Regulation of VEGF expression by HIF-1α in the femoral head cartilage following ischemia osteonecrosis

Scientific Reports

Volumn 2, Issue , 2012, Pages

  Zhang, Chi ^a,b,c   Li, Yang ^a   Cornelia, Reuel ^a   Swisher, Susanne ^a   Kim, Harry ^a,b  

^a TEXAS SCOTTISH RITE HOSPITAL FOR CHILDREN   (United States)

^b Department of Orthopedic Surgery ^*  (United States)

^c UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; VASCULOTROPIN A;

ANGIOGENESIS; ANIMAL; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CELL CULTURE; CELL HYPOXIA; FEMUR HEAD; FEMUR HEAD NECROSIS; GENE EXPRESSION REGULATION; GENETICS; ISCHEMIA; METABOLISM; MORTALITY; PATHOLOGY; PHYSIOLOGY; SWINE; UPREGULATION; VASCULARIZATION;

ANIMALS; CARTILAGE, ARTICULAR; CELL HYPOXIA; CELLS, CULTURED; CHONDROCYTES; FEMUR HEAD; FEMUR HEAD NECROSIS; GENE EXPRESSION REGULATION; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; ISCHEMIA; NEOVASCULARIZATION, PHYSIOLOGIC; SUS SCROFA; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84867024998     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep00650     Document Type: Article

References (25)

1. Molloy, M. K. & MacMahon, B. Incidence of Legg-Perthes disease (osteochondritis deformans). N Engl J Med 275, 988-90 (1966).
2. Glimcher, M. J. & Kenzora, J. E. The biology of osteonecrosis of the human femoral head and its clinical implications. III. Discussion of the etiology and genesis of the pathological sequelae; commments on treatment. Clin Orthop Relat Res 273-312 (1979). (Pubitemid 9254515)
3. Kim, H. K. & Su, P. H. Development of flattening and apparent fragmentation following ischemic necrosis of the capital femoral epiphysis in a piglet model. J Bone Joint Surg Am 84-A, 1329-34 (2002). (Pubitemid 35407576)
4. Kim, H. K., Su, P. H. & Qiu, Y. S. Histopathologic changes in growth-plate cartilage following ischemic necrosis of the capital femoral epiphysis. An experimental investigation in immature pigs. J Bone Joint Surg Am 83-A, 688-97 (2001).
5. Kim, H. K. et al. Increased VEGF expression in the epiphyseal cartilage after ischemic necrosis of the capital femoral epiphysis. J Bone Miner Res 19, 2041-8 (2004). (Pubitemid 41103419)
6. Provot, S. & Schipani, E. Fetal growth plate: a developmental model of cellular adaptation to hypoxia. Ann N Y Acad Sci 1117, 26-39 (2007). (Pubitemid 350191292)
7. Giaccia, A. J., Simon, M. C. & Johnson, R. The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease. Genes Dev 18, 2183-94 (2004). (Pubitemid 39209567)
8. Rajpurohit, R., Koch, C. J., Tao, Z., Teixeira, C. M. & Shapiro, I. M. Adaptation of chondrocytes to low oxygen tension: relationship between hypoxia and cellular metabolism. J Cell Physiol 168, 424-32 (1996). (Pubitemid 26308754)
9. Schipani, E. et al. Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival. Genes Dev 15, 2865-76 (2001). (Pubitemid 33042056)
10. Pfander, D., Cramer, T., Schipani, E. & Johnson, R. S. HIF-1alpha controls extracellular matrix synthesis by epiphyseal chondrocytes. J Cell Sci 116, 1819-26 (2003). (Pubitemid 36582168)
11. Gerber, H. P. et al. VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. NatMed 5, 623-8 (1999).
12. Semenza, G. L. Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. Annu Rev Cell Dev Biol 15, 551-78 (1999). (Pubitemid 32250386)
13. Kung, A. L., Wang, S., Klco, J. M., Kaelin,W. G. & Livingston, D. M. Suppression of tumor growth through disruption of hypoxia-inducible transcription. NatMed 6, 1335-40 (2000). (Pubitemid 32001016)
14. Ryan, H. E. et al. Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth. Cancer Res 60, 4010-5 (2000). (Pubitemid 30636574)
15. Zelzer, E. et al. VEGFA is necessary for chondrocyte survival during bone development. Development 131, 2161-71 (2004). (Pubitemid 38702047)
16. Kotch, L. E., Iyer, N.V., Laughner, E.&Semenza, G. L. Defective vascularization of HIF-1alpha-null embryos is not associated with VEGF deficiency but with mesenchymal cell death. Dev Biol 209, 254-67 (1999). (Pubitemid 29230878)
17. Komori, T. et al. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89, 755-64 (1997). (Pubitemid 27516178)
18. Zelzer, E. et al. Tissue specific regulation of VEGF expression during bone development requires Cbfa1/Runx2. Mech Dev 106, 97-106 (2001). (Pubitemid 32701077)
19. Nakashima, K. et al. The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 108, 17-29 (2002). (Pubitemid 34137009)
20. Zhang, C. et al. Inhibition of Wnt signaling by the osteoblast-specific transcription factor Osterix. Proc Natl Acad Sci USA 105, 6936-41 (2008). (Pubitemid 351754508)
21. Tang, W. et al. Transcriptional regulation of Vascular Endothelial Growth Factor (VEGF) by osteoblast-specific transcription factor Osterix (Osx) in osteoblasts. J Biol Chem 287, 1671-8 (2012).
22. Chen, D., Tian, W., Li, Y., Tang, W. & Zhang, C. Osteoblast-specific transcription factor Osterix (Osx) and HIF-1alpha cooperatively regulate gene expression of vascular endothelial growth factor (VEGF). Biochem Biophys Res Commun 424, 176-81 (2012).
23. McAndrew,M. P.&Weinstein, S. L.Along-term follow-up of Legg-Calve-Perthes disease. J Bone Joint Surg Am 66, 860-9 (1984).
24. Zhang, C. et al. Hypoxia-inducible factor-1 is a positive regulator of Sox9 activity in femoral head osteonecrosis. Bone 48, 507-13 (2011).
25. Tang, W., Li, Y., Osimiri, L. & Zhang, C. Osteoblast-specific transcription factor Osterix (Osx) is an upstream regulator of Satb2 during bone formation. J Biol Chem 286, 32995-3002 (2011).