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Volumn 27, Issue 10, 2012, Pages 1302-1307

Childhood medulloblastoma: The paradigm shift in molecular stratification and treatment profile

Author keywords

medulloblastoma; molecular subgroup classification; pediatric

Indexed keywords

MEMBRANE PROTEIN; SHH PROTEIN; UNCLASSIFIED DRUG; VISMODEGIB; WNT PROTEIN;

EID: 84866873464     PISSN: 08830738     EISSN: 17088283     Source Type: Journal    
DOI: 10.1177/0883073812449690     Document Type: Review
Times cited : (14)

References (26)
  • 1
    • 34347207046 scopus 로고    scopus 로고
    • 4th ed. Lyon, France: International Agency for Research on Cancer; 2007. Lyon, France: International Agency for Research on Cancer;
    • Louis DN WHO Classification of Tumors of the Central Nervous System. 4 th ed. Lyon, France: International Agency for Research on Cancer; 2007. Lyon, France: International Agency for Research on Cancer ; 2007:
    • (2007) WHO Classification of Tumors of the Central Nervous System
    • Louis, D.N.1
  • 2
    • 77956227746 scopus 로고    scopus 로고
    • Childhood medulloblastoma: Novel approaches to the classification of a heterogeneous disease
    • Ellison DW. Childhood medulloblastoma: novel approaches to the classification of a heterogeneous disease. Acta Neuropathol. 2010 ; 120 (3). 305-316
    • (2010) Acta Neuropathol , vol.120 , Issue.3 , pp. 305-316
    • Ellison, D.W.1
  • 3
    • 79953146403 scopus 로고    scopus 로고
    • Predicting relapse in patients with medulloblastoma by integrating evidence from clinical and genomic features
    • Tamayo P, Cho Y, Tsherniak A, et al. Predicting relapse in patients with medulloblastoma by integrating evidence from clinical and genomic features. J Clin Oncol. 2011 ; 29 (11). 1415-1423
    • (2011) J Clin Oncol , vol.29 , Issue.11 , pp. 1415-1423
    • Tamayo, P.1    Cho, Y.2    Tsherniak, A.3
  • 4
    • 52449119078 scopus 로고    scopus 로고
    • Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features
    • Kool M, Koster J, Bunt J, et al. Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features. PLoS ONE. 2008 ; 3 (8). e3088
    • (2008) PLoS ONE , vol.3 , Issue.8 , pp. 3088
    • Kool, M.1    Koster, J.2    Bunt, J.3
  • 5
    • 79951910309 scopus 로고    scopus 로고
    • Survival and prognostic factors of early childhood medulloblastoma: An international meta-analysis
    • Rutowski S, von Hoff K, Emser A, et al. Survival and prognostic factors of early childhood medulloblastoma: an international meta-analysis. J Clin Oncol. 2010 ; 28 ((33)). 4961-4968
    • (2010) J Clin Oncol , vol.28 , Issue.33 , pp. 4961-4968
    • Rutowski, S.1    Von Hoff, K.2    Emser, A.3
  • 6
    • 79954428982 scopus 로고    scopus 로고
    • Risk stratification of medulloblastoma: A paradigm for future childhood brain tumor management strategies
    • Packer RJ. Risk stratification of medulloblastoma: a paradigm for future childhood brain tumor management strategies. Curr Neurol Neurosci Rep. 2011 ; 11 ((2)). 124-126
    • (2011) Curr Neurol Neurosci Rep , vol.11 , Issue.2 , pp. 124-126
    • Packer, R.J.1
  • 7
    • 78650811198 scopus 로고    scopus 로고
    • Subtypes of medulloblastoma have distinct developmental origins
    • Gibson P, Tong Y, Robinson G, et al. Subtypes of medulloblastoma have distinct developmental origins. Nature. 2010 ; 468 (7327). 1095-1099
    • (2010) Nature , vol.468 , Issue.7327 , pp. 1095-1099
    • Gibson, P.1    Tong, Y.2    Robinson, G.3
  • 8
    • 80051665525 scopus 로고    scopus 로고
    • Mutations in CDON, encoding a hedgehog receptor, result in holoprosencephaly and defective interactions with other hedgehog receptors
    • Bae G, Domene S, Roessler E, et al. Mutations in CDON, encoding a hedgehog receptor, result in holoprosencephaly and defective interactions with other hedgehog receptors. Am J Hum Genet. 2011 ; 89 (2). 231-240
    • (2011) Am J Hum Genet , vol.89 , Issue.2 , pp. 231-240
    • Bae, G.1    Domene, S.2    Roessler, E.3
  • 9
    • 77954397956 scopus 로고    scopus 로고
    • The cellular and developmental biology of medulloblastoma current perspectives on experimental therapeutics
    • Srivastava VK, Nalbantoglu J. The cellular and developmental biology of medulloblastoma current perspectives on experimental therapeutics. Cancer Biol Ther. 2010 ; 9 (11). 843-852
    • (2010) Cancer Biol Ther , vol.9 , Issue.11 , pp. 843-852
    • Srivastava, V.K.1    Nalbantoglu, J.2
  • 10
    • 77955453157 scopus 로고    scopus 로고
    • Medulloblastoma: A disease with disorganized developmental signaling cascades
    • Baryawno N, Sveinbjornsson B, Kogner PV, Johnson JI. Medulloblastoma: a disease with disorganized developmental signaling cascades. Cell Cycle. 2010 ; 9 (13). 2548-2554
    • (2010) Cell Cycle , vol.9 , Issue.13 , pp. 2548-2554
    • Baryawno, N.1    Sveinbjornsson, B.2    Kogner, P.V.3    Johnson, J.I.4
  • 11
    • 73249116358 scopus 로고    scopus 로고
    • Medulloblastoma: Role of developmental pathways, DNA repair signaling and other players
    • Saran A. Medulloblastoma: role of developmental pathways, DNA repair signaling and other players. Curr Mol Med. 2009 ; 9 ((9)). 1046-1057
    • (2009) Curr Mol Med , vol.9 , Issue.9 , pp. 1046-1057
    • Saran, A.1
  • 12
    • 58149301313 scopus 로고    scopus 로고
    • Cerebellar granule cells: Insights into proliferation, differentiation, and role in medulloblastoma pathogenesis
    • Behesti H, Marino S. Cerebellar granule cells: insights into proliferation, differentiation, and role in medulloblastoma pathogenesis. Int J Biochem Cell Biol. 2009 ; 41 (3). 435-445
    • (2009) Int J Biochem Cell Biol , vol.41 , Issue.3 , pp. 435-445
    • Behesti, H.1    Marino, S.2
  • 13
  • 14
    • 79958127479 scopus 로고    scopus 로고
    • Heterogeneity of familial medulloblastoma and contribution of germline PTCH1 and SUFU mutations to sporadic medulloblastoma
    • Slade I, Murray A, Hanks S, et al. Heterogeneity of familial medulloblastoma and contribution of germline PTCH1 and SUFU mutations to sporadic medulloblastoma. Fam Cancer. 2011 ; 10 ((2)). 337-342
    • (2011) Fam Cancer , vol.10 , Issue.2 , pp. 337-342
    • Slade, I.1    Murray, A.2    Hanks, S.3
  • 15
    • 79955034739 scopus 로고    scopus 로고
    • Medulloblastoma comprises four distinct molecular variants
    • Northcott PA, Korshunov A, Witt H, et al. Medulloblastoma comprises four distinct molecular variants. J Clin Oncol. 2011 ; 29 ((11)). 1408-1414
    • (2011) J Clin Oncol , vol.29 , Issue.11 , pp. 1408-1414
    • Northcott, P.A.1    Korshunov, A.2    Witt, H.3
  • 16
    • 33646362581 scopus 로고    scopus 로고
    • Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations
    • Thompson MC, Fuller C, Hogg TL, et al. Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations. J Clin Oncol. 2006 ; 24 (12). 1924-1931
    • (2006) J Clin Oncol , vol.24 , Issue.12 , pp. 1924-1931
    • Thompson, M.C.1    Fuller, C.2    Hogg, T.L.3
  • 17
    • 79954991010 scopus 로고    scopus 로고
    • Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome
    • Cho YJ, Tsherniak A, Tamayo P, et al. Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome. J Clin Oncol. 2010 ; 29 (11). 1424-1430
    • (2010) J Clin Oncol , vol.29 , Issue.11 , pp. 1424-1430
    • Cho, Y.J.1    Tsherniak, A.2    Tamayo, P.3
  • 18
    • 79954992066 scopus 로고    scopus 로고
    • Definition of disease-risk stratification groups in childhood medulloblastoma using combined clinical, pathologic and molecular variables
    • Ellison DW, Kocak M, Dalton J, et al. Definition of disease-risk stratification groups in childhood medulloblastoma using combined clinical, pathologic and molecular variables. J Clin Oncol. 2011 ; 29 (11). 1400-1407
    • (2011) J Clin Oncol , vol.29 , Issue.11 , pp. 1400-1407
    • Ellison, D.W.1    Kocak, M.2    Dalton, J.3
  • 19
    • 79954444747 scopus 로고    scopus 로고
    • Medulloblastoma: Clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroups
    • Ellison DW, Dalton J, Kocak M, et al. Medulloblastoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroups. Acta Neuropathol. 2011 ; 121 ((3)). 381-396
    • (2011) Acta Neuropathol , vol.121 , Issue.3 , pp. 381-396
    • Ellison, D.W.1    Dalton, J.2    Kocak, M.3
  • 20
    • 84860821444 scopus 로고    scopus 로고
    • Molecular subgroups of medulloblastoma: The current consensus
    • Taylor MD, Northcott PA, Korshunov A, et al. Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol. 2012 ; 123 (4). 465-472
    • (2012) Acta Neuropathol , vol.123 , Issue.4 , pp. 465-472
    • Taylor, M.D.1    Northcott, P.A.2    Korshunov, A.3
  • 21
    • 70349244812 scopus 로고    scopus 로고
    • Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449
    • Rudin CM, Hann CL, Laterra J, et al. Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449. N Engl J Med. 2009 ; 361 (12). 1173-1178
    • (2009) N Engl J Med , vol.361 , Issue.12 , pp. 1173-1178
    • Rudin, C.M.1    Hann, C.L.2    Laterra, J.3
  • 22
    • 20444468917 scopus 로고    scopus 로고
    • Targeting medulloblastoma: Small-molecule inhibitors of the sonic hedgehog pathway as potential therapeutics
    • Romer J, Curran T. Targeting medulloblastoma: small-molecule inhibitors of the sonic hedgehog pathway as potential therapeutics. Cancer Res. 2005 ; 65 (12). 4975-4978
    • (2005) Cancer Res , vol.65 , Issue.12 , pp. 4975-4978
    • Romer, J.1    Curran, T.2
  • 23
    • 79960935826 scopus 로고    scopus 로고
    • Hedgehog fights back: Mechanisms of acquired resistance against smoothened antagonists
    • Metcalfe C, de Sauvage FJ. Hedgehog fights back: mechanisms of acquired resistance against smoothened antagonists. Cancer Res. 2011 ; 71 (15). 5057-5061
    • (2011) Cancer Res , vol.71 , Issue.15 , pp. 5057-5061
    • Metcalfe, C.1    De Sauvage, F.J.2
  • 24
    • 70350496540 scopus 로고    scopus 로고
    • Smoothened mutation confers resistance to a hedgehog pathway inhibitor in medulloblastoma
    • Yauch RL, Dijkgraff GJ, Akicke B, et al. Smoothened mutation confers resistance to a hedgehog pathway inhibitor in medulloblastoma. Science. 2009 ; 326 (5952). 572-574
    • (2009) Science , vol.326 , Issue.5952 , pp. 572-574
    • Yauch, R.L.1    Dijkgraff, G.J.2    Akicke, B.3
  • 25
    • 75149180021 scopus 로고    scopus 로고
    • Small-molecule inhibitors of phosphatidylinositol 3-kinase/Akt signaling inhibit Wnt/B-catenin pathway cross-talk and suppress medulloblastoma growth
    • Baryawno N, Sveinbjornsson B, Eksborg S, et al. Small-molecule inhibitors of phosphatidylinositol 3-kinase/Akt signaling inhibit Wnt/B-catenin pathway cross-talk and suppress medulloblastoma growth. Cancer Res. 2010 ; 70 (1). 266-276
    • (2010) Cancer Res , vol.70 , Issue.1 , pp. 266-276
    • Baryawno, N.1    Sveinbjornsson, B.2    Eksborg, S.3
  • 26
    • 77958060845 scopus 로고    scopus 로고
    • Interfering with resistance to smoothened antagonists by inhibition of the PI3 K pathway in medulloblastoma
    • Buonamici S, Williams J, Morrissey M, et al. Interfering with resistance to smoothened antagonists by inhibition of the PI3 K pathway in medulloblastoma. Sci Transl Med. 2010 ; 2 (51). 51-70
    • (2010) Sci Transl Med , vol.2 , Issue.51 , pp. 51-70
    • Buonamici, S.1    Williams, J.2    Morrissey, M.3


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