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Volumn 57, Issue , 2012, Pages 217-224
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Synthesis and biological evaluation of ester prodrugs of benzafibrate as orally active hypolipidemic agents
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Author keywords
Benzafibrate; Hypolipidemic activity; Physicochemical properties; Prodrugs
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Indexed keywords
2 [4 [2 [(4 CHLOROBENZOYL)AMINO]ETHYL]PHENOXY] 2 METHYLPROPANOIC ACID 1 ACETOXYETHYL ESTER;
2 [4 [2 [(4 CHLOROBENZOYL)AMINO]ETHYL]PHENOXY] 2 METHYLPROPANOIC ACID 1 ISOPROPOXYCARBONYLOXYETHYL ESTER;
2 [4 [2 [(4 CHLOROBENZOYL)AMINO]ETHYL]PHENOXY] 2 METHYLPROPANOIC ACID 2 ACETOXYETHYL ESTER;
2 [4 [2 [(4 CHLOROBENZOYL)AMINO]ETHYL]PHENOXY] 2 METHYLPROPANOIC ACID 2 MORPHOLIN 4 YL ETHYL ESTER;
2 [4 [2 [(4 CHLOROBENZOYL)AMINO]ETHYL]PHENOXY] 2 METHYLPROPANOIC ACID 2,2 DIMETHYLPROPIONYLOXYMETHYL ESTER;
2 [4 [2 [(4 CHLOROBENZOYL)AMINO]ETHYL]PHENOXY] 2 METHYLPROPANOIC ACID 5 METHYL 2 OXO[1,3]DIOXOL 4 YLMETHYL ESTER;
2 [4 [2 [(4 CHLOROBENZOYL)AMINO]ETHYL]PHENOXY] 2 METHYLPROPANOIC ACID ISOPROPOXYCARBONYLOXYMETHYL ESTER;
ANTILIPEMIC AGENT;
BEZAFIBRATE;
PRODRUG;
UNCLASSIFIED DRUG;
ANIMAL EXPERIMENT;
ANIMAL MODEL;
ARTICLE;
CHOLESTEROL BLOOD LEVEL;
CONTROLLED STUDY;
DOSE RESPONSE;
DRUG ACTIVITY;
DRUG EFFICACY;
DRUG POTENCY;
DRUG SCREENING;
DRUG STABILITY;
DRUG SYNTHESIS;
EXPERIMENTAL MODEL;
HYPOLIPIDEMIC ACTIVITY;
LIPOPHILICITY;
MALE;
MOUSE;
NONHUMAN;
PARTICLE SIZE;
PARTITION COEFFICIENT;
TRIACYLGLYCEROL BLOOD LEVEL;
ADMINISTRATION, ORAL;
ANIMALS;
BEZAFIBRATE;
DRUG ADMINISTRATION SCHEDULE;
DRUG STABILITY;
ESTERS;
HYDROGEN-ION CONCENTRATION;
HYDROPHOBIC AND HYDROPHILIC INTERACTIONS;
HYPOLIPIDEMIC AGENTS;
MALE;
MICE;
OCTANOLS;
PRODRUGS;
STRUCTURE-ACTIVITY RELATIONSHIP;
TRIGLYCERIDES;
WATER;
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EID: 84867048942
PISSN: 02235234
EISSN: 17683254
Source Type: Journal
DOI: 10.1016/j.ejmech.2012.08.036 Document Type: Article |
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Times cited : (13)
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References (21)
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