Conformation of beta2glycoprotein i and its effect on coagulation

Thrombosis Research

Volumn 130, Issue SUPPL.1, 2012, Pages

  Ninivaggi, Marisa ^a,b   Kelchtermans, Hilde ^a,b   Lindhout, Theo ^a,b   De Laat, Bas ^a,b,c,d  

^a Synapse BV   (Netherlands)

^b MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^c SANQUIN RESEARCH   (Netherlands)

^d UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

2glycoprotein I; Antiphospholipid syndrome; Conformation; Thrombin generation

Indexed keywords

BETA2 GLYCOPROTEIN 1; PHOSPHOLIPID; THROMBIN; THROMBOPLASTIN;

ANTICOAGULATION; ANTIPHOSPHOLIPID SYNDROME; ARTICLE; BLOOD CELL; BLOOD CLOTTING; CONFORMATIONAL TRANSITION; ENZYME LINKED IMMUNOSORBENT ASSAY; HEMOSTASIS; HUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; THROMBOSIS;

AMINO ACID SEQUENCE; ANIMALS; ANTIPHOSPHOLIPID SYNDROME; BETA 2-GLYCOPROTEIN I; BLOOD COAGULATION; HUMANS; MOLECULAR SEQUENCE DATA; PHOSPHOLIPIDS; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBIN; THROMBOPLASTIN;

EID: 84867040954     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2012.08.269     Document Type: Article

References (27)

1. S. Wijetilleka, T. Scoble, and M. Khamashta Novel insights into pathogenesis, diagnosis and treatment of antiphospholipid syndrome Curr Opin Rheumatol 24 2012 473 481
2. R. Cervera, J.C. Piette, J. Font, M.A. Khamashta, Y. Shoenfeld, and M.T. Camps Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients Arthritis Rheum 46 2002 1019 1027
3. S. Miyakis, M.D. Lockshin, T. Atsumi, D.W. Branch, R.L. Brey, and R. Cervera International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS) J Thromb Haemost 4 2006 295 306
4. V. Pengo, A. Tripodi, G. Reber, J.H. Rand, T.L. Ortel, and M. Galli Update of the guidelines for lupus anticoagulant detection. Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the International Society on Thrombosis and Haemostasis J Thromb Haemost 7 2009 1737 1740
5. M.I. Kamboh, D.K. Sanghera, H. Mehdi, C.S. Nestlerode, Q. Chen, and O. Khalifa Single nucleotide polymorphisms in the coding region of the apolipoprotein H (beta2-glycoprotein I) gene and their correlation with the protein polymorphism, anti-beta2glycoprotein I antibodies and cardiolipin binding: description of novel haplotypes and their evolution Ann Hum Genet 68 2004 285 299
6. Y. Sheng, A. Sali, H. Herzog, J. Lahnstein, and S.A. Krilis Site-directed mutagenesis of recombinant human beta 2-glycoprotein I identifies a cluster of lysine residues that are critical for phospholipid binding and anti-cardiolipin antibody activity J Immunol 157 1996 3744 3751
7. B. de Laat, R.H. Derksen, R.T. Urbanus, and P.G. de Groot IgG antibodies that recognize epitope Gly40-Arg43 in domain I of beta 2-glycoprotein I cause LAC, and their presence correlates strongly with thrombosis Blood 105 2005 1540 1545
8. B. de Laat, V. Pengo, I. Pabinger, J. Musial, A.E. Voskuyl, and I.E. Bultink The association between circulating antibodies against domain I of beta2-glycoprotein I and thrombosis: an international multicenter study J Thromb Haemost 7 2009 1767 1773
9. G.M. Iverson, S. Reddel, E.J. Victoria, K.A. Cockerill, Y.X. Wang, and M.A. Marti-Renom Use of single point mutations in domain I of beta 2-glycoprotein I to determine fine antigenic specificity of antiphospholipid autoantibodies J Immunol 169 2002 7097 7103
10. I. Schousboe, and M.S. Rasmussen Synchronized inhibition of the phospholipid mediated autoactivation of factor XII in plasma by beta 2-glycoprotein I and anti-beta 2-glycoprotein I Thromb Haemost 73 1995 798 804
11. I. Schousboe Inositolphospholipid-accelerated activation of prekallikrein by activated factor XII and its inhibition by beta 2-glycoprotein I Eur J Biochem 176 1988 629 636
12. T. McNally, I.J. Mackie, D.A. Isenberg, and S.J. Machin beta 2 glycoprotein-I inhibits factor XII activation on triglyceride rich lipoproteins: the effect of antibodies from plasma of patients with antiphospholipid syndrome Thromb Haemost 76 1996 220 225
13. S. Rahgozar, B. Giannakopoulos, X. Yan, J. Wei, J. Cheng Qi, and R. Gemmell Beta2-glycoprotein I protects thrombin from inhibition by heparin cofactor II: potentiation of this effect in the presence of anti-beta2- glycoprotein I autoantibodies Arthritis Rheum 58 2008 1146 1155
14. B. Bouma, P.G. de Groot, J.M. van den Elsen, R.B. Ravelli, A. Schouten, and M.J. Simmelink Adhesion mechanism of human beta(2)-glycoprotein I to phospholipids based on its crystal structure EMBO J 18 1999 5166 5174
15. R. Schwarzenbacher, K. Zeth, K. Diederichs, A. Gries, G.M. Kostner, and P. Laggner Crystal structure of human beta2-glycoprotein I: implications for phospholipid binding and the antiphospholipid syndrome EMBO J 18 1999 6228 6239
16. M. Hammel, M. Kriechbaum, A. Gries, G.M. Kostner, P. Laggner, and R. Prassl Solution structure of human and bovine beta(2)-glycoprotein I revealed by small-angle X-ray scattering J Mol Biol 321 2002 85 97
17. C. Agar, G.M. van Os, M. Morgelin, R.R. Sprenger, J.A. Marquart, and R.T. Urbanus Beta2-glycoprotein I can exist in 2 conformations: implications for our understanding of the antiphospholipid syndrome Blood 116 2010 1336 1343
18. P.G. de Groot, and J.C. Meijers beta(2) -Glycoprotein I: evolution, structure and function J Thromb Haemost 9 2011 1275 1284
19. Y. Aoyama, Y.L. Chan, and I.G. Wool The primary structure of rat beta 2-glycoprotein I Nucleic Acids Res 17 1989 6401
20. H.E. Schultze, and H. Haupt Über ein bischer unbekanntes niedermolekulares b2-Globulin des Humanserums Naturwissenschaften 48 1961 719
21. J. Lozier, N. Takahashi, and F.W. Putnam Complete amino acid sequence of human plasma beta 2-glycoprotein I Proc Natl Acad Sci U S A 81 1984 3640 3644
22. N. Ohkura, Y. Hagihara, T. Yoshimura, Y. Goto, and H. Kato Plasmin can reduce the function of human beta2 glycoprotein I by cleaving domain V into a nicked form Blood 91 1998 4173 4179
23. B. de Laat, R.H. Derksen, M. van Lummel, M.T. Pennings, and P.G. de Groot Pathogenic anti-beta2-glycoprotein I antibodies recognize domain I of beta2-glycoprotein I only after a conformational change Blood 107 2006 1916 1924
24. C. Agar, P.G. de Groot, M. Morgelin, S.D. Monk, G. van Os, and J.H. Levels beta(2)-glycoprotein I: a novel component of innate immunity Blood 117 2011 6939 6947
25. L. Pelkmans, and B. de Laat Antibodies against domain I of beta2-glycoprotein I: the one and only? Lupus 21 2012 769 772
26. H.C. Hemker, P. Giesen, R. Al Dieri, V. Regnault, E. de Smedt, and R. Wagenvoord Calibrated automated thrombin generation measurement in clotting plasma Pathophysiol Haemost Thromb 33 2003 4 15
27. C. Agar, P.G. de Groot, J.A. Marquart, and J.C. Meijers Evolutionary conservation of the lipopolysaccharide binding site of beta(2)-glycoprotein I Thromb Haemost 106 2011 1069 1075