SCOPUS 정보 검색 플랫폼

Volumn 57, Issue , 2012, Pages 74-84

Synthesis and biological evaluation of 2-benzylamino-4(5)-(6-methylpyridin- 2-yl)-5(4)-([1,2,4]triazolo[1,5-a]-pyridin-6-yl)thiazoles as transforming growth factor-β type 1 receptor kinase inhibitors

(10) Krishnaiah, Maddeboina a Jin, Cheng Hua a Sreenu, Domalapally a Subrahmanyam, Vura Bala a Rao, Kota Sudhakar a Son, Do Hyun b Park, Hyun Ju b Kim, Seung Won a Sheen, Yhun Yhong a Kim, Dae Kee a

a Ewha Womans University (South Korea)

b Sungkyunkwan University (South Korea)

Author keywords

ALK5 inhibitor; Cancer; Cell based luciferase reporter assay; Docking; Fibrosis; Kinase assay; TGF

Indexed keywords

2 BENZYLAMINO 4(5) (6 METHYLPYRIDIN 2 YL) 5(4) (1,2,4 TRIAZOLO[1,5 A]PYRIDIN 6 YL)THIAZOLE DERIVATIVE; BROMINE; DRUG METABOLITE; IN 1130; LUCIFERASE; MITOGEN ACTIVATED PROTEIN KINASE 14; N (3 FLUOROBENZYL) 4 (6 METHYLPYRIDIN 2 YL) 5 (1,2,4 TRIAZOLO[1,5 A]PYRIDIN 6 YL)THIAZOL 2 AMINE; NITROGEN; PROTEIN SERINE THREONINE KINASE INHIBITOR; SB 505124; SB 505154; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1 KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BINDING SITE; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME INHIBITOR INTERACTION; ENZYME PHOSPHORYLATION; HUMAN; HYDROGEN BOND; IC 50; IMMUNOBLOTTING; MOUSE; NONHUMAN; OXIDATION; PROTEIN PHOSPHORYLATION; STRUCTURE ACTIVITY RELATION;

CELL LINE, TRANSFORMED; ENZYME ASSAYS; GENES, REPORTER; HUMANS; KERATINOCYTES; LUCIFERASES; MOLECULAR DOCKING SIMULATION; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; TRANSFECTION;

EID: 84867021810 PISSN: 02235234 EISSN: 17683254 Source Type: Journal
DOI: 10.1016/j.ejmech.2012.09.011 Document Type: Article

Times cited : (20)

References (26)

1
- 0031438047
- C.H. Heldin, K. Miyazono, and P. ten Dijke Nature 390 1997 465 471
- (1997) Nature , vol.390 , pp. 465-471
- Heldin, C.H.¹ Miyazono, K.² Ten Dijke, P.³

2
- 0142104985
- R. Derynck, and Y.E. Zhang Nature 425 2003 577 584
- (2003) Nature , vol.425 , pp. 577-584
- Derynck, R.¹ Zhang, Y.E.²

3
- 14844337071
- W. Wang, V. Koka, and H.Y. Lan Nephrology 10 2005 48 56
- (2005) Nephrology , vol.10 , pp. 48-56
- Wang, W.¹ Koka, V.² Lan, H.Y.³

4
- 33751302009
- H. Lim, and Y.Z. Zhu Cell. Mol. Life Sci. 63 2006 2584 2596
- (2006) Cell. Mol. Life Sci. , vol.63 , pp. 2584-2596
- Lim, H.¹ Zhu, Y.Z.²

5
- 33847210725
- L. Gu, Y.-J. Zhu, X. Yang, Z.-J. Guo, W.-B. Xu, and X.-L. Tian Acta Pharmacol. Sin. 28 2007 382 391
- (2007) Acta Pharmacol. Sin. , vol.28 , pp. 382-391
- Gu, L.¹ Zhu, Y.-J.² Yang, X.³ Guo, Z.-J.⁴ Xu, W.-B.⁵ Tian, X.-L.⁶

6
- 2642585736
- F.W. Shek, and R.C. Benyon Eur. J. Gastroenterol. Hepatol. 16 2004 123 126
- (2004) Eur. J. Gastroenterol. Hepatol. , vol.16 , pp. 123-126
- Shek, F.W.¹ Benyon, R.C.²

7
- 33745515023
- B. Bierie, and H.L. Moses Nat. Rev. Cancer 6 2006 506 520
- (2006) Nat. Rev. Cancer , vol.6 , pp. 506-520
- Bierie, B.¹ Moses, H.L.²

8
- 30944441065
- S.G. Rane, J.-H. Lee, and H.-M. Lin Cytokine Growth Factor Rev. 17 2006 107 119
- (2006) Cytokine Growth Factor Rev. , vol.17 , pp. 107-119
- Rane, S.G.¹ Lee, J.-H.² Lin, H.-M.³

9
- 33745082823
- M. Dong, and G.C. Blobe Blood 107 2006 4589 4596
- (2006) Blood , vol.107 , pp. 4589-4596
- Dong, M.¹ Blobe, G.C.²

10
- 1342265719
- S.D. Byfield, C. Major, N.J. Laping, and A.B. Roberts Mol. Pharmacol. 65 2004 744 752
- (2004) Mol. Pharmacol. , vol.65 , pp. 744-752
- Byfield, S.D.¹ Major, C.² Laping, N.J.³ Roberts, A.B.⁴

11
- 19944421105
- A.-C. de Gouville, V. Boullay, G. Krysa, J. Pilot, J.-M. Brusq, F. Loriolle, J.-M. Gauthier, S.A. Papworth, A. Laroze, F. Gellibert, and S. Huet Br. J. Pharmacol. 145 2005 166 177
- (2005) Br. J. Pharmacol. , vol.145 , pp. 166-177
- De Gouville, A.-C.¹ Boullay, V.² Krysa, G.³ Pilot, J.⁴ Brusq, J.-M.⁵ Loriolle, F.⁶ Gauthier, J.-M.⁷ Papworth, S.A.⁸ Laroze, A.⁹ Gellibert, F.¹⁰ Huet, S.¹¹

12
- 7444226411
- M. Uhl, S. Aulwurm, J. Wischhusen, M. Weiler, J.Y. Ma, R. Almirez, R. Mangadu, Y.-W. Liu, M. Platten, U. Herrlinger, A. Murphy, D.A. Wong, W. Wick, L.S. Higgins, and M. Weller Cancer Res. 64 2004 7954 7961
- (2004) Cancer Res. , vol.64 , pp. 7954-7961
- Uhl, M.¹ Aulwurm, S.² Wischhusen, J.³ Weiler, M.⁴ Ma, J.Y.⁵ Almirez, R.⁶ Mangadu, R.⁷ Liu, Y.-W.⁸ Platten, M.⁹ Herrlinger, U.¹⁰ Murphy, A.¹¹ Wong, D.A.¹² Wick, W.¹³ Higgins, L.S.¹⁴ Weller, M.¹⁵

13
- 37149042061
- L. Bueno, D.P. de Alwis, C. Pitou, J. Yingling, M. Lahn, S. Glatt, and I. Troconiz Eur. J. Cancer 44 2008 142 150
- (2008) Eur. J. Cancer , vol.44 , pp. 142-150
- Bueno, L.¹ De Alwis, D.P.² Pitou, C.³ Yingling, J.⁴ Lahn, M.⁵ Glatt, S.⁶ Troconiz, I.⁷

14
- 84870055174
- World Patent WO 2005/103028 A1
- D.-K. Kim, Y.-J. Bang, H.-T. Kim, I.-S. Cho, M.-S. Park, Y.J. An, J.H. Choi, World Patent WO 2005/103028 A1 (2005).
- (2005)
- Kim, D.-K.¹ Bang, Y.-J.² Kim, H.-T.³ Cho, I.-S.⁴ Park, M.-S.⁵ An, Y.J.⁶ Choi, J.H.⁷

15
- 80052951712
- C.H. Jin, D. Sreenu, M. Krishnaiah, V.B. Subrahmanyam, K.S. Rao, A.V.N. Mohan, C.-Y. Park, J.-Y. Son, D.-H. Son, H.-J. Park, Y.Y. Sheen, and D.-K. Kim Eur. J. Med. Chem. 46 2011 3917 3925
- (2011) Eur. J. Med. Chem. , vol.46 , pp. 3917-3925
- Jin, C.H.¹ Sreenu, D.² Krishnaiah, M.³ Subrahmanyam, V.B.⁴ Rao, K.S.⁵ Mohan, A.V.N.⁶ Park, C.-Y.⁷ Son, J.-Y.⁸ Son, D.-H.⁹ Park, H.-J.¹⁰ Sheen, Y.Y.¹¹ Kim, D.-K.¹²

16
- 33748939751
- J.-A. Moon, H.-T. Kim, I.-S. Cho, Y.Y. Sheen, and D.-K. Kim Kidney Int. 70 2006 1234 1243
- (2006) Kidney Int. , vol.70 , pp. 1234-1243
- Moon, J.-A.¹ Kim, H.-T.² Cho, I.-S.³ Sheen, Y.Y.⁴ Kim, D.-K.⁵

17
- 61349100681
- L. Long, A. Crosby, X. Yang, M. Southwood, P.D. Upton, D.-K. Kim, and N.W. Morrell Circulation 119 2009 566 576
- (2009) Circulation , vol.119 , pp. 566-576
- Long, L.¹ Crosby, A.² Yang, X.³ Southwood, M.⁴ Upton, P.D.⁵ Kim, D.-K.⁶ Morrell, N.W.⁷

18
- 39349112853
- Y.W. Kim, Y.K. Kim, J.Y. Lee, K.T. Chang, H.J. Lee, D.-K. Kim, and Y.Y. Sheen Xenobiotica 38 2008 325 339
- (2008) Xenobiotica , vol.38 , pp. 325-339
- Kim, Y.W.¹ Kim, Y.K.² Lee, J.Y.³ Chang, K.T.⁴ Lee, H.J.⁵ Kim, D.-K.⁶ Sheen, Y.Y.⁷

19
- 84870059508
- World Patent WO 2006026305 A1
- W.-C. Lee, L. Sun, C. Chuaqui, M. Cornebise, J. Singh, F. Shan, World Patent WO 2006026305 A1 (2006).
- (2006)
- Lee, W.-C.¹ Sun, L.² Chuaqui, C.³ Cornebise, M.⁴ Singh, J.⁵ Shan, F.⁶

20
- 84870056465
- World Patent WO 2004111046 A2
- N. Dodic, F. Donche, F.J. Gellibert, World Patent WO 2004111046 A2 (2004).
- (2004)
- Dodic, N.¹ Donche, F.² Gellibert, F.J.³

21
- 84870055173
- World Patent WO 2003087304 A2
- W.-C. Lee, L. Sun, F. Shan, C. Chuaqui, Z. Zheng, R.C. Petter, World Patent WO 2003087304 A2 (2003).
- (2003)
- Lee, W.-C.¹ Sun, L.² Shan, F.³ Chuaqui, C.⁴ Zheng, Z.⁵ Petter, R.C.⁶

22
- 0026496172
- J.L. Wrana, L. Attisano, J. Carcamo, A. Zentella, J. Doody, M. Laiho, X.-F. Wang, and J. Massague Cell 71 1992 1003 1014
- (1992) Cell , vol.71 , pp. 1003-1014
- Wrana, J.L.¹ Attisano, L.² Carcamo, J.³ Zentella, A.⁴ Doody, J.⁵ Laiho, M.⁶ Wang, X.-F.⁷ Massague, J.⁸

23
- 63149132683
- F. Gellibert, M.-H. Fouchet, V.-L. Nguyen, R. Wang, G. Krysa, A.-C. de Gouville, S. Huet, and N. Dodic Bioorg. Med. Chem. Lett. 19 2009 2277 2281
- (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 2277-2281
- Gellibert, F.¹ Fouchet, M.-H.² Nguyen, V.-L.³ Wang, R.⁴ Krysa, G.⁵ De Gouville, A.-C.⁶ Huet, S.⁷ Dodic, N.⁸

24
- 0036714017
- I. Yakymovych, U. Engström, S. Grimsby, C.-H. Heldin, and S. Souchelnytskyi Biochemistry 41 2002 11000 11007
- (2002) Biochemistry , vol.41 , pp. 11000-11007
- Yakymovych, I.¹ Engström, U.² Grimsby, S.³ Heldin, C.-H.⁴ Souchelnytskyi, S.⁵

25
- 0032102902
- P.A. Eyers, M. Craxton, N. Morrice, P. Cohen, and M. Goedert Chem. Biol. 5 1998 321 328
- (1998) Chem. Biol. , vol.5 , pp. 321-328
- Eyers, P.A.¹ Craxton, M.² Morrice, N.³ Cohen, P.⁴ Goedert, M.⁵

26
- 84863011208
- C.-Y. Park, D.-K. Kim, and Y.Y. Sheen Cancer Sci. 102 2011 1889 1896
- (2011) Cancer Sci. , vol.102 , pp. 1889-1896
- Park, C.-Y.¹ Kim, D.-K.² Sheen, Y.Y.³

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.