Synthesis and antiviral evaluation of bis(POM) prodrugs of (E)-[4′-phosphono-but-2′-en-1′-yl]purine nucleosides

European Journal of Medicinal Chemistry

Volumn 57, Issue , 2012, Pages 126-133

  Pradère, Ugo ^a   Roy, Vincent ^a   Montagu, Aurélien ^a   Sari, Ozkan ^a   Hamada, Manabu ^a   Balzarini, Jan ^b   Snoeck, Robert ^b   Andrei, Graciela ^b   Agrofoglio, Luigi A ^a  

^a UNIVERSITÉ D'ORLÉANS   (France)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Acyclic nucleoside phosphonate; Antiviral evaluation; Mitsunobu reaction; Prodrugs

Indexed keywords

(4' PHOSPHONOBUT 2' EN 1' YL)PURINE NUCLEOSIDE DERIVATIVE; 2 AMINO 6 (4 ISOPROPYL)PHENYLAMINOPURINE; 2 AMINO 6 CYCLOHEXYLAMINOPURINE; 2 AMINO 6 N BUTYLAMINOPURINE; 6 (4 ISOPROPYL)PHENYLAMINOPURINE; 6 ALLYLAMINOPURINE; 6 N BUTYLAMINOPURINE; 6 N CYCLOHEXYLADENINE; ADEFOVIR DIPIVOXIL; BIS(PIVALOYLOXYMETHYL); BIS(PIVALOYLOXYMETHYL) 4 BROMOBUT 2 EN 1 YL PHOSPHONATE; BIS(PIVALOYLOXYMETHYL) 4 HYDROXYBUT 2 EN 1 YL PHOSPHONATE; BIS(PIVALOYLOXYMETHYL)ALLYL PHOSPHONATE; BIS(PIVALOYLOXYMETHYL)BUT 1,3 DIEN 1 YL PHOSPHONATE; N 3 [4' BIS(PIVALOYLOXYMETHYL)PHOSPHINYLBUT 2' ENYL] 3,9 DIHYDRO 9 OXO 5H IMIDAZO[1,2 A]PURINE; N 9 [4' BIS(PIVALOYLOXYMETHYL)PHOSPHINYL 2' BUTENYL] 2 AMINO 6 CYCLOPROPYLAMINOPURINE; N 9 [4' BIS(PIVALOYLOXYMETHYL)PHOSPHINYL 2' BUTENYL] 6 CYCLOPROPYLAMINOPURINE; N 9 [4' BIS(PIVALOYLOXYMETHYL)PHOSPHINYLBUT 2' ENYL] 2 AMINO 6 BUTYLAMINOPURINE; N 9 [4' BIS(PIVALOYLOXYMETHYL)PHOSPHINYLBUT 2' ENYL] 2 AMINO 6 CHLOROPURINE; N 9 [4' BIS(PIVALOYLOXYMETHYL)PHOSPHINYLBUT 2' ENYL] 2,6 DIAMINOPURINE; N 9 [4' BIS(PIVALOYLOXYMETHYL)PHOSPHINYLBUT 2' ENYL] 6 ALLYLAMINOPURINE; N 9 [4' BIS(PIVALOYLOXYMETHYL)PHOSPHINYLBUT 2' ENYL] 6 BUTYLAMINOPURINE; N 9 [4' BIS(PIVALOYLOXYMETHYL)PHOSPHINYLBUT 2' ENYL] 6 CHLOROPURINE; N 9 [4' BIS(PIVALOYLOXYMETHYL)PHOSPHINYLBUT 2' ENYL]ADENINE; N 9 [4' BIS(PIVALOYLOXYMETHYL)PHOSPHINYLBUT 2' ENYL]GUANINE; N 9 [4' BIS(PIVALOYLOXYMETHYL)PHOSPHINYLBUT 2' ENYL]HYPOXANTHINE; PRODRUG; PURINE NUCLEOSIDE DERIVATIVE; TENOFOVIR DISOPROXIL; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CYTOTOXICITY; DNA VIRUS; DRUG STRUCTURE; DRUG SYNTHESIS; HERPES SIMPLEX VIRUS 1; HERPES SIMPLEX VIRUS 2; HUMAN CYTOMEGALOVIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; MITSUNOBU REACTION; NONHUMAN; RNA VIRUS; VARICELLA ZOSTER VIRUS;

ANIMALS; ANTIVIRAL AGENTS; CERCOPITHECUS AETHIOPS; DNA VIRUSES; DOGS; DRUG DESIGN; DRUG DISCOVERY; HELA CELLS; HUMANS; MADIN DARBY CANINE KIDNEY CELLS; ORGANOPHOSPHONATES; PRODRUGS; PURINE NUCLEOSIDES; RNA VIRUSES; VERO CELLS; VIRAL PLAQUE ASSAY;

EID: 84866976536     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.08.042     Document Type: Article

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