Arsenite-induced autophagy is associated with proteotoxicity in human lymphoblastoid cells

Toxicology and Applied Pharmacology

Volumn 264, Issue 2, 2012, Pages 255-261

  Bolt, Alicia M ^a   Zhao, Fei ^a   Pacheco, Samantha ^a   Klimecki, Walter T ^a  

^a UNIVERSITY OF ARIZONA   (United States)

Author keywords

Arsenite; Autophagy; ER stress; Lymphoblastoid cell lines; Proteotoxicity

Indexed keywords

ARSENIC TRIOXIDE; ARSENITE SODIUM; GLUCOSE REGULATED PROTEIN 78; PROTEIN P62;

ARTICLE; AUTOPHAGY; CELL LINE; CHOP GENE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; GENE; GENE EXPRESSION; GRP78 GENE; HUMAN; HUMAN CELL; LYMPHOBLASTOID CELL; PROTEIN AGGREGATION; TOXICITY; UNFOLDED PROTEIN RESPONSE;

AMINES; ANALYSIS OF VARIANCE; ARSENITES; AUTOPHAGY; BLOTTING, WESTERN; CELL LINE; CELL PROLIFERATION; ENDOPLASMIC RETICULUM STRESS; HUMANS; INDICATORS AND REAGENTS; LYMPHATIC SYSTEM; LYSOSOMES; MICROARRAY ANALYSIS; PROTEOME; PROTEOSTASIS DEFICIENCIES; RNA; UNFOLDED PROTEIN RESPONSE;

EID: 84866866411     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2012.08.006     Document Type: Article

References (33)

1. Abedin M.J., Wang D., McDonnell M.A., Lehmann U., Kelekar A. Autophagy delays apoptotic death in breast cancer cells following DNA damage. Cell Death Differ. 2007, 14:500-510.
2. Bellot G., Garcia-Medina R., Gounon P., Chiche J., Roux D., Pouyssegur J., Mazure N.M. Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains. Mol. Cell. Biol. 2009, 29:2570-2581.
3. Bjorkoy G., Lamark T., Brech A., Outzen H., Perander M., Overvatn A., Stenmark H., Johansen T. p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J. Cell Biol. 2005, 171:603-614.
4. Bolt A.M., Byrd R.M., Klimecki W.T. Autophagy is the predominant process induced by arsenite in human lymphoblastoid cell lines. Toxicol. Appl. Pharmacol. 2010, 244:366-373.
5. Bolt A.M., Douglas R.M., Klimecki W.T. Arsenite exposure in human lymphoblastoid cell lines induces autophagy and coordinated induction of lysosomal genes. Toxicol. Lett. 2010, 199:153-159.
6. Bush K.T., Goldberg A.L., Nigam S.K. Proteasome inhibition leads to a heat-shock response, induction of endoplasmic reticulum chaperones, and thermotolerance. J. Biol. Chem. 1997, 272:9086-9092.
7. Cline D.J., Thorpe C., Schneider J.P. Effects of As(III) binding on alpha-helical structure. J. Am. Chem. Soc. 2003, 125:2923-2929.
8. Costa C.Z., da Rosa S.E., de Camargo M.M. The unfolded protein response: how protein folding became a restrictive aspect for innate immunity and B lymphocytes. Scand. J. Immunol. 2011, 73:436-448.
9. Ding W.X., Ni H.M., Gao W., Hou Y.F., Melan M.A., Chen X., Stolz D.B., Shao Z.M., Yin X.M. Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival. J. Biol. Chem. 2007, 282:4702-4710.
10. Gregersen N., Bross P. Protein misfolding and cellular stress: an overview. Methods Mol. Biol. 2010, 648:3-23.
11. Harding H.P., Novoa I., Zhang Y., Zeng H., Wek R., Schapira M., Ron D. Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol. Cell 2000, 6:1099-1108.
12. Haze K., Yoshida H., Yanagi H., Yura T., Mori K. Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress. Mol. Biol. Cell 1999, 10:3787-3799.
13. Hiller M.M., Finger A., Schweiger M., Wolf D.H. ER degradation of a misfolded luminal protein by the cytosolic ubiquitin-proteasome pathway. Science 1996, 273:1725-1728.
14. Kaufman R.J., Back S.H., Song B., Han J., Hassler J. The unfolded protein response is required to maintain the integrity of the endoplasmic reticulum, prevent oxidative stress and preserve differentiation in beta-cells. Diabetes Obes. Metab. 2010, 12(Suppl. 2):99-107.
15. Kiffin R., Christian C., Knecht E., Cuervo A.M. Activation of chaperone-mediated autophagy during oxidative stress. Mol. Biol. Cell 2004, 15:4829-4840.
16. Kirkpatrick D.S., Dale K.V., Catania J.M., Gandolfi A.J. Low-level arsenite causes accumulation of ubiquitinated proteins in rabbit renal cortical slices and HEK293 cells. Toxicol. Appl. Pharmacol. 2003, 186:101-109.
17. Kouroku Y., Fujita E., Tanida I., Ueno T., Isoai A., Kumagai H., Ogawa S., Kaufman R.J., Kominami E., Momoi T. ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation. Cell Death Differ. 2007, 14:230-239.
18. Lerner R.S., Nicchitta C.V. mRNA translation is compartmentalized to the endoplasmic reticulum following physiological inhibition of cap-dependent translation. RNA 2006, 12:775-789.
19. Myeku N., Figueiredo-Pereira M.E. Dynamics of the degradation of ubiquitinated proteins by proteasomes and autophagy: association with sequestosome 1/p62. J. Biol. Chem. 2011, 286:22426-22440.
20. Nakagawa I., Amano A., Mizushima N., Yamamoto A., Yamaguchi H., Kamimoto T., Nara A., Funao J., Nakata M., Tsuda K., Hamada S., Yoshimori T. Autophagy defends cells against invading group A Streptococcus. Science 2004, 306:1037-1040.
21. Ogata M., Hino S., Saito A., Morikawa K., Kondo S., Kanemoto S., Murakami T., Taniguchi M., Tanii I., Yoshinaga K., Shiosaka S., Hammarback J.A., Urano F., Imaizumi K. Autophagy is activated for cell survival after endoplasmic reticulum stress. Mol. Cell. Biol. 2006, 26:9220-9231.
22. Onodera J., Ohsumi Y. Autophagy is required for maintenance of amino acid levels and protein synthesis under nitrogen starvation. J. Biol. Chem. 2005, 280:31582-31586.
23. Pankiv S., Clausen T.H., Lamark T., Brech A., Bruun J.A., Outzen H., Overvatn A., Bjorkoy G., Johansen T. p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J. Biol. Chem. 2007, 282:24131-24145.
24. Ramadan D., Rancy P.C., Nagarkar R.P., Schneider J.P., Thorpe C. Arsenic(III) species inhibit oxidative protein folding in vitro. Biochemistry 2009, 48:424-432.
25. Settembre C., Di Malta C., Polito V.A., Garcia Arencibia M., Vetrini F., Erdin S., Erdin S.U., Huynh T., Medina D., Colella P., Sardiello M., Rubinsztein D.C., Ballabio A. TFEB links autophagy to lysosomal biogenesis. Science 2011, 332:1429-1433.
26. Simon R., Lam A., Li M., Ngan M., Menenzes S., Zhao Y. Analysis of gene expression data using BRB-Array Tools. Cancer Inform. 2007, 3:11-17.
27. Taylor G.M., Raghuwanshi S.K., Rowe D.T., Wadowsky R.M., Rosendorff A. Endoplasmic reticulum stress causes EBV lytic replication. Blood 2011, 118:5528-5539.
28. Wanker E.E., Scherzinger E., Heiser V., Sittler A., Eickhoff H., Lehrach H. Membrane filter assay for detection of amyloid-like polyglutamine-containing protein aggregates. Methods Enzymol. 1999, 309:375-386.
29. Xu X., Zhao Y., Simon R. Gene set expression comparison kit for BRB-ArrayTools. Bioinformatics 2008, 24:137-139.
30. Yao T.P. The role of ubiquitin in autophagy-dependent protein aggregate processing. Genes Cancer 2010, 1:779-786.
31. Yorimitsu T., Nair U., Yang Z., Klionsky D.J. Endoplasmic reticulum stress triggers autophagy. J. Biol. Chem. 2006, 281:30299-30304.
32. Zhang Q.Y., Mao J.H., Liu P., Huang Q.H., Lu J., Xie Y.Y., Weng L., Zhang Y., Chen Q., Chen S.J., Chen Z. A systems biology understanding of the synergistic effects of arsenic sulfide and Imatinib in BCR/ABL-associated leukemia. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:3378-3383.
33. Zhou X., Sun X., Cooper K.L., Wang F., Liu K.J., Hudson L.G. Arsenite interacts selectively with zinc finger proteins containing C3H1 or C4 motifs. J. Biol. Chem. 2011, 286:22855-22863.