PCV2 induces apoptosis and modulates calcium homeostasis in piglet lymphocytes in vitro

Research in Veterinary Science

Volumn 93, Issue 3, 2012, Pages 1525-1530

  Lv, Yingjun ^a   Dai, Lei ^a   Han, Huili ^a   Zhang, Shuxia ^a  

^a NANJING AGRICULTURAL UNIVERSITY   (China)

Author keywords

Ca2+ i; Apoptosis; Lymphocyte; Piglet; Porcine circovirus type 2

Indexed keywords

ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE 1; ADENOSINE TRIPHOSPHATE 4; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM ION; CALMODULIN; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR 1; MESSENGER RNA; RYANODINE RECEPTOR 1; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; CELL ASSAY; CHROMATIN CONDENSATION; CHROMOSOME SEGREGATION; CIRCOVIRUS; CONTROLLED STUDY; DNA FRAGMENTATION; ENDOPLASMIC RETICULUM; IN VITRO STUDY; INOCULATION; LEUKOCYTE STRUCTURE; LYMPHOCYTE; MOLECULAR INTERACTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PIGLET; PORCINE CIRCOVIRUS TYPE 2; PROTEIN BINDING;

ANIMALS; CALCIUM; CELLS, CULTURED; CIRCOVIRUS; HOMEOSTASIS; LYMPHOCYTES; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SWINE;

PORCINE CIRCOVIRUS 2;

EID: 84866866594     PISSN: 00345288     EISSN: 15322661     Source Type: Journal    
DOI: 10.1016/j.rvsc.2012.04.003     Document Type: Article

References (23)

1. Allan G.M., McNeilly F., Kennedy S., Daft B., Clarke E.G., Ellis J.A., Haines D.M., Meehan B.M., Adair B.M. Isolation of porcine circovirus-like viruses from pigs with a wasting disease in the USA and Europe. Journal of Veterinary Diagnostic Investigation 1998, 10:3-10.
2. Allan G.M., McNeilly F., Ellis J., Krakowka S., Botner A., McCullough K., Nauwynck H., Kennedy S., Meehan B., Charreyre C. PMWS: experimental model and co-infections. Veterinary Microbiology 2004, 98:165-168.
3. Berridge M.J., Lipp P., Bootman M.D. The versatility and universality of calcium signaling. Nature Reviews Molecular Cell Biology 2000, 1:11-21.
4. Carafoli E. The calcium-signalling saga: tap water and protein crystals. Nature Reviews Molecular Cell Biology 2003, 4:326-332.
5. Chang H.W., Jeng C.R., Lin C.M., Liu J.J., Chang C.C., Tsai Y.C., Chia M.Y., Pang V.F. The involvement of Fas/FasL interaction in porcine circovirus type 2 and porcine reproductive and respiratory syndrome virus co-inoculation-associated lymphocyte apoptosis in vitro. Veterinary Microbiology 2007, 122:72-82.
6. 2+-calpain and caspase-3 dependent pathway. Pharmacological Research 2003, 48:571-578.
7. Government, J.P.P.S. (Ed.), 2008. Administrative Measures for Laboratory Animals in Jiangsu Province. Gazette of Jiangsu province people's government. pp. 10-14.
8. 2+ indicators with greatly improved fluorescence properties. Journal of Biological Chemistry 1985, 260:3440-3450.
9. Hajnóczky G., Davies E., Madesh M. Calcium signaling and apoptosis. Biochemical and Biophysical Research Communications 2003, 304:445-454.
10. Heath-Engel H.M., Shore G.C. Mitochondrial membrane dynamics, cristae remodelling and apoptosis. Biochimica Et Biophysica Acta-Molecular Cell Research 2006, 1763:549-560.
11. Karuppannan A.K., Kwang J. ORF3 of porcine circovirus 2 enhances the in vitro and in vivo spread of the of the virus. Virology 2011, 410:248-256.
12. Kim J., Chae C. Necrotising lymphadenitis associated with porcine circovirus type 2 in pigs. Veterinary Record 2005, 156:177-178.
13. Krakstad C., Herfindal L., Gjersten B.T., Bøe R., Vintermyr O.K., Fladmark K.E., Døskeland S.O. CaM-kinase II -dependent commitment to microcystin-induced apoptosis is coupled to cell budding, but not to shrinkage or chromatin hypercondensation. Cell Death and Differentiation 2006, 13:1191-1202.
14. Liu Y., Templeton D.M. Cadmium activates CaMK-II and initiates CaMK-II-dependent apoptosis in mesangial cells. FEBS Letters 2007, 581:1481-1486.
15. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001, 25:402-408.
16. Mandrioli L., Sarli G., Panarese S., Baldoni S., Marcato P.S. Apoptosis and proliferative activity in lymph node reaction in postweaning multisystemic wasting syndrome (PMWS). Veterinary Immunology and Immunopathology 2004, 97:25-37.
17. 2+ transfer in the control of apoptosis. Oncogene 2008, 27:6407-6418.
18. Segalés J., Domingo M. Postweaning multisystemic wasting syndrome (PMWS) in pigs. A review. The Veterinary Quarterly 2002, 24:109-124.
19. Segalés J., Rosell C., Domingo M. Pathological findings associated with naturally acquired porcine circovirus type 2 associated disease. Veterinary Microbiology 2004, 98:137-149.
20. 2+ signaling is involved in the estradiol-induced breast cancer epithelial cell growth. Molecular Cancer 2010, 9:156.
21. Wang X., Jiang P., Li Y., Jiang W., Dong X. Protection of pigs against post-weaning multisystemic wasting syndrome by a recombinant adenovirus expressing the caspid protein of porcine circovirus type 2. Veterinary Microbiology 2007, 121:215-224.
22. Yoshida S., Yamamura S., Ohoyama K., Nakagawa M., Motomura E., Kaneko S., Okada M. Effect of valproate on neurotransmission associated with ryanodine receptors. Neuroscience Research 2010, 68:322-328.
23. Yu S., Halbur P.G., Thacker E. Effect of porcine circovirus type 2 infection and replication on activated porcine peripheral blood mononuclear cells in vitro. Veterinary Immunology and Immunopathology 2009, 127:350-356.