Preprotachykinin-a gene disruption attenuates nociceptive sensitivity after opioid administration and incision by peripheral and spinal mechanisms in mice

Journal of Pain

Volumn 13, Issue 10, 2012, Pages 997-1007

  Sahbaie, Peyman ^a,b   Shi, Xiaoyou ^a,b   Li, Xiangqi ^a,b   Liang, Deyong ^a,b   Guo, Tian Zhi ^a,b   Qiao, Yanli ^a   Yeomans, David C ^a   Kingery, Wade S ^a,b   David Clark, J ^a,b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA PALO ALTO HEALTH CARE SYSTEM   (United States)

Author keywords

Cytokines; NGF; opioid induced hyperalgesia; skin incision; substance P

Indexed keywords

GRANULOCYTE COLONY STIMULATING FACTOR; INTERLEUKIN 1BETA; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; NERVE GROWTH FACTOR; NEUROKININ 1 RECEPTOR ANTAGONIST; OPIATE; PREPROTACHYKININ; SEROTONIN 3 RECEPTOR; SUBSTANCE P;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GANGLION; GENE; GENE DISRUPTION; HYPERALGESIA; INCISION; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PAIN THRESHOLD; PREPROTACHYKININ A GENE; SIGNAL TRANSDUCTION; SPINAL CORD; UPREGULATION; WILD TYPE;

ANALGESICS, OPIOID; ANIMALS; CHEMOKINE CCL3; GRANULOCYTE COLONY-STIMULATING FACTOR; HYPERALGESIA; INDOLES; INTERLEUKIN-1BETA; INTERLEUKIN-6; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MORPHINE; NEUROKININ-1 RECEPTOR ANTAGONISTS; PAIN; PAIN MEASUREMENT; PHYSICAL STIMULATION; PIPERIDINES; PROTEIN PRECURSORS; SKIN; SPINAL CORD; TACHYKININS; UP-REGULATION;

EID: 84866922782     PISSN: 15265900     EISSN: 15288447     Source Type: Journal    
DOI: 10.1016/j.jpain.2012.07.009     Document Type: Article

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