Deletion of an ATP-binding cassette protein subfamily C transporter in Leishmania donovani results in increased virulence

Molecular and Biochemical Parasitology

Volumn 185, Issue 2, 2012, Pages 165-169

  Zhang, Wen Wei ^a   Matlashewski, Greg ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

ABC transporter gene; ABCC9; Deletion; Differentially distributed genes; Hypervirulence; Leishmania donovani

Indexed keywords

ABC TRANSPORTER;

AMASTIGOTE; ARTICLE; COMPARATIVE GENE MAPPING; GENE DELETION; GENE IDENTIFICATION; GENE SEQUENCE; LEISHMANIA BRAZILIENSIS; LEISHMANIA DONOVANI; LEISHMANIA MEXICANA; LEISHMANIASIS; NONHUMAN; PARASITE VIRULENCE; PRIORITY JOURNAL; PROTEIN FAMILY; PROTOZOAL GENETICS; PSEUDOGENE; TROPISM; WILD TYPE;

AMINO ACID SEQUENCE; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; GENE DELETION; GENE EXPRESSION REGULATION; LEISHMANIA DONOVANI; LEISHMANIASIS, VISCERAL; MICE; MOLECULAR SEQUENCE DATA; PROTOZOAN PROTEINS; SEQUENCE ANALYSIS, DNA; VIRULENCE;

LEISHMANIA BRAZILIENSIS; LEISHMANIA DONOVANI; LEISHMANIA INFANTUM; LEISHMANIA MAJOR; LEISHMANIA MEXICANA; MUS;

EID: 84866945260     PISSN: 01666851     EISSN: 18729428     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2012.07.006     Document Type: Article

References (22)

1. C.S. Peacock, K. Seeger, D. Harris, L. Murphy, J.C. Ruiz, and M.A. Quail Comparative genomic analysis of three Leishmania species that cause diverse human disease Nature Genetics 39 2007 839 847
2. M.B. Rogers, J.D. Hilley, N.J. Dickens, J. Wilkes, P.A. Bates, and D.P. Depledge Chromosome and gene copy number variation allow major structural change between species and strains of Leishmania Genome Research 21 12 2011 2129 2142
3. W.W. Zhang, and G. Matlashewski Loss of virulence in Leishmania donovani deficient in an amastigote-specific protein, A2 Proceedings of the National Academy of Sciences of the United States of America 94 1997 8807 8811
4. W.W. Zhang, and G. Matlashewski Characterization of the A2-A2rel gene cluster in Leishmania donovani: involvement of A2 in visceralization during infection Molecular Microbiology 39 2001 935 948
5. W.W. Zhang, S. Mendez, A. Ghosh, P. Myler, A. Ivens, and J. Clos Comparison of the A2 gene locus in Leishmania donovani and Leishmania major and its control over cutaneous infection Journal of Biological Chemistry 278 37 2003 35508 35515
6. W.W. Zhang, and G. Matlashewski Screening Leishmania donovani specific genes required for visceral infection Molecular Microbiology 77 2010 505 517
7. F. Raymond, S. Boisvert, G. Roy, J.F. Ritt, D. Légaré, and A. Isnard Genome sequencing of the lizard parasite Leishmania tarentolae reveals loss of genes associated to the intracellular stage of human pathogenic species Nucleic Acids Research 40 3 2012 1131 1147
8. P. Leprohon, D. Légaré, and M. Ouellette Intracellular localization of the ABCC proteins of Leishmania and their role in resistance to antimonials Antimicrobial Agents and Chemotherapy 53 6 2009 2646 2649
9. G.D. Kruhl, and M.G. Belinsky The MRP family of drug efflux pumps Oncogene 22 2003 7537 7552
10. P. Leprohon, D. Légaré, I. Girard, B. Papadopoulou, and M. Ouellette Modulation of Leishmania ABC protein gene expression through life stages and among drug-resistant parasites Eukaryotic Cell 5 10 2006 1713 1725
11. A. Rochette, F. Raymond, J. Corbeil, M. Ouellette, and B. Papadopoulou Whole-genome comparative RNA expression profiling of axenic and intracellular amastigote forms of Leishmania infantum Molecular and Biochemical Parasitology 165 1 2009 32 47
12. A.M. ten Bokum, F. Movahedzadeh, R. Frita, G.J. Bancroft, and N.G. Stoker The case for hypervirulence through gene deletion in Mycobacterium tuberculosis Trends in Microbiology 16 9 2008 436 441
13. S.F. Zhou, L.L. Wang, Y.M. Di, C.C. Xue, W. Duan, and C.G. Li Substrates and inhibitors of human multidrug resistance associated proteins and the implications in drug development Current Medicinal Chemistry 15 20 2008 1981 2039
14. D. Keppler Multidrug resistance proteins (MRPs, ABCCs): importance for pathophysiology and drug therapy Handbook of Experimental Pharmacology 201 2011 299 323
15. M. Ouellette, F. Fase-Fowler, and P. Borst The amplified H circle of methotrexateresistant Leishmania tarentolae contains a novel P-glycoprotein gene EMBO Journal 9 1990 1027 1033
16. H.L. 16.Callahan, and S.M. Beverley Heavy metal resistance: a new role for Pglycoproteins in Leishmania Journal of Biological Chemistry 266 1991 18427 18430
17. A. Haimeur, C. Brochu, P. Genest, B. Papadopoulou, and OuelletteM. Amplification of the ABC transporter gene PGPA and increased trypanothione levels in potassium antimonyl tartrate (SbIII) resistant Leishmania tarentolae Molecular and Biochemical Parasitology 108 2000 131 135
18. F. Gamarro, M.J. Chiquero, M.V. Amador, D. Légaré, M. Ouellette, and S. Castanys P-glycoprotein overexpression in methotrexate- resistant Leishmania tropica Biochemical Pharmacology 47 1994 1939 1947
19. A.C. Coelho, S.M. Beverley, and P.C. Cotrim Functional genetic identification of PRP1,an ABC transporter superfamily member conferring pentamidine resistance in Leishmania major Molecular and Biochemical Parasitology 130 2003 83 90
20. J.M. Pérez-Victoria, A. Parodi-Talice, C. Torres, F. Gamarro, and S. Castanys ABC transporters in the protozoan parasite Leishmania International Microbiology 4 2001 159 166
21. V. Sauvage, D. Aubert, S. Escotte-Binet, and I. Villena The role of ATP-binding cassette (ABC) proteins in protozoan parasites Molecular and Biochemical Parasitology 167 2 2009 81 94
22. W.W. Zhang, K.F. Chan, Z. Song, and G. Matlashewski Expression of a Leishmania donovani nucleotide sugar transporter in Leishmania major enhances survival in visceral organs Experimental Parasitology 129 4 2011 337 345