Tolerogenic versus inflammatory activity of peripheral blood monocytes and dendritic cells subpopulations in systemic lupus erythematosus

Clinical and Developmental Immunology

Volumn 2012, Issue , 2012, Pages

  Carvalheiro, Tiago ^a   Rodrigues, Ana ^b   Lopes, Ana ^b   Inês, Luís ^c,d,e   Velada, Isabel ^a   Ribeiro, Andreia ^a   Martinho, António ^a   Silva, José A P ^c   Pais, Maria L ^a   Paiva, Artur ^a  

^a Centro de Histocompatibilidade do Centro Coimbra   (Portugal)

^b College of Health Technology of Coimbra ^*  (Portugal)

^c CENTRO HOSPITALAR E UNIVERSITÁRIO DE COIMBRA   (Portugal)

^d UNIVERSITY OF BEIRA INTERIOR   (Portugal)

^e UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; CARBON TETRACHLORIDE; CXCL9 CHEMOKINE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; CCL2 PROTEIN, HUMAN; CXCL10 PROTEIN, HUMAN; CXCL9 PROTEIN, HUMAN; ICOSLG PROTEIN, HUMAN; INDUCIBLE T CELL COSTIMULATOR LIGAND;

ADULT; ARTICLE; BONE MARROW CELL; CELL FUNCTION; CELL POPULATION; CELL SELECTION; CLINICAL ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; MALE; MONOCYTE; PRIORITY JOURNAL; PURIFICATION; SYSTEMIC LUPUS ERYTHEMATOSUS; BIOSYNTHESIS; BLOOD; GENETICS; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; INFLAMMATION; METABOLISM; MONONUCLEAR CELL;

ADULT; CHEMOKINE CCL2; CHEMOKINE CXCL10; CHEMOKINE CXCL9; DENDRITIC CELLS; FEMALE; HUMANS; INDUCIBLE T-CELL CO-STIMULATOR LIGAND; INFLAMMATION; INTERFERON-ALPHA; LEUKOCYTES, MONONUCLEAR; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; RNA, MESSENGER; SELF TOLERANCE;

EID: 84866981904     PISSN: 17402522     EISSN: 17402530     Source Type: Journal    
DOI: 10.1155/2012/934161     Document Type: Article

References (62)

1. Doria A., Zen M., Canova M., Bettio S., Bassi N., Nalotto L., Rampudda M., Ghirardello A., Iaccarino L., SLE diagnosis and treatment: when early is early. Autoimmunity Reviews 2010 10 1 55 60 2-s2.0-78149359043 10.1016/j.autrev.2010.08.014
2. Mok C. C., Lau C. S., Pathogenesis of systemic lupus erythematosus. Journal of Clinical Pathology 2003 56 7 481 490 2-s2.0-0037668545 10.1136/jcp.56.7.481 (Pubitemid 36819418)
3. Smith P. P., Gordon C., Systemic lupus erythematosus: clinical presentations. Autoimmunity Reviews 2010 10 1 43 45 2-s2.0-78149361405 10.1016/j.autrev.2010.08.016
4. Fransen J. H., Vlag J. V. D., Ruben J., Adema G. J., Berden J. H., Hilbrands L. B., The role of dendritic cells in the pathogenesis of systemic lupus erythematosus. Arthritis Research and Therapy 2010 12 2, article 207 2-s2.0-77957012651 10.1186/ar2966
5. Gaipl U. S., Munoz L. E., Grossmayer G., Lauber K., Franz S., Sarter K., Voll R. E., Winkler T., Kuhn A., Kalden J., Kern P., Herrmann M., Clearance deficiency and systemic lupus erythematosus (SLE). Journal of Autoimmunity 2007 28 2-3 114 121 2-s2.0-34247590859 10.1016/j.jaut.2007.02.005 (Pubitemid 46680499)
6. Herrmann M., Voll R. E., Zoller O. M., Hagenhofer M., Ponner B. B., Kalden J. R., Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosus. Arthritis and Rheumatism 1998 41 7 1241 1250 (Pubitemid 28313427)
7. Katsiari C. G., Liossis S. N. C., Sfikakis P. P., The pathophysiologic role of monocytes and macrophages in systemic lupus erythematosus: a reappraisal. Seminars in Arthritis and Rheumatism 2010 39 6 491 503 2-s2.0-77953123031 10.1016/j.semarthrit.2008.11.002
8. Li Y., Lee P. Y., Reeves W. H., Monocyte and macrophage abnormalities in systemic lupus erythematosus. Archivum Immunologiae et Therapiae Experimentalis 2010 58 5 355 364 2-s2.0-77956135982 10.1007/s00005-010-0093-y
9. Seitz H. M., Matsushima G. K., Dendritic cells in systemic lupus erythematosus. International Reviews of Immunology 2010 29 2 184 210 2-s2.0-77952510795 10.3109/08830181003602507
10. Henriques A., Inês L., Carvalheiro T., Couto M., Andrade Â., Pedreiro S., Laranjeira P., Morgado J. M., Pais M. L., da Silva J. A. P., Paiva A., Functional characterization of peripheral blood dendritic cells and monocytes in systemic lupus erythematosus. Rheumatology International 2012 32 4 863 869 2-s2.0-78650951039 10.1007/s00296-010-1709-6
11. Gerl V., Lischka A., Panne D., Gromann P., Berthold R., Hoyer B. F., Biesen R., Bruns A., Alexander T., Jacobi A., Dörner T., Burmester G. R., Radbruch A., Hiepe F., Blood dendritic cells in systemic lupus erythematosus exhibit altered activation state and chemokine receptor function. Annals of the Rheumatic Diseases 2010 69 7 1370 1377 2-s2.0-77955004621 10.1136/ard.2009. 111021
12. Okamoto A., Fujio K., Okamura T., Yamamoto K., Regulatory T-cell-associated cytokines in systemic lupus erythematosus. Journal of Biomedicine and Biotechnology 2011 2011 463412
13. Thompson A. G., Thomas R., Induction of immune tolerance by dendritic cells: implications for preventative and therapeutic immunotherapy of autoimmune disease. Immunology and Cell Biology 2002 80 6 509 519 2-s2.0-0036431735 10.1046/j.1440-1711.2002.01114.x (Pubitemid 35335013)
14. Rutella S., Danese S., Leone G., Tolerogenic dendritic cells: cytokine modulation comes of age. Blood 2006 108 5 1435 1440 2-s2.0-33748162638 10.1182/blood-2006-03-006403 (Pubitemid 44316106)
15. Tuettenberg A., Huter E., Hubo M., Horn J., Knop J., Grimbacher B., Kroczek R. A., Stoll S., Jonuleit H., The role of ICOS in directing T cell responses: ICOS-dependent induction of T cell anergy by tolerogenic dendritic cells. Journal of Immunology 2009 182 6 3349 3356 2-s2.0-65449156015 10.4049/jimmunol.0802733
16. Yang J. H., Zhang J., Cai Q., Zhao D. B., Wang J., Guo P. E., Liu L., Han X. H., Shen Q., Expression and function of inducible costimulator on peripheral blood T cells in patients with systemic lupus erythematosus. Rheumatology 2005 44 10 1245 1254 2-s2.0-27144527844 10.1093/rheumatology/keh724 (Pubitemid 41487957)
17. Kawamoto M., Harigai M., Hara M., Kawaguchi Y., Tezuka K., Tanaka M., Sugiura T., Katsumata Y., Fukasawa C., Ichida H., Higami S., Kamatani N., Expression and function of inducible co-stimulator in patients with systemic lupus erythematosus: possible involvement in excessive interferon- γ and anti-double-stranded DNA antibody production. Arthritis Research and Therapy 2006 8 3, article R62 2-s2.0-34247551065 10.1186/ar1928
18. Witsch E. J., Peiser M., Hutloff A., ICOS and CD28 reversely regulate IL-10 on re-activation of human effector T cells with mature dendritic cells. European Journal of Immunology 2002 32 9 2680 2686
19. Her M., Kim D., Oh M., Jeong H., Choi I., Increased expression of soluble inducible costimulator ligand (ICOSL) in patients with systemic lupus erythematosus. Lupus 2009 18 6 501 507 2-s2.0-65149102534 10.1177/ 0961203308099176
20. Colvin B. L., Sumpter T. L., Tokita D., Salati J., Mellor A. L., Thomson A. W., Allostimulatory activity of bone marrow-derived plasmacytoid dendritic cells is independent of indoleamine dioxygenase but regulated by inducible costimulator ligand expression. Human Immunology 2009 70 5 313 320 2-s2.0-65049083279 10.1016/j.humimm.2009.01.021
21. Niewold T. B., Interferon alpha as a primary pathogenic factor in human lupus. Journal of Interferon and Cytokine Research 2011 31 12 887 892
22. Gilliet M., Cao W., Liu Y. J., Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases. Nature Reviews Immunology 2008 8 8 594 606 2-s2.0-48749085127 10.1038/nri2358
23. Rönnblom L., Alm G. V., Eloranta M. L., Type I interferon and lupus. Current Opinion in Rheumatology 2009 21 5 471 477 2-s2.0-69549088916 10.1097/BOR.0b013e32832e089e
24. Hoffman R. W., T cells in the pathogenesis of systemic lupus erythematosus. Frontiers in Bioscience 2001 6 D1369 D1378 2-s2.0-0035487709
25. Sallusto F., Lanzavecchia A., Understanding dendritic cell and T-lymphocyte traffic through the analysis of chemokine receptor expression. Immunological Reviews 2000 177 134 140 2-s2.0-0033658153
26. Sule S., Rosen A., Petri M., Akhter E., Andrade F., Abnormal production of pro- and anti-inflammatory cytokines by lupus monocytes in response to apoptotic cells. PLoS ONE 2011 6 3 2-s2.0-79952646821 10.1371/journal.pone. 0017495 e17495
27. Yu S. L., Kuan W. P., Wong C. K., Li E. K., Tam L. S., Immunopathological roles of cytokines, chemokines, signaling molecules, and pattern-recognition receptors in systemic lupus erythematosus. Clinical and Developmental Immunology 2012 2012 715190
28. Bauer J. W., Petri M., Batliwalla F. M., Koeuth T., Wilson J., Slattery C., Panoskaltsis-Mortari A., Gregersen P. K., Behrens T. W., Baechler E. C., Interferon-regulated chemokines as biomarkers of systemic lupus erythematosus disease activity: a validation study. Arthritis and Rheumatism 2009 60 10 3098 3107 2-s2.0-70349777469 10.1002/art.24803
29. Lit L. C. W., Wong C. K., Tam L. S., Li E. K. M., Lam C. W. K., Raised plasma concentration and ex vivo production of inflammatory chemokines in patients with systemic lupus erythematosus. Annals of the Rheumatic Diseases 2006 65 2 209 215 2-s2.0-31144436101 10.1136/ard.2005.038315 (Pubitemid 43131995)
30. Bombardier C., Gladman D. D., Urowitz M. B., Caron D., Chi Hsing Chang, Derivation of the SLEDAI: a disease activity index for lupus patients. Arthritis and Rheumatism 1992 35 6 630 640 2-s2.0-0026777352 10.1002/art.1780350606
31. Gladman D. D., Ibaez D., Urowltz M. B., Systemic lupus erythematosus disease activity index 2000. Journal of Rheumatology 2002 29 2 288 291 2-s2.0-0036158415 (Pubitemid 34118775)
32. Griffiths B., Mosca M., Gordon C., Assessment of patients with systemic lupus erythematosus and the use of lupus disease activity indices. Best Practice and Research 2005 19 5 685 708 2-s2.0-24344491492 10.1016/j.berh.2005.03.010 (Pubitemid 41258578)
33. Crespo I., Paiva A., Couceiro A., Pimentel P., Orfão A., Regateiro F., Immunophenotypic and functional characterization of cord blood dendritic cells. Stem Cells and Development 2004 13 1 63 70 2-s2.0-2342422456 10.1089/154732804773099263 (Pubitemid 38560043)
34. Morgado J. M., Pratas R., Laranjeira P., Henriques A., Crespo I., Regateiro F., Paiva A., The phenotypical and functional characteristics of cord blood monocytes and CD 14-/ low /CD 16 + dendritic cells can be relevant to the development of cellular immune responses after transplantation. Transplant Immunology 2008 19 1 55 63 2-s2.0-40849100582 10.1016/j.trim.2007.11.002
35. Vandesompele J., De Preter K., Pattyn F., Poppe B., Van Roy N., De Paepe A., Speleman F., Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biology 2002 3 7 RESEARCH0034 2-s2.0-0037129827
36. Ding D., Mehta H., McCune W. J., Kaplan M. J., Aberrant phenotype and function of myeloid dendritic cells in systemic lupus erythematosus. Journal of Immunology 2006 177 9 5878 5889 2-s2.0-33750348046 (Pubitemid 44628801)
37. Loureno S. V., De Carvalho F. R. G., Boggio P., Sotto M. N., Vilela M. A. C., Rivitti E. A., Nico M. M. S., Lupus erythematosus: clinical and histopathological study of oral manifestations and immunohistochemical profile of the inflammatory infiltrate. Journal of Cutaneous Pathology 2007 34 7 558 564 2-s2.0-34250345679 10.1111/j.1600-0560.2006.00652.x (Pubitemid 46920256)
38. Gillis J. Z., Panopalis P., Schmajuk G., Ramsey-Goldman R., Yazdany J., Systematic review of the literature informing the systemic lupus erythematosus indicators project: reproductive health care quality indicators. Arthritis Care and Research 2011 63 1 17 30 2-s2.0-79952231197 10.1002/acr.20327
39. Watanabe M., Takagi Y., Kotani M., Hara Y., Inamine A., Hayashi K., Ogawa S., Takeda K., Tanabe K., Abe R., Down-regulation of ICOS ligand by interaction with ICOS functions as a regulatory mechanism for immune responses. Journal of Immunology 2008 180 8 5222 5234 2-s2.0-45949106108
40. Saxena R., Mahajan T., Mohan C., Lupus nephritis: current update. Arthritis Research & Therapy 2011 13 5, article 240
41. Vermi W., Riboldi E., Wittamer V., Gentili F., Luini W., Marrelli S., Vecchi A., Franssen J. D., Communi D., Massardi L., Sironi M., Mantovani A., Parmentier M., Facchetti F., Sozzani S., Role of ChemR23 in directing the migration of myeloid and plasmacytoid dendritic cells to lymphoid organs and inflamed skin. Journal of Experimental Medicine 2005 201 4 509 515 2-s2.0-20044369873 10.1084/jem.20041310 (Pubitemid 40289541)
42. Dall'Era M. C., Cardarelli P. M., Preston B. T., Witte A., Davis J. C., Type I interferon correlates with serological and clinical manifestations of SLE. Annals of the Rheumatic Diseases 2005 64 12 1692 1697 2-s2.0-27944464836 10.1136/ard.2004.033753 (Pubitemid 41667141)
43. Rönnblom L., Alm G. V., Systemic lupus erythematosus and the type I interferon system. Arthritis Research and Therapy 2003 5 2 68 75 2-s2.0-0038639795 (Pubitemid 36849752)
44. Kirou K. A., Lee C., George S., Louca K., Peterson M. G. E., Crow M. K., Activation of the interferon- α pathway identifies a subgroup of systemic lupus erythematosus patients with distinct serologic features and active disease. Arthritis and Rheumatism 2005 52 5 1491 1503 2-s2.0-18644384042 10.1002/art.21031 (Pubitemid 40663941)
45. Fitzgerald-Bocarsly P., Dai J., Singh S., Plasmacytoid dendritic cells and type I IFN: 50 years of convergent history. Cytokine and Growth Factor Reviews 2008 19 1 3 19 2-s2.0-39049165088 10.1016/j.cytogfr.2007.10.006
46. Niewold T. B., Clark D. N., Salloum R., Poole B. D., Interferon alpha in systemic lupus erythematosus. Journal of Biomedicine and Biotechnology 2010 2010 2-s2.0-77955350698 10.1155/2010/948364 948364
47. Blomberg S., Eloranta M. L., Magnusson M., Alm G. V., Rönnblom L., Expression of the markers BDCA-2 and BDCA-4 and production of interferon- α by plasmacytoid dendritic cells in systemic lupus erythematosus. Arthritis and Rheumatism 2003 48 9 2524 2532 2-s2.0-0141633010 10.1002/art.11225 (Pubitemid 37129430)
48. Cederblad B., Blomberg S., Vallin H., Perers A., Alm G. V., Rönnblom L., Patients with systemic lupus erythematosus have reduced numbers of circulating natural interferon- α -producing cells. Journal of Autoimmunity 1998 11 5 465 470 2-s2.0-0032191321 10.1006/jaut.1998.0215 (Pubitemid 28520202)
49. Båve U., Magnusson M., Eloranta M. L., Perers A., Alm G. V., Rönnblom L., Fc γ RIIa is expressed on natural IFN- α -producing cells (plasmacytoid dendritic cells) and is required for the IFN- α production induced by apoptotic cells combined with Lupus IgG. Journal of Immunology 2003 171 6 3296 3302 2-s2.0-0041832267 (Pubitemid 37093557)
50. Vallin H., Blomberg S., Alm G. V., Cederblad B., Rönnblom L., Patients with systemic lupus erythematosus (SLE) have a circulating inducer of interferon-alpha (IFN- α) production acting on leucocytes resembling immature dendritic cells. Clinical and Experimental Immunology 1999 115 1 196 202 2-s2.0-0032950459 10.1046/j.1365-2249.1999.00772.x (Pubitemid 29030385)
51. Baechler E. C., Batliwalla F. M., Karypis G., Gaffney P. M., Ortmann W. A., Espe K. J., Shark K. B., Grande W. J., Hughes K. M., Kapur V., Gregersen P. K., Behrens T. W., Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus. Proceedings of the National Academy of Sciences of the United States of America 2003 100 5 2610 2615 2-s2.0-0344492212 10.1073/pnas.0337679100 (Pubitemid 36297546)
52. Vilá L. M., Molina M. J., Mayor A. M., Cruz J. J., Ríos-Olivares E., Ríos Z., Association of serum MIP-1 α MIP-1 β and RANTES with clinical manifestations, disease activity, and damage accrual in systemic lupus erythematosus. Clinical Rheumatology 2007 26 5 718 722 2-s2.0-34147161266 10.1007/s10067-006-0387-y (Pubitemid 46554079)
53. Steinbach F., Henke F., Krause B., Thiele B., Burmester G. R., Hiepe F., Monocytes from systemic lupus erythematous patients are severely altered in phenotype and lineage flexibility. Annals of the Rheumatic Diseases 2000 59 4 283 288 2-s2.0-0034068331 10.1136/ard.59.4.283 (Pubitemid 30305570)
54. Bauer J. W., Baechler E. C., Petri M., Batliwalla F. M., Crawford D., Ortmann W. A., Espe K. J., Li W., Patel D. D., Gregersen P. K., Behrens T. W., Elevated serum levels of interferon-regulated chemokines are biomarkers for active human systemic lupus erythematosus. PLoS Medicine 2006 3 12, article e491 2-s2.0-33845877145 10.1371/journal.pmed.0030491 (Pubitemid 46026445)
55. Fu Q., Chen X., Cui H., Guo Y., Chen J., Shen N., Bao C., Association of elevated transcript levels of interferon-inducible chemokines with disease activity and organ damage in systemic lupus erythematosus patients. Arthritis Research and Therapy 2008 10 5, article R112 2-s2.0-54049102860 10.1186/ar2510
56. Deshmane S. L., Kremlev S., Amini S., Sawaya B. E., Monocyte chemoattractant protein-1 (MCP-1): an overview. Journal of Interferon and Cytokine Research 2009 29 6 313 325 2-s2.0-66149172257 10.1089/jir.2008.0027
57. Lee E. Y., Lee Z. H., Song Y. W., CXCL10 and autoimmune diseases. Autoimmunity Reviews 2009 8 5 379 383 2-s2.0-61349166620 10.1016/j.autrev.2008. 12.002
58. Kong K. O., Tan A. W., Thong B. Y. H., Lian T. Y., Cheng Y. K., Teh C. L., Koh E. T., Chng H. H., Law W. G., Lau T. C., Leong K. P., Leung B. P., Howe H. S., Enhanced expression of interferon-inducible protein-10 correlates with disease activity and clinical manifestations in systemic lupus erythematosus. Clinical and Experimental Immunology 2009 156 1 134 140 2-s2.0-61849179867 10.1111/j.1365-2249.2009.03880.x
59. Karonitsch T., Feierl E., Steiner C. W., Dalwigk K., Korb A., Binder N., Rapp A., Steiner G., Scheinecker C., Smolen J., Aringer M., Activation of the interferon- γ signaling pathway in systemic lupus erythematosus peripheral blood mononuclear cells. Arthritis and Rheumatism 2009 60 5 1463 1471 2-s2.0-66049126061 10.1002/art.24449
60. - dendritic cells. Clinical Immunology 2001 100 3 325 338 2-s2.0-16644376342 10.1006/clim.2001.5072 (Pubitemid 32808383)
61. Alvarez D., Vollmann E. H., von Andrian U. H., Mechanisms and consequences of dendritic cell migration. Immunity 2008 29 3 325 342 2-s2.0-51349132659 10.1016/j.immuni.2008.08.006
62. Bonasio R., von Andrian U. H., Generation, migration and function of circulating dendritic cells. Current Opinion in Immunology 2006 18 4 503 511 2-s2.0-33745420942 10.1016/j.coi.2006.05.011 (Pubitemid 43947581)