Phase II study of consolidation chemotherapy after adjuvant or primary concurrent chemoradiation using paclitaxel and carboplatin to treat high-risk early-stage or locally advanced cervical cancer

Cancer Research and Treatment

Volumn 44, Issue 2, 2012, Pages 97-103

  Kim, Hee Seung ^a   Kim, Mi Kyung ^a   Kim, Hak Jae ^a   Han, Seung Su ^b   Kim, Jae Weon ^a  

^a Seoul National University College of Medicine   (South Korea)

^b Chung Ang University College of Medicine   (South Korea)

Author keywords

Carboplatin; Chemoradiotherapy; Consolidation chemotherapy; Paclitaxel; Uterine cervical neoplasms

Indexed keywords

CARBOPLATIN; PACLITAXEL;

ADJUVANT THERAPY; ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER ADJUVANT THERAPY; CANCER PATIENT; CANCER STAGING; CANCER SURGERY; CHEMORADIOTHERAPY; CHEMOTHERAPY INDUCED NAUSEA AND VOMITING; CLINICAL ARTICLE; CONSOLIDATION CHEMOTHERAPY; CONSTIPATION; CONTROLLED STUDY; CYSTITIS; DIARRHEA; DRUG EFFICACY; EXTERNAL BEAM RADIOTHERAPY; FEMALE; FEVER; HEMATURIA; HIGH RISK PATIENT; HUMAN; LEUKOPENIA; MULTIMODALITY CANCER THERAPY; MULTIPLE CYCLE TREATMENT; NEUTROPENIA; OVERALL SURVIVAL; PERIPHERAL NEUROPATHY; PHASE 2 CLINICAL TRIAL; PROGRESSION FREE SURVIVAL; TREATMENT RESPONSE; UTERINE CERVIX CANCER;

EID: 84866893998     PISSN: 15982998     EISSN: 20059256     Source Type: Journal    
DOI: 10.4143/crt.2012.44.2.97     Document Type: Article

References (23)

1. Suh DH, Kim JW, Kim K, Kang SB. Major clinical research advances in gynecologic cancer in 2010. J Gynecol Oncol. 2010;21:209-18.
2. National Comprehensive Cancer Network. Cervical cancer clinical practice guidelines in oncology (v.I.2011) [Internet]. Fort Washington, PA: National Comprehensive Cancer Network; [cited 2010 Dec 24]. Available from: http://www.Nccn.Org.
3. Green JA, Kirwan JM, Tierney JF, Symonds P, Fresco L, Collingwood M, et al. Survival and recurrence after concomitant chemotherapy and radiotherapy for cancer of the uterine cervix: a systematic review and meta-analysis. Lancet. 2001;358:781-6.
4. Rose PG, Bundy BN, Watkins EB, Thigpen JT, Deppe G, Maiman MA, et al. Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. N Engl J Med. 1999;340:1144-53.
5. Petera J, Odraózka K, Frgala T, Spacek J. External beam radiotherapy and high-dose brachytherapy combined with cisplatin and paclitaxel in patients with advanced cervical carcinoma. Gynecol Oncol. 2005;99:334-8.
6. Kim YS, Shin SS, Nam JH, Kim YT, Kim YM, Kim JH, et al. Prospective randomized comparison of monthly fluorouracil and cisplatin versus weekly cisplatin concurrent with pelvic radiotherapy and high-dose rate brachytherapy for locally advanced cervical cancer. Gynecol Oncol. 2008;108:195-200.
7. Vrdoljak E, Prskalo T, Omrcen T, Situm K, Boraska T, Frleta Ilic N, et al. Concomitant chemobrachyradiotherapy with ifosfamide and cisplatin followed by consolidation chemotherapy in locally advanced squamous cell carcinoma of the uterine cervix: results of a phase II study. Int J Radiat Oncol Biol Phys. 2005;61:824-9.
8. Chung YL, Jian JJ, Cheng SH, Hsieh CI, Tan TD, Chang HJ, et al. Extended-field radiotherapy and high-dose-rate brachytherapy with concurrent and adjuvant cisplatin-based chemotherapy for locally advanced cervical cancer: a phase I/II study. Gynecol Oncol. 2005;97:126-35.
9. Choi CH, Lee JW, Kim TJ, Kim WY, Nam HR, Kim BG, et al. Phase II study of consolidation chemotherapy after concurrent chemoradiation in cervical cancer: preliminary results. Int J Radiat Oncol Biol Phys. 2007;68:817-22.
10. Ozols RF, Bundy BN, Greer BE, Fowler JM, Clarke-Pearson D, Burger RA, et al. Phase III trial of carboplatin and paclitaxel compared with cisplatin and paclitaxel in patients with optimally resected stage III ovarian cancer: a Gynecologic Oncology Group study. J Clin Oncol. 2003;21:3194-200.
11. Piccart MJ, Bertelsen K, James K, Cassidy J, Mangioni C, Simonsen E, et al. Randomized intergroup trial of cisplatin-paclitaxel versus cisplatin-cyclophosphamide in women with advanced epithelial ovarian cancer: three-year results. J Natl Cancer Inst. 2000;92:699-708.
12. Saito I, Kitagawa R, Fukuda H, Shibata T, Katsumata N, Konishi I, et al. A phase III trial of paclitaxel plus carboplatin versus paclitaxel plus cisplatin in stage IVB, persistent or recurrent cervical cancer: Gynecologic Cancer Study Group/Japan Clinical Oncology Group Study (JCOG0505). Jpn J Clin Oncol. 2010;40:90-3.
13. Korean Gynecologic Oncology Group. A phase II trial of radiation therapy with concurrent paclitaxel/carboplatin chemotherapy in high-risk cervical cancer patients after radical hysterectomy [Internet]. ClinicalTrials.gov; [cited 2012 Jan 18]. Available from: http://clinicaltrialgov/ct2/show/NCT00340184?term=paclitaxel+and+carboplatin+and+concurrent+chemorad iation+and+cervical+cancer&rank=2.
14. Kim K, Chie EK, Wu HG, Ha SW, Kim JS, Kim IA, et al. Efficacy of paclitaxel and carboplatin as a regimen for postoperative concurrent chemoradiotherapy of high risk uterine cervix cancer. Gynecol Oncol. 2006;101:398-402.
15. Lee MY, Wu HG, Kim K, Ha SW, Kim JS, Kim IA, et al. Concurrent radiotherapy with paclitaxel/carboplatin chemotherapy as a definitive treatment for squamous cell carcinoma of the uterine cervix. Gynecol Oncol. 2007;104:95-9.
16. Therasse P, Arbuck SG, Eisenhauer EA, Wanders J, Kaplan RS, Rubinstein L, et al. New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst. 2000;92:205-16.
17. de Vos FY, Bos AM, Gietema JA, Pras E, Van der Zee AG, de Vries EG, et al. Paclitaxel and carboplatin concurrent with radiotherapy for primary cervical cancer. Anticancer Res. 2004;24:345-8.
18. Peters WA 3rd, Liu PY, Barrett RJ 2nd, Stock RJ, Monk BJ, Berek JS, et al. Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early-stage cancer of the cervix. J Clin Oncol. 2000;18:1606-13.
19. Zhang MQ, Liu SP, Wang XE. Concurrent chemoradiotherapy with paclitaxel and nedaplatin followed by consolidation chemotherapy in locally advanced squamous cell carcinoma of the uterine cervix: preliminary results of a phase II study. Int J Radiat Oncol Biol Phys. 2010;78:821-7.
20. Wang X, Liu R, Ma B, Yang K, Tian J, Jiang L, et al. High dose rate versus low dose rate intracavity brachytherapy for locally advanced uterine cervix cancer. Cochrane Database Syst Rev. 2010;(7):CD007563.
21. Monk BJ, Sill MW, McMeekin DS, Cohn DE, Ramondetta LM, Boardman CH, et al. Phase III trial of four cisplatin-containing doublet combinations in stage IVB, recurrent, or persistent cervical carcinoma: a Gynecologic Oncology Group study. J Clin Oncol. 2009;27:4649-55.
22. Kitagawa R, Katsumata N, Yamanaka Y, Ando M, Fujiwara Y, Kasamatsu T. Phase II trial of paclitaxel and carboplatin in patients with recurrent or metastatic cervical carcinoma. J Clin Oncol. 2004;22(14S):5048.
23. Higgins R, Bussey M, Naumann W, Hall J, Tait D, Haake M. Concurrent carboplatin and paclitaxel with pelvic radiation therapy in the primary treatment of cervical cancer. Am J Obstet Gynecol. 2007;197:205.e1-5.