Synthesis and pharmacological evaluation of pyrazolo[4,3-c]cinnoline derivatives as potential anti-inflammatory and antibacterial agents

European Journal of Medicinal Chemistry

Volumn 57, Issue , 2012, Pages 176-184

  Tonk, Rajiv Kumar ^a   Bawa, Sandhya ^a   Chawla, Gita ^a   Deora, Girdhar Singh ^b   Kumar, Suresh ^a   Rathore, Vandana ^b   Mulakayala, Naveen ^b   Rajaram, Azad ^c   Kalle, Arunasree M ^c   Afzal, Obaid ^a  

^a HAMDARD UNIVERSITY   (India)

^b INSTITUTE OF LIFE SCIENCES   (India)

^c UNIVERSITY OF HYDERABAD   (India)

Author keywords

Anti inflammatory agent; Antibacterial agent; COX 2 inhibitors; Docking simulations; Pyrazolo 4,3 c cinnoline; Ulcerogenic activity

Indexed keywords

(4 AMINOPHENYL)(7 CHLORO 8 FLUORO 3 METHYL 1H PYRAZOLO[4,3 C]CINNOLIN 1 YL)METHANONE; (7 CHLORO 8 FLUORO 3 METHYL 1H PYRAZOLO[4,3 C]CINNOLIN 1 YL)(2,4 DICHLOROPHENYL)METHANONE; (7 CHLORO 8 FLUORO 3 METHYL 1H PYRAZOLO[4,3 C]CINNOLIN 1 YL)(3,4 DIMETHOXYPHENYL)METHANONE; (7 CHLORO 8 FLUORO 3 METHYL 1H PYRAZOLO[4,3 C]CINNOLIN 1 YL)(4 CHLOROPHENYL)METHANONE; (7 CHLORO 8 FLUORO 3 METHYL 1H PYRAZOLO[4,3 C]CINNOLIN 1 YL)(4 FLUOROPHENYL)METHANONE; (7 CHLORO 8 FLUORO 3 METHYL 1H PYRAZOLO[4,3 C]CINNOLIN 1 YL)(4 METHOXYPHENYL)METHANONE; (7 CHLORO 8 FLUORO 3 METHYL 1H PYRAZOLO[4,3 C]CINNOLIN 1 YL)(4 METHYLPHENYL)METHANONE; (7 CHLORO 8 FLUORO 3 METHYL 1H PYRAZOLO[4,3 C]CINNOLIN 1 YL)(4 NITROPHENYL)METHANONE; (7 CHLORO 8 FLUORO 3 METHYL 1H PYRAZOLO[4,3 C]CINNOLIN 1 YL)(PHENYL)METHANONE; 1 (7 CHLORO 8 FLUORO 3 METHYL 1H PYRAZOLO[4,3 C]CINNOLIN 1 YL) 2 (2,4 DICHLOROPHENOXY)ETHANONE; 1 (7 CHLORO 8 FLUORO 3 METHYL 1H PYRAZOLO[4,3 C]CINNOLIN 1 YL) 2 (NAPHTHALEN 1 YL)ETHANONE; 1 (7 CHLORO 8 FLUORO 3 METHYL 1H PYRAZOLO[4,3 C]CINNOLIN 1 YL) 2 PHENOXYETHANONE; 1 (7 CHLORO 8 FLUORO 3 METHYL 1H PYRAZOLO[4,3 C]CINNOLIN 1 YL) 2 PHENYLETHANONE; ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT; CIPROFLOXACIN; CYCLOOXYGENASE 2; NAPROXEN; PYRAZOLE DERIVATIVE; PYRAZOLO[4,3 C]CINNOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SAFETY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ASSAY; ENZYME INHIBITION; ESCHERICHIA COLI; LIPID PEROXIDATION; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; NONHUMAN; PAW EDEMA; PSEUDOMONAS AERUGINOSA; RAT; STAPHYLOCOCCUS AUREUS; STOMACH MUCOSA INJURY; ULCEROGENESIS;

ADMINISTRATION, ORAL; ANIMALS; ANTI-BACTERIAL AGENTS; ANTI-INFLAMMATORY AGENTS; CARRAGEENAN; CYCLOOXYGENASE 2; EDEMA; ESCHERICHIA COLI; HETEROCYCLIC COMPOUNDS, 2-RING; INFLAMMATION; LIPID PEROXIDATION; MICROBIAL SENSITIVITY TESTS; MOLECULAR DOCKING SIMULATION; NAPROXEN; PSEUDOMONAS AERUGINOSA; PYRAZOLES; RATS; RATS, WISTAR; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP; ULCER;

EID: 84867085510     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.08.045     Document Type: Article

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