. Aging and the human pituitary gland. Mayo Clin Proc 1993, 68:971-977.
35. Teramoto A., Hirakawa K., Sanno N., et al. Incidental pituitary lesions in 1,000 unselected autopsy specimens. Radiology 1994, 193:161-164.
36. Camaris C., Balleine R., Little D. Microadenomas of the human pituitary. Pathology 1995, 27:8-11.
37. Tomita T., Gates E. Pituitary adenomas and granular cell tumors. Incidence, cell type, and location of tumor in 100 pituitary glands at autopsy. Am J Clin Pathol 1999, 111:817-825.
38. Kurosaki M., Saeger W., Lüdecke D.K. Pituitary tumors in the elderly. Pathol Res Pract 2001, 197:493-497.
39. Buurman H., Saeger W. Subclinical adenomas in postmortem pituitaries: classification and correlations to clinical data. Eur J Endocrinol 2006, 154:753-758.
40. Rittierodt M., Hori A. Pre-morbid morphological conditions of the human pituitary. Neuropathology 2007, 27:43-48.
41. Furgal-Borzych A., Lis G.J., Litwin J.A., et al. Increased incidence of pituitary microadenomas in suicide victims. Neuropsychology 2007, 55:163-166.
42. Kim J.H., Seo J.S., Lee B.W., et al. The characteristics of incidental pituitary microadenomas in 120 Korean forensic autopsy cases. J Korean Med Sci 2007, 22(Suppl):S61-S65.
43. Adhakhani K., Kadivar M., Kazemi-Esfeh S., et al. Prevalence of pituitary incidentaloma in the Iranian cadavers. Indian J Pathol Microbiol 2011, 54:692-694.
44. Auer R.N., Alakija P., Sutherland G.R. Asymptomatic large pituitary adenomas discovered at autopsy. Surg Neurol 1996, 46:28-31.
45. Wolpert S.M., Molitch M.E., Goldman J.A., et al. Size, shape and appearance of the normal female pituitary gland. AJNR Am J Neuroradiol 1984, 5:263-267.
46. Peyster R.G., Adler L.P., Viscarello R.R., et al. CT of the normal pituitary gland. Neuroradiology 1986, 28:161-165.
47. Chong B.W., Kucharczyk A.W., Singer W., et al. Pituitary gland MR: a comparative study of healthy volunteers and patients with microadenomas. AJNR Am J Neuroradiol 1994, 15:675-679.
48. Hall W.A., Luciano M.G., Doppman J.L., et al. Pituitary magnetic resonance imaging in normal human volunteers: occult adenomas in the general population. Ann Intern Med 1994, 120:817-820.
49. Nammour G.M., Ybarra J., Naheedy M.H., et al. Incidental pituitary macroadenoma: a population-based study. Am J Med Sci 1997, 314:287-291.
50. Yue N.C., Longsteth W.T., Elster A.D., et al. Clinically serious abnormalities found incidentally at MR imaging of the brain: data from the Cardiovascular Health Study. Radiology 1997, 202:41-46.
51. Vernooij M.W., Ikram A., Tanghe H.L., et al. Incidental findings on brain MRI in the general population. N Engl J Med 2007, 357:1821-1828.
52. Chacko A.G., Chandy M.J. Incidental pituitary macroadenomas. Br J Neurosurg 1992, 6:233-236.
53. Donovan L.E., Corenblum B. The natural history of the pituitary incidentaloma. Arch Intern Med 1995, 153:181-183.
54. Reincke M., Allolio B., Saeger W., et al. The 'incidentaloma' of the pituitary gland. Is neurosurgery required?. JAMA 1990, 263:2772-2776.
55. Nishizawa S., Ohta S., Yokoyama T., et al. Therapeutic strategy for incidentally found pituitary tumors (" pituitary incidentalomas"). Neurosurgery 1998, 43:1344-1348.
56. Feldkamp J., Santen R., Harms E., et al. Incidentally discovered pituitary lesions: high frequency of macroadenomas and hormone-secreting adenomas - results of a prospective study. Clin Endocrinol 1999, 51:109-113.
57. Igarashi T., Saeki N., Yamaura A. Long-term magnetic resonance imaging follow-up of asymptomatic sellar tumors. Their natural history and surgical indications. Neurol Med Chir (Tokyo) 1999, 39:592-599.
58. Sanno N., Oyama K., Tahara S., et al. A survey of pituitary incidentaloma in Japan. Eur J Endocrinol 2003, 149:123-127.
59. Fainstein Day P., Guitelman M., Artese R., et al. Retrospective multicentric study of pituitary incidentalomas. Pituitary 2004, 7:145-148.
60. Arita K., Tominaga A., Sugiyama K., et al. Natural course of incidentally found nonfunctioning pituitary adenoma, with special reference to pituitary apoplexy during follow-up examination. J Neurosurg 2006, 104:884-891.
61. Karavitaki N., Collison K., Halliday J., et al. What is the natural history of nonoperated, nonfunctioning pituitary adenomas?. Clin Endocrinol 2007, 67:938-943.
62. Dekkers O.M., Hammer S., de Keizer R.J., et al. The natural course of non-functioning pituitary macroadenomas. Eur J Endocrinol 2007, 156:217-224.
63. Dekkers O.M., Pereira A.M., Romijn J.A. Treatment and follow-up of clinically nonfunctioning pituitary macroadenomas. J Clin Endocrinol Metab 2008, 93:3717-3726.
64. Freda P.U., Beckers M., Katznelson L., et al. Pituitary incidentaloma: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 2011, 96:894-904.
65. Angeli A., Terzolo M. Adrenal incidentaloma-a modern disease with old complications. J Clin Endocrinol Metab 2002, 87:4869-4871.
66. Scheithauer B.W., Jaap A.J., Horvath E., et al. Clinically silent corticotroph tumors of the pituitary gland. Neurosurgery 2000, 47:723-729.
67. Bradley K.J., Wass J.A., Turner H.E. Non-functioning pituitary adenomas with positive immunoreactivity for ACTH behave more aggressively than ACTH immunonegative tumours but do not recur more frequently. Clin Endocrinol 2003, 58:59-64.
68. Soto-Ares G., Cortet-Rudelli C., Assaker R., et al. MRI protocol technique in the optimal therapeutic strategy of nonfunctioning pituitary adenomas. Eur J Endocrinol 2002, 146:179-186.
69. Park P., Chandler W.F., Barkan A.L., et al. The role of radiation therapy after surgical resection of nonfunctional pituitary macroadenomas. Neurosurgery 2004, 55:100-106.
70. Baldeweg S.E., Pollock J.R., Powell M., et al. A spectrum of behaviour in silent corticotroph pituitary adenomas. Br J Neurosurg 2005, 19:38-42.
71. Lopez J.A., Kleinschmidt-DeMasters B.K., Sze C.I., et al. Silent corticotroph adenomas: further clinical and pathological observations. Hum Pathol 2004, 35:1137-1147.
72. King J.T., Justice A.C., Aron D.C. Management of incidental pituitary microadenomas: a cost-effectiveness analysis. J Clin Endocrinol Metab 1997, 82:3625-3632.
73. Krikorian A., Aron D. Evaluation and management of pituitary incidentalomas-revisiting an acquaintance. Nat Clin Pract Endocrinol Metab 2006, 2:138-145.
74. Chanson P., Young J. Pituitary incidentalomas. Endocrinologist 2003, 13:124-135.
75. Casanueva F.F., Molitch M.E., Schlechte J.A., et al. Guidelines of the Pituitary Society for the diagnosis and management of prolactinomas. Clin Endocrinol 2006, 65:265-273.
76. Molitch M.E., Reichlin S. Hypothalamic hyperprolactinemia: neuroendocrine regulation of prolactin secretion in patients with lesions of the hypothalamus and pituitary stalk. Prolactin. Basic and clinical correlates 1985, 709-719. Liviana Press, Padova (Italy). R.M. MacLeod, M.O. Thorner, U. Scapagnini (Eds.).
77. Arafah M.B., Neki K.E., Gold R.S., et al. Dynamics of prolactin secretion in patients with hypopituitarism and pituitary macroadenomas. J Clin Endocrinol Metab 1995, 80:3507-3512.
78. Karavitaki N., Thanabalasingham G., Shore H.C., et al. Do the limits of serum prolactin in disconnection hyperprolactinaemia need re-definition? A study of 226 patients with histologically verified non-functioning pituitary macroadenoma. Clin Endocrinol 2006, 65:524-529.
79. St-Jean E., Blain F., Comtois R. High prolactin levels may be missed by immunoradiometric assay in patients with macroprolactinomas. Clin Endocrinol 1996, 44:305-309.
80. Barkan A.L., Chandler W.F. Giant pituitary prolactinoma with falsely low serum prolactin: the pitfall of the "high-dose hook effect": case report. Neurosurgery 1998, 42:913-915.
81. The Growth Hormone Research Society, The Pituitary Society Consensus Conference Biochemical assessment and long-term monitoring in patients with acromegaly. J Clin Endocrinol Metab 2004, 89:3099-3102.
82. Arnaldi G., Angeli A., Atkinson A.B., et al. Diagnosis and complications of Cushing's syndrome: a consensus statement. J Clin Endocrinol Metab 2003, 88:5593-5602.
83. Findling J.W., Raff H. Cushing's syndrome: important issues in diagnosis and management. J Clin Endocrinol Metab 2006, 91:3746-3753.
84. Carroll T., Raff H., Findling J.W. Late-night salivary cortisol measurement in the diagnosis of Cushing's syndrome. Nat Clin Pract Endocrinol Metab 2008, 4:344-350.
85. Yuen K.C., Cook D.M., Sahasranam P., et al. Prevalence of GH and other anterior pituitary hormone deficiencies in adults with nonsecreting pituitary microadenomas and normal serum IGF-1 levels. Clin Endocrinol 2008, 69:292-298.
86. Toogood A.A., Stewart P.M. Hypopituitarism: clinical features, diagnosis, and management. Endocrinol Metab Clin North Am 2008, 37:235-271.
87. Petersenn S., Quabbe H.J., Schöfl C., et al. The rational use of pituitary stimulation tests. Dtsch Arztebl Int 2010, 107:437-443.
88. Fernández-Balsells M.M., Murad M.H., Barwise A., et al. Natural history of nonfunctioning pituitary adenomas and incidentalomas: a systematic review and metaanalysis. J Clin Endocrinol Metab 2011, 96:905-912.
89. Melmed S., Casanueva F.F., Hoffman A.R., et al. Diagnosis and treatment of hyperprolactinemia: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 2011, 96:273-288.
90. Melmed S., Colao A., Barkan A., et al. A guideline for acromegaly management: an update. J Clin Endocrinol Metab 2009, 94:1509-1517.
91. Biller B.M., Grossman A.B., Stewart P.M., et al. Treatment of adrenocorticotropin-dependent Cushing's syndrome: a consensus statement. J Clin Endocrinol Metab 2008, 93:2454-2462.
92. Arafah A.M. Reversible hypopituitarism in patients with large nonfunctioning pituitary adenomas. J Clin Endocrinol Metab 1986, 62:1173-1179.
93. Shomali M.E., Katznelson L. Medical therapy of gonadotropin-producing and nonfunctioning pituitary adenomas. Pituitary 2002, 5:89-98.
94. Colao A., Di Somma C., Pivonello R., et al. Medical therapy for clinically non-functioning pituitary adenomas. Endocr Relat Cancer 2008, 15:905-915.
95. Honegger J., Zimmermann S., Psaras T., et al. Growth modeling of non-functioning pituitary adenomas in patients referred for surgery. Eur J Endocrinol 2008, 158:287-294.