Exercise training with weight loss and either a high- or low-glycemic index diet reduces metabolic syndrome severity in older adults

Annals of Nutrition and Metabolism

Volumn 61, Issue 2, 2012, Pages 135-141

  Malin, Steven K ^a   Niemi, Nicole ^a   Solomon, Thomas P J ^a   Haus, Jacob M ^a   Kelly, Karen R ^a   Filion, Julianne ^a,b   Rocco, Michael ^b   Kashyap, Sangeeta R ^a,c   Barkoukis, Hope ^d   Kirwan, John P ^a,d  

^a LERNER RESEARCH INSTITUTE   (United States)

^b Departments of Preventive Cardiology   (United States)

^c Diabetes and Metabolism   (United States)

^d CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aging; Diabetes; Impaired glucose tolerance; Lifestyle modification; Obesity

Indexed keywords

CARBOHYDRATE; FAT; FATTY ACID; GLUCOSE; HIGH DENSITY LIPOPROTEIN; PROTEIN; TRIACYLGLYCEROL;

ADULT; AEROBIC EXERCISE; AGE DISTRIBUTION; AGED; AGING; ARTICLE; BLOOD PRESSURE; BODY COMPOSITION; BODY MASS; CALORIC INTAKE; CARBOHYDRATE INTAKE; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; DISEASE SEVERITY; EXERCISE; FAT INTAKE; FEMALE; GLUCOSE BLOOD LEVEL; GLYCEMIC INDEX; GLYCEMIC LOAD; HIGH FIBER DIET; HUMAN; INSULIN RESISTANCE; MALE; METABOLIC SYNDROME X; PRIORITY JOURNAL; PROTEIN INTAKE; SCORING SYSTEM; TRIACYLGLYCEROL BLOOD LEVEL; WAIST CIRCUMFERENCE; WEIGHT REDUCTION;

AGED; BLOOD GLUCOSE; BLOOD PRESSURE; BODY COMPOSITION; BODY MASS INDEX; CHOLESTEROL, HDL; DIET; EXERCISE; FEMALE; GLYCEMIC INDEX; HUMANS; INSULIN; INSULIN RESISTANCE; INTERVENTION STUDIES; MALE; METABOLIC SYNDROME X; OBESITY; TRIGLYCERIDES; WAIST CIRCUMFERENCE; WEIGHT LOSS;

EID: 84866922022     PISSN: 02506807     EISSN: 14219697     Source Type: Journal    
DOI: 10.1159/000342084     Document Type: Article

References (36)

1. Ford E, Giles W, Dietz W: Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA 2002; 287: 356-359. (Pubitemid 34251969)
2. Orchard TJ, Temprosa M, Goldberg R, Haffner S, Ratner R, Marcovina S, Fowler S, Diabetes Prevention Program Research Group. The effect of metformin and intensive lifestyle intervention on the metabolic syndrome: the Diabetes Prevention Program randomized trial. Ann Intern Med 2005; 142: 611-619. (Pubitemid 40529957)
3. Katzmarzyk P, Leon A, Wilmore J, Skinner J, Rao DC, Rankinen T, Bouchard C: Targeting the metabolic syndrome with exercise: evidence from the HERITAGE Family Study. Med Sci Sports Exerc 2003; 35: 1703-1709. (Pubitemid 37221901)
4. Villareal D, Miller B, Banks M, Fontana L, Sinacore D, Klein S: Effect of lifestyle intervention on metabolic coronary heart disease risk factors in obese older adults. Am J Clin Nutr 2006; 84: 1317-1323. (Pubitemid 44912812)
5. Stewart K, Bacher A, Turner K, Lim J, Hees P, Shapiro E, Tayback M, Ouyang P: Exercise and risk factors associated with metabolic syndrome in older adults. Am J Prev Med 2005; 28: 9-18. (Pubitemid 40051320)
6. Joseph LS, Prigeon RL, Blumenthal JB, Ryan AS, Goldberg A: Weight loss and low-intensity exercise for the treatment of metabolic syndrome in obese postmenopausal women. J Gerontol Biol Sci Med Sci 2011; 66: 1022-1029.
7. Yassine HN, Marchetti CM, Krishnan R, Vrobel T, Gonzalez F, Kirwan JP: Effects of exercise and caloric restriction on insulin resistance and cardiometabolic risk factors in older obese adults-a randomized clinical trial. J Gerontol Biol Sci Med Sci 2009; 64: 90-95.
8. Ludwig D: The glycemic index: physiological mechanisms relating to obesity, diabetes, and cardiovascular disease. JAMA 2002; 287: 2414-2423. (Pubitemid 34495441)
9. Rizkalla S, Taghrid L, Laromiguiere M, Huet D, Boillot J, Rigoir A, Elgrably F, Slama G: Improved plasma glucose control, wholebody glucose utilization, and lipid profile on a low-glycemic index diet in type 2 diabetic men: a randomized controlled trial. Diabetes Care 2004; 27: 1866-1872. (Pubitemid 38989224)
10. Wolever TMS, Mehling C, Chiasson J, Josse RG, Leiter LA, Maheux P, Rabasa Lhoret R, Rodger NW, Ryan EA: Low glycaemic index diet and disposition index in type 2 diabetes (the Canadian Trial of Carbohydrates in Diabetes): a randomised controlled trial. Diabetologia 2008; 51: 1607-1615.
11. Kirwan JP, Barkoukis H, Brooks L, Marchetti CM, Stetzer B, Gonzalez F: Exercise training and dietary glycemic load may have synergistic effects on insulin resistance in older obese adults. Ann Nutr Metab 2009; 55: 326-333.
12. Solomon TPJ, Haus JM, Kelly KR, Cook M, Riccardi M, Rocco M, Kashyap SR, Barkoukis H, Kirwan JP: Randomized trial on the effects of a 7-d low-glycemic diet and exercise intervention on insulin resistance in older obese humans. Am J Clin Nutr 2009; 90: 1222-1229.
13. Kelly KR, Haus JM, Solomon TP, Patrick Melin A, Cook M, Rocco M, Barkoukis H, Kirwan JP: A low-glycemic index diet and exercise intervention reduces TNF(alpha) in isolated mononuclear cells of older, obese adults. J Nutr 2011; 141: 1089-1094.
14. Solomon TPJ, Haus JM, Kelly KR, Cook M, Filion J, Rocco M, Kashyap SR, Watanabe R, Barkoukis H, Kirwan JP: A low-glycemic index diet combined with exercise reduces insulin resistance, postprandial hyperinsulinemia, and glucose-dependent insulinotropic polypeptide responses in obese, prediabetic humans. Am J Clin Nutr 2010; 92: 1359-1368.
15. Grundy S, Cleeman J, Daniels S, Donato K, Eckel R, Franklin B, Gordon D, Krauss R, Savage P, Smith S, Spertus J, Costa F: Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute scientific statement: executive summary. Crit Pathw Cardiol 2005; 4: 198-203.
16. Johnson J, Slentz C, Houmard J, Samsa G, Duscha B, Aiken L, McCartney J, Tanner C, Kraus W: Exercise training amount and intensity effects on metabolic syndrome (from Studies of a Targeted Risk Reduction Intervention through Defined Exercise). Am J Cardiol 2007; 100: 1759.
17. Frayn KN: Calculation of substrate oxidation rates in vivo from gaseous exchange. J Appl Physiol 1983; 55: 628-634. (Pubitemid 13044099)
18. Kuo CC, Fattor JA, Henderson GC, Brooks GA: Lipid oxidation in fit young adults during postexercise recovery. J Appl Physiol 2005; 99: 349-356. (Pubitemid 40934502)
19. Lakka T, Laaksonen D: Physical activity in prevention and treatment of the metabolic syndrome. Appl Physiol Nutr Metab 2007; 32: 76-88.
20. Hassinen M, Lakka T, Savonen K, Litmanen H, Kiviaho L, Laaksonen D, Komulainen P, Rauramaa R: Cardiorespiratory fitness as a feature of metabolic syndrome in older men and women: the Dose-Responses to Exercise Training study (DR's EXTRA). Diabetes Care 2008; 31: 1242-1247.
21. Schenk S, Harber M, Shrivastava C, Burant C, Horowitz J: Improved insulin sensitivity after weight loss and exercise training is mediated by a reduction in plasma fatty acid mobilization, not enhanced oxidative capacity. J Physiol 2009; 587: 4949-4961.
22. Mittendorfer B, Magkos F, Fabbrini E, Mohammed BS, Klein S: Relationship between body fat mass and free fatty acid kinetics in men and women. Obesity 2009; 17: 1872-1877.
23. Kraus W, Houmard J, Duscha B, Knetzger K, Wharton M, McCartney J, Bales C, Henes S, Samsa G, Otvos J, Kulkarni K, Slentz C: Effects of the amount and intensity of exercise on plasma lipoproteins. N Engl J Med 2002; 347: 1483-1492. (Pubitemid 35257587)
24. O'Leary VB, Marchetti CM, Krishnan R, Stetzer B, Gonzalez F, Kirwan JP: Exerciseinduced reversal of insulin resistance in obese elderly is associated with reduced visceral fat. J Appl Physiol 2006; 100: 1584-1589.
25. Ross R, Janssen I, Dawson J, Kungl A, Kuk JL, Wong SL, Nguyen-Duy T, Lee S, Kilpatrick K, Hudson R: Exercise-induced reduction in obesity and insulin resistance in women: a randomized controlled trial. Obes Res 2004; 12: 789-798. (Pubitemid 41127314)
26. Fagard RH: Exercise is good for your blood pressure: effects of endurance training and resistance training. Clin Exp Pharmacol Physiol 2006; 33: 853-856. (Pubitemid 44215143)
27. Kahn SE, Prigeon RL, Schwartz RS, Fujimoto WY, Knopp RH, Brunzell JD, Porte D: Obesity, body fat distribution, insulin sensitivity and islet beta-cell function as explanations for metabolic diversity. J Nutr 2001; 131: 354S-360S. (Pubitemid 32115380)
28. Bateman L, Slentz C, Willis L, Shields AT, Piner L, Bales C, Houmard J, Kraus W: Comparison of aerobic versus resistance exercise training effects on metabolic syndrome (from the Studies of a Targeted Risk Reduction Intervention Through Defined Exercise-STRRIDE-AT/RT). Am J Cardiol 2011; 108: 838-844.
29. Potteiger J, Claytor R, Hulver M, Hughes M, Carper M, Richmond S, Thyfault J: Resistance exercise and aerobic exercise when paired with dietary energy restriction both reduce the clinical components of metabolic syndrome in previously physically inactive males. Eur J Appl Physiol 2011, Epub ahead of print.
30. Segal KR, Edano A, Abalos A, Albu J, Blando L, Tomas MB, Pi-Sunyer FX: Effect of exercise training on insulin sensitivity and glucose metabolism in lean, obese, and diabetic men. J Appl Physiol 1991; 71: 2402-2411.
31. Kemmler W, Von Stengel S, Engelke K, Kalender W: Exercise decreases the risk of metabolic syndrome in elderly females. Med Sci Sports Exerc 2009; 41: 297-305.
32. Ong K, Tso AWK, Lam KSL, Cherny S, Sham P, Cheung BMY: Using glycosylated hemoglobin to define the metabolic syndrome in United States adults. Diabetes Care 2010; 33: 1856-1858.
33. Houmard JA, Tanner CJ, Slentz CA, Duscha BD, McCartney JS, Kraus WE: Effect of the volume and intensity of exercise training on insulin sensitivity. J Appl Physiol 2004; 96: 101.
34. Cheong S, McCargar L, Paty B, Tudor Locke C, Bell R: The First Step First Bite Program: guidance to increase physical activity and daily intake of low-glycemic index foods. J Am Diet Assoc 2009; 109: 1411-1416.
35. Solomon TPJ, Haus JM, Marchetti CM, Stanley W, Kirwan JP: Effects of exercise training and diet on lipid kinetics during free fatty acid-induced insulin resistance in older obese humans with impaired glucose tolerance. Am J Physiol Endocrinol Metab 2009; 297:E552-E559.
36. Haus JM, Solomon TPJ, Lu L, Jesberger J, Barkoukis H, Flask C, Kirwan JP: Intramyocellular lipid content and insulin sensitivity are increased following a short-term low-glycemic index diet and exercise intervention. Am J Physiol Endocrinol Metab 2011; 301:E511-E516.