The osteogenic response of undifferentiated human adipose-derived stem cells under mechanical stimulation

Cells Tissues Organs

Volumn 196, Issue 4, 2012, Pages 313-324

  Du, Hong Ming ^a   Zheng, Xiao Hui ^a   Wang, Li Ya ^a   Tang, Wei ^a   Liu, Lei ^a   Jing, Wei ^a   Lin, Yun Feng ^a   Tian, Wei Dong ^a   Long, Jie ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Chemical stimulation; Human adipose derived stem cells; Osteogenic differentiation; Stretch loading

Indexed keywords

ALKALINE PHOSPHATASE; COLLAGEN TYPE 1; MESSENGER RNA; OSTEONECTIN; OSTEOPONTIN; TRANSCRIPTION FACTOR RUNX2;

ADIPOSE DERIVED STEM CELL; ARTICLE; CELL DIFFERENTIATION; CELL ISOLATION; COLORIMETRY; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MECHANICAL STIMULATION; OSTEOBLAST; OSTEOGENIC DIFFERENTIATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN FLAP; WESTERN BLOTTING;

ADIPOCYTES; ADOLESCENT; ADULT; CELL DIFFERENTIATION; CELLS, CULTURED; FEMALE; HUMANS; OSTEOGENESIS; SKIN; STEM CELLS; TISSUE ENGINEERING; YOUNG ADULT;

EID: 84866942788     PISSN: 14226405     EISSN: 14226421     Source Type: Journal    
DOI: 10.1159/000335905     Document Type: Article

References (50)

1. Al-Salleeh, F., M.W. Beatty, R.A. Reinhardt, T.M. Petro, L. Crouch (2008) Human osteogenic protein-1 induces osteogenic differentiation of adipose-derived stem cells harvested from mice. Arch Oral Biol 53: 928-936.
2. Aubin, J.E. (1998) Bone stem cells. J Cell Biochem Suppl 30-31: 73-82.
3. Aubin, J.E. (1999) Osteoprogenitor cell frequency in rat bone marrow stromal populations: role for heterotypic cell-cell interactions in osteoblast differentiation. J Cell Biochem 72: 396-410.
4. Aubin, J.E. (2001) Regulation of osteoblast formation and function. Rev Endocr Metab Disord 2: 81-94.
5. Aubin, J.E., F. Liu, L. Malaval, A.K. Gupta (1995) Osteoblast and chondroblast differentiation. Bone 17: 77S-83S.
6. Brighton, C.T., B. Strafford, S.B. Gross, D.F. Leatherwood, J.L. Williams, S.R. Pollack (1991) The proliferative and synthetic response of isolated calvarial bone cells of rats to cyclic biaxial mechanical strain. J Bone Joint Surg Am 73: 320-331.
7. Buckley, M.J., A.J. Banes, L.G. Levin, B.E. Sumpio, M. Sato, R. Jordan, J. Gilbert, G.W. Link, R. Tran Son Tay (1988) Osteoblasts increase their rate of division and align in response to cyclic mechanical tension in vitro. Bone Miner 4: 225-236.
8. Butler, D.L., S.A. Goldstein, F. Guilak (2000) Functional tissue engineering: the role of biomechanics. J Biomech Eng 122: 570-575.
9. Butler, D.L., N. Juncosa-Melvin, G.P. Boivin, M.T. Galloway, J.T. Shearn, C. Gooch, H. Awad (2008) Functional tissue engineering for tendon repair: a multidisciplinary strategy using mesenchymal stem cells, bioscaffolds, and mechanical stimulation. J Orthop Res 26: 1-9.
10. Canceddaa, R., P. Giannonic, M. Mastrogiacomo (2007) A tissue engineering approach to bone repair in large animal models and in clinical practice. Biomaterials 28: 4240-4250.
11. Cassella, J.P., R. Pereira, J.S. Khillan, D.J. Prockop, N. Garrington, S.Y. Ali (1994) An ultrastructural, microanalytical, and spectroscopic study of bone from a transgenic mouse with a COL1.A1 pro-alpha-1 mutation. Bone 15: 611-619.
12. Derubeis, A.R., R. Cancedda (2004) Bone marrow stromal cells (BMSCs) in bone engineering: limitations and recent advances. Ann Biomed Eng 32: 160-165.
13. De Ugarte, D.A., K. Morizono, A. Elbarbary, Z. Alfonso, P.A. Zuk, M. Zhu, J.L. Dragoo, P. Ashjian, B. Thomas, P. Benhaim, I. Chen, J. Fraser, M.H. Hedrick (2003) Comparison of multi-lineage cells from human adipose tissue and bone marrow. Cells Tissues Organs 174: 101-109.
14. Dicker, A., K. Le Blanc, G. Aström, V. van Harmelen, C. Götherström, L. Blomqvist, P. Arner, M. Rydén (2005) Functional studies of mesenchymal stem cells derived from adult human adipose tissue. Exp Cell Res 308: 283-290.
15. Friedl, G., H. Schmidt, I. Rehak, G. Kostner, K. Schauenstein, R. Windhager (2007) Undifferentiated human mesenchymal stem cells (hMSCs) are highly sensitive to mechanical strain: transcriptionally controlled early osteo-chondrogenic response in vitro. Osteoarthritis Cartilage 15: 1293-1300.
16. Goldyn, A.M., B.A. Rioja, J.P. Spatz, C. Ballestrem, R. Kemkemer (2009) Force-induced cell polarisation is linked to RhoA-driven microtubule-independent focal-adhesion sliding. J Cell Sci 122: 3644-3651.
17. Hanson, A.D., S.W. Marvel, S.H. Bernacki, A.J. Banes, J. van Aalst, E.G. Loboa (2009) Osteogenic effects of rest inserted and continuous cyclic tensile strain on hASC lines with disparate osteodifferentiation capabilities. Ann Biomed Eng 37: 955-965.
18. Kafienah, W., S. Mistry, S.C. Dickinson, T.J. Sims, I. Learmonth, A.P. Hollander (2007) Three-dimensional cartilage tissue engineering using adult stem cells from osteoarthritis patients. Arthritis Rheum 56: 177-187.
19. Kakudo, N., A. Shimotsuma, S. Miyake, S. Kushida, K. Kusumoto (2008) Bone tissue engineering using human adipose-derived stem cells and honeycomb collagen scaffold. J Biomed Mater Res A 84: 191-197.
20. Karsenty, G., P. Ducy, M. Starbuck, M. Priemel, J. Shen, V. Geoffroy, M. Amling (1999) CBFA1 as a regulator of osteoblast differentiation and function. Bone 25: 107-108.
21. Katanosaka, Y., J.H. Bao, T. Komatsu, T. Suemori, A. Yamada, S. Mohri, K. Naruse (2008) Analysis of cyclic-stretching responses using cell-adhesion-patterned cells. J Biotechnol 133: 82-89.
22. Kearney, E.M., E. Farrell, P.J. Prendergast, V.A. Campbell (2010) Tensile strain as a regulator of mesenchymal stem cell osteogenesis. Ann Biomed Eng 38: 1767-1779.
23. Kern, B., J. Shen, M. Starbuck, G. Karsenty (2001) Cbfa1 contributes to the osteoblast-specific expression of type I collagen genes. J Biol Chem 276: 7101-7107.
24. Koike, M., H. Shimokawa, Z. Kanno, K. Ohya, K. Soma (2005) Effects of mechanical strain on proliferation and differentiation of bone marrow stromal cell line ST2. J Bone Miner Metab 23: 219-225.
25. Komori, T. (2003) Requisite roles of Runx2 and Cbfb in skeletal development. J Bone Miner Metab 21: 193-197.
26. Lee, W.C., T.M. Maul, D.A. Vorp, J.P. Rubin, K.G. Marra (2007) Effects of uniaxial cyclic strain on adipose-derived stem cell morphology, proliferation, and differentiation. Biomech Model Mechanobiol 6: 265-273.
27. Li, Y.J., N.N. Batra, L. You, S.C. Meier, I.A. Coe, C.E. Yellowley, C.R. Jacobs (2004) Oscillatory fluid flow affects human marrow stromal cell proliferation and differentiation. J Orthop Res 22: 1283-1289.
28. Lin, Y., L. Liu, Z. Li, J. Qiao, L. Wu, W. Tang, X. Zheng, X. Chen, Z. Yan, W. Tian (2006) Pluripotency potential of human adipose-derived stem cells marked with exogenous green fluorescent protein. Mol Cell Biochem 291: 1-10.
29. Lin, Y., T. Wang, L. Wu, W. Jing, X. Chen, Z. Li, L. Liu, W. Tang, X. Zheng, W. Tian (2007) Ectopic and in situ bone formation of adipose tissue-derived stromal cells in biphasic calcium phosphate nano composite. J Biomed Mater Res A 81: 900-910.
30. Liu, F., L. Malaval, J.E. Aubin (1997) The mature osteoblast phenotype is characterized by extensive plasticity. Exp Cell Res 232: 97-105.
31. Malaval, L., N.M. Wade-Guéye, M. Boudiffa, J. Fei, R. Zirngibl, F. Chen, N. Laroche, J.P. Roux, B. Burt-Pichat, F. Duboeuf, G. Boivin, P. Jurdic, M.H. Lafage-Proust, J. Amédée, L. Vico, J. Rossant, J.E. Aubin (2008) Bone sialoprotein plays a functional role in bone formation and osteoclastogenesis. J Exp Med 205: 1145-1153.
32. Martin, I., D. Wendt, M. Hebere (2004) The role of bioreactors in tissue engineering. Trends Biotechnol 22: 80-86.
33. Maurer, P., C. Hohenadl, E. Hohenester, W. Göhring, R. Timpl, J. Engel (1995) The C-terminal portion of BM-40 (SPARC/osteonectin) is an autonomously folding and crystallisable domain that binds calcium and collagen IV. J Mol Biol 253: 347-357.
34. Murray, D.W., N. Rushton (1990) The effect of strain on bone cell prostaglandin E 2 release: a new experimental method. Calcif Tissue Int 47: 35-39.
35. Nagatomi, J., B.P. Arulanandam, D.W. Metzger, A. Meunier, R. Bizios (2001) Frequency and duration dependent effects of cyclic pressure on select bone cell functions. Tissue Eng 7: 717-728.
36. Ogawa, R., H. Mizuno, A. Watanabe, M. Migita, T. Shimada, H. Hyakusoku (2004) Osteogenic and chondrogenic differentiation by adipose-derived stem cells harvested from GFP transgenic mice. Biochem Biophys Res Commun 313: 871-877.
37. Park, J.S., J.S. Chu, C. Cheng, F. Chen, D. Chen, S. Li (2004) Differential effects of equiaxial and uniaxial strain on mesenchymal stem cells. Biotechnol Bioeng 88: 359-368.
38. Pinero, G.J., M.C. Farach-Carson, R.E. Devoll, J.E. Aubin, J.C. Brunn, W.T. Butler (1995) Bone matrix proteins in osteogenesis and remodelling in the neonatal rat mandible as studied by immunolocalization of osteopontin, bone sialoprotein, alpha 2HS-glycoprotein and alkaline phosphatase. Arch Oral Biol 40: 145-155.
39. Sahoo, S., H. Ouyang, J.C. Goh, T.E. Tay, S.L. Toh (2006) Characterization of a novel polymeric scaffold for potential application in tendon/ ligament tissue engineering. Tissue Eng 12: 91-99.
40. Sato, M., E. Morii, T. Komori, H. Kawahata, M. Sugimoto, K. Terai, H. Shimizu, T. Yasui, H. Ogihara, N. Yasui, T. Ochi, Y. Kitamura, Y. Ito, S. Nomura (1998) Transcriptional regulation of osteopontin gene in vivo by PEBP2alphaA/CBFA1 and ETS1 in the skeletal tissues. Oncogene 17: 1517-1525.
41. Shui, C., T.C. Spelsberg, B.L. Riggs, S. Khosla (2003) Changes in Runx2/Cbfa1 expression and activity during osteoblastic differentiation of human bone marrow stem cells. J Bone Miner Res 18: 213-221.
42. Stein, G.S., J.B. Lian (1993) Molecular mechanisms mediating proliferation/differentiation interrelationships during progressive development of the osteoblast phenotype. Endocr Rev 14: 424-442.
43. Sumanasinghe, R.D., S.H. Bernacki, E.G. Loboa (2006) Osteogenic differentiation of human mesenchymal stem cells in collagen matrices: effect of uniaxial cyclic tensile strain on bone morphogenetic protein (BMP-2) mRNA expression. Tissue Eng 12: 3459-3465.
44. Wang, J.H., G. Yang, Z. Li (2005) Controlling cell responses to cyclic mechanical stretching. Ann Biomed Eng 33: 337-342.
45. Wei, Y., X. Sun, W. Wang, Y. Hu (2007) Adiposederived stem cells and chondrogenesis. Cytotherapy 9: 712-716.
46. Weyts, F.A., B. Bosmans, R. Niesing, J.P. van Leeuwen, H. Weinans (2003) Mechanical control of human osteoblast apoptosis and proliferation in relation to differentiation. Calcif Tissue Int 82: 505-512.
47. Wu, L., Y. Wu, Y. Lin, W. Jing, X. Nie, J. Qiao, L. Liu, W. Tang, W. Tian (2007) Osteogenic differentiation of adipose derived stem cells promoted by overexpression of osterix. Mol Cell Biochem 301: 83-92.
48. You, J., C.E. Yellowley, H.J. Donahue, Y. Zhang, Q. Chen, C.R. Jacobs (2000) Substrate deformation levels associated with routine physical activity are less stimulatory to bone cells relative to loading induced oscillatory fluid flow. J Biomech Eng 122: 387-393.
49. Zheng, B., B. Cao, G. Li, J. Huard (2006) Mouse adipose-derived stem cells undergo multilineage differentiation in vitro but primarily osteogenic and chondrogenic differentiation in vivo. Tissue Eng 12: 1891-1901.
50. Zuk, P.A., M. Zhu, P. Ashjian, D.A. De Ugarte, J.I. Huang, H. Mizuno, Z.C. Alfonso, J.K. Fraser, P. Benhaim, M.H. Hedrick (2002) Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 13: 4279-4295.