메뉴 건너뛰기




Volumn 4, Issue 9, 2012, Pages 1537-1547

Contributions of Epstein-Barr nuclear antigen 1 (EBNA1) to cell immortalization and survival

Author keywords

EBNA1; NF B; Nm23 H1; Oxidative stress; p53; PML; ROS; STAT1; Survivin; USP7

Indexed keywords

EPSTEIN BARR VIRUS ANTIGEN 1; NUCLEOSIDE DIPHOSPHATE KINASE A; PROTEIN P53; SURVIVIN;

EID: 84867026753     PISSN: 19994915     EISSN: None     Source Type: Journal    
DOI: 10.3390/v4091537     Document Type: Review
Times cited : (97)

References (67)
  • 1
    • 0024392383 scopus 로고
    • Viral latency and transformation: The strategy of Epstein-Barr virus
    • doi:10.1016/0092-8674(89)90394-2
    • Klein, G. Viral latency and transformation: The strategy of Epstein-Barr virus. Cell 1989, 58, 5-8. doi:10.1016/0092-8674(89)90394-2
    • (1989) Cell , vol.58 , pp. 5-8
    • Klein, G.1
  • 2
    • 1642334164 scopus 로고    scopus 로고
    • Persistence of the Epstein-Barr virus and the origins of associated lymphomas
    • doi:10.1056/NEJMra032015
    • Thorley-Lawson, D.A.; Gross, A. Persistence of the Epstein-Barr virus and the origins of associated lymphomas. N. Engl. J. Med. 2004, 350, 1328-1337. doi:10.1056/NEJMra032015
    • (2004) N. Engl. J. Med , vol.350 , pp. 1328-1337
    • Thorley-Lawson, D.A.1    Gross, A.2
  • 3
    • 0021988550 scopus 로고
    • Stable replication of plasmids derived from Epstein-Barr virus in various mammalian cells
    • doi:10.1038/313812a0
    • Yates, J.L.; Warren, N.; Sugden, B. Stable replication of plasmids derived from Epstein-Barr virus in various mammalian cells. Nature 1985, 313, 812-815. doi:10.1038/313812a0
    • (1985) Nature , vol.313 , pp. 812-815
    • Yates, J.L.1    Warren, N.2    Sugden, B.3
  • 4
    • 0022257860 scopus 로고
    • Mapping of genetic elements of Epstein-Barr virus that facilitate extrachromosomal persistence of Epstein-Barr virus-derived plasmids in human cells
    • Lupton, S.; Levine, A.J. Mapping of genetic elements of Epstein-Barr virus that facilitate extrachromosomal persistence of Epstein-Barr virus-derived plasmids in human cells. Mol. Cell. Biol. 1985, 5, 2533-2542.
    • (1985) Mol. Cell. Biol , vol.5 , pp. 2533-2542
    • Lupton, S.1    Levine, A.J.2
  • 5
    • 0021887852 scopus 로고
    • A putative origin of replication of plasmids derived from Epstein-Barr virus is composed of two cis-acting components
    • Reisman, D.; Yates, J.; Sugden, B. A putative origin of replication of plasmids derived from Epstein-Barr virus is composed of two cis-acting components. Mol. Cell. Biol. 1985, 5, 1822-1832.
    • (1985) Mol. Cell. Biol , vol.5 , pp. 1822-1832
    • Reisman, D.1    Yates, J.2    Sugden, B.3
  • 6
    • 0022134525 scopus 로고
    • Sequence-specific DNA binding of the Epstein-Barr virus nuclear antigen (EBNA1) to clustered sites in the plasmid maintenance region
    • doi:10.1016/0092-8674(85)90282-X
    • Rawlins, D.R.; Milman, G.; Hayward, S.D.; Hayward, G.S. Sequence-specific DNA binding of the Epstein-Barr virus nuclear antigen (EBNA1) to clustered sites in the plasmid maintenance region. Cell 1985, 42, 859-868. doi:10.1016/0092-8674(85)90282-X
    • (1985) Cell , vol.42 , pp. 859-868
    • Rawlins, D.R.1    Milman, G.2    Hayward, S.D.3    Hayward, G.S.4
  • 7
    • 79951499910 scopus 로고    scopus 로고
    • EBNA1 in viral DNA replication and persistence
    • In, Robertson, E.S., Ed.; Caister Academic Press: Norwich, UK
    • Frappier, L. EBNA1 in viral DNA replication and persistence. In Epstein-Barr Virus: Latency and Transformation; Robertson, E.S., Ed.; Caister Academic Press: Norwich, UK, 2010; pp. 37-59.
    • (2010) Epstein-Barr Virus: Latency and Transformation , pp. 37-59
    • Frappier, L.1
  • 8
    • 0028932082 scopus 로고
    • An EBNA1 dependent enhancer acts from a distance of 10 kilobase pairs to increase expression of the Epstein-Barr virus lmp gene
    • Gahn, T.; Sugden, B. An EBNA1 dependent enhancer acts from a distance of 10 kilobase pairs to increase expression of the Epstein-Barr virus lmp gene. J. Virol. 1995, 69, 2633-2636.
    • (1995) J. Virol , vol.69 , pp. 2633-2636
    • Gahn, T.1    Sugden, B.2
  • 9
    • 0022818246 scopus 로고
    • Trans activation of an Epstein-Barr viral transcripitonal enhancer by the Epstein-Barr viral nuclear antigen 1
    • Reisman, D.; Sugden, B. Trans activation of an Epstein-Barr viral transcripitonal enhancer by the Epstein-Barr viral nuclear antigen 1. Mol. Cell. Biol. 1986, 6, 3838-3846.
    • (1986) Mol. Cell. Biol , vol.6 , pp. 3838-3846
    • Reisman, D.1    Sugden, B.2
  • 10
    • 0024392383 scopus 로고
    • Viral latency and transformation: The strategy of Epstein-Barr virus
    • doi:10.1016/0092-8674(89)90394-2
    • Klein, G. Viral latency and transformation: The strategy of Epstein-Barr virus. Cell 1989, 58, 5-8. doi:10.1016/0092-8674(89)90394-2
    • (1989) Cell , vol.58 , pp. 5-8
    • Klein, G.1
  • 11
    • 1642334164 scopus 로고    scopus 로고
    • Persistence of the Epstein-Barr virus and the origins of associated lymphomas
    • doi:10.1056/NEJMra032015
    • Thorley-Lawson, D.A.; Gross, A. Persistence of the Epstein-Barr virus and the origins of associated lymphomas. N. Engl. J. Med. 2004, 350, 1328-1337. doi:10.1056/NEJMra032015
    • (2004) N. Engl. J. Med , vol.350 , pp. 1328-1337
    • Thorley-Lawson, D.A.1    Gross, A.2
  • 13
    • 33749039167 scopus 로고    scopus 로고
    • Transcriptional activation by EBV nuclear antigen 1 is essential for the expression of EBV's transforming genes
    • Altmann, M.; Pich, D.; Ruiss, R.; Wang, J.; Sugden, B.; Hammerschmidt, W. Transcriptional activation by EBV nuclear antigen 1 is essential for the expression of EBV's transforming genes. Proc. Natl. Acad. Sci. U. S. A. 2006,103, 14188-14193.
    • (2006) Proc. Natl. Acad. Sci. U.S. A , vol.103 , pp. 14188-14193
    • Altmann, M.1    Pich, D.2    Ruiss, R.3    Wang, J.4    Sugden, B.5    Hammerschmidt, W.6
  • 14
    • 0344630245 scopus 로고    scopus 로고
    • Epstein-Barr virus provide a survival factor to Burkitt's lymphomas
    • Kennedy, G.; Komano, J.; Sugden, B. Epstein-Barr virus provide a survival factor to Burkitt's lymphomas. Proc. Natl. Acad. Sci. U. S. A. 2003, 100, 14269-14274.
    • (2003) Proc. Natl. Acad. Sci. U.S. A , vol.100 , pp. 14269-14274
    • Kennedy, G.1    Komano, J.2    Sugden, B.3
  • 16
    • 33644821804 scopus 로고    scopus 로고
    • Sirnas against the Epstein-Barr virus latency replication factor, EBNA 1, inhibit its function and growth of EBV-dependent tumor cells
    • doi:10.1016/j.virol.2005.11.021
    • Yin, Q.; Flemington, E.K. Sirnas against the Epstein-Barr virus latency replication factor, EBNA 1, inhibit its function and growth of EBV-dependent tumor cells. Virology 2006, 346, 385-393. doi:10.1016/j.virol.2005.11.021
    • (2006) Virology , vol.346 , pp. 385-393
    • Yin, Q.1    Flemington, E.K.2
  • 17
    • 0030014205 scopus 로고    scopus 로고
    • Expression of Epstein-Barr virus nuclear antigen-1 induces B cell neoplasia in transgenic mice
    • Wilson, J.B.; Bell, J.L.; Levine, A.J. Expression of Epstein-Barr virus nuclear antigen-1 induces B cell neoplasia in transgenic mice. EMBO J. 1996, 15, 3117-3126.
    • (1996) EMBO J , vol.15 , pp. 3117-3126
    • Wilson, J.B.1    Bell, J.L.2    Levine, A.J.3
  • 18
    • 0036667330 scopus 로고    scopus 로고
    • Bcl-xL and rag genes are induced and the response to IL-2 enhanced in EmuEBNA-1 transgenic mouse lymphocytes
    • doi:10.1038/sj.onc.1205490
    • Tsimbouri, P.; Drotar, M.E.; Coy, J.L.; Wilson, J.B. Bcl-xL and rag genes are induced and the response to IL-2 enhanced in EmuEBNA-1 transgenic mouse lymphocytes. Oncogene 2002, 21, 5182-5187. doi:10.1038/sj.onc.1205490
    • (2002) Oncogene , vol.21 , pp. 5182-5187
    • Tsimbouri, P.1    Drotar, M.E.2    Coy, J.L.3    Wilson, J.B.4
  • 20
    • 41949087403 scopus 로고    scopus 로고
    • Epstein-Barr virus nuclear antigen 1 does not cause lymphoma in c57bl/6j mice
    • doi:10.1128/JVI.02596-07
    • Kang, M.S.; Soni, V.; Bronson, R.; Kieff, E. Epstein-Barr virus nuclear antigen 1 does not cause lymphoma in c57bl/6j mice. J. Virol. 2008, 82, 4180-4183. doi:10.1128/JVI.02596-07
    • (2008) J. Virol , vol.82 , pp. 4180-4183
    • Kang, M.S.1    Soni, V.2    Bronson, R.3    Kieff, E.4
  • 21
    • 0035909916 scopus 로고    scopus 로고
    • Epstein-Barr virus nuclear antigen 1 activates transcription from episomal but not integrated DNA and does not alter lymphocyte growth
    • Kang, M.S.; Hung, S.C.; Kieff, E. Epstein-Barr virus nuclear antigen 1 activates transcription from episomal but not integrated DNA and does not alter lymphocyte growth. Proc. Natl. Acad. Sci. U. S. A. 2001, 98, 15233-15238.
    • (2001) Proc. Natl. Acad. Sci. U.S. A , vol.98 , pp. 15233-15238
    • Kang, M.S.1    Hung, S.C.2    Kieff, E.3
  • 22
    • 10544223747 scopus 로고    scopus 로고
    • Enhanced malignant progression of nasopharyngeal carcinoma cells mediated by the expression of Epstein-Barr nuclear antigen 1 in vivo
    • doi:10.1002/(SICI)1096-9896(199611)180:3<243::AID-PATH655>3.0.CO;2-7
    • Sheu, L.F.; Chen, A.; Meng, C.L.; Ho, K.C.; Lee, W.H.; Leu, F.J.; Chao, C.F. Enhanced malignant progression of nasopharyngeal carcinoma cells mediated by the expression of Epstein-Barr nuclear antigen 1 in vivo. J. Pathol.1996, 180, 243-248. doi:10.1002/(SICI)1096-9896(199611)180:3<243::AID-PATH655>3.0.CO;2-7
    • (1996) J. Pathol , vol.180 , pp. 243-248
    • Sheu, L.F.1    Chen, A.2    Meng, C.L.3    Ho, K.C.4    Lee, W.H.5    Leu, F.J.6    Chao, C.F.7
  • 23
    • 74549158466 scopus 로고    scopus 로고
    • Expression of Epstein-Barr nuclear antigen 1 in gastric carcinoma cells is associated with enhanced tumorigenicity and reduced cisplatin sensitivity
    • Cheng, T.C.; Hsieh, S.S.; Hsu, W.L.; Chen, Y.F.; Ho, H.H.; Sheu, L.F. Expression of Epstein-Barr nuclear antigen 1 in gastric carcinoma cells is associated with enhanced tumorigenicity and reduced cisplatin sensitivity. Int. J. Oncol.2010, 36, 151-160.
    • (2010) Int. J. Oncol , vol.36 , pp. 151-160
    • Cheng, T.C.1    Hsieh, S.S.2    Hsu, W.L.3    Chen, Y.F.4    Ho, H.H.5    Sheu, L.F.6
  • 24
    • 0032926452 scopus 로고    scopus 로고
    • Expression of Epstein-Barr virus nuclear antigen 1 is associated with enhanced expression of cd25 in the hodgkin cell line l428
    • Kube, D.; Vockerodt, M.; Weber, O.; Hell, K.; Wolf, J.; Haier, B.; Grasser, F.A.; Muller-Lantzsch, N.; Kieff, E.; Diehl, V. Expression of Epstein-Barr virus nuclear antigen 1 is associated with enhanced expression of cd25 in the hodgkin cell line l428. J. Virol. 1999, 73, 1630-1636.
    • (1999) J. Virol , vol.73 , pp. 1630-1636
    • Kube, D.1    Vockerodt, M.2    Weber, O.3    Hell, K.4    Wolf, J.5    Haier, B.6    Grasser, F.A.7    Muller-Lantzsch, N.8    Kieff, E.9    Diehl, V.10
  • 25
    • 34648834046 scopus 로고    scopus 로고
    • Epstein-Barr virus latent nuclear antigens can induce metastasis in a nude mouse model
    • doi:10.1128/JVI.00886-07
    • Kaul, R.; Murakami, M.; Choudhuri, T.; Robertson, E.S. Epstein-Barr virus latent nuclear antigens can induce metastasis in a nude mouse model. J. Virol. 2007, 81, 10352-10361. doi:10.1128/JVI.00886-07
    • (2007) J. Virol , vol.81 , pp. 10352-10361
    • Kaul, R.1    Murakami, M.2    Choudhuri, T.3    Robertson, E.S.4
  • 26
    • 0041529593 scopus 로고    scopus 로고
    • Protein profiling with Epstein-Barr nuclear antigen 1 reveals an interaction with the herpesvirus-associated ubiquitin-specific protease HAUSP/USP7
    • Holowaty, M.N.; Zeghouf, M.; Wu, H.; Tellam, J.; Athanasopoulos, V.; Greenblatt, J.; Frappier, L. Protein profiling with Epstein-Barr nuclear antigen 1 reveals an interaction with the herpesvirus-associated ubiquitin-specific protease HAUSP/USP7. J. Biol. Chem. 2003, 278, 29987-29994.
    • (2003) J. Biol. Chem , vol.278 , pp. 29987-29994
    • Holowaty, M.N.1    Zeghouf, M.2    Wu, H.3    Tellam, J.4    Athanasopoulos, V.5    Greenblatt, J.6    Frappier, L.7
  • 27
    • 0037061508 scopus 로고    scopus 로고
    • Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization
    • Li, M.; Chen, D.; Shiloh, A.; Luo, J.; Nikolaev, A.Y.; Qin, J.; Gu, W. Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature 2002, 416, 648-653.
    • (2002) Nature , vol.416 , pp. 648-653
    • Li, M.1    Chen, D.2    Shiloh, A.3    Luo, J.4    Nikolaev, A.Y.5    Qin, J.6    Gu, W.7
  • 28
    • 1842421376 scopus 로고    scopus 로고
    • A dynamic role of HAUSP in the p53-mdm2 pathway
    • Li, M.; Brooks, C.L.; Kon, N.; Gu, W. A dynamic role of HAUSP in the p53-mdm2 pathway. Mol. Cell 2004, 13,879-886.
    • (2004) Mol. Cell , vol.13 , pp. 879-886
    • Li, M.1    Brooks, C.L.2    Kon, N.3    Gu, W.4
  • 30
    • 0348111469 scopus 로고    scopus 로고
    • Protein interaction domains of the ubiqutin specific protease, USP7/HAUSP
    • Holowaty, M.N.; Sheng, Y.; Nguyen, T.; Arrowsmith, C.; Frappier, L. Protein interaction domains of the ubiqutin specific protease, USP7/HAUSP. J. Biol. Chem. 2003, 278, 47753-47761.
    • (2003) J. Biol. Chem , vol.278 , pp. 47753-47761
    • Holowaty, M.N.1    Sheng, Y.2    Nguyen, T.3    Arrowsmith, C.4    Frappier, L.5
  • 31
    • 20144386721 scopus 로고    scopus 로고
    • Structure of the p53 binding domain of HAUSP/USP7 bound to Epstein-Barr nuclear antigen 1 implications for EBV-mediated immortalization
    • Saridakis, V.; Sheng, Y.; Sarkari, F.; Holowaty, M.N.; Shire, K.; Nguyen, T.; Zhang, R.G.; Liao, J.; Lee, W.; Edwards, A.M. Structure of the p53 binding domain of HAUSP/USP7 bound to Epstein-Barr nuclear antigen 1 implications for EBV-mediated immortalization. Mol. Cell 2005, 18, 25-36.
    • (2005) Mol. Cell , vol.18 , pp. 25-36
    • Saridakis, V.1    Sheng, Y.2    Sarkari, F.3    Holowaty, M.N.4    Shire, K.5    Nguyen, T.6    Zhang, R.G.7    Liao, J.8    Lee, W.9    Edwards, A.M.10
  • 33
    • 33244490784 scopus 로고    scopus 로고
    • Structural basis of competitive recognition of p53 and mdm2 by HAUSP/USP7: Implications for the regulation of the p53-mdm2 pathway
    • Hu, M.; Gu, L.; Li, M.; Jeffrey, P.D.; Gu, W.; Shi, Y. Structural basis of competitive recognition of p53 and mdm2 by HAUSP/USP7: Implications for the regulation of the p53-mdm2 pathway. PLoS Biol. 2006, 4, e27.
    • (2006) PLoS Biol , vol.4
    • Hu, M.1    Gu, L.2    Li, M.3    Jeffrey, P.D.4    Gu, W.5    Shi, Y.6
  • 34
    • 55449133376 scopus 로고    scopus 로고
    • Epstein-Barr nuclear antigen 1 contributes to nasopharyngeal carcinoma through disruption of PML nuclear bodies
    • doi:10.1371/journal.ppat.1000170
    • Sivachandran, N.; Sarkari, F.; Frappier, L. Epstein-Barr nuclear antigen 1 contributes to nasopharyngeal carcinoma through disruption of PML nuclear bodies. PLoS Pathog. 2008, 4, e1000170. doi:10.1371/journal.ppat.1000170
    • (2008) PLoS Pathog , vol.4
    • Sivachandran, N.1    Sarkari, F.2    Frappier, L.3
  • 35
    • 84862958150 scopus 로고    scopus 로고
    • Contributions of the Epstein-Barr virus EBNA 1 protein to gastric carcinoma
    • doi:10.1128/JVI.05623-11
    • Sivachandran, N.; Dawson, C.W.; Young, L.S.; Liu, F.F.; Middeldorp, J.; Frappier, L. Contributions of the Epstein-Barr virus EBNA 1 protein to gastric carcinoma. J. Virol. 2012, 86, 60-68. doi:10.1128/JVI.05623-11
    • (2012) J. Virol , vol.86 , pp. 60-68
    • Sivachandran, N.1    Dawson, C.W.2    Young, L.S.3    Liu, F.F.4    Middeldorp, J.5    Frappier, L.6
  • 36
    • 44849143636 scopus 로고    scopus 로고
    • New insights into the role of PML in tumour suppression
    • doi:10.1038/cr.2008.58
    • Salomoni, P.; Ferguson, B.J.; Wyllie, A.H.; Rich, T. New insights into the role of PML in tumour suppression. Cell Res. 2008, 18, 622-640. doi:10.1038/cr.2008.58
    • (2008) Cell Res , vol.18 , pp. 622-640
    • Salomoni, P.1    Ferguson, B.J.2    Wyllie, A.H.3    Rich, T.4
  • 37
    • 36448975490 scopus 로고    scopus 로고
    • Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies
    • doi:10.1038/nrm2277
    • Bernardi, R.; Pandolfi, P.P. Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies. Nat. Rev. Mol. Cell Biol. 2007, 8, 1006-1016. doi:10.1038/nrm2277
    • (2007) Nat. Rev. Mol. Cell Biol , vol.8 , pp. 1006-1016
    • Bernardi, R.1    Pandolfi, P.P.2
  • 38
    • 2442711599 scopus 로고    scopus 로고
    • PML nuclear bodies and apoptosis
    • doi:10.1038/sj.onc.1207533
    • Takahashi, Y.; Lallemand-Breitenbach, V.; Zhu, J.; de The, H. PML nuclear bodies and apoptosis. Oncogene2004, 23, 2819-2824. doi:10.1038/sj.onc.1207533
    • (2004) Oncogene , vol.23 , pp. 2819-2824
    • Takahashi, Y.1    Lallemand-Breitenbach, V.2    Zhu, J.3    de The, H.4
  • 43
    • 78651471295 scopus 로고    scopus 로고
    • Role of promyelocytic leukemia protein in host antiviral defense
    • doi:10.1089/jir.2010.0111
    • Geoffroy, M.C.; Chelbi-Alix, M.K. Role of promyelocytic leukemia protein in host antiviral defense. J. Interf. Cytokine Res. 2011, 31, 145-158. doi:10.1089/jir.2010.0111
    • (2011) J. Interf. Cytokine Res , vol.31 , pp. 145-158
    • Geoffroy, M.C.1    Chelbi-Alix, M.K.2
  • 44
    • 34347348272 scopus 로고    scopus 로고
    • PML and PML nuclear bodies: Implications in antiviral defence
    • doi:10.1016/j.biochi.2007.01.004
    • Everett, R.D.; Chelbi-Alix, M.K. PML and PML nuclear bodies: Implications in antiviral defence. Biochimie 2007,89, 819-830. doi:10.1016/j.biochi.2007.01.004
    • (2007) Biochimie , vol.89 , pp. 819-830
    • Everett, R.D.1    Chelbi-Alix, M.K.2
  • 45
    • 79952219169 scopus 로고    scopus 로고
    • Entrapment of viral capsids in nuclear PML cages is an intrinsic antiviral host defense against varicella-zoster virus
    • Reichelt, M.; Wang, L.; Sommer, M.; Perrino, J.; Nour, A.M.; Sen, N.; Baiker, A.; Zerboni, L.; Arvin, A.M. Entrapment of viral capsids in nuclear PML cages is an intrinsic antiviral host defense against varicella-zoster virus. PLoS Pathog. 2011, 7, e1001266.
    • (2011) PLoS Pathog , vol.7
    • Reichelt, M.1    Wang, L.2    Sommer, M.3    Perrino, J.4    Nour, A.M.5    Sen, N.6    Baiker, A.7    Zerboni, L.8    Arvin, A.M.9
  • 46
    • 0035969103 scopus 로고    scopus 로고
    • DNA viruses and viral proteins that interact with PML nuclear bodies
    • doi:10.1038/sj.onc.1204759
    • Everett, R.D. DNA viruses and viral proteins that interact with PML nuclear bodies. Oncogene 2001, 20, 7266-7273. doi:10.1038/sj.onc.1204759
    • (2001) Oncogene , vol.20 , pp. 7266-7273
    • Everett, R.D.1
  • 47
    • 77957965855 scopus 로고    scopus 로고
    • Epstein-Barr virus nuclear antigen 1 hijacks the host kinase CK2 to disrupt PML nuclear bodies
    • doi:10.1128/JVI.01183-10
    • Sivachandran, N.; Cao, J.Y.; Frappier, L. Epstein-Barr virus nuclear antigen 1 hijacks the host kinase CK2 to disrupt PML nuclear bodies. J. Virol. 2010, 84, 11113-11123. doi:10.1128/JVI.01183-10
    • (2010) J. Virol , vol.84 , pp. 11113-11123
    • Sivachandran, N.1    Cao, J.Y.2    Frappier, L.3
  • 48
    • 84863599916 scopus 로고    scopus 로고
    • Functions of the Epstein-Barr virus EBNA1 protein in viral reactivation and lytic infection
    • doi:10.1128/JVI.00013-12
    • Sivachandran, N.; Wang, X.; Frappier, L. Functions of the Epstein-Barr virus EBNA1 protein in viral reactivation and lytic infection. J. Virol. 2012, 86, 6146-6158. doi:10.1128/JVI.00013-12
    • (2012) J. Virol , vol.86 , pp. 6146-6158
    • Sivachandran, N.1    Wang, X.2    Frappier, L.3
  • 50
    • 50649105487 scopus 로고    scopus 로고
    • CK2 mediates phosphorylation and ubiquitin-mediated degradation of the PML tumor suppressor
    • doi:10.1007/s11010-008-9812-7
    • Scaglioni, P.P.; Yung, T.M.; Choi, S.C.; Baldini, C.; Konstantinidou, G.; Pandolfi, P.P. CK2 mediates phosphorylation and ubiquitin-mediated degradation of the PML tumor suppressor. Mol. Cell Biochem. 2008, 316,149-154. doi:10.1007/s11010-008-9812-7
    • (2008) Mol. Cell Biochem , vol.316 , pp. 149-154
    • Scaglioni, P.P.1    Yung, T.M.2    Choi, S.C.3    Baldini, C.4    Konstantinidou, G.5    Pandolfi, P.P.6
  • 51
    • 79551649719 scopus 로고    scopus 로고
    • The herpesvirus associated ubiquitin specific protease, USP7, is a negative regulator of PML proteins and PML nuclear bodies
    • Sarkari, F.; Wang, X.; Nguyen, T.; Frappier, L. The herpesvirus associated ubiquitin specific protease, USP7, is a negative regulator of PML proteins and PML nuclear bodies. PLoS One 2011, 6, e16598.
    • (2011) PLoS One , vol.6
    • Sarkari, F.1    Wang, X.2    Nguyen, T.3    Frappier, L.4
  • 52
    • 79958067517 scopus 로고    scopus 로고
    • Arsenic mediated disruption of promyelocytic leukemia protein nuclear bodies induces ganciclovir susceptibility in Epstein-Barr positive epithelial cells
    • doi:10.1016/j.virol.2011.04.005
    • Sides, M.D.; Block, G.J.; Shan, B.; Esteves, K.C.; Lin, Z.; Flemington, E.K.; Lasky, J.A. Arsenic mediated disruption of promyelocytic leukemia protein nuclear bodies induces ganciclovir susceptibility in Epstein-Barr positive epithelial cells. Virology 2011, 416, 86-97. doi:10.1016/j.virol.2011.04.005
    • (2011) Virology , vol.416 , pp. 86-97
    • Sides, M.D.1    Block, G.J.2    Shan, B.3    Esteves, K.C.4    Lin, Z.5    Flemington, E.K.6    Lasky, J.A.7
  • 53
    • 34250331222 scopus 로고    scopus 로고
    • Epstein-Barr virus-encoded EBNA1 regulates cellular gene transcription and modulates the STAT1 and TGFβ signaling pathways
    • Wood, V.H.; O'Neil, J.D.; Wei, W.; Stewart, S.E.; Dawson, C.W.; Young, L.S. Epstein-Barr virus-encoded EBNA1 regulates cellular gene transcription and modulates the STAT1 and TGFβ signaling pathways. Oncogene2007, 26, 4135-4147.
    • (2007) Oncogene , vol.26 , pp. 4135-4147
    • Wood, V.H.1    O'Neil, J.D.2    Wei, W.3    Stewart, S.E.4    Dawson, C.W.5    Young, L.S.6
  • 54
    • 33846202008 scopus 로고    scopus 로고
    • STAT1 as a key modulator of cell death
    • doi:10.1016/j.cellsig.2006.09.003
    • Kim, H.S.; Lee, M.S. STAT1 as a key modulator of cell death. Cell. Signal. 2007, 19, 454-465. doi:10.1016/j.cellsig.2006.09.003
    • (2007) Cell. Signal , vol.19 , pp. 454-465
    • Kim, H.S.1    Lee, M.S.2
  • 55
    • 38049105629 scopus 로고    scopus 로고
    • Down-regulation of the TGF-beta target gene, PTPRK, by the Epstein-Barr virus encoded EBNA 1 contributes to the growth and survival of hodgkin lymphoma cells
    • doi:10.1182/blood-2006-11-059881
    • Flavell, J.R.; Baumforth, K.R.; Wood, V.H.; Davies, G.L.; Wei, W.; Reynolds, G.M.; Morgan, S.; Boyce, A.; Kelly, G.L.; Young, L.S. Down-regulation of the TGF-beta target gene, PTPRK, by the Epstein-Barr virus encoded EBNA 1 contributes to the growth and survival of hodgkin lymphoma cells. Blood 2008, 111, 292-301. doi:10.1182/blood-2006-11-059881
    • (2008) Blood , vol.111 , pp. 292-301
    • Flavell, J.R.1    Baumforth, K.R.2    Wood, V.H.3    Davies, G.L.4    Wei, W.5    Reynolds, G.M.6    Morgan, S.7    Boyce, A.8    Kelly, G.L.9    Young, L.S.10
  • 56
    • 76749150968 scopus 로고    scopus 로고
    • Epstein-Barr virus-encoded EBNA 1 inhibits the canonical NF-κB pathway in carcinoma cells by inhibiting IKK phosphorylation
    • doi:10.1186/1476-4598-9-1
    • Valentine, R.; Dawson, C.W.; Hu, C.; Shah, K.M.; Owen, T.J.; Date, K.L.; Maia, S.P.; Shao, J.; Arrand, J.R.; Young, L.S. Epstein-Barr virus-encoded EBNA 1 inhibits the canonical NF-κB pathway in carcinoma cells by inhibiting IKK phosphorylation. Mol. Cancer 2010, 9, doi:10.1186/1476-4598-9-1
    • (2010) Mol. Cancer , vol.9
    • Valentine, R.1    Dawson, C.W.2    Hu, C.3    Shah, K.M.4    Owen, T.J.5    Date, K.L.6    Maia, S.P.7    Shao, J.8    Arrand, J.R.9    Young, L.S.10
  • 57
    • 79951518607 scopus 로고    scopus 로고
    • Molecular targets of oxidative stress
    • doi:10.1042/BJ20101695
    • Avery, S.V. Molecular targets of oxidative stress. Biochem. J. 2011, 434, 201-210. doi:10.1042/BJ20101695
    • (2011) Biochem. J , vol.434 , pp. 201-210
    • Avery, S.V.1
  • 58
    • 44449120173 scopus 로고    scopus 로고
    • Epstein-Barr virus induces an oxidative stress during the early stages of infection in B lymphocytes, epithelial, and lymphoblastoid cell lines
    • doi:10.1007/s11010-008-9755-z
    • Lassoued, S.; Ben Ameur, R.; Ayadi, W.; Gargouri, B.; Ben Mansour, R.; Attia, H. Epstein-Barr virus induces an oxidative stress during the early stages of infection in B lymphocytes, epithelial, and lymphoblastoid cell lines. Mol. Cell Biochem. 2008, 313, 179-186. doi:10.1007/s11010-008-9755-z
    • (2008) Mol. Cell Biochem , vol.313 , pp. 179-186
    • Lassoued, S.1    Ben Ameur, R.2    Ayadi, W.3    Gargouri, B.4    Ben Mansour, R.5    Attia, H.6
  • 61
    • 79958170345 scopus 로고    scopus 로고
    • The Epstein-Barr virus nuclear antigen-1 promotes telomere dysfunction via induction of oxidative stress
    • doi:10.1038/leu.2011.35
    • Kamranvar, S.A.; Masucci, M.G. The Epstein-Barr virus nuclear antigen-1 promotes telomere dysfunction via induction of oxidative stress. Leukemia 2011, 25, 1017-1025. doi:10.1038/leu.2011.35
    • (2011) Leukemia , vol.25 , pp. 1017-1025
    • Kamranvar, S.A.1    Masucci, M.G.2
  • 62
    • 84855935664 scopus 로고    scopus 로고
    • Changes in the nasopharyngeal carcinoma nuclear proteome induced by the EBNA 1 protein of Epstein-Barr virus reveal potential roles for EBNA1 in metastasis and oxidative stress responses
    • doi:10.1128/JVI.05648-11
    • Cao, J.Y.; Mansouri, S.; Frappier, L. Changes in the nasopharyngeal carcinoma nuclear proteome induced by the EBNA 1 protein of Epstein-Barr virus reveal potential roles for EBNA1 in metastasis and oxidative stress responses.J. Virol. 2012, 86, 382-394. doi:10.1128/JVI.05648-11
    • (2012) J Virol , vol.86 , pp. 382-394
    • Cao, J.Y.1    Mansouri, S.2    Frappier, L.3
  • 63
    • 13744251264 scopus 로고    scopus 로고
    • Epstein-Barr virus nuclear antigen 1 interacts with Nm23-H1 in lymphoblastoid cell lines and inhibits its ability to suppress cell migration
    • doi:10.1128/JVI.79.3.1559-1568.2005
    • Murakami, M.; Lan, K.; Subramanian, C.; Robertson, E.S. Epstein-Barr virus nuclear antigen 1 interacts with Nm23-H1 in lymphoblastoid cell lines and inhibits its ability to suppress cell migration. J. Virol. 2005, 79, 1559-1568. doi:10.1128/JVI.79.3.1559-1568.2005
    • (2005) J. Virol , vol.79 , pp. 1559-1568
    • Murakami, M.1    Lan, K.2    Subramanian, C.3    Robertson, E.S.4
  • 65
    • 78650746034 scopus 로고    scopus 로고
    • Epstein-Barr virus nuclear antigen 1 (EBNA 1) confers resistance to apoptosis in EBV-positive B-lymphoma cells through up-regulation of survivin
    • doi:10.1016/j.virol.2010.10.029
    • Lu, J.; Murakami, M.; Verma, S.C.; Cai, Q.; Haldar, S.; Kaul, R.; Wasik, M.A.; Middeldorp, J.; Robertson, E.S. Epstein-Barr virus nuclear antigen 1 (EBNA 1) confers resistance to apoptosis in EBV-positive B-lymphoma cells through up-regulation of survivin. Virology 2011, 410, 64-75. doi:10.1016/j.virol.2010.10.029
    • (2011) Virology , vol.410 , pp. 64-75
    • Lu, J.1    Murakami, M.2    Verma, S.C.3    Cai, Q.4    Haldar, S.5    Kaul, R.6    Wasik, M.A.7    Middeldorp, J.8    Robertson, E.S.9
  • 66
    • 0036170706 scopus 로고    scopus 로고
    • Separation of the DNA replication, segregation, and transcriptional activation functions of Epstein-Barr nuclear antigen 1
    • doi:10.1128/jvi.76.5.2480-2490.2002
    • Wu, H.; Kapoor, P.; Frappier, L. Separation of the DNA replication, segregation, and transcriptional activation functions of Epstein-Barr nuclear antigen 1. J. Virol. 2002, 76, 2480-2490. doi:10.1128/jvi.76.5.2480-2490.2002
    • (2002) J. Virol , vol.76 , pp. 2480-2490
    • Wu, H.1    Kapoor, P.2    Frappier, L.3
  • 67
    • 0141669153 scopus 로고    scopus 로고
    • EBNA 1, a bifunctional transcriptional activator
    • doi:10.1128/MCB.23.19.6901-6908.2003
    • Kennedy, G.; Sugden, B. EBNA 1, a bifunctional transcriptional activator. Mol. Cell Biol. 2003, 23, 6901-6908. doi:10.1128/MCB.23.19.6901-6908.2003
    • (2003) Mol. Cell Biol , vol.23 , pp. 6901-6908
    • Kennedy, G.1    Sugden, B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.