Cyclosporine A Enhances Th2 Bias at the Maternal-Fetal Interface in Early Human Pregnancy with Aid of the Interaction between Maternal and Fetal Cells

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Piao, Hai Lan ^a   Wang, Song Cun ^a   Tao, Yu ^a   Zhu, Rui ^a   Sun, Chan ^a   Fu, Qiang ^a   Du, Mei Rong ^a   Li, Da Jin ^a,b  

^a FUDAN UNIVERSITY   (China)

^b HAINAN MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN A; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 4; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL INTERACTION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOKINE RESPONSE; DECIDUA; DRUG MECHANISM; EMBRYO; FEMALE; FETUS; FIRST TRIMESTER PREGNANCY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCOMPETENT CELL; IMMUNOREGULATION; IN VITRO STUDY; INTERFERON PRODUCTION; MOTHER FETUS RELATIONSHIP; STROMA CELL; TH1 CELL; TH2 CELL; TROPHOBLAST;

ADULT; CELL COMMUNICATION; COCULTURE TECHNIQUES; CYCLOSPORINE; DECIDUA; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTERFERON-GAMMA; INTERLEUKIN-10; INTERLEUKIN-4; PREGNANCY; PREGNANCY TRIMESTER, FIRST; TH1 CELLS; TH1-TH2 BALANCE; TH2 CELLS; TROPHOBLASTS; TUMOR NECROSIS FACTOR-ALPHA;

MURINAE;

EID: 84866950561     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0045275     Document Type: Article

References (39)

1. Zhou WH, Du MR, Dong L, Yu J, Li DJ, (2008) Chemokine CXCL12 promotes the cross-talk between trophoblasts and decidual stromal cells in human first-trimester pregnancy. Hum Reprod 23: 2669-2679.
2. Fan DX, Duan J, Li MQ, Xu B, Li DJ, et al. (2011) The decidual gamma-delta T cells up-regulate the biological functions of trophoblasts via IL-10 secretion in early human pregnancy. Clin Immunol 141: 284-292.
3. Munoz-Suano A, Hamilton AB, Betz AG, (2011) Gimme shelter: the immune system during pregnancy. Immunol Rev 241: 20-38.
4. Giannubilo SR, Landi B, Pozzi V, Sartini D, Cecati M, et al. (2012) The involvement of inflammatory cytokines in the pathogenesis of recurrent miscarriage. Cytokine 58: 50-56.
5. Calleja-Agius J, Schembri-Wismayer P, Calleja N, Brincat M, Spiteri D, (2011) Obstetric outcome and cytokine levels in threatened miscarriage. Gynecol Endocrinol 27: 121-127.
6. Guo PF, Du MR, Wu HX, Lin Y, Jin LP, et al. (2010) Thymic stromal lymphopoietin from trophoblasts induces dendritic cell-mediated regulatory TH2 bias in the decidua during early gestation in humans. Blood 116: 2061-2069.
7. Renaud SJ, Cotechini T, Quirt JS, Macdonald-Goodfellow SK, Othman M, et al. (2011) Spontaneous pregnancy loss mediated by abnormal maternal inflammation in rats is linked to deficient uteroplacental perfusion. J Immunol 186: 1799-1808.
8. Matthiesen L, Kalkunte S, Sharma S, (2012) Multiple pregnancy failures: an immunological paradigm. Am J Reprod Immunol 67: 334-340.
9. Sketris I, Yatscoff R, Keown P, Canafax DM, First MR, et al. (1995) Optimizing the use of cyclosporine in renal transplantation. Clin Biochem 28: 195-211.
10. Fujinaga S, Hirano D, Murakami H, Ohtomo Y, Shimizu T, (2012) Nephrotoxicity of once-daily cyclosporine A in minimal change nephrotic syndrome. Pediatr Nephrol 27: 671-674.
11. Germano V, Picchianti Diamanti A, Ferlito C, Podestà E, Salemi S, et al. (2011) Cyclosporine A in the long-term management of systemic lupus erythematosus. J Biol Regul Homeost Agents 25: 397-403.
12. Hetland ML, (2011) Modern treatment strategies in rheumatoid arthritis. Dan Med Bull 58: B4320.
13. O'Keefe SJ, Tamura J, Kincaid RL, Tocci MJ, O'Neill EA, (1992) FK-506 and CsA sensitive activation of the interleukin-2 promoter by calcineurin. Nature 357: 692-694.
14. Alvarez-Arroyo MV, Yague S, Wenger RM, Pereira DS, Jimenez S, et al. (2002) Cyclophilin-mediated pathways in the effect of cyclosporin A on endothelial cells: role of vascular endothelial growth factor. Circ Res 91: 202-209.
15. Yang F, Robotham JM, Grise H, Frausto S, Madan V, et al. (2010) A major determinant of cyclophilin dependence and cyclosporine susceptibility of hepatitis C virus identified by a genetic approach. PLoS Pathog 6: e1001118.
16. Wu X, Nguyen BC, Dziunycz P, Chang S, Brooks Y, et al. (2010) Opposing roles for calcineurin and ATF3 in squamous skin cancer. Nature 65: 368-372.
17. Periyasamy S, Hinds T Jr, Shemshedini L, Shou W, Sanchez ER, (2010) FKBP51 and Cyp40 are positive regulators of androgen-dependent prostate cancer cell growth and the targets of FK506 and cyclosporin A. Oncogene. 29: 1691-1701.
18. Lablanche S, Cottet-Rousselle C, Lamarche F, Benhamou PY, Halimi S, et al. (2011) Protection of pancreatic INS-1 β-cells from glucose- and fructose-induced cell death by inhibiting mitochondrial permeability transition with cyclosporin A or metformin. Cell Death Dis 2: e134.
19. Du MR, Dong L, Zhou WH, Yan FT, Li DJ, (2007) Cyclosporin A improves pregnant outcome by promoting functions of trophoblasts and inducing maternal tolerance to the allogeneic fetus. Biol Reprod 76: 906-914.
20. Zhou WH, Dong L, Du MR, Zhu XY, Li DJ, (2008) Cyclosporin A improves murine pregnancy outcome in abortion-prone matings: involvement of CD80/86 and CD28/CTLA-4. Reproduction 135: 385-395.
21. Royle C, Lim S, Xu B, Tooher J, Ogle R, et al. (2009) Effect of hypoxia and exogenous IL-10 on the pro-inflammatory cytokine TNF-alpha and the anti-angiogenic molecule soluble Flt-1 in placental villous explants. Cytokine. 47: 56-60.
22. Torricelli M, Voltolini C, Bloise E, Biliotti G, Giovannelli A, et al. (2009) Urocortin increases IL-4 and IL-10 secretion and reverses LPS-induced TNF-alpha release from human trophoblast primary cells. Am J Reprod Immunol 62: 224-231.
23. Segerer SE, Rieger L, Kapp M, Dombrowski Y, Muller N, et al. (2012) MIC-1 (a multifunctional modulator of dendritic cell phenotype and function) is produced by decidual stromal cells and trophoblasts. Hum Reprod 27: 200-209.
24. Wu X, Li DJ, Yuan MM, Zhu Y, Wang MY, (2004) The expression of CXCR4/CXCL12 in first-trimester human trophoblast cells. Biol Reprod 70: 1877-1885.
25. Tugwell P, Bombardier C, Gent M, Bennett KJ, Bensen WG, et al. (1990) Low-dose cyclosporine versus placebo in patients with rheumatoid arthritis. Lancet 335: 1051-1055.
26. Mor G, Cardenas I, Abrahams V, Guller S, (2011) Inflammation and pregnancy: the role of the immune system at the implantation site. Ann N Y Acad Sci 1221: 80-87.
27. Scott VL, Shack LA, Eells JB, Ryan PL, Donaldson JR, et al. (2011) Immunomodulator expression in trophoblasts from the feline immunodeficiency virus (FIV)-infected cat. Virol J 8: 336.
28. Torricelli M, Voltolini C, Bloise E, Biliotti G, Giovannelli A, (2009) Urocortin increases IL-4 and IL-10 secretion and reverses LPS-induced TNF-alpha release from human trophoblast primary cells. Am J Reprod Immunol 62: 224-231.
29. Kaur A, Kaur A, (2011) Recurrent pregnancy loss: TNF-α and IL-10 polymorphisms. J Hum Reprod Sci 4: 91-94.
30. Liu F, Guo J, Tian T, Wang H, Dong F, et al. (2011) Placental trophoblasts shifted Th1/Th2 balance toward Th2 and inhibited Th17 immunity at fetomaternal interface. APMIS 119: 597-604.
31. Du MR, Zhou WH, Dong L, Zhu XY, He YY, et al. (2008) Cyclosporin A promotes growth and invasiveness in vitro of human first-trimester trophoblast cells via MAPK3/MAPK1-mediated AP1 and Ca2+/calcineurin/NFAT signalling pathways. Biol Reprod 78: 1102-1110.
32. Du MR, Dong L, Zhou WH, Yan FT, Zhu XY, et al. (2007) Cyclosporine A induces titin expression via MAPK/ERK signalling and improves proliferative and invasive potential of human trophoblast cells. Hum Reprod 22: 2528-2537.
33. Zhou WH, Du MR, Dong L, Zhu XY, Yang JY, et al. (2007) Cyclosporin A promotes expression of matrix metalloproteinase 9 and 2 and invasiveness in vitro of the first-trimester human trophoblast cells via the mitogen-activated protein kinase pathway. Hum Reprod 22: 2743-2750.
34. Du MR, Zhou WH, Piao HL, Li MQ, Tang CL, et al. (2012) Cyclosporin A promotes crosstalk between human cytotrophoblast and decidual stromal cell through up-regulating CXCL12/CXCR4 interaction. Hum Reprod 27: 1955-1965.
35. Hanna J, Golaman-Wohl D, Hamani Y, Avraham I, Greenfield C, et al. (2006) Decidual NK cells regulate key developmental processes at the human fetal-maternal interface. Nat Med 12: 1065-1074.
36. Goerdt S, Orfanos CE, (1999) Other functions, other genes: alternative activation of antigen-presenting cells. Immunity 10: 137-142.
37. Sgro MD, Barozzino T, Mirghani HM, Sermer M, Moscato L, et al. (2002) Pregnancy outcome postrenal transplantation. Teratology 65: 5-9.
38. Cochat P, Decramer S, Robert-Gnansia E, Dubourg L, Audra P, (2004) Renal outcome of children exposed to cyclosporine in utero. Transplantation Proc 36: 208S-210S.
39. Backman L, Brandt I, Appelkvist EL, Dallner G, (1988) Tissue and subcellular localizations of 3H-cyclosporin A in mice. Pharmacol Toxicol 62: 110-117.