Small lymphocytic lymphoma and chronic lymphocytic leukemia: Are they the same disease?

Cancer Journal (United States)

Volumn 18, Issue 5, 2012, Pages 396-403

  Santos, Fabio P S ^a   O'Brien, Susan ^b  

^a HOSPITAL ISRAELITA ALBERT EINSTEIN   (Brazil)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

chronic lymphocytic leukemia; classification; diagnosis; Small lymphocytic lymphoma

Indexed keywords

CD38 ANTIGEN; CHEMOKINE RECEPTOR CCR1; CHEMOKINE RECEPTOR CCR3; INTEGRIN; PROTEIN KINASE ZAP 70;

ANEMIA; CANCER CLASSIFICATION; CANCER PROGNOSIS; CANCER SURVIVAL; CHROMOSOME DELETION 13; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL FEATURE; CYTOGENETICS; CYTOPENIA; DISEASE COURSE; GENE MUTATION; HEPATOMEGALY; HISTOPATHOLOGY; HUMAN; IMMUNOGLOBULIN HEAVY CHAIN GENE; IMMUNOGLOBULIN VARIABLE REGION; LYMPHOCYTOMA; LYMPHOCYTOSIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SPLENOMEGALY; SYSTEMIC DISEASE; THROMBOCYTOPENIA; TRISOMY 12; WORLD HEALTH ORGANIZATION;

B-LYMPHOCYTES; BONE MARROW; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOPHENOTYPING; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; LYMPH NODES; RECEPTORS, CHEMOKINE; WORLD HEALTH ORGANIZATION;

EID: 84866908716     PISSN: 15289117     EISSN: 1540336X     Source Type: Journal    
DOI: 10.1097/PPO.0b013e31826cda2d     Document Type: Review

References (96)

1. Müller-Hermelink HK, Montserrat E, Catovsky D, et al. Chronic lymphocytic leukemia/small lymphocytic lymphoma. In: Swerdlow SH, Campo E, Harris NL, et al, eds. World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues. Lyon, France: IARC Press; 2008:180-182.
2. Hallek M, Cheson BD, Catovsky D, et al. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. Blood. 2008; 111:5446-5456.
3. Dores GM, Anderson WF, Curtis RE, et al. Chronic lymphocytic leukaemia and small lymphocytic lymphoma: overview of the descriptive epidemiology. Br J Haematol. 2007;139:809-819.
4. Viswanatha DS, Montgomery KD, Foucar K. Mature B-cell neoplasms. In: Jaffe ES, Harris NL, Vardiman JW, et al, eds. Hematopathology. St Louis, MO: Sauders Elsevier; 2011.
5. Morrison WH, Hoppe RT, Weiss LM, et al. Small lymphocytic lymphoma. J Clin Oncol. 1989;7:598-606.
6. Armitage JO, Weisenburger DD. New approach to classifying non- Hodgkin's lymphomas: clinical features of the major histologic subtypes. Non-Hodgkin's Lymphoma Classification Project. J Clin Oncol. 1998;16:2780-2795.
7. Tsimberidou AM, Wen S, O'Brien S, et al. Assessment of chronic lymphocytic leukemia and small lymphocytic lymphoma by absolute lymphocyte counts in 2,126 patients: 20 years of experience at the University of Texas M.D. Anderson Cancer Center. J Clin Oncol. 2007; 25:4648-4656.
8. Harris NL, Jaffe ES, Stein H, et al. A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood. 1994;84:1361-1392.
9. National Cancer Institute sponsored study of classifications of non- Hodgkin's lymphomas: summary and description of a working formulation for clinical usage. The Non-Hodgkin's Lymphoma Pathologic Classification Project. Cancer. 1982;49:2112-2135.
10. Groves FD, Linet MS, Travis LB, et al. Cancer surveillance series: non- Hodgkin's lymphoma incidence by histologic subtype in the United States from 1978 through 1995. J Natl Cancer Inst. 2000;92:1240-1251.
11. Groves FD, Linet MS, Devesa SS. Patterns of occurrence of the leukaemias. Eur J Cancer. 1995;31A:941-949.
12. Goldin LR, Slager SL, Caporaso NE. Familial chronic lymphocytic leukemia. Curr Opin Hematol. 2010;17:350-355.
13. Wang SS, Slager SL, Brennan P, et al. Family history of hematopoietic malignancies and risk of non-Hodgkin lymphoma (NHL): a pooled analysis of 10 211 cases and 11 905 controls from the International Lymphoma Epidemiology Consortium (InterLymph). Blood. 2007; 109:3479-3488.
14. Cerhan JR, Janney CA, Vachon CM, et al. Anthropometric characteristics, physical activity, and risk of non-Hodgkin's lymphoma subtypes and B-cell chronic lymphocytic leukemia: a prospective study. Am J Epidemiol. 2002;156:527-535.
15. Pan SY, Mao Y, Ugnat AM, et al. Physical activity, obesity, energy intake, and the risk of non-Hodgkin's lymphoma: a population-based case-control study. Am J Epidemiol. 2005;162:1162-1173.
16. Chen Y, Zheng T, Lan Q, et al. Cytokine polymorphisms in TH1/TH2 pathway genes, body mass index, and risk of non-Hodgkin lymphoma. 2011;117:585-590.
17. Pangalis GA, Nathwani BN, Rappaport H. Malignant lymphoma, well differentiated lymphocytic: its relationship with chronic lymphocytic leukemia and macroglobulinemia of Waldenstrom. Cancer. 1977;39: 999-1010.
18. Evans HL, Butler JJ, Youness EL. Malignant lymphoma, small lymphocytic type: a clinicopathologic study of 84 cases with suggested criteria for intermediate lymphocytic lymphoma. Cancer. 1978;41:1440-1455.
19. Ben-Ezra J, Burke JS, Swartz WG, et al. Small lymphocytic lymphoma: a clinicopathologic analysis of 268 cases. Blood. 1989;73:579-587.
20. Ahmed S, Shahid RK, Sison CP, et al. Orbital lymphomas: a clinicopathologic study of a rare disease. Am J Med Sci. 2006;331:79-83.
21. Fehr M, Templeton A, Cogliatti S, et al. Primary manifestation of small lymphocytic lymphoma in the prostate. Onkologie. 2009;32:586-588.
22. Demirci H, Shields CL, Karatza EC, et al. Orbital lymphoproliferative tumors: analysis of clinical features and systemic involvement in 160 cases. Ophthalmology. 2008;115:1626-1631, 1631e1-1631e3.
23. Carver JD, Calverley D, Shen P. Chronic lymphocytic leukemia/small lymphocytic lymphoma presenting in urinary bladder without peripheral blood lymphocytosis: case report and literature review. Leuk Lymphoma. 2006;47:1163-1165.
24. Rai KR, Sawitsky A, Cronkite EP, et al. Clinical staging of chronic lymphocytic leukemia. Blood. 1975;46:219-234.
25. Zent CS, Ding W, Reinalda MS, et al. Autoimmune cytopenia in chronic lymphocytic leukemia/small lymphocytic lymphoma: changes in clinical presentation and prognosis. Leuk Lymphoma. 2009;50:1261-1268.
26. Kyasa MJ, Parrish RS, Schichman SA, et al. Autoimmune cytopenia does not predict poor prognosis in chronic lymphocytic leukemia/small lymphocytic lymphoma. Am J Hematol. 2003;74:1-8.
27. Cobcroft R. Pure red cell aplasia associated with small lymphocytic lymphoma. Br J Haematol. 2001;113:260.
28. Yin CC, Lin P, Carney DA, et al. Chronic lymphocytic leukemia/small lymphocytic lymphoma associated with IgM paraprotein. Am J Clin Pathol. 2005;123:594-602.
29. Ellison DJ, Nathwani BN, Cho SY, et al. Interfollicular small lymphocytic lymphoma: the diagnostic significance of pseudofollicles. Hum Pathol. 1989;20:1108-1118.
30. Gupta D, Lim MS, Medeiros LJ, et al. Small lymphocytic lymphoma with perifollicular, marginal zone, or interfollicular distribution. Mod Pathol. 2000;13:1161-1166.
31. Tsimberidou AM, Keating MJ. Richter syndrome: biology, incidence, and therapeutic strategies. Cancer. 2005;103:216-228.
32. Matolcsy A, Inghirami G, Knowles DM. Molecular genetic demonstration of the diverse evolution of Richter's syndrome (chronic lymphocytic leukemia and subsequent large cell lymphoma). Blood. 1994;83: 1363-1372.
33. Chan WC, Dekmezian R. Phenotypic changes in large cell transformation of small cell lymphoid malignancies. Cancer. 1986;57:1971-1978.
34. Catrina Reading F, Schlette EJ, Stewart JM, et al. Fine-needle aspiration biopsy findings in patients with small lymphocytic lymphoma transformed to Hodgkin lymphoma. Am J Clin Pathol. 2007;128:571-578.
35. Tsimberidou AM, O'Brien S, Kantarjian HM, et al. Hodgkin transformation of chronic lymphocytic leukemia: the M. D. Anderson Cancer Center experience. Cancer. 2006;107:1294-1302.
36. Fraser CR, Wang W, Gomez M, et al. Transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma to interdigitating dendritic cell sarcoma: evidence for transdifferentiation of the lymphoma clone. Am J Clin Pathol. 2009;132:928-939.
37. Palumbo GA, Parrinello N, Fargione G, et al. CD200 expression may help in differential diagnosis between mantle cell lymphoma and B-cell chronic lymphocytic leukemia. Leuk Res. 2009;33:1212-1216.
38. Batata A, Shen B. Relationship between chronic lymphocytic leukemia and small lymphocytic lymphoma. A comparative study of membrane phenotypes in 270 cases. Cancer. 1992;70:625-632.
39. Braylan RC, Jaffe ES, Mann RB, et al. Surface receptors of human neoplastic lymphoreticular cells. Haematol Blood Transfus. 1977; 20:47-53.
40. Wang CY, Good RA, Ammirati P, et al. Identification of a p69,71 complex expressed on human T cells sharing determinants with B-type chronic lymphatic leukemic cells. J Exp Med. 1980;151:1539-1544.
41. Knowles DM 2nd, Halper JP, Azzo W, et al. Reactivity of monoclonal antibodies Leu1 and OKT1 with malignant human lymphoid cells. Correlation with conventional cell markers. Cancer. 1983;52:1369-1377.
42. Batata A, Shen B. The importance of surface immunoglobulin, mouse rosettes, and CD5 in the immunophenotyping of chronic lymphocytic leukemia and reactive lymphocytosis. Cancer. 1991;68:355-361.
43. Cossman J, Neckers LM, Hsu S, et al. Low-grade lymphomas. Expression of developmentally regulated B-cell antigens. Am J Pathol. 1984; 115:117-124.
44. Batata A, Shen B. Mouse rosettes and surface immunoglobulin in small lymphocytic lymphoma. Importance in immunophenotyping and differential diagnosis. Cancer. 1992;69:1021-1030.
45. Burns BF, Warnke RA, Doggett RS, et al. Expression of a T-cell antigen (Leu-1) by B-cell lymphomas. Am J Pathol. 1983;113:165-171.
46. Dorfman DM, Pinkus GS. Distinction between small lymphocytic and mantle cell lymphoma by immunoreactivity for CD23. Mod Pathol. 1994;7:326-331.
47. Dorfman DM, Shahsafaei A. CD200 (OX-2 membrane glycoprotein) expression in B cell-derived neoplasms. Am J Clin Pathol. 2010;134: 726-733.
48. Dohner H, Stilgenbauer S, Benner A, et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med. 2000;343: 1910-1916.
49. Calin GA, Dumitru CD, Shimizu M, et al. Frequent deletions and downregulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2002;99: 15524-15529.
50. Daudignon A, Poulain S, Morel P, et al. Increased trisomy 12 frequency and a biased IgVH 3-21 gene usage characterize small lymphocytic lymphoma. Leuk Res. 2010;34:580-584.
51. Hamblin TJ, Davis Z, Gardiner A, et al. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood. 1999;94:1848-1854.
52. Thieblemont C, Nasser V, Felman P, et al. Small lymphocytic lymphoma, marginal zone B-cell lymphoma, and mantle cell lymphoma exhibit distinct gene-expression profiles allowing molecular diagnosis. Blood. 2004;103:2727-2737.
53. Rosenwald A, Alizadeh AA, Widhopf G, et al. Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia. J Exp Med. 2001;194:1639-1647.
54. Rawstron AC, Bennett FL, O'Connor SJ, et al. Monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia. N Engl J Med. 2008; 359:575-583.
55. Landgren O, Albitar M, Ma W, et al. B-cell clones as early markers for chronic lymphocytic leukemia. N Engl J Med. 2009;360:659-667.
56. Gibson SE, Swerdlow SH, Ferry JA, et al. Reassessment of small lymphocytic lymphoma in the era of monoclonal B-cell lymphocytosis. Haematologica. 2011;96:1144-1152.
57. Gribben JG, O'Brien S. Update on therapy of chronic lymphocytic leukemia. J Clin Oncol. 2011;29:544-550.
58. DimopoulouMN, AngelopoulouMK, Vassilakopoulos TP, et al. B-chronic lymphocytic leukemia (B-CLL), small lymphocytic lymphoma (SLL) and Waldenstrom's macroglobulinemia (MW): a comparative fish analysis [abstract]. Blood. 2004;104:Abstract 4801.
59. Autio K, Aalto Y, Franssila K, et al. Low number of DNA copy number changes in small lymphocytic lymphoma. Haematologica. 1998;83: 690-692.
60. Stokke T, DeAngelis P, Smedshammer L, et al. Loss of chromosome 11q21-23.1 and 17p and gain of chromosome 6p are independent prognostic indicators in B-cell non-Hodgkin's lymphoma. Br J Cancer. 2001;85:1900-1913.
61. Balatti V, Bottoni A, Palamarchuk A, et al. NOTCH1 mutations in CLL associated with trisomy 12. Blood. 2012;119:329-331.
62. Lopez C, Delgado J, Costa D, et al. Different distribution of NOTCH1 mutations in chronic lymphocytic leukemia with isolated trisomy 12 or associated with other chromosomal alterations. Genes Chromosomes Cancer. 2012;51:881-889.
63. Del Giudice I, Rossi D, Chiaretti S, et al. NOTCH1 mutations in +12 chronic lymphocytic leukemia (CLL) confer an unfavorable prognosis, induce a distinctive transcriptional profiling and refine the intermediate prognosis of +12 CLL. Haematologica. 2012;97:437-441.
64. Thorselius M, Krober A, Murray F, et al. Strikingly homologous immunoglobulin gene rearrangements and poor outcome in VH3-21-using chronic lymphocytic leukemia patients independent of geographic origin and mutational status. Blood. 2006;107:2889-2894.
65. Howard M, Grimaldi JC, Bazan JF, et al. Formation and hydrolysis of cyclic ADP-ribose catalyzed by lymphocyte antigen CD38. Science. 1993;262:1056-1059.
66. Zupo S, Rugari E, Dono M, et al. CD38 signaling by agonistic monoclonal antibody prevents apoptosis of human germinal center B cells. Eur J Immunol. 1994;24:1218-1222.
67. Funaro A, Morra M, Calosso L, et al. Role of the human CD38 molecule in B cell activation and proliferation. Tissue Antigens. 1997;49:7-15.
68. Damle RN, Wasil T, Fais F, et al. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood. 1999;94:1840-1847.
69. Ibrahim S, Keating M, Do KA, et al. CD38 expression as an important prognostic factor in B-cell chronic lymphocytic leukemia. Blood. 2001; 98:181-186.
70. Malavasi F, Deaglio S, Damle R, et al. CD38 and chronic lymphocytic leukemia: a decade later. Blood. 2011;118:3470-3478.
71. Vaisitti T, Aydin S, Rossi D, et al. CD38 increases CXCL12-mediated signals and homing of chronic lymphocytic leukemia cells. Leukemia. 2010;24:958-969.
72. Jaksic O, Paro MM, Kardum Skelin I, et al. CD38 on B-cell chronic lymphocytic leukemia cells has higher expression in lymph nodes than in peripheral blood or bone marrow. Blood. 2004;103:1968-1969.
73. Cyster JG. Chemokines and cell migration in secondary lymphoid organs. Science. 1999;286:2098-2102.
74. Burger JA. Nurture versus nature: the microenvironment in chronic lymphocytic leukemia. Hematol Am Soc Hematol Educ Prog. 2011; 2011:96-103.
75. Wong S, Fulcher D. Chemokine receptor expression in B-cell lymphoproliferative disorders. Leuk Lymphoma. 2004;45:2491-2496.
76. Forster R, Schubel A, Breitfeld D, et al. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell. 1999;99:23-33.
77. Ghobrial IM, Bone ND, Stenson MJ, et al. Expression of the chemokine receptors CXCR4 and CCR7 and disease progression in B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma. Mayo Clin Proc. 2004;79:318-325.
78. Trentin L, Cabrelle A, Facco M, et al. Homeostatic chemokines drive migration of malignant B cells in patients with non-Hodgkin lymphomas. Blood. 2004;104:502-508.
79. Barczyk M, Carracedo S, Gullberg D. Integrins. Cell Tissue Res. 2010; 339:269-280.
80. Pals ST, den Otter A, Miedema F, et al. Evidence that leukocyte function- associated antigen-1 is involved in recirculation and homing of human lymphocytes via high endothelial venules. J Immunol. 1988; 140:1851-1853.
81. InghiramiG,WieczorekR,ZhuBY, et al. Differential expression of LFA-1 molecules in non-Hodgkin's lymphoma and lymphoid leukemia Blood. 1988;72:1431-1434.
82. Pinto A, Carbone A, Gloghini A, et al. Differential expression of cell adhesion molecules in B-zone small lymphocytic lymphoma and other well-differentiated lymphocytic disorders. Cancer. 1993;72:894-904.
83. Domingo A, Gonzalez-Barca E, Castellsague X, et al. Expression of adhesion molecules in 113 patients with B-cell chronic lymphocytic leukemia: relationship with clinico-prognostic features. Leuk Res. 1997;21:67-73.
84. De Paoli P, Basaglia G, Gennari D, et al. Differential expression of LFA-1 alpha molecule in clinical stages of chronic B-lymphocytic leukemia patients. Eur J Haematol. 1990;45:234-235.
85. Shanafelt TD, Geyer SM, Bone ND, et al. CD49d expression is an independent predictor of overall survival in patients with chronic lymphocytic leukaemia: a prognostic parameter with therapeutic potential. Br J Haematol. 2008;140:537-546.
86. Zucchetto A, Bomben R, Dal Bo M, et al. CD49d in B-cell chronic lymphocytic leukemia: correlated expression with CD38 and prognostic relevance. Leukemia. 2006;20:523-525; author reply 528-529.
87. Gattei V, Bulian P, Del Principe MI, et al. Relevance of CD49d protein expression as overall survival and progressive disease prognosticator in chronic lymphocytic leukemia. Blood. 2008;111:865-873.
88. Elices MJ, Osborn L, Takada Y, et al. VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site. Cell. 1990;60:577-584.
89. Burger JA, Burger M, Kipps TJ. Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells. Blood. 1999;94: 3658-3667.
90. de la Fuente MT, Casanova B, Moyano JV, et al. Engagement of alpha4beta1 integrin by fibronectin induces in vitro resistance of B chronic lymphocytic leukemia cells to fludarabine. J Leukoc Biol. 2002;71:495-502.
91. de la Fuente MT, Casanova B, Garcia-Gila M, et al. Fibronectin interaction with alpha4beta1 integrin prevents apoptosis in B cell chronic lymphocytic leukemia: correlation with Bcl-2 and Bax. Leukemia. 1999; 13:266-274.
92. Shanafelt TD, Hanson C, Dewald GW, et al. Karyotype evolution on fluorescent in situ hybridization analysis is associated with short survival in patients with chronic lymphocytic leukemia and is related to CD49d expression. J Clin Oncol. 2008;26:e5Ye6.
93. Alimzhanov MB, Kuprash DV, Kosco-Vilbois MH, et al. Abnormal development of secondary lymphoid tissues in lymphotoxin beta-deficient mice. Proc Natl Acad Sci U S A. 1997;94:9302-9307.
94. Nagy B, Ferrer A, Larramendy ML, et al. Lymphotoxin beta expression is high in chronic lymphocytic leukemia but low in small lymphocytic lymphoma: a quantitative real-time reverse transcriptase polymerase chain reaction analysis. Haematologica. 2003;88:654-658.
95. Wang L, Lawrence MS, Wan Y, et al. SF3B1 and other novel cancer genes in chronic lymphocytic leukemia. N Engl J Med. 2011;365: 2497-2506.
96. Trbusek M, Stano-Kozubik K, Malcikova J, et al. Deep sequencing identifies TP53 mutations before their clonal selection by therapy in chronic lymphocytic leukemia. Presented at the Annual Meeting of the European Hematology Association 2012. Abstract 0578.