Analysis of stem-cell-like properties of human CD161++IL-18Rα + memory CD8+ T cells

International Immunology

Volumn 24, Issue 10, 2012, Pages 625-636

  Havenith, Simone H C ^a   Yong, Si La ^a   Henson, Sian M ^b   Piet, Berber ^a   Idu, Mirza M ^a   Koch, Sven D ^a   Jonkers, René E ^a   Kragten, Natasja A M ^a   Akbar, Arne N ^b   Van Lier, René A W ^c   Ten Berge, Ineke J M ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c SANQUIN RESEARCH   (Netherlands)

Author keywords

CD161; MAIT cells; Memory stem cells; Telomere erosion

Indexed keywords

ALDEHYDE DEHYDROGENASE; B LYMPHOCYTE INDUCED MATURATION PROTEIN 1; CD161 ANTIGEN; CHEMOKINE RECEPTOR; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 18 RECEPTOR ALPHA; LYMPHOCYTE RECEPTOR; PROTEIN KLRG1; TELOMERASE; UNCLASSIFIED DRUG;

ARTICLE; BLOOD; BONE MARROW; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CYTOKINE PRODUCTION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LYMPH NODE; LYMPHOCYTE FUNCTION; LYMPHOCYTE MIGRATION; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPLEEN; STEM CELL; T LYMPHOCYTE ACTIVATION; TELOMERE;

CD8-POSITIVE T-LYMPHOCYTES; HUMANS; IMMUNOLOGIC MEMORY; INTERLEUKIN-18 RECEPTOR ALPHA SUBUNIT; MICROSCOPY, ELECTRON, SCANNING TRANSMISSION; NK CELL LECTIN-LIKE RECEPTOR SUBFAMILY B; STEM CELLS; TELOMERASE; TELOMERE; TELOMERE HOMEOSTASIS;

EID: 84867127165     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxs069     Document Type: Article

References (37)

1. Harty, J. T. and Badovinac, V. P. 2008. Shaping and reshaping CD8+ T-cell memory. Nat. Rev. Immunol. 8:107-119.
2. Appay, V., van Lier, R. A., Sallusto, F. and Roederer, M. 2008. Phenotype and function of human T lymphocyte subsets: consensus and issues. Cytometry A 73:975-983.
3. Le, B. L., Martin, E., Peguillet, I. et al. 2010. Antimicrobial activity of mucosal-associated invariant T cells. Nat. Immunol. 11:701-708.
4. Turtle, C. J., Swanson, H. M., Fujii, N., Estey, E. H. and Riddell, S. R. 2009. A distinct subset of self-renewing human memory CD8+ T cells survives cytotoxic chemotherapy. Immunity 31:834-844.
5. Chaudhary, P. M. and Roninson, I. B. 1993. Induction of multidrug resistance in human cells by transient exposure to different chemotherapeutic drugs. J. Natl. Cancer Inst. 85:632-639.
6. Mizutani, T., Masuda, M., Nakai, E. et al. 2008. Genuine functions of P-glycoprotein (ABCB1). Curr. Drug Metab. 9:167-174.
7. Choudhuri, S. and Klaassen, C. D. 2006. Structure, function, expression, genomic organization, and single nucleotide polymorphisms of human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) efflux transporters. Int. J. Toxicol. 25:231-259.
8. Neuenhahn, M. and Busch, D. H. 2009. The quest for CD8+ memory stem cells. Immunity 31:702-704.
9. Billerbeck, E., Kang, Y. H., Walker, L. et al. 2010. Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties. Proc. Natl. Acad. Sci. U. S. A. 107:3006-3011.
10. Dusseaux, M., Martin, E., Serriari, N. et al. 2011. Human MAIT cells are xenobiotic resistant, tissue-targeted, CD161hi IL-17 secreting T cells. Blood 117:1250-1259.
11. Piet, B., de Bree, G. J., Smids-Dierdorp, B. S. et al. 2011. CD8+ T cells with an intraepithelial phenotype upregulate cytotoxic function upon influenza infection in human lung. J. Clin. Invest. 121:2254-2263.
12. He, X., Janeway, C. A., Jr., Levine, M. et al. 2002. Dual receptor T cells extend the immune repertoire for foreign antigens. Nat. Immunol. 3:127-134.
13. Plunkett, F. J., Franzese, O., Finney, H. M. et al. 2007. The loss of telomerase activity in highly differentiated CD8+CD28-. J. Immunol. 178:7710-7719.
14. Reed, J. R., Vukmanovic-Stejic, M., Fletcher, J. M. et al. 2004. Telomere erosion in memory T cells induced by telomerase inhibition at the site of antigenic challenge in vivo. J. Exp. Med. 199:1433-1443.
15. Bratke, K., Kuepper, M., Bade, B., Virchow, J. C., Jr. and Luttmann, W. 2005. Differential expression of human granzymes A, B, and K in natural killer cells and during CD8+ T cell differentiation in peripheral blood. Eur. J. Immunol. 35:2608-2616.
16. Hamann, D., Baars, P. A., Rep, M. H. et al. 1997. Phenotypic and functional separation of memory and effector human CD8+ T cells. J. Exp. Med. 186:1407-1418.
17. Harari, A., Enders, F. B., Cellerai, C., Bart, P. A. and Pantaleo, G. 2009. Distinct profiles of cytotoxic granules in memory CD8 T cells correlate with function, differentiation stage, and antigen exposure. J. Virol. 83:2862-2871.
18. Voehringer, D., Koschella, M. and Pircher, H. 2002. Lack of proliferative capacity of human effector and memory T cells expressing killer cell lectinlike receptor G1 (KLRG1). Blood 100:3698-3702.
19. Henson, S. M. and Akbar, A. N. 2009. KLRG1-more than a marker for T cell senescence. Age (Dordr.). Blood 2011; 117: 1250-1259
20. Angelosanto, J. M. and Wherry, E. J. 2010. Transcription factor regulation of CD8+ T-cell memory and exhaustion. Immunol. Rev. 236:167-175.
21. Hertoghs, K. M., Moerland, P. D., van, S. A. et al. 2010. Molecular profiling of cytomegalovirus-induced human CD8+ T cell differentiation. J. Clin. Invest. 120:4077-4090.
22. van Lier, R. A., ten Berge, I. J. and Gamadia, L. E. 2003. Human CD8(+) T-cell differentiation in response to viruses. Nat. Rev. Immunol. 3:931-939.
23. Sladek, N. E. 2003. Human aldehyde dehydrogenases: potential pathological, pharmacological, and toxicological impact. J. Biochem. Mol. Toxicol. 17:7-23.
24. Alison, M. R., Guppy, N. J., Lim, S. M. and Nicholson, L. J. 2010. Finding cancer stem cells: are aldehyde dehydrogenases fit for purpose? J. Pathol. 222:335-344.
25. Bromley, S. K., Mempel, T. R. and Luster, A. D. 2008. Orchestrating the orchestrators: chemokines in control of T cell traffic. Nat. Immunol. 9:970-980.
26. Kim, C. H., Kunkel, E. J., Boisvert, J. et al. 2001. Bonzo/ CXCR6 expression defines type 1-polarized T-cell subsets with extralymphoid tissue homing potential. J. Clin. Invest. 107:595-601.
27. Sallusto, F., Lenig, D., Forster, R., Lipp, M. and Lanzavecchia, A. 1999. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature. 401:708-712.
28. Northfield, J. W., Kasprowicz, V., Lucas, M. et al. 2008. CD161 expression on hepatitis C virus-specific CD8+ T cells suggests a distinct pathway of T cell differentiation. Hepatology 47:396-406.
29. Turtle, C. J., Delrow, J., Joslyn, R. C. et al. 2011. Innate signals overcome acquired TCR signaling pathway regulation and govern the fate of human CD161(hi) CD8alpha semi-invariant T cells. Blood 118:2752-2762.
30. Walker, L. J., Kang, Y. H., Smith, M. O. et al. 2012. Human MAIT and CD8alphaalpha cells develop from a pool of type-17 precommitted CD8+ T cells. Blood 119:422-433.
31. Batliwalla, F. M., Rufer, N., Lansdorp, P. M. and Gregersen, P. K. 2000. Oligoclonal expansions in the CD8(+)CD28(-) T cells largely explain the shorter telomeres detected in this subset: analysis by flow FISH. Hum. Immunol. 61:951-958.
32. Monteiro, J., Batliwalla, F., Ostrer, H. and Gregersen, P. K. 1996. Shortened telomeres in clonally expanded CD28-CD8+ T cells imply a replicative history that is distinct from their CD28+CD8+ counterparts. J. Immunol. 156:3587-3590.
33. Romero, P., Zippelius, A., Kurth, I. et al. 2007. Four functionally distinct populations of human effector-memory CD8+ T lymphocytes. J. Immunol. 178:4112-4119.
34. Lin, J., Epel, E., Cheon, J. et al. 2010. Analyses and comparisons of telomerase activity and telomere length in human T and B cells: insights for epidemiology of telomere maintenance. J. Immunol. Methods 352:71-80.
35. Vermeulen, L., Sprick, M. R., Kemper, K., Stassi, G. and Medema, J. P. 2008. Cancer stem cells--old concepts, new insights. Cell Death. Differ. 15:947-958.
36. Alison, M. R., Islam, S. and Wright, N. A. 2010. Stem cells in cancer: instigators and propagators? J. Cell Sci. 123:2357-2368.
37. Gattinoni, L., Lugli, E., Ji, Y. et al. 2011. A human memory T cell subset with stem cell-like properties. Nat. Med. 17:1290-1297.