Evaluation of the association between runtrelated transcription factor 2 expression and intervertebral disk aging in dogs

American Journal of Veterinary Research

Volumn 73, Issue 10, 2012, Pages 1553-1559

  Itoh, Hisanori ^a   Hara, Yasushi ^a   Tagawa, Masahiro ^a   Kato, Tsuyoshi ^b   Ochi, Hiroki ^a   Koga, Daisuke ^b   Okawa, Atsushi ^b   Asou, Yoshinori ^b  

^a NIPPON VETERINARY AND LIFE SCIENCE UNIVERSITY   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGENASE 3; COMPLEMENTARY DNA; MESSENGER RNA; RNA DIRECTED DNA POLYMERASE; TRANSCRIPTION FACTOR RUNX2;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; DOG; FEMALE; GENE AMPLIFICATION; IMMUNOHISTOCHEMISTRY; INTERVERTEBRAL DISK DEGENERATION; INTERVERTEBRAL DISK HERNIA; LUMBAR VERTEBRA; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEUS PULPOSUS; PROTEIN EXPRESSION; THORACIC SPINE; AGING; ANIMAL; ANIMAL DISEASE; DOG DISEASE; GENETICS; HISTOLOGY; INTERVERTEBRAL DISK; METABOLISM; PATHOLOGY; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; VERTEBRA;

ANIMALIA; CANIS FAMILIARIS;

AGING; ANIMALS; CORE BINDING FACTOR ALPHA 1 SUBUNIT; DNA, COMPLEMENTARY; DOG DISEASES; DOGS; IMMUNOHISTOCHEMISTRY; INTERVERTEBRAL DISC; INTERVERTEBRAL DISC DISPLACEMENT; LUMBAR VERTEBRAE; MAGNETIC RESONANCE IMAGING; MATRIX METALLOPROTEINASE 13; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEQUENCE ANALYSIS, DNA; SEQUENCE ANALYSIS, PROTEIN; THORACIC VERTEBRAE;

EID: 84867034441     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.73.10.1553     Document Type: Article

References (31)

1. Goupille P, Jayson MI, Valat JP, et al. Matrix metalloproteinases: the clue to intervertebral disc degeneration? Spine 1998;23:1612-1626.
2. Matrisian LM. Metalloproteinases and their inhibitors in matrix remodeling. Trends Genet 1990;6:121-125.
3. Knauper V, Lopez-Otin C, Smith B, et al. Biochemical characterization of human collagenase-3. J Biol Chem 1996;271:1544-1550.
4. Reboul P, Pelletier JP, Tardif G, et al. The new collagenase, collagenase-3, is expressed and synthesized by human chondrocytes but not by synoviocytes. A role in osteoarthritis. J Clin Invest 1996;97:2011-2019.
5. Anderson DG, Izzo MW, Hall DJ, et al. Comparative gene expression profiling of normal and degenerative discs: analysis of a rabbit annular laceration model. Spine 2002;27:1291-1296.
6. MacLean JJ, Lee CR, Alini M, et al. The effects of short-term load duration on anabolic and catabolic gene expression in the rat tail intervertebral disc. J Orthop Res 2005;23:1120-1127.
7. Omlor GW, Lorenz H, Engelleiter K, et al. Changes in gene expression and protein distribution at different stages of mechanically induced disc degeneration-an in vivo study on the New Zealand white rabbit. J Orthop Res 2006;24:385-392.
8. Roberts S, Bains MA, Kwan A, et al. Type X collagen in the human invertebral disc: an indication of repair or remodelling? Histochem J 1998;30:89-95.
9. Takao T, Iwaki T, Kondo J, et al. Immunohistochemistry of chondromodulin-I in the human intervertebral discs with special reference to the degenerative changes. Histochem J 2000;32:545-550.
10. Boos N, Weissbach S, Rohrbach H, et al. Classification of agerelated changes in lumbar intervertebral discs: 2002 Volvo Award in basic science. Spine 2002;27:2631-2644.
11. Cappello R, Bird JL, Pfeiffer D, et al. Notochordal cell produce and assemble extracellular matrix in a distinct manner, which may be responsible for the maintenance of healthy nucleus pulposus. Spine 2006;31:873-883.
12. Enomoto H, Enomoto-Iwamoto M, Iwamoto M, et al. Cbfa1 is a positive regulatory factor in chondrocyte maturation. J Biol Chem 2000;275:8695-8702.
13. Jimenez MJ, Balbin M, Lopez JM, et al. Collagenase 3 is a target of Cbfa1, a transcription factor of the runt gene family involved in bone formation. Mol Cell Biol 1999;19:4431-4442.
14. Zheng Q, Zhou G, Morello R, et al. Type X collagen gene regulation by Runx2 contributes directly to its hypertrophic chondrocyte-specific expression in vivo. J Cell Biol 2003;162:833-842.
15. Kamekura S, Kawasaki Y, Hoshi K, et al. Contribution of runtrelated transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability. Arthritis Rheum 2006;54:2462-2470.
16. Trout JJ, Buckwalter JA, Moore KC, et al. Ultrastructure of the human intervertebral disc. I. Changes in notochordal cells with age. Tissue Cell 1982;14:359-369.
17. Hunter CJ, Matyas JR, Duncan NA. Cytomorphology of notochordal and chondrocytic cells from the nucleus pulposus: a species comparison. J Anat 2004;205:357-362.
18. Hansen HJ. A pathologic-anatomical study on disc degeneration in dog, with special reference to the so-called enchondrosis intervertebralis. Acta Orthop Scand Suppl 1952;11:1-117.
19. Benneker LM, Heini PF, Anderson SE, et al. Correlation of radiographic and MRI parameters to morphological and biochemical assessment of intervertebral disc degeneration. Eur Spine J 2005;14:27-35.
20. Haughton V. Imaging intervertebral disc degeneration. J Bone Joint Surg Am 2006;88(suppl 2):15-20.
21. Thompson JP, Pearce RH, Schechter MT, et al. Preliminary evaluation of a scheme for grading the gross morphology of the human intervertebral disc. Spine 1990;15:411-415.
22. Sato S, Kimura A, Ozdemir J, et al. The distinct role of the Runx proteins in chondrocyte differentiation and intervertebral disc degeneration: findings in murine models and in human disease. Arthritis Rheum 2008;58:2764-2775.
23. Tsuchida S, Yamada R, Ikemoto S, et al. Molecular cloning of a cDNA coding for feline liver xanthine dehydrogenase. J Vet Med Sci 2001;63:353-355.
24. Enomoto H, Inoki I, Komiya K, et al. Vascular endothelial growth factor isoforms and their receptors are expressed in human osteoarthritic cartilage. Am J Pathol 2003;162:171-181.
25. Haro H, Kato T, Komori H, et al. Vascular endothelial growth factor (VEGF)-induced angiogenesis in herniated disc resorption. J Orthop Res 2002;20:409-415.
26. Itoh H, Asou Y, Hara Y, et al. Enhanced type X collagen expression in the extruded nucleus pulposus of the chondrodystrophoid dog. J Vet Med Sci 2008;70:37-42.
27. Bernard TN Jr. Lumbar discography followed by computed tomography. Refining the diagnosis of low-back pain. Spine 1990;15:690-707.
28. Haro H, Shinomiya K, Komori H, et al. Upregulated expression of chemokines in herniated nucleus pulposus resorption. Spine 1996;21:1647-1652.
29. Komori H, Shinomiya K, Nakai O, et al. The natural history of herniated nucleus pulposus with radiculopathy. Spine 1996;21:225-229.
30. Costessi A, Pines A, D'Andrea P, et al. Extracellular nucleotides activate Runx2 in the osteoblast-like HOBIT cell line: a possible molecular link between mechanical stress and osteoblasts' response. Bone 2005;36:418-432.
31. Ziros PG, Gil AP, Georgakopoulos T, et al. The bone-specific transcriptional regulator Cbfa1 is a target of mechanical signals in osteoblastic cells. J Biol Chem 2002;277:23934-23941.