Enhancement of hepatoprotective efficacy of propolis by fabrication of liposomes, as a platform nano-formulation for multi-component natural medicine

Current Drug Delivery

Volumn 9, Issue 5, 2012, Pages 477-486

  Ambardekar, Rohan V ^a,b   Mahadik, Kakasaheb R ^a   Paradkar, Anant R ^a,b   Harsulkar, Abhay M ^a  

^a BHARATI VIDYAPEETH DEEMED UNIVERSITY   (India)

^b UNIVERSITY OF BRADFORD   (United Kingdom)

Author keywords

Factorial design; Hepatoprotective; Liposomes; Modified Ethanol Injection; Multi component natural medicine; Propolis

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CHOLESTEROL; LIPOSOME; PARACETAMOL; PHOSPHOLIPID; PROPOLIS; SILYMARIN; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CHOLESTEROL BLOOD LEVEL; COATED VESICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; DRUG FORMULATION; DRUG RELEASE; ENTRAPMENT EFFICIENCY; FACTORIAL DESIGN; FEMALE; HISTOPATHOLOGY; LIVER PROTECTION; LIVER TOXICITY; MALE; NANOFABRICATION; NANOFORMULATION; NATURAL MEDICINE; NONHUMAN; PHOSPHOLIPID BLOOD LEVEL; PHYSICAL CHEMISTRY; PHYTOCHEMISTRY; PRIORITY JOURNAL; RAT; TRANSMISSION ELECTRON MICROSCOPY; VESICLE DIAMETER; ZETA POTENTIAL;

ACETAMINOPHEN; ALANINE TRANSAMINASE; ALKALINE PHOSPHATASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; DRUG-INDUCED LIVER INJURY; FEMALE; LIPID PEROXIDATION; LIPOSOMES; MALE; PARTICLE SIZE; PROPOLIS; PROTECTIVE AGENTS; RATS; RATS, WISTAR;

EID: 84866974493     PISSN: 15672018     EISSN: 18755704     Source Type: Journal    
DOI: 10.2174/156720112802650653     Document Type: Article

References (31)

1. Drummond, D.C.; Meyer, O.; Hong, K.; Kirpotin, D.B.; Papahadjopoulos, D. Optimizing liposomes for delivery of chemotherapeutic agents to solid tumors. Pharmacol. Rev., 1999, 51(4), 691-744.
2. Pinto-Alphandary, H.; Andremont, A.; Couvreur, P., Targeted delivery of antibiotics using liposomes and nanoparticles: research and applications. Int. J. Antimicrob. Agents, 2000, 13(3), 155-168.
3. Nishikawa, M.; Hashida, M. Nonviral approaches satisfying various requirements for effective in vivo gene therapy. Biol. Pharm. Bull., 2002, 25(3), 275-283.
4. Rao, M.; Alving, C.R. Delivery of lipids and liposomal proteins to the cytoplasm and Golgi of antigen-presenting cells. Adv. Drug Deliv. Reviews, 2000, 41(2), 171-188.
5. Ann, C.M.; Blair, H.; Liang, L.; Brey, R.N.; Brayden, D.; Hirst, B.H. Targeting polymerised liposome vaccine carriers to intestinal M cells. Vaccine, 2001, 20 (1-2), 208-217.
6. Fujii, Y.; Aramaki, Y.; Hara, T.; Yachi, K.; Kikuchi, H.; Tsuchiya, S. Enhancement of systemic and mucosal immune responses following oral administration of liposomes. Immunol. Lett., 1993, 36(1), 65-69.
7. Gregoriadis, G.E.; Neerunjun, D. Homing of liposomes to target cells. Biochem. Bioph. Res. Co., 1975, 65(2), 537-544.
8. Weissmann, G.; Bloomgarden, D.; Kaplan, R.; Cohen, C.; Hoffstein, S.; Collins, T.; Gotlieb, A.; Nagle, D. A general method for the introduction of enzymes, by means of immunoglobulin-coated liposomes, into lysosomes of deficient cells. Pro. Natl. Acad. Sci., 1975, 72(1), 88-92.
9. Banno, Y.; Ohki, K.; Nozawa, Y. Targeting of asialofetuin sugar chain-bearing liposomes to liver lysosomes. Biochem. Int., 1983, 7(4), 455-61.
10. Sweeney, L.G.; Wang, Z.; Loebenberg, R.; Wong, J.P.; Lange, C.F.; Finlay, W.H. Spray-freeze-dried liposomal ciprofloxacin powder for inhaled aerosol drug delivery. Int. J. Pharm., 2005, 305(1-2), 180-185.
11. Van Winden, E.C.A.; Crommelin, D.J.A. Short term stability of freeze-dried, lyoprotected liposomes. J. Control. Release, 1999, 58(1), 69-86.
12. Okada, J.I.; Cohen, S.; Langer, R. In vitro evaluation of polymerized liposomes as an oral drug delivery system. Pharm. Res., 1995, 12 (4), 576-582.
13. Dong, C.; Rogers, J.A. Polymer-coated liposomes; stability and release of ASA from carboxymethyl chitin-coated liposomes. J. Control. Release, 1991, 17(3), 217-224.
14. Werner, C.; Wendel, A. Hepatic uptake and antihepatotoxic properties of vitamin E and liposomes in the mouse. Chem-Biol. Interact., 1990, 75(1), 83-92.
15. Halliwell, B.; Gutteridge, J.M. Lipid peroxidation, oxygen radicals, cell damage, and antioxidant therapy. Lancet, 1984, 1(8391), 1396-7.
16. Mourelle, M.; Muriel, P.; Favari, L.; Franco, T. Prevention of ccl4 induced liver cirrhosis by silymarin. Fund. Clin. Pharmacol., 1989, 3(3), 183-191.
17. Banskota, A. H.; Tezuka, Y.; Adnyana, I.K.; Ishii, E.; Midorikawa, K.; Matsushige, K.; Kadota, S. Hepatoprotective and anti Helicobacter pylori activities of constituents from Brazilian propolis. Phytomedicine, 2001, 8(1), 16-23.
18. Ghisalberti, E.L. Propolis: a review. Bee World, 1979, 60, 59-84.
19. Greenaway, W.; May, J.; Scaysbrook, T.; Whatley, F. Identification by gas chromatography-mass spectrometry of 150 compounds in propolis. Z. Naturfor. C., 1990, 46, 111-121.
20. Banskota, A.H.; Tezuka, Y.; Kadota, S. Recent progress in pharmacological research of propolis. Phytother. Res., 2001, 15(7), 561-571.
21. Banskota, A.H.; Tezuka, Y.; Adnyana, I.K.; Midorikawa, K.; Matsushige, K.; Message, D.; Huertas, A.A.G.; Kadota, S. Cytotoxic, hepatoprotective and free radical scavenging effects of propolis from Brazil, Peru, the Netherlands and China. J. Ethnopharmacol., 2000, 72(1-2), 239-246.
22. Bhadauria, M.; Nirala, S.K.; Shukla, S., Multiple treatment of propolis extract ameliorates carbon tetrachloride induced liver injury in rats. Food Chem. Toxicol., 2008, 46(8), 2703-2712.
23. Padamwar, M.N.; Pokharkar, V.B., Development of vitamin loaded topical liposomal formulation using factorial design approach: Drug deposition and stability. Int. J. Pharm., 2006, 320(1-2), 37-44.
24. Fry, D.W.; White, J.C.; Goldman, I.D., Rapid separation of low molecular weight solutes from liposomes without dilution. Anal. Biochem., 1978, 90(2), 809-15.
25. Bruschi, M.L.; de Freitas, O.; Lara, E.H. G.E.; Panzeri, H.; Gremio, M.P.D.; Jones, D.S. Precursor system of liquid crystalline phase containing propolis microparticles for the treatment of periodontal disease: development and characterization. Drug Dev. Ind. Phar., 2008, 34(3), 267-278.
26. Bafna, A.; Pimple, B.; Patil, M.; Badgujar, N.; Kadam, P. Protective effect of Tamarindus indica linn against paracetamol-induced hepatotoxicity in rats. Indian J. Pharm. Sci., 2007, 69(6), 827-831.
27. Reitman, S.; Frankel, S. Colorimetric method for determination of serum glutamic oxaloacetic and glutamic pyruvate transaminases. Am. J. Clin. Pathol., 1957, 28, 56-63.
28. King, E.J.; Armstrong, A.R. A convenient method for determining serum and bile phosphatase activity. Can. Med. Assoc. J., 1934, 31(4), 376-81.
29. Ohkawa, H.; Ohishi, N.; Yagi, K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem., 1979, 95(2), 351-358.
30. Bradford, A.; Atkinson, J.; Fuller, N.; Rand, R.P. The effect of vitamin E on the structure of membrane lipid assemblies. J. Lipid Res., 2003, 44(10), 1940-1945.
31. Wallace, J.L. Acetaminophen hepatotoxicity: NO to the rescue. Brit. J. Pharmacol., 2004, 143(1), 1-2.