High rejection rates with low dose immunosuppression in old for old kidney transplantation

Transplantationsmedizin: Organ der Deutschen Transplantationsgesellschaft

Volumn 23, Issue 2, 2011, Pages 118-126

  Meier, Markus ^a   Bode, Wibke ^a   Nitschke, Martin ^a   Wong, Waichi ^b   Ison, Michael G ^c   Kramer, Jan ^a   Jabs, Wolfram J ^d   Bürk, Conny G ^a   Lehnert, Hendrik ^a   Fricke Prof , Lutz ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

^d VIVANTES KLINIKUM IM FRIEDRICHSHAIN   (Germany)

Author keywords

Calcineurin inhibitor; European senior program; Kidney transplantation; Low dose tacrolimus; Old for old transplantation

Indexed keywords

EID: 84867099500     PISSN: 09469648     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Wolfe RA, Ashby VB, Milford EL, Ojo AO, Ettenger RE, Agodoa LY et al. (1999) Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant. N Engl J Med 341: 1725-1730
2. Meier-Kriesche HU, Ojo AO, Cibrik DM, Hanson JA, Leichtman AB, Magee JC et al. (2000) Relationship of recipient age and development of chronic allograft failure. Transplantation 70: 306-310
3. Frei U, Noeldeke J, Machold-Fabrizii V, Arbogast H, Margreiter R, Fricke L et al. (2008) Prospective age-matching in elderly kidney transplant recipients - a 5-Year analysis of the European Senior Program. Am J Transplant 8: 50-57
4. Cecka JM (2004) The OPTN/UNOS renal transplant registry. Clin Transpl: 1-16
5. Martins PN, Pratschke J, Pascher A, Fritsche L, Frei U, Neuhaus P et al. (2005) Age and immune response in organ transplantation. Transplantation 79: 127-132
6. Arbogast H, Hückelheim H, Schneeberger H, Illner WD, Tarabichi A, Fertmann J et al. (2005) A cal-cineurin antagonist-free induction/maintenance strategy for immunosuppression in elderly recipients of renal allografts from elderly cadaver donors: long-term results from a prospective single centre trial. Clin Transplant 19: 309-315
7. Guba M, Rentsch M, Wimmer CD, Uemueksuez A, Illner WD, Schönermarck U et al. (2008) Calcineurin-inhibitor avoidance in elderly renal allograft recipients using ATG and basiliximab combined with mycophenolate mofetil. Transpl Int 21: 637-45
8. Giessing M, Budde K, Fritsche L, Slowinski T, Tuerk I, Schoenberger B et al. (2003) "Old-for-old"cadaveric renal transplantation: surgical findings, perioperative complications and outcome. Eur Urol 44: 701-708
9. Smits JM, Persijn GG, van Houwelingen HC, Claas FH, Frei U (2002) Evaluation of the Eurotransplant Senior Program. The results of the first year. Am J Transplant 2: 664-670
10. Voiculescu A, Schlieper G, Hetzel GR, Hollenbeck M, Ivens K, Willers R et al. (2002) Kidney transplantation in the elderly: age-matching as compared to HLA-matching: a single center experience. Transplantation 73: 1356-1359
11. Chavalitdhamrong D, Gill J, Takemoto S, Madhira BR, Cho YW, Shah T et al. (2008) Patient and Graft Outcomes from Deceased Kidney Donors Age 70 Years and Older: An Analysis of the Organ Procurement Transplant Network/United Network of Organ Sharing Database. Transplantation 85: 1573-1579
12. Epstein M (1996) Aging and the kidney. J Am Soc Nephrol 7: 1106-1122
13. De Fijter JW (2009) An old virtue to improve senior programs. Transpl Int 22: 259-268
14. Pratschke J, Merk V, Reutzel-Selke A, Pascher A, Denecke C, Lun A et al. (2009) Potent early immune response after kidney transplantation in patients of the European senior transplant program. Transplantation 87: 992-1000
15. Feutren G, Mihatsch MJ (1992) Risk factors for cyclosporine induced nephropathy in patients with autoimmune diseases. International Kidney Biopsy Registry of Cyclosporine in Autoimmune Diseases. N Engl J Med 326: 1654-1560
16. Ekberg H, Tedesco-Silva H, Demirbas A, Vítko S, Nashan B, Gürkan A et al. (2007) Reduced exposure to calcineurin inhibitors in renal transplantation. N Engl J Med 357: 2562-2575
17. Vega O, Cárdenas G, Correa-Rotter R, Alberú J, Morales-Buenrostro LE (2008) Basiliximab vs. limited-dose daclizumab (2mg/kg) administered in a single or two separated doses in kidney transplantation. Rev Invest Clin 60: 82-86
18. Stratta RJ, Alloway RR, Lo A, Hodge E (2003) Twodose Daclizumab regimen in simultaneous kidney pancreas transplantation: primary endpoint analysis of a multicenter, randomized study. Transplantation 75: 1260-1266
19. Gaston RS, Kaplan B, Shah T, Cibrik D, Shaw LM, Angelis L et al. (2009) Fixed-or Controlled-Dose Mycophenolate Mofetil with Standard-or Reduced-Dose Calcineurin Inhibitors: The Opticept Trial. Am J Transplant 9: 1607-1619
20. Van Gelder T, Tedesco Silva H, de Fijter JW, Budde K, Kuypers D, Arns W (2010) et al. Renal transplant patients at high risk of acute rejection benefit from adequate exposure to mycophenolic acid. Transplantation 89: 595-599
21. Andrés A, Budde K, Clavien PA, Becker T, Kessler M, Pisarski P et al. (2009) A randomized trial comparing renal function in older kidney transplant patients following delayed versus immediate tacrolimus administration. Transplantation 88: 1101-1108
22. Reutzel-Selke A, Jurisch A, Denecke C, Pascher A, Martins PN, Kessler H et al. (2007) Donor age intensifies the early immune response after transplantation. Kidney Int 71: 629-636
23. De Fijter JW, Mallat MJ, Doxiadis II, Ringers J, Rosendaal FR, Claas FH et al. (2001) Increased immunogenicity and cause of graft loss of old donor kidneys. J Am Soc Nephrol 12: 1538-46
24. Meier-Kriesche HU, Ojo A, Hanson J, Cibrik D, Lake K, Agodoa LY et al. (2000) Increased immunosuppressive vulnerability in elderly renal transplant recipients. Transplantation 69: 885-889
25. Theodorakis J, Schneeberger H, Illner WD, Stangl M, Zanker B, Land W et al. (2000) Nephrotoxicityfree, mycophenolate mofetil-based induction/ maintenance immunosuppression in elderly recipients of renal allografts from elderly cadaveric donors. Transplant Proc 32: 9S-11S
26. Land W, Vincenti F (2005) Toxicity-sparing protocols using mycophenolate-mofetil in renal transplantation. Transplantation 80: S221-234
27. Collini A, Kalmar P, Dhamo A, Ruggieri G, Carmellini M Collinie A et al. (2009) Renal Transplantation from very old donors: How far can we go? Transplantation 87: 1830-1836