Prospective randomized comparison of monthly fluorouracil and cisplatin versus weekly cisplatin concurrent with pelvic radiotherapy and high-dose rate brachytherapy for locally advanced cervical cancer

Gynecologic Oncology

Volumn 108, Issue 1, 2008, Pages 195-200

  Kim, Young Seok ^a   Shin, Seong Soo ^a   Nam, Joo Hyun ^a   Kim, Young Tak ^a   Kim, Yong Man ^a   Kim, Jong Hoon ^a   Choi, Eun Kyung ^a  

^a Asan Medical Center   (South Korea)

Author keywords

Cervical cancer; Chemoradiotherapy

Indexed keywords

CISPLATIN; FLUOROURACIL;

ACUTE TOXICITY; ADULT; ADVANCED CANCER; AGED; ARTICLE; BRACHYTHERAPY; CANCER COMBINATION CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER SURVIVAL; CHRONIC TOXICITY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; EXTERNAL BEAM RADIOTHERAPY; FEMALE; FOLLOW UP; GASTROINTESTINAL TOXICITY; HEMATOLOGIC DISEASE; HUMAN; MAJOR CLINICAL STUDY; MULTIPLE CYCLE TREATMENT; OVERALL SURVIVAL; PARAAORTIC LYMPH NODE; PATIENT COMPLIANCE; PELVIS; PRIORITY JOURNAL; RADIATION DOSE; RANDOMIZED CONTROLLED TRIAL; SURVIVAL RATE; SURVIVAL TIME; TREATMENT DURATION; TREATMENT OUTCOME; TREATMENT PLANNING; URINARY TRACT DISEASE; UROGENITAL TRACT DISEASE; UTERINE CERVIX CANCER;

ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BRACHYTHERAPY; CISPLATIN; COMBINED MODALITY THERAPY; DISEASE-FREE SURVIVAL; DRUG ADMINISTRATION SCHEDULE; FEMALE; FLUOROURACIL; FOLLOW-UP STUDIES; HUMANS; MIDDLE AGED; NEOPLASM STAGING; PATIENT COMPLIANCE; TREATMENT OUTCOME; UTERINE CERVICAL NEOPLASMS;

EID: 37349003352     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2007.09.022     Document Type: Article

References (19)

1. Keys H.M., Bundy B.N., Stehman F.B., Muderspach L.I., Chafe W.E., Suggs III C.L., et al. Cisplatin, radiation, and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage IB cervical carcinoma. N Engl J Med 340 (1999) 1154-1161
2. Morris M., Eifel P.J., Lu J., Grigsby P.W., Levenback C., Stevens R.E., et al. Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high-risk cervical cancer. N Engl J Med 340 (1999) 1137-1143
3. Peters III W.A., Liu P.Y., Barrett II R.J., Stock R.J., Monk B.J., Berek J.S., et al. Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early-stage cancer of the cervix. J Clin Oncol 18 (2000) 1606-1613
4. Rose P.G., Bundy B.N., Watkins E.B., Thigpen J.T., Deppe G., Maiman M.A., et al. Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. N Engl J Med 340 (1999) 1144-1153
5. Whitney C.W., Sause W., Bundy B.N., Malfetano J.H., Hannigan E.V., Fowler Jr. W.C., et al. Randomized comparison of fluorouracil plus cisplatin versus hydroxyurea as an adjunct to radiation therapy in stage IIB-IVA carcinoma of the cervix with negative para-aortic lymph nodes: a Gynecologic Oncology Group and Southwest Oncology Group study. J Clin Oncol 17 (1999) 1339-1348
6. Lanciano R., Calkins A., Bundy B.N., Parham G., Lucci III J.A., Moore D.H., et al. Randomized comparison of weekly cisplatin or protracted venous infusion of fluorouracil in combination with pelvic radiation in advanced cervix cancer: a gynecologic oncology group study. J Clin Oncol 23 (2005) 8289-8295
7. Ikushima H., Osaki K., Furutani S., Yamashita K., Kawanaka T., Kishida Y., et al. Chemoradiation therapy for cervical cancer: toxicity of concurrent weekly cisplatin. Radiat Med 24 (2006) 115-121
8. Poti Z., Patyanik M., and Nemeskeri C. Radiochemotherapy of cervical carcinoma. (Necessity of dose reduction in chemotherapy). Orv Hetil 147 (2006) 1315-1320
9. Nyongesa C., Ruff P., Donde B., and Kotzen J. A phase I study of concurrent cisplatin chemotherapy in patients with carcinoma of the cervix receiving pelvic radiotherapy. Int J Gynecol Cancer 16 (2006) 1614-1619
10. Watanabe Y., Nakai H., Shimaoka M., Tobiume T., Tsuji I., and Hoshiai H. Feasibility of concurrent cisplatin use during primary and adjuvant chemoradiation therapy: a phase I study in Japanese patients with cancer of the uterine cervix. Int J Clin Oncol 11 (2006) 309-313
11. Souhami L., Seymour R., Roman T.N., Stanimir G.W., Trudeau M., Clark B.G., et al. Weekly cisplatin plus external beam radiotherapy and high dose rate brachytherapy in patients with locally advanced carcinoma of the cervix. Int J Radiat Oncol Biol Phys 27 (1993) 871-878
12. Chen S.W., Liang J.A., Hung Y.C., Yeh L.S., Chang W.C., Lin W.C., et al. Concurrent weekly cisplatin plus external beam radiotherapy and high-dose rate brachytherapy for advanced cervical cancer: a control cohort comparison with radiation alone on treatment outcome and complications. Int J Radiat Oncol Biol Phys 66 (2006) 1370-1377
13. Chung Y.L., Jian J.J., Cheng S.H., Hsieh C.I., Tan T.D., Chang H.J., et al. Extended-field radiotherapy and high-dose-rate brachytherapy with concurrent and adjuvant cisplatin-based chemotherapy for locally advanced cervical cancer: a phase I/II study. Gynecol Oncol 97 (2005) 126-135
14. Sood B.M., Gorla G., Gupta S., Garg M., Deore S., Runowicz C.D., et al. Two fractions of high-dose-rate brachytherapy in the management of cervix cancer: clinical experience with and without chemotherapy. Int J Radiat Oncol Biol Phys 53 (2002) 702-706
15. Strauss H.G., Kuhnt T., Laban C., Puschmann D., Pigorsch S., Dunst J., et al. Chemoradiation in cervical cancer with cisplatin and high-dose rate brachytherapy combined with external beam radiotherapy. Results of a phase-II study. Strahlenther Onkol 178 (2002) 378-385
16. Kaplan E.L., and Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 53 (1958) 457-481
17. Mantel N. Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother Rep 50 (1966) 163-170
18. Fyles A.W., Pintilie M., Kirkbride P., Levin W., Manchul L.A., and Rawlings G.A. Prognostic factors in patients with cervix cancer treated by radiation therapy: results of a multiple regression analysis. Radiother Oncol 35 (1995) 107-117
19. Serkies K., and Jassem J. Concurrent weekly cisplatin and radiotherapy in routine management of cervical cancer: a report on patient compliance and acute toxicity. Int J Radiat Oncol Biol Phys 60 (2004) 814-821