Novel pyrimidopyrimidine derivatives for inhibition of cellular proliferation and motility induced by h-prune in breast cancer

European Journal of Medicinal Chemistry

Volumn 57, Issue , 2012, Pages 41-50

  Virgilio, Antonella ^a   Spano, Daniela ^a,b   Esposito, Veronica ^a   Di Dato, Valeria ^a,b   Citarella, Giuseppe ^a   Marino, Natascia ^b   Maffia, Veronica ^b   De Martino, Daniela ^a,b   De Antonellis, Pasqualino ^a,b   Galeone, Aldo ^a   Zollo, Massimo ^a,b  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b CEINGE BIOTECNOLOGIE AVANZATE   (Italy)

Author keywords

Breast cancer; cAMP; Cellular motility; h Prune; Phosphodiesterase

Indexed keywords

1,1' [4,8 BIS(4 METHOXYBENZYLAMINO)PYRIMIDO[5,4 D]PYRIMIDINE 2,6 DIYL]DIPYRROLIDIN 3 OL; 2,2' [4,8 BIS(4 METHOXYBENZYLAMINO)PYRIMIDO[5,4 D]PYRIMIDINE 2,6 DIYL]BIS(AZANEDIYL)DICYCLOHEXANOL; BETA ACTIN; CYCLIC AMP PHOSPHODIESTERASE; DIPYRIDAMOLE; PROTEIN H PRUNE; PYRIMIDO[5,4 D]PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER INHIBITION; CANCER INVASION; CANCER MODEL; CELL MIGRATION; CELL MOTILITY; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPH NODE METASTASIS; NONHUMAN; STRUCTURE ACTIVITY RELATION;

3',5'-CYCLIC-AMP PHOSPHODIESTERASES; BREAST NEOPLASMS; CARRIER PROTEINS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; DIFFUSION CHAMBERS, CULTURE; DIPYRIDAMOLE; FEMALE; HUMANS; NEOPLASM PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84867060033     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.08.020     Document Type: Article

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