Functional characterization of enzymes involved in cysteine biosynthesis and H2S production in Trypanosoma cruzi

Molecular and Biochemical Parasitology

Volumn 185, Issue 2, 2012, Pages 114-120

  Marciano, Daniela ^a   Santana, Marianela ^a   Nowicki, Cristina ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Cystathionine synthase; Cystathionine lyase; Cysteine synthase; Transsulfuration pathway; Trypanosoma cruzi

Indexed keywords

CYSTATHIONINE BETA SYNTHASE; CYSTATHIONINE GAMMA LYASE; CYSTEINE SYNTHASE; HOMOCYSTEINE; HYDROGEN SULFIDE; REACTIVE OXYGEN METABOLITE;

AMASTIGOTE; ARTICLE; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME SYNTHESIS; EPIMASTIGOTE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRYPANOSOMA CRUZI;

ANIMALS; CYSTATHIONINE BETA-SYNTHASE; CYSTATHIONINE GAMMA-LYASE; CYSTEINE; CYSTEINE SYNTHASE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; HYDROGEN SULFIDE; KINETICS; LIFE CYCLE STAGES; PROTOZOAN PROTEINS; SULFUR; TRYPANOSOMA CRUZI;

HEXAPODA; MAMMALIA; TRYPANOSOMA CRUZI;

EID: 84866916863     PISSN: 01666851     EISSN: 18729428     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2012.07.009     Document Type: Article

References (29)

1. M.P. Barrett, R.J. Burchmore, A. Stich, J.O. Lazzari, A.C. Frasch, and J.J. Cazzulo The trypanosomiases Lancet 362 2003 1469 1480
2. J. Urbina, and R. Docampo Specific chemotherapy of Chagas disease: controversies and advances Trends in Parasitology 19 2003 495 501
3. R.L. Krauth-Siegel, and M.A. Comini Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism Biochimica et Biophysica Acta 1780 2008 1236 1248
4. T. Nozaki, Y. Shigeta, Y. Saito-Nakano, M. Imada, and W. Kruger Characterization of transsulfuration and cysteine biosynthetic pathways in the protozoan hemoflagelate, Trypanosoma cruzi Journal of Biological Chemistry 276 2001 6516 6523
5. R.A. Williams, G.D. Westrop, and G.H. Coombs Two pathways for cysteine biosynthesis in Leishmania major Biochemical Journal 420 2009 451 462
6. D. Marciano, M. Santana, B.S. Mantilla, A.M. Silber, C. Marino-Buslje, and C. Nowicki Biochemical characterization of serine acetyltransferase and cysteine desulfhydrase from Leishmania major Molecular and Biochemical Parasitology 173 2010 170 174
7. S. Singh, and R. Banerjee PLP-dependent H(2)S biogenesis Biochimica et Biophysica Acta 1814 2011 1518 1527
8. 2S signals through protein S-sulfhydration Science Signaling 2 2009 ra72
9. M.M. Gadalla, and S.H. Snyder Hydrogen sulfide as a gasotransmitter Journal of Neurochemistry 113 2010 14 26
10. 2S: a universal defense against antibiotics in bacteria Science 334 2011 986 990
11. B.M. Franke de Cazzulo, J. Martínez, M.J. North, G.H. Coombs, and J.J. Cazzulo Effects of proteinase inhibitors on the growth and differentiation of Trypanosoma cruzi FEMS Microbiology Letters 124 1994 81 86
12. E. Medina-Acosta, and G.A. Cross Rapid isolation of DNA from trypanosomatid protozoa using a simple 'mini-prep' procedure Molecular and Biochemical Parasitology 59 1993 327 329
13. H. Schägger, and G. von Jagow Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa Analytical Biochemistry 166 1987 368 379
14. M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Analytical Biochemistry 72 1976 248 254
15. R.D.B. Fraser, and E. Suzuki The use of least squares in the data analysis S.J. Leach, Physic princ. and tech. of protein. chem., vol. 21 1973 301 355
16. M. Gaitonde A spectrophotometric method for direct determination of cysteine Biochemical Journal 104 1967 627 633
17. 2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia Journal of Biological Chemistry 284 2009 11601 11612
18. C. Steegborn, T. Clausen, P. Sondermann, U. Jacob, M. Worbs, and S. Marinkovic Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration Journal of Biological Chemistry 274 1999 12675 12684
19. R.A. Da Silva, D.C. Bartholomeu, and S.M.R. Teixeira Control mechanisms of tubulin gene expression in Trypanosoma cruzi International Journal for Parasitology 36 2006 87 96
20. E.W. Miles, and J.P. Kraus Cystathionine β synthase: structure, function, regulation and location of homocystinuria-causing mutations Journal of Biological Chemistry 279 2004 29871 29874
21. M. Wirtz, M. Droux, and R. Hell O-acetylserine (thiol) lyase: an enigmatic enzyme of plant cysteine biosynthesis revisited in Arabidopsis thaliana Journal of Experimental Botany 404 2004 1785 1798
22. 2S biogenesis via alternative trans-sulfuration reactions Journal of Biological Chemistry 284 2009 22457 22466
23. A. Messerschmidt, M. Worbs, C. Steegborn, M.C. Wahl, R. Huber, and B. Laber Determinants of enzymatic specificity in the Cys-Met-metabolism PLP-dependent enzymes family: crystal structure of cystathionine gamma-lyase from yeast and intrafamiliar structure comparison Biological Chemistry 384 2003 373 386
24. 2S Journal of Biological Chemistry 284 2009 3076 3085
25. M. Wirtz, and R. Hell Functional analysis of the cysteine synthase protein complex from plants: structural, biochemical and regulatory properties Journal of Plant Physiology 163 2006 273 286
26. T. Nozaki, T. Asai, S. Kobayashi, F. Ikegami, M. Noji, and K. Saito Molecular cloning and characterization of the genes encoding two isoforms of cysteine synthase in the enteric protozoan parasite Entamoeba histolytica Molecular and Biochemical Parasitology 97 1998 33 44
27. Y. Kimura, and H. Kimura Hydrogen sulfide protects neurons from oxidative stress FASEB Journal 18 2004 1165 1167
28. V. Vitvitsky, E. Mosharov, M. Tritt, F. Ataullakhanov, and R. Banerjee Redox regulation of homocysteine-dependent glutathione synthesis Redox Report 8 2003 57 63
29. A. Parodi-Talice, V. Monteiro-Goes, N. Arrambide, A.R. Avila, R. Duran, and A. Correa Proteomic analysis of metacyclic trypomastigotes undergoing Trypanosoma cruzi metacyclogenesis Journal of Mass Spectrometry 42 2007 1422 1432