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Volumn 44, Issue 6, 2012, Pages 547-551

The effect of monoclonal antibody cetuximab (C225) in combination with tyrosine kinase inhibitor gefitinib (ZD1839) on colon cancer cell lines

Author keywords

Cetuximab; Colon cancer; Drug combinations; Epidermal growth factor receptor; Gefitinib

Indexed keywords


EID: 84866921118     PISSN: 00313025     EISSN: 14653931     Source Type: Journal    
DOI: 10.1097/PAT.0b013e32835817a2     Document Type: Article
Times cited : (9)

References (24)
  • 1
  • 2
    • 0035884307 scopus 로고    scopus 로고
    • Targeting the epidermal growth factor receptor: A clinical reality
    • Baselga J. Targeting the epidermal growth factor receptor: a clinical reality. J Clin Oncol 2001; 19: 41-4.
    • (2001) J Clin Oncol , vol.19 , pp. 41-44
    • Baselga, J.1
  • 3
    • 0037106273 scopus 로고    scopus 로고
    • Targeting the epidermal growth factor receptor for cancer therapy
    • Mendelsohn J. Targeting the epidermal growth factor receptor for cancer therapy. J Clin Oncol 2002; 20: 1-13.
    • (2002) J Clin Oncol , vol.20 , pp. 1-13
    • Mendelsohn, J.1
  • 4
    • 0041629450 scopus 로고    scopus 로고
    • Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer
    • Mendelsohn J, Baselga J. Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer. J Clin Oncol 2003; 21: 2787-99.
    • (2003) J Clin Oncol , vol.21 , pp. 2787-2799
    • Mendelsohn, J.1    Baselga, J.2
  • 5
    • 3442891161 scopus 로고    scopus 로고
    • Dualagent molecular targeting of the epidermal growth factor receptor (EGFR): Combining anti-EGFR antibody with tyrosine kinase inhibitor
    • Huang S, Armstrong EA, Benavente S, et al. Dualagent molecular targeting of the epidermal growth factor receptor (EGFR): combining anti-EGFR antibody with tyrosine kinase inhibitor. Cancer Res 2004; 64: 5355-62.
    • (2004) Cancer Res , vol.64 , pp. 5355-5362
    • Huang, S.1    Armstrong, E.A.2    Benavente, S.3
  • 6
    • 5144229336 scopus 로고    scopus 로고
    • Combined epidermal growth factor receptor targeting with the tyrosine kinase inhibitor gefitinib (ZD1839) and the monoclonal antibody cetuximab (IMC-C225): Superiority singleagent receptor targeting
    • Matar P, Rojo F, Cassia R, et al. Combined epidermal growth factor receptor targeting with the tyrosine kinase inhibitor gefitinib (ZD1839) and the monoclonal antibody cetuximab (IMC-C225): superiority singleagent receptor targeting. Clin Cancer Res 2004; 10: 6487-501.
    • (2004) Clin Cancer Res , vol.10 , pp. 6487-6501
    • Matar, P.1    Rojo, F.2    Cassia, R.3
  • 7
    • 17444378212 scopus 로고    scopus 로고
    • Epidermal growth factor receptor double targeting by a tyrosine kinase inhibitor (Iressa) and a monoclonal antibody (Cetuximab). Impact on cell growth and molecular factors
    • Fischel JL, Formento P, Milano G. Epidermal growth factor receptor double targeting by a tyrosine kinase inhibitor (Iressa) and a monoclonal antibody (Cetuximab). Impact on cell growth and molecular factors. Br J Cancer 2005; 92: 1063-8.
    • (2005) Br J Cancer , vol.92 , pp. 1063-1068
    • Fischel, J.L.1    Formento, P.2    Milano, G.3
  • 8
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
    • Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983; 65: 55-63.
    • (1983) J Immunol Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 9
    • 0021118703 scopus 로고
    • Quantitative analysis of dose-effect relationships: The combined effects ofmultiple drugs or enzyme inhibitors
    • Chou TC, Talalay P. Quantitative analysis of dose-effect relationships: the combined effects ofmultiple drugs or enzyme inhibitors. Adv Enzyme Regul 1984; 22: 27-55.
    • (1984) Adv Enzyme Regul , vol.22 , pp. 27-55
    • Chou, T.C.1    Talalay, P.2
  • 10
    • 0033561522 scopus 로고    scopus 로고
    • Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck
    • Huang SM, Bock JM, Harari PM. Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck. Cancer Res 1999; 59: 1935-40.
    • (1999) Cancer Res , vol.59 , pp. 1935-1940
    • Huang, S.M.1    Bock, J.M.2    Harari, P.M.3
  • 11
    • 0036143027 scopus 로고    scopus 로고
    • Effect of epidermal growth factor receptor tyrosine kinase inhibition on epithelial proliferation in normal and premalignant breast
    • Chan KC, Knox WF, Gee JM, et al. Effect of epidermal growth factor receptor tyrosine kinase inhibition on epithelial proliferation in normal and premalignant breast. Cancer Res 2002; 62: 122-8.
    • (2002) Cancer Res , vol.62 , pp. 122-128
    • Chan, K.C.1    Knox, W.F.2    Gee, J.M.3
  • 12
    • 0036690404 scopus 로고    scopus 로고
    • Effects of the epidermal growth factor receptor inhibitor OSI-774, Tarceva, on downstream signaling pathways and apoptosis in human pancreatic adenocarcinoma
    • Ng SSW, Tsao MS, Nicklee T, et al. Effects of the epidermal growth factor receptor inhibitor OSI-774, Tarceva, on downstream signaling pathways and apoptosis in human pancreatic adenocarcinoma. Mol Cancer Ther 2002; 1: 777-83.
    • (2002) Mol Cancer Ther , vol.1 , pp. 777-783
    • Ssw, N.1    Tsao, M.S.2    Nicklee, T.3
  • 13
    • 0036251746 scopus 로고    scopus 로고
    • Investigation of the prognostic value of coexpressed erbB family members for the survival of colorectal cancer patients after curative surgery
    • Lee JC, Wang ST, Chow NH, et al. Investigation of the prognostic value of coexpressed erbB family members for the survival of colorectal cancer patients after curative surgery. Eur J Cancer 2002; 38: 1065-71.
    • (2002) Eur J Cancer , vol.38 , pp. 1065-1071
    • Lee, J.C.1    Wang, S.T.2    Chow, N.H.3
  • 14
    • 0036228640 scopus 로고    scopus 로고
    • Systemic treatment of colorectal cancer
    • Tebbutt NC, Cattell E, Midgley R, et al. Systemic treatment of colorectal cancer. Eur J Cancer 2002; 38: 1000-15.
    • (2002) Eur J Cancer , vol.38 , pp. 1000-1015
    • Tebbutt, N.C.1    Cattell, E.2    Midgley, R.3
  • 15
    • 0028116305 scopus 로고
    • Antibody-induced epidermal growth factor dimerization mediates inhibition of autocrine proliferation of A431 squamous carcinoma cells
    • Fan Z, Lu Y, Wu X, et al. Antibody-induced epidermal growth factor dimerization mediates inhibition of autocrine proliferation of A431 squamous carcinoma cells. J Biol Chem 1994; 269: 27595-602.
    • (1994) J Biol Chem , vol.269 , pp. 27595-27602
    • Fan, Z.1    Lu, Y.2    Wu, X.3
  • 16
    • 0027442527 scopus 로고
    • Therapeutic potential of chimeric and murine anti-(epidermal growth factor receptor) antibodies in a metastasis model for human melanoma
    • Naramura M, Gillies SD, Mendelsohn J, et al. Therapeutic potential of chimeric and murine anti-(epidermal growth factor receptor) antibodies in a metastasis model for human melanoma. Cancer Immunol Immunother 1993; 37: 343-9.
    • (1993) Cancer Immunol Immunother , vol.37 , pp. 343-349
    • Naramura, M.1    Gillies, S.D.2    Mendelsohn, J.3
  • 17
    • 0037388251 scopus 로고    scopus 로고
    • ZD1839, a specific epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, induces the formation of inactive EGFR/HER2 and EGFR/HER3 heterodimers and prevents heregulin signaling in HER2-overexpressing breast cancer cells
    • Anido J, Matar P, Albanell J, et al. ZD1839, a specific epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, induces the formation of inactive EGFR/HER2 and EGFR/HER3 heterodimers and prevents heregulin signaling in HER2-overexpressing breast cancer cells. Clin Cancer Res 2003; 9: 1274-83.
    • (2003) Clin Cancer Res , vol.9 , pp. 1274-1283
    • Anido, J.1    Matar, P.2    Albanell, J.3
  • 18
    • 0035476803 scopus 로고    scopus 로고
    • The tyrosine kinase inhibitor ZD1839 ('Iressa') inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells
    • Moasser MM, Basso A, Averbuch SD, et al. The tyrosine kinase inhibitor ZD1839 ('Iressa') inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells. Cancer Res 2001; 61: 7184-8.
    • (2001) Cancer Res , vol.61 , pp. 7184-7188
    • Moasser, M.M.1    Basso, A.2    Averbuch, S.D.3
  • 19
    • 0035893560 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (HER1) tyrosine kinase inhibitor ZD1839 (Iressa) inhibits HER2/ Neu(erb-2)-overexpressing breast cancer cells in vitro and in vivo
    • Moulder SL, Yakes M, Muthuswamy SK, et al. Epidermal growth factor receptor (HER1) tyrosine kinase inhibitor ZD1839 (Iressa) inhibits HER2/ Neu(erb-2)-overexpressing breast cancer cells in vitro and in vivo. Cancer Res 2001; 61: 8887-95.
    • (2001) Cancer Res , vol.61 , pp. 8887-8895
    • Moulder, S.L.1    Yakes, M.2    Muthuswamy, S.K.3
  • 20
    • 2142641698 scopus 로고    scopus 로고
    • Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor
    • Saltz LB, Meropol NJ, Loehrer PJ, et al. Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. J Clin Oncol 2004; 22: 1201-8.
    • (2004) J Clin Oncol , vol.22 , pp. 1201-1208
    • Saltz, L.B.1    Meropol, N.J.2    Loehrer, P.J.3
  • 21
    • 0036016095 scopus 로고    scopus 로고
    • ZD1839: Targeting the epidermal growth factor receptor in cancer therapy
    • Herbst RS. ZD1839: targeting the epidermal growth factor receptor in cancer therapy. Expert Opin Investig Drugs 2002; 11: 837-49.
    • (2002) Expert Opin Investig Drugs , vol.11 , pp. 837-849
    • Herbst, R.S.1
  • 22
    • 1842791537 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic properties of EGFR inhibitors under clinical investigation
    • Thomas SM, Grandis Jr. Pharmacokinetic and pharmacodynamic properties of EGFR inhibitors under clinical investigation. Cancer Treat Rev 2004; 30: 255-68.
    • (2004) Cancer Treat Rev , vol.30 , pp. 255-268
    • Thomas, S.M.1    Grandis, J.R.2
  • 23
    • 0034788453 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors: From rational design to clinical trials
    • Traxler P, Bold G, Buchdunger E, et al. Tyrosine kinase inhibitors: from rational design to clinical trials. Med Res Rev 2001; 21: 499-512.
    • (2001) Med Res Rev , vol.21 , pp. 499-512
    • Traxler, P.1    Bold, G.2    Buchdunger, E.3
  • 24
    • 0035939330 scopus 로고    scopus 로고
    • Studies leading to the identification of ZD1839 (IRESSA): An orally active, selective epidermal growth factor receptor tyrosine kinase inhibitor targeted to the treatment of cancer
    • Barker AJ, Gibson KH, Grundy W, et al. Studies leading to the identification of ZD1839 (IRESSA): an orally active, selective epidermal growth factor receptor tyrosine kinase inhibitor targeted to the treatment of cancer. Bioorganic Med Chem Lett 2001; 11: 1911-4.
    • (2001) Bioorganic Med Chem Lett , vol.11 , pp. 1911-1914
    • Barker, A.J.1    Gibson, K.H.2    Grundy, W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.