Safe, long-term hepatic expression of anti-HCV shRNA in a nonhuman primate model

Molecular Therapy

Volumn 20, Issue 9, 2012, Pages 1737-1749

  Suhy, David A ^a   Kao, Shih Chu ^a   Mao, Tin ^a   Whiteley, Laurence ^b   Denise, Hubert ^b   Souberbielle, Bernard ^b   Burdick, Andrew D ^b   Hayes, Kyle ^b   Wright, J Fraser ^c,d   Lavender, Helen ^b   Roelvink, Peter ^a   Kolykhalov, Alexander ^a   Brady, Kevin ^b   Moschos, Sterghios A ^b   Hauck, Bernd ^c   Zelenaia, Olga ^c   Zhou, Shangzhen ^d   Scribner, Curt ^a   High, Katherine A ^c,e   Renison, Sara H ^a   Corbau, Romu ^b   more..

^a Tacere Therapeutics   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^c CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SHORT HAIRPIN RNA; SHORT HAIRPIN RNA 19; SHORT HAIRPIN RNA 22; SHORT HAIRPIN RNA 6; TT 033; UNCLASSIFIED DRUG; VIRUS ANTIBODY; VIRUS RNA; VIRUS VECTOR;

ADENO ASSOCIATED VIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DISEASE COURSE; DRUG SAFETY; ENZYME INHIBITION; FEMALE; GENE EXPRESSION; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; LIVER TOXICITY; MACACA FASCICULARIS; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OUTCOME ASSESSMENT; REPLICON; RNA INTERFERENCE; RNA SEQUENCE; SINGLE DRUG DOSE; VIRUS GENOME;

ADENO-ASSOCIATED VIRUS; HEPATITIS C VIRUS; PRIMATES;

EID: 84867088984     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2012.119     Document Type: Article

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