TNF-α/IL-2 ratio discriminates latent from active tuberculosis in immunocompetent children: A pilot study

Pediatric Research

Volumn 72, Issue 4, 2012, Pages 370-374

  Gourgouillon, Nadège ^a   De Lauzanne, Agathe ^a   Cottart, Charles Henry ^b   Curis, Emmanuel ^c   Debord, Camille ^a   Guérin El Khourouj, Valérie ^a   Pédron, Béatrice ^a   Faye, Albert ^a   Sterkers, Ghislaine ^a  

^a HÔPITAL ROBERT DEBRÉ   (France)

^b HÔPITAL CHARLES FOIX   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BCG VACCINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 2; INTERLEUKIN 23; INTERLEUKIN 4; INTERLEUKIN 5; MYCOBACTERIUM ANTIGEN; TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; AGE DISTRIBUTION; ANTIGEN EXPRESSION; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; FEMALE; FRANCE; HUMAN; IMMUNE RESPONSE; IMMUNOASSAY; IMMUNOCOMPETENCE; LATENT TUBERCULOSIS; LUMINEX ASSAY; MALE; MYCOBACTERIUM TUBERCULOSIS; PILOT STUDY; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; TH1 CELL; TH2 CELL; TUBERCULIN TEST; TUBERCULOSIS;

ADOLESCENT; BIOLOGICAL MARKERS; CHILD; CHILD, PRESCHOOL; DIAGNOSIS, DIFFERENTIAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; IMMUNOCOMPETENCE; IMMUNOLOGIC TESTS; INFANT; INTERFERON-GAMMA RELEASE TESTS; INTERLEUKIN-2; LATENT TUBERCULOSIS; MALE; MYCOBACTERIUM TUBERCULOSIS; PILOT PROJECTS; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; SPUTUM; TUBERCULIN TEST; TUBERCULOSIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84867060726     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1038/pr.2012.89     Document Type: Article

References (23)

1. WHO report. Global tuberculosis control 2011. WHO, 2011. (http://www. who.int/tb/publications/global-report/2011/gtbr11-full.pdf.)
2. Feja K, Saiman L. Tuberculosis in children. Clin Chest Med 2005;26: 295-312, vii.
3. Stenger S. Immunological control of tuberculosis: role of tumour necrosis factor and more. Ann Rheum Dis 2005;64:Suppl 4:iv24-8.
4. Ferrara G, Losi M, D'Amico R, et al. Use in routine clinical practice of two commercial blood tests for diagnosis of infection with Mycobacterium tuberculosis: a prospective study. Lancet 2006;367:1328-34.
5. van de Vosse E, Hoeve MA, Ottenhoff TH. Human genetics of intracellular infectious diseases: molecular and cellular immunity against mycobacteria and salmonellae. Lancet Infect Dis 2004;4:739-49.
6. Rook GA. Th2 cytokines in susceptibility to tuberculosis. Curr Mol Med 2007;7:327-37.
7. Lalor MK, Smith SG, Floyd S, et al. Complex cytokine profiles induced by BCG vaccination in UK infants. Vaccine 2010;28:1635-41.
8. Wilkinson KA, Wilkinson RJ. Polyfunctional T cells in human tuberculosis. Eur J Immunol 2010;40:2139-42.
9. Harari A, Rozot V, Enders FB, et al. Dominant TNF-a+ Mycobacterium tuberculosis-specific CD4+ T cell responses discriminate between latent infection and active disease. Nat Med 2011;17:372-6.
10. Soares AP, Scriba TJ, Joseph S, et al. Bacillus Calmette-Guin vaccination of human newborns induces T cells with complex cytokine and phenotypic profiles. J Immunol 2008;180:3569-77.
11. Jasmer RM, Nahid P, Hopewell PC. Clinical practice. Latent tuberculosis infection. N Engl J Med 2002;347:1860-6.
12. Debord C, De Lauzanne A, Gourgouillon N, et al. Interferon-gamma release assay performance for diagnosing tuberculosis disease in 0-to 5-year-old children. Pediatr Infect Dis J 2011;30:995-7.
13. Al-Attiyah R, Madi N, El-Shamy AS, Wiker H, Andersen P, Mustafa A. Cytokine profiles in tuberculosis patients and healthy subjects in response to complex and single antigens of Mycobacterium tuberculosis. FEMS Immunol Med Microbiol 2006;47:254-61.
14. Ottenhoff TH, Verreck FA, Hoeve MA, van de Vosse E. Control of human host immunity to mycobacteria. Tuberculosis (Edinb) 2005;85:53-64.
15. Turner J, Gonzalez-Juarrero M, Ellis DL, et al. In vivo IL-10 production reactivates chronic pulmonary tuberculosis in C57BL/6 mice. J Immunol 2002;169:6343-51.
16. Lin PL, Flynn JL. Understanding latent tuberculosis: a moving target. J Immunol 2010;185:15-22.
17. Lighter-Fisher J, Peng CH, Tse DB. Cytokine responses to QuantiFERON? peptides, purified protein derivative and recombinant ESAT-6 in children with tuberculosis. Int J Tuberc Lung Dis 2010;14:1548-55.
18. Chegou NN, Black GF, Kidd M, van Helden PD, Walzl G. Host markers in QuantiFERON supernatants differentiate active TB from latent TB infection: preliminary report. BMC Pulm Med 2009;9:21.
19. Sutherland JS, Adetifa IM, Hill PC, Adegbola RA, Ota MO. Pattern and diversity of cytokine production differentiates between Myco-bacterium tuberculosis infection and disease. Eur J Immunol 2009; 39:723-9.
20. Biselli R, Mariotti S, Sargentini V, et al. Detection of interleukin-2 in addition to interferon-gamma discriminates active tuberculosis patients, latently infected individuals, and controls. Clin Microbiol Infect 2010; 16:1282-4.
21. Pantaleo G, Harari A. Functional signatures in antiviral T-cell immunity for monitoring virus-associated diseases. Nat Rev Immunol 2006;6:417-23.
22. Team RDC. A Language and Environment for Statistical Computing. R Fundation for Statistical Computing, Vienna, Austria, 2011. (http://www.r- project.org/links.html).
23. Tobias J, Sander O, Beerenwinkel N, Lengauer RT. 2009. ROCR: Visualizing the performance of scoring classifiers. R package version 0.0-4. (http://CRAN.R-project.org/package=ROCR.).